Physiologie moléculaire et physiopathologie des canaux ioniques – IPMC

Recherche

Intranet

Thème

Physiopathologie moléculaire des phospholipases A2 et de leurs médiateurs

Canaux ioniques et douleur

Membres

Chercheur INSERM

Marie-Emmanuelle KERROS

Nicolas GILBERT

Sylvain FELICIANGELI

Chercheur INSERM

Franck CHATELAIN

Delphine BICHET

Catherine HEURTEAUX

Chercheur émérite

Présentation

Un constituant remarquable des cellules est leur membrane plasmique qui les isole du milieu extracellulaire. Cette membrane est formée de lipides et de protéines qui sont nécessaires à la cellule pour échanger du matériel (ions, nutriments et déchets) et de l’information avec les autres cellules. La majorité des cibles des médicaments actuels sont des protéines de ce type.

L’objectif de l’équipe est d’identifier de nouveaux mécanismes généraux de régulation et de mise en place des protéines de la membrane en prenant comme modèle d’étude une classe particulière de canaux ioniques que nous avons découverts, les canaux potassiques à deux domaines pore (K2P). Un second volet de notre activité est plus directement orienté vers la médecine et a pour but de mieux définir le rôle de ces canaux dans la douleur et dans certaines maladies génétiques associées à des désordres de l’excitabilité des neurones et du développement. Il s’agit à terme d’améliorer le diagnostic et le traitement de ces maladies.

L’équipe est membre du Laboratoire d’excellence Canaux ioniques d’intérêt thérapeutique (LabEx ICST), de la Fédération hospitalo-universitaire FHU Inovpain et du réseau international de recherche IRN Ionic du CNRS.

Événements

F. LESAGE invite le Dr Eric RÖTTINGER

« Marine-related Science at UniCA: The Research Federation MARRES & Nematostella vectensis, a sea anemone to study stress-response, regeneration & longevity«

D. BICHET invite le Dr SHI-Bing YANG

« Insights into the pathogenic mechanism of theTALK1-L114P channel in maturity-onset diabetes of the youngs »

F. LESAGE invite le Dr. Vincent DUSASTRE

« Publishing in High Impact Journals »

Delphine BICHET invite le Pr. Philippe SEGUELA

« Ion channels in pain circuits: from ASICs to the ACC »

Delphine BICHET invite le Dr. Shi-Bing YANG

« Neural Circuit Basis of Social Investigative Behaviour »

Thèse de Nicolas GILBERT

« Rôle des canaux potassiques à deux domaines pore de la famille THIK dans la nociception« Directrice de thèse : Dr […]

Actualités

Publication IPMC / Nature com. / Équipe Lesage

Lien vers Nature Communications Lien vers article CNRS : Comment un canal potassique se transforme en canal sodique Lien vers […]

IPMC / Forum de l'orientation à Antibes

Le samedi 7 décembre, trois établissements scolaires antibois ont organisé, avec leurs associations de parents d’élèves, le Forum de l’Orientation […]

Projets

Implication physiologique et physiopathologique du canal TRAAK.

Description: Le laboratoire s’intéresse aux canaux potassiques de la famille des canaux à deux domaines pores, et plus récemment à […]

Publications

Chatelain FC, Gilbert N, Bichet D, Jauch A, Feliciangeli S, Lesage F, Bignucolo O, Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH., Nat Commun 2024 May; 15(1): 3849.

Oliveira-Mendes BBR, Alameh M, Montnach J, Ollivier B, Gibaud S, Feliciangeli S, Lesage F, Charpentier F, Loussouarn G, De Waard M, Baró I, Predicting hERG repolarization power at 37°C from recordings at room temperature., Clin Transl Med 2023 May; 13(5): e1266.

Landra-Willm A, Karapurkar A, Duveau A, Chassot AA, Esnault L, Callejo G, Bied M, Häfner S, Lesage F, Wdziekonski B, Baron A, Fossat P, Marsollier L, Gasull X, Boué-Grabot E, Kienzler MA, Sandoz G, A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals., Nat Commun 2023 Mar; 14(1): 1160.

Alameh M, Oliveira-Mendes BR, Kyndt F, Rivron J, Denjoy I, Lesage F, Schott JJ, De Waard M, Loussouarn G, A need for exhaustive and standardized characterization of ion channels activity. The case of KV11.1., Front Physiol 2023 ; 14(): 1132533.

Khoubza L, Gilbert N, Kim EJ, Chatelain FC, Feliciangeli S, Abelanet S, Kang D, Lesage F, Bichet D, Alkaline-sensitive two-pore domain potassium channels form functional heteromers in pancreatic β-cells., J Biol Chem 2022 Oct; 298(10): 102447.

C Karwautz, Yx Zhou, Marie-Emmanuelle Kerros, Markus G Weinbauer, C Griebler, Bottom-Up Control of the Groundwater Microbial Food-Web in an Alpine Aquifer, Frontiers in Ecology and Evolution, 2022, 10, ⟨10.3389/fevo.2022.854228⟩.

Glogowska E, Arhatte M, Chatelain FC, Lesage F, Xu A, Grashoff C, Discher DE, Patel A, Honoré E, Piezo1 and Piezo2 foster mechanical gating of K2P channels., Cell Rep 2021 Nov; 37(9): 110070.

Barbara B R Oliveira‐mendes, Sylvain Feliciangeli, Mélissa Ménard, Frank Chatelain, Malak Alameh, Jérôme Montnach, Sébastien Nicolas, Béatrice Ollivier, Julien Barc, Isabelle Baró, Jean-Jacques Schott, Vincent Probst, Florence Kyndt, Isabelle Denjoy, Florian Lesage, Gildas Loussouarn, Michel de Waard, A standardised hERG phenotyping pipeline to evaluate KCNH2 genetic variant pathogenicity, Clinical and Translational Medicine, 2021, 11 (11), ⟨10.1002/ctm2.609⟩.

Luc Bastian, Carlo Mologni, Nathalie Vigier, Germain Bayon, Henry Lamb, Delphine Bosch, Marie-Emmanuelle Kerros, Christophe Colin, Marie Revel, Co-variations of climate and silicate weathering in the Nile Basin during the Late Pleistocene, Quaternary Science Reviews, 2021, 264, pp.107012. ⟨10.1016/j.quascirev.2021.107012⟩.

Pedrotti ML, Petit S, Eyheraguibel B, Kerros ME, Elineau A, Ghiglione JF, Loret JF, Rostan A, Gorsky G, Pollution by anthropogenic microfibers in North-West Mediterranean Sea and efficiency of microfiber removal by a wastewater treatment plant., Sci Total Environ 2021 Mar; 758(): 144195.

Khoubza L, Chatelain FC, Feliciangeli S, Lesage F, Bichet D, Physiological roles of heteromerization: focus on the two-pore domain potassium channels., J Physiol 2021 Feb; 599(4): 1041-1055.

