Delphine BICHET

Le samedi 7 décembre, trois établissements scolaires antibois ont organisé, avec leurs associations de parents d’élèves, le Forum de l’Orientation […]

Projets

Projet

2025

Implication physiologique et physiopathologique du canal TRAAK.

Description: Le laboratoire s’intéresse aux canaux potassiques de la famille des canaux à deux domaines pores, et plus récemment à […]

Publications

2024

Chatelain FC, Gilbert N, Bichet D, Jauch A, Feliciangeli S, Lesage F, Bignucolo O, Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH., Nat Commun 2024 May; 15(1): 3849.

2022

Khoubza L, Gilbert N, Kim EJ, Chatelain FC, Feliciangeli S, Abelanet S, Kang D, Lesage F, Bichet D, Alkaline-sensitive two-pore domain potassium channels form functional heteromers in pancreatic β-cells., J Biol Chem 2022 Oct; 298(10): 102447.

2021

Khoubza L, Chatelain FC, Feliciangeli S, Lesage F, Bichet D, Physiological roles of heteromerization: focus on the two-pore domain potassium channels., J Physiol 2021 Feb; 599(4): 1041-1055.

2021

Choveau FS, Ben Soussia I, Bichet D, Chatelain FC, Feliciangeli S, Lesage F, Corrigendum: Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels., Front Pharmacol 2021 ; 12(): 795920.

2021

Choveau FS, Ben Soussia I, Bichet D, Franck CC, Feliciangeli S, Lesage F, Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels., Front Pharmacol 2021 ; 12(): 755826.

2020

Lamyaa Khoubza, Franck C Chatelain, Sylvain Feliciangeli, Florian Lesage, Delphine Bichet, Physiological roles of heteromerization: focus on the two-pore domain potassium channels, The Journal of Physiology, 2020.

2019

Ben Soussia I, El Mouridi S, Kang D, Leclercq-Blondel A, Khoubza L, Tardy P, Zariohi N, Gendrel M, Lesage F, Kim EJ, Bichet D, Andrini O, Boulin T, Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels., Nat Commun 2019 Feb; 10(1): 787.

2018

Ismail Ben Soussia, Frank Choveau, Sandy Blin, Eun-Jin Kim, Sylvain Feliciangeli, Franck Claude Chatelain, Dawon Kang, Delphine Bichet, Florian Lesage, Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels, Frontiers in Molecular Neuroscience, 2018, 11, ⟨10.3389/fnmol.2018.00301⟩.

2016

Blin S, Ben Soussia I, Kim EJ, Brau F, Kang D, Lesage F, Bichet D, Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties., Proc Natl Acad Sci U S A 2016 Apr; 113(15): 4200-5.

2015

Feliciangeli S, Chatelain FC, Bichet D, Lesage F, The family of K2P channels: salient structural and functional properties., J Physiol 2015 Jun; 593(12): 2587-603.

2015

Bichet D, Blin S, Feliciangeli S, Chatelain FC, Bobak N, Lesage F, Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2., Pflugers Arch 2015 May; 467(5): 1121-31.

2014

Delphine Bichet, Christophe Duranton, Hélène Hirbec, Stephan Kellenberger, Jean Mérot, Lauriane Ulmann, Fabien van Coppenolle, The 19 th Ion Channel Meeting, September 2008, France, Channels, 2014, 3 (1), pp.69-72. ⟨10.4161/chan.3.1.7777⟩.

2014

Blin S, Chatelain FC, Feliciangeli S, Kang D, Lesage F, Bichet D, Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels., J Biol Chem 2014 Oct; 289(41): 28202-12.

2013

Chatelain FC, Bichet D, Feliciangeli S, Larroque MM, Braud VM, Douguet D, Lesage F, Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane., J Biol Chem 2013 Dec; 288(49): 35081-92.

2012

Chatelain FC, Bichet D, Douguet D, Feliciangeli S, Bendahhou S, Reichold M, Warth R, Barhanin J, Lesage F, TWIK1, a unique background channel with variable ion selectivity., Proc Natl Acad Sci U S A 2012 Apr; 109(14): 5499-504.

2010

Patel A, Sharif-Naeini R, Folgering JR, Bichet D, Duprat F, Honoré E, Canonical TRP channels and mechanotransduction: from physiology to disease states., Pflugers Arch 2010 Aug; 460(3): 571-81.

2010

Sharif-Naeini R, Folgering JH, Bichet D, Duprat F, Delmas P, Patel A, Honoré E, Sensing pressure in the cardiovascular system: Gq-coupled mechanoreceptors and TRP channels., J Mol Cell Cardiol 2010 Jan; 48(1): 83-9.