Choveau FS, Ben Soussia I, Bichet D, Chatelain FC, Feliciangeli S, Lesage F, Corrigendum: Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels., Front Pharmacol 2021 ; 12(): 795920.

Choveau FS, Ben Soussia I, Bichet D, Franck CC, Feliciangeli S, Lesage F, Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels., Front Pharmacol 2021 ; 12(): 755826.

Cansell C, Stobbe K, Sanchez C, Le Thuc O, Mosser CA, Ben-Fradj S, Leredde J, Lebeaupin C, Debayle D, Fleuriot L, Brau F, Devaux N, Benani A, Audinat E, Blondeau N, Nahon JL, Rovère C, Dietary fat exacerbates postprandial hypothalamic inflammation involving glial fibrillary acidic protein-positive cells and microglia in male mice., Glia 2021 Jan; 69(1): 42-60.

Lamyaa Khoubza, Franck C Chatelain, Sylvain Feliciangeli, Florian Lesage, Delphine Bichet, Physiological roles of heteromerization: focus on the two-pore domain potassium channels, The Journal of Physiology, 2020.

Busserolles J, Ben Soussia I, Pouchol L, Marie N, Meleine M, Devilliers M, Judon C, Schopp J, Clémenceau L, Poupon L, Chapuy E, Richard S, Noble F, Lesage F, Ducki S, Eschalier A, Lolignier S, TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects., Br J Pharmacol 2020 Oct; 177(20): 4782-4795.

Cooper A, Butto T, Hammer N, Jagannath S, Fend-Guella DL, Akhtar J, Radyushkin K, Lesage F, Winter J, Strand S, Roeper J, Zechner U, Schweiger S, Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome., Nat Commun 2020 Jan; 11(1): 480.

Kedzierski M, Falcou-Préfol M, Kerros ME, Henry M, Pedrotti ML, Bruzaud S, A machine learning algorithm for high throughput identification of FTIR spectra: Application on microplastics collected in the Mediterranean Sea., Chemosphere 2019 Nov; 234(): 242-251.

Ben Soussia I, El Mouridi S, Kang D, Leclercq-Blondel A, Khoubza L, Tardy P, Zariohi N, Gendrel M, Lesage F, Kim EJ, Bichet D, Andrini O, Boulin T, Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels., Nat Commun 2019 Feb; 10(1): 787.

Royal P, Andres-Bilbe A, Ávalos Prado P, Verkest C, Wdziekonski B, Schaub S, Baron A, Lesage F, Gasull X, Levitz J, Sandoz G, Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK., Neuron 2019 Jan; 101(2): 232-245.e6.

Markus G Weinbauer, S Suominen, J Jezbera, Marie-Emmanuelle Kerros, Sophie Marro, John Dolan, K Simek, Shifts in cell size and community composition of bacterioplankton due to grazing by heterotrophic flagellates: evidence from a marine system, Aquatic Microbial Ecology, 2019, 83 (3), pp.295--308. ⟨10.3354/ame01919⟩.

Markus G Weinbauer, Davide Oregioni, Grosskurth, A, Marie Emmanuelle Kerros, T. Harder, Michael Dubow, Jean-Pierre Gattuso, Cornelia Maier, Diversity of bacteria associated with the cold water corals Lophelia pertusa and Madrepora oculata, Mediterranean Cold-Water Corals: Past, Present and Future, 2019.

Inoue M, Matsuoka H, Lesage F, Harada K, Lack of p11 expression facilitates acidity-sensing function of TASK1 channels in mouse adrenal medullary cells., FASEB J 2019 Jan; 33(1): 455-468.

Kedzierski M, Villain J, Falcou-Préfol M, Kerros ME, Henry M, Pedrotti ML, Bruzaud S, Microplastics in Mediterranean Sea: A protocol to robustly assess contamination characteristics., PLoS One 2019 ; 14(2): e0212088.

Maria Luiza Pedrotti, Maria Grazia Mazzocchi, Fabien Lombard, François Galgani, Marie Emmanuelle Kerros, Maryvonne Henry, Amanda Elineau, Stéphanie Petit, María Luz Fernandez-De-Puelles, Stéphane Gasparini, Valentina Tirelli, Jean-Louis Jamet, Gabriel Gorsky, TARA Mediterranean Expedition: Assessing the Impact of Microplastics on Mediterranean Ecosystem, pp.25-29, 2018, ⟨10.1007/978-3-319-71279-6_4⟩.

Ismail Ben Soussia, Frank Choveau, Sandy Blin, Eun-Jin Kim, Sylvain Feliciangeli, Franck Claude Chatelain, Dawon Kang, Delphine Bichet, Florian Lesage, Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels, Frontiers in Molecular Neuroscience, 2018, 11, ⟨10.3389/fnmol.2018.00301⟩.

Luc Bastian, Nathalie Vigier, Stéphanie Reynaud, Marie-Emmanuelle Kerros, Marie Revel, Germain Bayon, Lithium Isotope Composition of Marine Biogenic Carbonates and Related Reference Materials, Geostandards and Geoanalytical Research, 2018, 42 (3), pp.403-415. ⟨10.1111/ggr.12218⟩.

Mathilde Falcou-Préfol, Mikael Kedzierski, Jonathan Villain, Marie Emmanuelle Kerros, Amanda Elineau, Maria Luiza Pedrotti, Stephane Bruzaud, Statistical Methodology for Identifying Microplastic Samples Collected During TARA Mediterranean Campaign, SPRINGER INTERNATIONAL PUBLISHING AG, 2018, ⟨10.1007/978-3-319-71279-6_5⟩.

Schwingshackl A, Lopez B, Teng B, Luellen C, Lesage F, Belperio J, Olcese R, Waters CM, Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins., Am J Physiol Lung Cell Mol Physiol 2017 Dec; 313(6): L1030-L1046.

Buehler PK, Bleiler D, Tegtmeier I, Heitzmann D, Both C, Georgieff M, Lesage F, Warth R, Thomas J, Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice., Respir Physiol Neurobiol 2017 Oct; 244(): 17-25.

Bobak N, Feliciangeli S, Chen CC, Ben Soussia I, Bittner S, Pagnotta S, Ruck T, Biel M, Wahl-Schott C, Grimm C, Meuth SG, Lesage F, Recombinant tandem of pore-domains in a Weakly Inward rectifying K+ channel 2 (TWIK2) forms active lysosomal channels., Sci Rep 2017 Apr; 7(1): 649.

Vivier D, Soussia IB, Rodrigues N, Lolignier S, Devilliers M, Chatelain FC, Prival L, Chapuy E, Bourdier G, Bennis K, Lesage F, Eschalier A, Busserolles J, Ducki S, Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity., J Med Chem 2017 Feb; 60(3): 1076-1088.

Guillaume Bourdin, Frédéric Gazeau, Marie-Emmanuelle Kerros, Sophie Marro, Maria Luiza Pedrotti, Dynamics of transparent exopolymeric particles and their precursors during a mesocosm experiment: Impact of ocean acidification, Estuarine, Coastal and Shelf Science, 2017, 186, pp.112-124. ⟨10.1016/j.ecss.2016.02.007⟩.

Christensen AH, Chatelain FC, Huttner IG, Olesen MS, Soka M, Feliciangeli S, Horvat C, Santiago CF, Vandenberg JI, Schmitt N, Olesen SP, Lesage F, Fatkin D, The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size., J Mol Cell Cardiol 2016 Aug; 97(): 24-35.

Vivier D, Bennis K, Lesage F, Ducki S, Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?, J Med Chem 2016 Jun; 59(11): 5149-57.

Ronjat M, Feng W, Dardevet L, Dong Y, Al Khoury S, Chatelain FC, Vialla V, Chahboun S, Lesage F, Darbon H, Pessah IN, De Waard M, In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide., Proc Natl Acad Sci U S A 2016 Apr; 113(17): E2460-8.

Blin S, Ben Soussia I, Kim EJ, Brau F, Kang D, Lesage F, Bichet D, Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties., Proc Natl Acad Sci U S A 2016 Apr; 113(15): 4200-5.

Feliciangeli S, Chatelain FC, Bichet D, Lesage F, The family of K2P channels: salient structural and functional properties., J Physiol 2015 Jun; 593(12): 2587-603.

Bichet D, Blin S, Feliciangeli S, Chatelain FC, Bobak N, Lesage F, Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2., Pflugers Arch 2015 May; 467(5): 1121-31.

Pereira V, Busserolles J, Christin M, Devilliers M, Poupon L, Legha W, Alloui A, Aissouni Y, Bourinet E, Lesage F, Eschalier A, Lazdunski M, Noël J, Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception., Pain 2014 Dec; 155(12): 2534-2544.

Delphine Bichet, Christophe Duranton, Hélène Hirbec, Stephan Kellenberger, Jean Mérot, Lauriane Ulmann, Fabien van Coppenolle, The 19 th Ion Channel Meeting, September 2008, France, Channels, 2014, 3 (1), pp.69-72. ⟨10.4161/chan.3.1.7777⟩.

Blin S, Chatelain FC, Feliciangeli S, Kang D, Lesage F, Bichet D, Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels., J Biol Chem 2014 Oct; 289(41): 28202-12.

Comoglio Y, Levitz J, Kienzler MA, Lesage F, Isacoff EY, Sandoz G, Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid., Proc Natl Acad Sci U S A 2014 Sep; 111(37): 13547-52.

Chen H, Chatelain FC, Lesage F, Altered and dynamic ion selectivity of K+ channels in cell development and excitability., Trends Pharmacol Sci 2014 Sep; 35(9): 461-9.

Xiao Z, Cilz NI, Kurada L, Hu B, Yang C, Wada E, Combs CK, Porter JE, Lesage F, Lei S, Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer’s disease model., J Neurosci 2014 May; 34(20): 7027-42.

Rodrigues N, Bennis K, Vivier D, Pereira V, C Chatelain F, Chapuy E, Deokar H, Busserolles J, Lesage F, Eschalier A, Ducki S, Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel., Eur J Med Chem 2014 Mar; 75(): 391-402.

Stebe S, Schellig K, Lesage F, Breer H, Fleischer J, The thermosensitive potassium channel TREK-1 contributes to coolness-evoked responses of Grueneberg ganglion neurons., Cell Mol Neurobiol 2014 Jan; 34(1): 113-22.

Chatelain FC, Bichet D, Feliciangeli S, Larroque MM, Braud VM, Douguet D, Lesage F, Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane., J Biol Chem 2013 Dec; 288(49): 35081-92.

Chatelain FC, Mazzuca M, Larroque MM, Rogemond V, Honnorat J, Lesage F, An ion channel chip for diagnosis and prognosis of autoimmune neurological disorders., Recent Pat CNS Drug Discov 2013 Dec; 8(3): 171-9.

Wang S, Benamer N, Zanella S, Kumar NN, Shi Y, Bévengut M, Penton D, Guyenet PG, Lesage F, Gestreau C, Barhanin J, Bayliss DA, TASK-2 channels contribute to pH sensitivity of retrotrapezoid nucleus chemoreceptor neurons., J Neurosci 2013 Oct; 33(41): 16033-44.

Bandulik S, Tauber P, Penton D, Schweda F, Tegtmeier I, Sterner C, Lalli E, Lesage F, Hartmann M, Barhanin J, Warth R, Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system., Endocrinology 2013 Aug; 154(8): 2712-22.

Hao J, Padilla F, Dandonneau M, Lavebratt C, Lesage F, Noël J, Delmas P, Kv1.1 channels act as mechanical brake in the senses of touch and pain., Neuron 2013 Mar; 77(5): 899-914.

Wang W, Putra A, Schools GP, Ma B, Chen H, Kaczmarek LK, Barhanin J, Lesage F, Zhou M, The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartments., Front Cell Neurosci 2013 ; 7(): 246.

Penton D, Bandulik S, Schweda F, Haubs S, Tauber P, Reichold M, Cong LD, El Wakil A, Budde T, Lesage F, Lalli E, Zennaro MC, Warth R, Barhanin J, Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension., Endocrinology 2012 Oct; 153(10): 4740-8.

Tadmouri A, Kiyonaka S, Barbado M, Rousset M, Fablet K, Sawamura S, Bahembera E, Pernet-Gallay K, Arnoult C, Miki T, Sadoul K, Gory-Faure S, Lambrecht C, Lesage F, Akiyama S, Khochbin S, Baulande S, Janssens V, Andrieux A, Dolmetsch R, Ronjat M, Mori Y, De Waard M, Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy., EMBO J 2012 Sep; 31(18): 3730-44.

Chatelain FC, Bichet D, Douguet D, Feliciangeli S, Bendahhou S, Reichold M, Warth R, Barhanin J, Lesage F, TWIK1, a unique background channel with variable ion selectivity., Proc Natl Acad Sci U S A 2012 Apr; 109(14): 5499-504.

Peyronnet R, Sharif-Naeini R, Folgering JH, Arhatte M, Jodar M, El Boustany C, Gallian C, Tauc M, Duranton C, Rubera I, Lesage F, Pei Y, Peters DJ, Somlo S, Sachs F, Patel A, Honoré E, Duprat F, Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels., Cell Rep 2012 Mar; 1(3): 241-50.

Maria Luiza Pedrotti, Sarah Fiorini, Marie-Emmanuelle Kerros, Jack J. Middelburg, Jean-Pierre Gattuso, Variable production of transparent exopolymeric particles by haploid and diploid life stages of coccolithophores grown under different CO2 concentrations, Journal of Plankton Research, 2012, 34 (5), pp.388-398. ⟨10.1093/plankt/fbs012⟩.

Mirkovic K, Palmersheim J, Lesage F, Wickman K, Behavioral characterization of mice lacking Trek channels., Front Behav Neurosci 2012 ; 6(): 60.

Winter C, Kerros ME, Weinbauer MG, Effects of sodium azide on the abundance of prokaryotes and viruses in marine samples., PLoS One 2012 ; 7(5): e37597.

Lesage F, Barhanin J, Molecular physiology of pH-sensitive background K(2P) channels., Physiology (Bethesda) 2011 Dec; 26(6): 424-37.

Martin S, Richier S, Pedrotti ML, Dupont S, Castejon C, Gerakis Y, Kerros ME, Oberhänsli F, Teyssié JL, Jeffree R, Gattuso JP, Early development and molecular plasticity in the Mediterranean sea urchin Paracentrotus lividus exposed to CO2-driven acidification., J Exp Biol 2011 Apr; 214(Pt 8): 1357-68.

Sophie Richier, Sarah Fiorini, Marie-Emmanuelle Kerros, Peter Von Dassow, Jean-Pierre Gattuso, Response of the calcifying coccolithophore Emiliania huxleyi to low pH/high pCO(2): from physiology to molecular level, Marine Biology, 2011, 158 (3), pp.551-560. ⟨10.1007/s00227-010-1580-8⟩.

Noël J, Sandoz G, Lesage F, Molecular regulations governing TREK and TRAAK channel functions., Channels (Austin) 2011 ; 5(5): 402-9.

Richier S, Fiorini S, Kerros ME, von Dassow P, Gattuso JP, Response of the calcifying coccolithophore Emiliania huxleyi to low pH/high pCO2: from physiology to molecular level., Mar Biol 2011 ; 158(3): 551-560.

Patel A, Sharif-Naeini R, Folgering JR, Bichet D, Duprat F, Honoré E, Canonical TRP channels and mechanotransduction: from physiology to disease states., Pflugers Arch 2010 Aug; 460(3): 571-81.

Feliciangeli S, Tardy MP, Sandoz G, Chatelain FC, Warth R, Barhanin J, Bendahhou S, Lesage F, Potassium channel silencing by constitutive endocytosis and intracellular sequestration., J Biol Chem 2010 Feb; 285(7): 4798-805.

Christian Gestreau, Dirk Heitzmann, Joerg Thomas, V. Dubreuil, Sascha Bandulik, Markus Reichold, Saïd Bendahhou, Patricia Pierson, Christina Sterner, Julie Peyronnet-Roux, Chérif Benfriha, Ines Tegtmeier, Hannah Ehnes, Michael Georgieff, Florian Lesage, Jean-Francois Brunet, Christo Goridis, Richard Warth, Jacques Barhanin, Task2 potassium channels set central respiratory CO 2 and O 2 sensitivity, Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (5), pp.2325-2330. ⟨10.1073/pnas.0910059107⟩.

Markus G Weinbauer, M. E. Kerros, C. Motegi, I. C. Wilhartitz, F. Rassoulzadegan, J. P. Torreton, Xavier Mari, Bacterial community composition and potential controlling mechanisms along a trophic gradient in a barrier reef system, Aquatic Microbial Ecology, 2010, 60 (1), pp.15-28. ⟨10.3354/ame01411⟩.

Sharif-Naeini R, Folgering JH, Bichet D, Duprat F, Delmas P, Patel A, Honoré E, Sensing pressure in the cardiovascular system: Gq-coupled mechanoreceptors and TRP channels., J Mol Cell Cardiol 2010 Jan; 48(1): 83-9.

Sharif-Naeini R, Folgering JH, Bichet D, Duprat F, Lauritzen I, Arhatte M, Jodar M, Dedman A, Chatelain FC, Schulte U, Retailleau K, Loufrani L, Patel A, Sachs F, Delmas P, Peters DJ, Honoré E, Polycystin-1 and -2 dosage regulates pressure sensing., Cell 2009 Oct; 139(3): 587-96.

Barbier-Chassefière V, Garcia-Filipe S, Yue XL, Kerros ME, Petit E, Kern P, Saffar JL, Papy-Garcia D, Caruelle JP, Barritault D, Matrix therapy in regenerative medicine, a new approach to chronic wound healing., J Biomed Mater Res A 2009 Sep; 90(3): 641-7.

Sandoz G, Douguet D, Chatelain F, Lazdunski M, Lesage F, Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue., Proc Natl Acad Sci U S A 2009 Aug; 106(34): 14628-33.

M.-L. Pedrotti, Sophie Beauvais, Marie-Emmanuelle Kerros, K. Iversen, F. Peters, Bacterial colonization of transparent exopolymeric particles in mesocosms under different turbulence intensities and nutrient conditions, Aquatic Microbial Ecology, 2009, 55 (3), pp.301-312. ⟨10.3354/ame01308⟩.

Richier S, Kerros ME, de Vargas C, Haramaty L, Falkowski PG, Gattuso JP, Light-dependent transcriptional regulation of genes of biogeochemical interest in the diploid and haploid life cycle stages of Emiliania huxleyi., Appl Environ Microbiol 2009 May; 75(10): 3366-9.

Guyon A, Tardy MP, Rovère C, Nahon JL, Barhanin J, Lesage F, Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels., J Neurosci 2009 Feb; 29(8): 2528-33.

Christian Winter, Marie-Emmanuelle Kerros, Markus G Weinbauer, Seasonal changes of bacterial and archaeal communities in the dark ocean: Evidence from the Mediterranean Sea, Limnology and Oceanography, 2009, 54 (1), pp.160-170. ⟨10.4319/lo.2009.54.1.0160⟩.

O. Bonilla-Findji, Emma Rochelle Newall, Markus G Weinbauer, M.D. Pizay, M.E. Kerros, Jean-Pierre Gattuso, Effect of seawater-freshwater cross-transplantations on viral dynamics and bacterial diversity and production, Aquatic Microbial Ecology, 2009, 54 (1), pp.1-11. ⟨10.3354/ame01256⟩.

C. Winter, M. E. Kerros, Markus G Weinbauer, Seasonal and depth-related dynamics of prokaryotes and viruses in surface and deep waters of the northwestern Mediterranean Sea, Deep Sea Research Part I: Oceanographic Research Papers, 2009, 56 (11), pp.1972-1982.

Bichet D, Duranton C, Hirbec H, Kellenberger S, Mérot J, Ulmann L, Van Coppenolle F, The 19th Ion Channel Meeting. September 2008, France., Channels (Austin) 2009 ; 3(1): 69-72.

Sandoz G, Tardy MP, Thümmler S, Feliciangeli S, Lazdunski M, Lesage F, Mtap2 is a constituent of the protein network that regulates twik-related K+ channel expression and trafficking., J Neurosci 2008 Aug; 28(34): 8545-52.

Philip Gottlieb, Joost Folgering, Rosario Maroto, Albert Raso, Thomas G Wood, Alex Kurosky, Charles Bowman, Delphine Bichet, Amanda Patel, Frederick Sachs, Boris Martinac, Owen P Hamill, Eric Honoré, Revisiting TRPC1 and TRPC6 mechanosensitivity., Pflügers Archiv European Journal of Physiology, 2008, 455 (6), pp.1097-103. ⟨10.1007/s00424-007-0359-3⟩.

Gottlieb P, Folgering J, Maroto R, Raso A, Wood TG, Kurosky A, Bowman C, Bichet D, Patel A, Sachs F, Martinac B, Hamill OP, Honoré E, Revisiting TRPC1 and TRPC6 mechanosensitivity., Pflugers Arch 2008 Mar; 455(6): 1097-103.

Heitzmann D, Derand R, Jungbauer S, Bandulik S, Sterner C, Schweda F, El Wakil A, Lalli E, Guy N, Mengual R, Reichold M, Tegtmeier I, Bendahhou S, Gomez-Sanchez CE, Aller MI, Wisden W, Weber A, Lesage F, Warth R, Barhanin J, Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis., EMBO J 2008 Jan; 27(1): 179-87.

Sandoz G, Lesage F, Protein complex analysis of native brain potassium channels by proteomics., Methods Mol Biol 2008 ; 491(): 113-23.

Ouidja MO, Petit E, Kerros ME, Ikeda Y, Morin C, Carpentier G, Barritault D, Brugère-Picoux J, Deslys JP, Adjou K, Papy-Garcia D, Structure-activity studies of heparan mimetic polyanions for anti-prion therapies., Biochem Biophys Res Commun 2007 Nov; 363(1): 95-100.

Mohand-Ouidir Ouidja, Emmanuel Petit, Marie-Emmanuelle Kerros, Yasunori Ikeda, Christophe Morin, Gilles Carpentier, Denis Barritault, Jeanne Brugère-Picoux, Jean-Philippe Deslys, Karim Adjou, Dulce Papy-Garcia, Structure–activity studies of heparan mimetic polyanions for anti-prion therapies, Biochemical and Biophysical Research Communications, 2007, 363 (1), pp.95-100. ⟨10.1016/j.bbrc.2007.08.113⟩.

Xavier Mari, M.-E. Kerros, Markus G Weinbauer, Virus Attachment to Transparent Exopolymeric Particles along Trophic Gradients in the Southwestern Lagoon of New Caledonia, Applied and Environmental Microbiology, 2007, 73 (16), pp.5245-5252. ⟨10.1128/AEM.00762-07⟩.

Feliciangeli S, Bendahhou S, Sandoz G, Gounon P, Reichold M, Warth R, Lazdunski M, Barhanin J, Lesage F, Does sumoylation control K2P1/TWIK1 background K+ channels?, Cell 2007 Aug; 130(3): 563-9.

Mari X, Kerros ME, Weinbauer MG, Virus attachment to transparent exopolymeric particles along trophic gradients in the southwestern lagoon of New Caledonia., Appl Environ Microbiol 2007 Aug; 73(16): 5245-52.

S. Garcia-Filipe, V. Barbier-Chassefiere, C. Alexakis, E. Huet, D. Ledoux, M. Kerros, E. Petit, D. Barritault, J. Caruelle, P. Kern, RGTA OTR4120, a heparan sulfate mimetic, is a possible long-term active agent to heal burned skin, Journal of Biomedical Materials Research Part A, 2007, 80A (1), pp.75-84. ⟨10.1002/jbm.a.30874⟩.

Garcia-Filipe S, Barbier-Chassefiere V, Alexakis C, Huet E, Ledoux D, Kerros ME, Petit E, Barritault D, Caruelle JP, Kern P, RGTA OTR4120, a heparan sulfate mimetic, is a possible long-term active agent to heal burned skin., J Biomed Mater Res A 2007 Jan; 80(1): 75-84.

Sandoz G, Thümmler S, Duprat F, Feliciangeli S, Vinh J, Escoubas P, Guy N, Lazdunski M, Lesage F, AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels., EMBO J 2006 Dec; 25(24): 5864-72.

Delphine Bichet, Dorien Peters, Amanda Jane Patel, Patrick Delmas, Eric Honoré, Cardiovascular Polycystins: Insights From Autosomal Dominant Polycystic Kidney Disease and Transgenic Animal Models, Trends in Cardiovascular Medicine, 2006, 16 (8), pp.292-298. ⟨10.1016/j.tcm.2006.07.002⟩.

Bichet D, Peters D, Patel AJ, Delmas P, Honoré E, Cardiovascular polycystins: insights from autosomal dominant polycystic kidney disease and transgenic animal models., Trends Cardiovasc Med 2006 Nov; 16(8): 292-8.

Zanzouri M, Lauritzen I, Duprat F, Mazzuca M, Lesage F, Lazdunski M, Patel A, Membrane potential-regulated transcription of the resting K+ conductance TASK-3 via the calcineurin pathway., J Biol Chem 2006 Sep; 281(39): 28910-8.

Bichet D, Grabe M, Jan YN, Jan LY, Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity., Proc Natl Acad Sci U S A 2006 Sep; 103(39): 14355-60.

Grabe M, Bichet D, Qian X, Jan YN, Jan LY, K+ channel selectivity depends on kinetic as well as thermodynamic factors., Proc Natl Acad Sci U S A 2006 Sep; 103(39): 14361-6.

D. Bichet, D. Peters, Patel Aj, P. Delmas, E. Honore, Cardiovascular Polycystins: Insights From Autosomal Dominant Polycystic Kidney Disease and Transgenic Animal Models., Trends in Cardiovascular Medicine, 2006, 16 (8), pp.292-298.

S. Garcia-Filipe, V. Barbier-Chassefiere, C. Alexakis, E. Huet, D. Ledoux, Me Kerros, E. Petit, D. Barritault, Jp Caruelle, P. Kern, RGTA OTR4120, a heparan sulfate mimetic, is a possible long-term active agent to heal burned skin., Journal of Biomedical Materials Research Part A, 2006, Epub ahead of print.

Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S, International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels., Pharmacol Rev 2005 Dec; 57(4): 527-40.

Ebensperger G, Ebensperger R, Herrera EA, Riquelme RA, Sanhueza EM, Lesage F, Marengo JJ, Tejo RI, Llanos AJ, Reyes RV, Fetal brain hypometabolism during prolonged hypoxaemia in the llama., J Physiol 2005 Sep; 567(Pt 3): 963-75.

Vamecq J, Vallée L, Lesage F, Gressens P, Stables JP, Antiepileptic popular ketogenic diet: emerging twists in an ancient story., Prog Neurobiol 2005 Jan; 75(1): 1-28.

Christophe Morin, Mohand-Ouidir Ouidja, Emmanuel Petit, Marie-Emmanuelle Kerros, Yasunori Ikeda, Gilles Carpentier, Denis Barritault, Jeanne Brugère-Picoux, Jean-Philippe Deslys, Karim Adjou, Dulce Papy-Garcia, Isabelle Barbosa, Stephanie Garcia, Arlette Duchesnay, Mustapha Oudghir, Guido Jenniskens, Hua-Quan Miao, Scott Guimond, José Cebrian, Jean-Pierre Caruelle, Toin E van Kuppevelt, Jeremy E Turnbull, Isabelle Martelly, A synthetic glycosaminoglycan mimetic (RGTA) modifies natural glycosaminoglycan species during myogenesis, Journal of Cell Science, 2004, 118, pp.253 - 264. ⟨10.1242/jcs.01607⟩.

Decressac S, Franco M, Bendahhou S, Warth R, Knauer S, Barhanin J, Lazdunski M, Lesage F, ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6., EMBO Rep 2004 Dec; 5(12): 1171-5.

Nicolas MT, Lesage F, Reyes R, Barhanin J, Demêmes D, Localization of TREK-1, a two-pore-domain K+ channel in the peripheral vestibular system of mouse and rat., Brain Res 2004 Aug; 1017(1-2): 46-52.

Warth R, Barrière H, Meneton P, Bloch M, Thomas J, Tauc M, Heitzmann D, Romeo E, Verrey F, Mengual R, Guy N, Bendahhou S, Lesage F, Poujeol P, Barhanin J, Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport., Proc Natl Acad Sci U S A 2004 May; 101(21): 8215-20.

Girard C, Lesage F, [Neuronal background two-P-domain potassium channels: molecular and functional aspects]., Med Sci (Paris) 2004 May; 20(5): 544-9.

Sandoz G, Lopez-Gonzalez I, Grunwald D, Bichet D, Altafaj X, Weiss N, Ronjat M, Dupuis A, De Waard M, Cavbeta-subunit displacement is a key step to induce the reluctant state of P/Q calcium channels by direct G protein regulation., Proc Natl Acad Sci U S A 2004 Apr; 101(16): 6267-72.

Bichet D, Lin YF, Ibarra CA, Huang CS, Yi BA, Jan YN, Jan LY, Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity., Proc Natl Acad Sci U S A 2004 Mar; 101(13): 4441-6.

Lesage F, Hibino H, Hudspeth AJ, Association of beta-catenin with the alpha-subunit of neuronal large-conductance Ca2+-activated K+ channels., Proc Natl Acad Sci U S A 2004 Jan; 101(2): 671-5.

Delphine Bichet, Friederike Haass, Lily Yeh Jan, Merging functional studies with structures of inward-rectifier K+ channels, Nature Reviews Neuroscience, 2003, 4 (12), pp.957-967. ⟨10.1038/nrn1244⟩.

Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS, International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels., Pharmacol Rev 2003 Dec; 55(4): 583-6.

Bichet D, Haass FA, Jan LY, Merging functional studies with structures of inward-rectifier K(+) channels., Nat Rev Neurosci 2003 Dec; 4(12): 957-67.

Chemin J, Girard C, Duprat F, Lesage F, Romey G, Lazdunski M, Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels., EMBO J 2003 Oct; 22(20): 5403-11.

Barriere H, Belfodil R, Rubera I, Tauc M, Lesage F, Poujeol C, Guy N, Barhanin J, Poujeol P, Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules., J Gen Physiol 2003 Aug; 122(2): 177-90.

Magloire H, Lesage F, Couble ML, Lazdunski M, Bleicher F, Expression and localization of TREK-1 K+ channels in human odontoblasts., J Dent Res 2003 Jul; 82(7): 542-5.

Hibino H, Pironkova R, Onwumere O, Rousset M, Charnet P, Hudspeth AJ, Lesage F, Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit., Proc Natl Acad Sci U S A 2003 Jan; 100(1): 307-12.

Lesage F, Pharmacology of neuronal background potassium channels., Neuropharmacology 2003 Jan; 44(1): 1-7.

Veronique Cornet, Delphine Bichet, Guillaume Sandoz, Isabelle Marty, Jacques Brocard, Emmanuel Bourinet, Yasuo Mori, Michel Villaz, Michel de Waard, Multiple determinants in voltage-dependent P/Q calcium channels control their retention in the endoplasmic reticulum, European Journal of Neuroscience, 2002, 16 (5), pp.883-895. ⟨10.1046/j.1460-9568.2002.02168.x⟩.

Cornet V, Bichet D, Sandoz G, Marty I, Brocard J, Bourinet E, Mori Y, Villaz M, De Waard M, Multiple determinants in voltage-dependent P/Q calcium channels control their retention in the endoplasmic reticulum., Eur J Neurosci 2002 Sep; 16(5): 883-95.

Bernard-Pierrot I, Delbé J, Rouet V, Vigny M, Kerros ME, Caruelle D, Raulais D, Barritault D, Courty J, Milhiet PE, Dominant negative effectors of heparin affin regulatory peptide (HARP) angiogenic and transforming activities., J Biol Chem 2002 Aug; 277(35): 32071-7.

Hibino H, Pironkova R, Onwumere O, Vologodskaia M, Hudspeth AJ, Lesage F, RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels., Neuron 2002 Apr; 34(3): 411-23.

Geib S, Sandoz G, Cornet V, Mabrouk K, Fund-Saunier O, Bichet D, Villaz M, Hoshi T, Sabatier JM, De Waard M, The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a beta -dependent manner., J Biol Chem 2002 Mar; 277(12): 10003-13.

Sandrine Geib, Guillaume Sandoz, Véronique Cornet, Kamel Mabrouk, Odile Fund-Saunier, Delphine Bichet, Michel Villaz, Toshinori Hoshi, Jean-Marc Sabatier, Michel de Waard, The Interaction between the I-II Loop and the III-IV Loop of Cav2.1 Contributes to Voltage-dependent Inactivation in a β-Dependent Manner, Journal of Biological Chemistry, 2002, 277 (12), pp.10003-10013. ⟨10.1074/jbc.M106231200⟩.

Soulié P, Héroult M, Bernard I, Kerros ME, Milhiet PE, Delbé J, Barritault D, Caruelle D, Courty J, Immunoassay for measuring the heparin-binding growth factors HARP and MK in biological fluids., J Immunoassay Immunochem 2002 ; 23(1): 33-48.

Guillaume Sandoz, Delphine Bichet, Veronique Cornet, Yasuo Mori, Ricardo Felix, Michel de Waard, Distinct properties and differential β subunit regulation of two C-terminal isoforms of the P/Q-type Ca 2+ -channel α 1A subunit, European Journal of Neuroscience, 2001, 14 (6), pp.987-997. ⟨10.1046/j.0953-816x.2001.01728.x⟩.

Terrenoire C, Lauritzen I, Lesage F, Romey G, Lazdunski M, A TREK-1-like potassium channel in atrial cells inhibited by beta-adrenergic stimulation and activated by volatile anesthetics., Circ Res 2001 Aug; 89(4): 336-42.

Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F, Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels., Biochem Biophys Res Commun 2001 Mar; 282(1): 249-56.

Delphine Bichet, Catherine Lecomte, Jean-Marc Sabatier, Ricardo Felix, Michel de Waard, Reversibility of the Ca2+ Channel α1–β Subunit Interaction, Biochemical and Biophysical Research Communications, 2000, 277 (3), pp.729-735. ⟨10.1006/bbrc.2000.3750⟩.

Lesage F, Lazdunski M, Molecular and functional properties of two-pore-domain potassium channels., Am J Physiol Renal Physiol 2000 Nov; 279(5): F793-801.

Lesage F, Terrenoire C, Romey G, Lazdunski M, Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors., J Biol Chem 2000 Sep; 275(37): 28398-405.

Ziad Fajloun, Edmond Carlier, Catherine Lecomte, Sandrine Geib, Eric Di Luccio, Delphine Bichet, Kamel Mabrouk, Hervé Rochat, Michel de Waard, Jean-Marc Sabatier, Chemical synthesis and characterization of Pi1, a scorpion toxin from Pandinus imperator active on K+ channels, European Journal of Biochemistry, 2000, 267 (16), pp.5149-5155. ⟨10.1046/j.1432-1327.2000.01577.x⟩.

Maingret F, Lauritzen I, Patel AJ, Heurteaux C, Reyes R, Lesage F, Lazdunski M, Honoré E, TREK-1 is a heat-activated background K(+) channel., EMBO J 2000 Jun; 19(11): 2483-91.

Andrew Escayg, Michel de Waard, David Lee, Delphine Bichet, Peter Wolf, Thomas Mayer, Janine Johnston, Robert Baloh, Thomas Sander, Miriam Meisler, Coding and Noncoding Variation of the Human Calcium-Channel β4-Subunit Gene CACNB4 in Patients with Idiopathic Generalized Epilepsy and Episodic Ataxia, American Journal of Human Genetics, 2000, 66 (5), pp.1531-1539. ⟨10.1086/302909⟩.

Duprat F, Lesage F, Patel AJ, Fink M, Romey G, Lazdunski M, The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK., Mol Pharmacol 2000 May; 57(5): 906-12.

Lesage F, Maingret F, Lazdunski M, Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel., FEBS Lett 2000 Apr; 471(2-3): 137-40.

Maingret F, Patel AJ, Lesage F, Lazdunski M, Honoré E, Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK., J Biol Chem 2000 Apr; 275(14): 10128-33.

Bearzatto B, Lesage F, Reyes R, Lazdunski M, Laduron PM, Axonal transport of TREK and TRAAK potassium channels in rat sciatic nerves., Neuroreport 2000 Apr; 11(5): 927-30.

Z. Fajloun, R. Kharrat, Lin Chen, C. Lecomte, E. Di Luccio, D. Bichet, M. El Ayeb, H. Rochat, P Danny Allen, I.N. Pessah, M. de Waard, J.M Sabatier, Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca 2+ release channel/ryanodine receptors, FEBS Letters, 2000, 469 (2-3), pp.179-185. ⟨10.1016/S0014-5793(00)01239-4⟩.

Delphine Bichet, Véronique Cornet, Sandrine Geib, Edmond Carlier, Stephen Volsen, Toshi Hoshi, Yasuo Mori, Michel de Waard, The I-II Loop of the Ca 2+ Channel α 1 Subunit Contains an Endoplasmic Reticulum Retention Signal Antagonized by the β Subunit, Neuron, 2000, 25 (1), pp.177-190. ⟨10.1016/s0896-6273(00)80881-8⟩.

Reyes R, Lauritzen I, Lesage F, Ettaiche M, Fosset M, Lazdunski M, Immunolocalization of the arachidonic acid and mechanosensitive baseline traak potassium channel in the nervous system., Neuroscience 2000 ; 95(3): 893-901.

Maingret F, Patel AJ, Lesage F, Lazdunski M, Honoré E, Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel., J Biol Chem 1999 Sep; 274(38): 26691-6.

Patel AJ, Honoré E, Lesage F, Fink M, Romey G, Lazdunski M, Inhalational anesthetics activate two-pore-domain background K+ channels., Nat Neurosci 1999 May; 2(5): 422-6.

Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M, Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure., J Biol Chem 1999 Apr; 274(17): 11751-60.

Denise Walker, Delphine Bichet, Sandrine Geib, Emiko Mori, Véronique Cornet, Terry Snutch, Yasuo Mori, Michel de Waard, A New β Subtype-specific Interaction in α1ASubunit Controls P/Q-type Ca2+ Channel Activation, Journal of Biological Chemistry, 1999, 274 (18), pp.12383-12390. ⟨10.1074/jbc.274.18.12383⟩.

Maingret F, Fosset M, Lesage F, Lazdunski M, Honoré E, TRAAK is a mammalian neuronal mechano-gated K+ channel., J Biol Chem 1999 Jan; 274(3): 1381-7.

Cécile Raymond, Bichet Delphine, Iborra Cecile, Martin-Moutot Nicole, Seagar Machael, Michel Dewaard, Antibodies against the beta subunit of voltage-dependent calcium channels in Lambert-Eaton myasthenic syndrome, Neuroscience, 1999, 90 (1), pp.269-277.

Cluzeaud F, Reyes R, Escoubet B, Fay M, Lazdunski M, Bonvalet JP, Lesage F, Farman N, Expression of TWIK-1, a novel weakly inward rectifying potassium channel in rat kidney., Am J Physiol 1998 Dec; 275(6): C1602-9.

Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M, Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney., J Biol Chem 1998 Nov; 273(47): 30863-9.

Patel AJ, Honoré E, Maingret F, Lesage F, Fink M, Duprat F, Lazdunski M, A mammalian two pore domain mechano-gated S-like K+ channel., EMBO J 1998 Aug; 17(15): 4283-90.

Lesage F, Lazdunski M, Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23., Genomics 1998 Aug; 51(3): 478-9.

Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M, A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids., EMBO J 1998 Jun; 17(12): 3297-308.

Denise Walker, Delphine Bichet, Kevin Campbell, Michel de Waard, A β4 Isoform-specific Interaction Site in the Carboxyl-terminal Region of the Voltage-dependent Ca2+ Channel α1A Subunit, Journal of Biological Chemistry, 1998, 273 (4), pp.2361-2367. ⟨10.1074/jbc.273.4.2361⟩.

Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M, TASK, a human background K+ channel to sense external pH variations near physiological pH., EMBO J 1997 Sep; 16(17): 5464-71.

Murer G, Adelbrecht C, Lauritzen I, Lesage F, Lazdunski M, Agid Y, Raisman-Vozari R, An immunocytochemical study on the distribution of two G-protein-gated inward rectifier potassium channels (GIRK2 and GIRK4) in the adult rat brain., Neuroscience 1997 Sep; 80(2): 345-57.

Lauritzen I, De Weille J, Adelbrecht C, Lesage F, Murer G, Raisman-Vozari R, Lazdunski M, Comparative expression of the inward rectifier K+ channel GIRK2 in the cerebellum of normal and weaver mutant mice., Brain Res 1997 Apr; 753(1): 8-17.

Salinas M, de Weille J, Guillemare E, Lazdunski M, Hugnot JP, Modes of regulation of shab K+ channel activity by the Kv8.1 subunit., J Biol Chem 1997 Mar; 272(13): 8774-80.

Lesage F, Lauritzen I, Duprat F, Reyes R, Fink M, Heurteaux C, Lazdunski M, The structure, function and distribution of the mouse TWIK-1 K+ channel., FEBS Lett 1997 Jan; 402(1): 28-32.

Fink M, Duprat F, Lesage F, Reyes R, Romey G, Heurteaux C, Lazdunski M, Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel., EMBO J 1996 Dec; 15(24): 6854-62.

Lesage F, Reyes R, Fink M, Duprat F, Guillemare E, Lazdunski M, Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge., EMBO J 1996 Dec; 15(23): 6400-7.

Vetter DE, Mann JR, Wangemann P, Liu J, McLaughlin KJ, Lesage F, Marcus DC, Lazdunski M, Heinemann SF, Barhanin J, Inner ear defects induced by null mutation of the isk gene., Neuron 1996 Dec; 17(6): 1251-64.

Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M, Romey G, K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current., Nature 1996 Nov; 384(6604): 78-80.

Fink M, Duprat F, Lesage F, Heurteaux C, Romey G, Barhanin J, Lazdunski M, A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression., J Biol Chem 1996 Oct; 271(42): 26341-8.

Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattéi MG, Lazdunski M, Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels., EMBO J 1996 Jul; 15(13): 3322-31.

Lesage F, Mattéi M, Fink M, Barhanin J, Lazdunski M, Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43., Genomics 1996 May; 34(1): 153-5.

Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J, TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure., EMBO J 1996 Mar; 15(5): 1004-11.

Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J, A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties., J Biol Chem 1996 Feb; 271(8): 4183-7.

Fink M, Duprat F, Heurteaux C, Lesage F, Romey G, Barhanin J, Lazdunski M, Dominant negative chimeras provide evidence for homo and heteromultimeric assembly of inward rectifier K+ channel proteins via their N-terminal end., FEBS Lett 1996 Jan; 378(1): 64-8.

Duprat F, Guillemare E, Romey G, Fink M, Lesage F, Lazdunski M, Honore E, Susceptibility of cloned K+ channels to reactive oxygen species., Proc Natl Acad Sci U S A 1995 Dec; 92(25): 11796-800.

Lesage F, Guillemare E, Fink M, Duprat F, Heurteaux C, Fosset M, Romey G, Barhanin J, Lazdunski M, Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels., J Biol Chem 1995 Dec; 270(48): 28660-7.

Lesage F, Fink M, Barhanin J, Lazdunski M, Mattéi MG, Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23., Genomics 1995 Oct; 29(3): 808-9.

Duprat F, Lesage F, Guillemare E, Fink M, Hugnot JP, Bigay J, Lazdunski M, Romey G, Barhanin J, Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers., Biochem Biophys Res Commun 1995 Jul; 212(2): 657-63.

Lesage F, Duprat F, Fink M, Guillemare E, Coppola T, Lazdunski M, Hugnot JP, Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain., FEBS Lett 1994 Oct; 353(1): 37-42.

Lesage F, Hugnot JP, Amri EZ, Grimaldi P, Barhanin J, Lazdunski M, Expression cloning in K+ transport defective yeast and distribution of HBP1, a new putative HMG transcriptional regulator., Nucleic Acids Res 1994 Sep; 22(18): 3685-8.

Honoré E, Guillemare E, Lesage F, Barhanin J, Lazdunski M, Injection of a K+ channel (Kv1.3) cRNA in fertilized eggs leads to functional expression in cultured myotomal muscle cells from Xenopus embryos., FEBS Lett 1994 Jul; 348(3): 259-62.

Honoré E, Barhanin J, Attali B, Lesage F, Lazdunski M, External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids., Proc Natl Acad Sci U S A 1994 Mar; 91(5): 1937-41.

Attali B, Lesage F, Ziliani P, Guillemare E, Honoré E, Waldmann R, Hugnot JP, Mattéi MG, Lazdunski M, Barhanin J, Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel., J Biol Chem 1993 Nov; 268(32): 24283-9.

Attali B, Guillemare E, Lesage F, Honoré E, Romey G, Lazdunski M, Barhanin J, The protein IsK is a dual activator of K+ and Cl- channels., Nature 1993 Oct; 365(6449): 850-2.

Chevillard C, Attali B, Lesage F, Fontes M, Barhanin J, Lazdunski M, Mattei MG, Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in situ hybridization and somatic cell hybridization., Genomics 1993 Jan; 15(1): 243-5.

Lesage F, Attali B, Lakey J, Honoré E, Romey G, Faurobert E, Lazdunski M, Barhanin J, Are Xenopus oocytes unique in displaying functional IsK channel heterologous expression?, Recept Channels 1993 ; 1(2): 143-52.

Guillemare E, Honoré E, Pradier L, Lesage F, Schweitz H, Attali B, Barhanin J, Lazdunski M, Effects of the level of mRNA expression on biophysical properties, sensitivity to neurotoxins, and regulation of the brain delayed-rectifier K+ channels Kv1.2., Biochemistry 1992 Dec; 31(49): 12463-8.

Lesage F, Attali B, Lazdunski M, Barhanin J, Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells., FEBS Lett 1992 Sep; 310(2): 162-6.

Honoré E, Attali B, Romey G, Lesage F, Barhanin J, Lazdunski M, Different types of K+ channel current are generated by different levels of a single mRNA., EMBO J 1992 Jul; 11(7): 2465-71.

Attali B, Honoré E, Lesage F, Lazdunski M, Barhanin J, Regulation of a major cloned voltage-gated K+ channel from human T lymphocytes., FEBS Lett 1992 Jun; 303(2-3): 229-32.

Honore E, Attali B, Lesage F, Barhanin J, Lazdunski M, Receptor-mediated regulation of IsK, a very slowly activating, voltage-dependent K+ channel in Xenopus oocytes., Biochem Biophys Res Commun 1992 May; 184(3): 1135-41.

Attali B, Romey G, Honoré E, Schmid-Alliana A, Mattéi MG, Lesage F, Ricard P, Barhanin J, Lazdunski M, Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes., J Biol Chem 1992 Apr; 267(12): 8650-7.

Lesage F, Attali B, Lazdunski M, Barhanin J, ISK, a slowly activating voltage-sensitive K+ channel. Characterization of multiple cDNAs and gene organization in the mouse., FEBS Lett 1992 Apr; 301(2): 168-72.

Honoré E, Attali B, Romey G, Heurteaux C, Ricard P, Lesage F, Lazdunski M, Barhanin J, Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart., EMBO J 1991 Oct; 10(10): 2805-11.