2009

Sharif-Naeini R, Folgering JH, Bichet D, Duprat F, Lauritzen I, Arhatte M, Jodar M, Dedman A, Chatelain FC, Schulte U, Retailleau K, Loufrani L, Patel A, Sachs F, Delmas P, Peters DJ, Honoré E, Polycystin-1 and -2 dosage regulates pressure sensing., Cell 2009 Oct; 139(3): 587-96.

2009

Bichet D, Duranton C, Hirbec H, Kellenberger S, Mérot J, Ulmann L, Van Coppenolle F, The 19th Ion Channel Meeting. September 2008, France., Channels (Austin) 2009 ; 3(1): 69-72.

2008

Philip Gottlieb, Joost Folgering, Rosario Maroto, Albert Raso, Thomas G Wood, Alex Kurosky, Charles Bowman, Delphine Bichet, Amanda Patel, Frederick Sachs, Boris Martinac, Owen P Hamill, Eric Honoré, Revisiting TRPC1 and TRPC6 mechanosensitivity., Pflügers Archiv European Journal of Physiology, 2008, 455 (6), pp.1097-103. ⟨10.1007/s00424-007-0359-3⟩.

2008

Gottlieb P, Folgering J, Maroto R, Raso A, Wood TG, Kurosky A, Bowman C, Bichet D, Patel A, Sachs F, Martinac B, Hamill OP, Honoré E, Revisiting TRPC1 and TRPC6 mechanosensitivity., Pflugers Arch 2008 Mar; 455(6): 1097-103.

2006

Delphine Bichet, Dorien Peters, Amanda Jane Patel, Patrick Delmas, Eric Honoré, Cardiovascular Polycystins: Insights From Autosomal Dominant Polycystic Kidney Disease and Transgenic Animal Models, Trends in Cardiovascular Medicine, 2006, 16 (8), pp.292-298. ⟨10.1016/j.tcm.2006.07.002⟩.

2006

Bichet D, Peters D, Patel AJ, Delmas P, Honoré E, Cardiovascular polycystins: insights from autosomal dominant polycystic kidney disease and transgenic animal models., Trends Cardiovasc Med 2006 Nov; 16(8): 292-8.

2006

Bichet D, Grabe M, Jan YN, Jan LY, Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity., Proc Natl Acad Sci U S A 2006 Sep; 103(39): 14355-60.

2006

Grabe M, Bichet D, Qian X, Jan YN, Jan LY, K+ channel selectivity depends on kinetic as well as thermodynamic factors., Proc Natl Acad Sci U S A 2006 Sep; 103(39): 14361-6.

2006

D. Bichet, D. Peters, Patel Aj, P. Delmas, E. Honore, Cardiovascular Polycystins: Insights From Autosomal Dominant Polycystic Kidney Disease and Transgenic Animal Models., Trends in Cardiovascular Medicine, 2006, 16 (8), pp.292-298.

2004

Sandoz G, Lopez-Gonzalez I, Grunwald D, Bichet D, Altafaj X, Weiss N, Ronjat M, Dupuis A, De Waard M, Cavbeta-subunit displacement is a key step to induce the reluctant state of P/Q calcium channels by direct G protein regulation., Proc Natl Acad Sci U S A 2004 Apr; 101(16): 6267-72.

2004

Bichet D, Lin YF, Ibarra CA, Huang CS, Yi BA, Jan YN, Jan LY, Evolving potassium channels by means of yeast selection reveals structural elements important for selectivity., Proc Natl Acad Sci U S A 2004 Mar; 101(13): 4441-6.

2003

Delphine Bichet, Friederike Haass, Lily Yeh Jan, Merging functional studies with structures of inward-rectifier K+ channels, Nature Reviews Neuroscience, 2003, 4 (12), pp.957-967. ⟨10.1038/nrn1244⟩.

2003

Bichet D, Haass FA, Jan LY, Merging functional studies with structures of inward-rectifier K(+) channels., Nat Rev Neurosci 2003 Dec; 4(12): 957-67.

2002

Veronique Cornet, Delphine Bichet, Guillaume Sandoz, Isabelle Marty, Jacques Brocard, Emmanuel Bourinet, Yasuo Mori, Michel Villaz, Michel de Waard, Multiple determinants in voltage-dependent P/Q calcium channels control their retention in the endoplasmic reticulum, European Journal of Neuroscience, 2002, 16 (5), pp.883-895. ⟨10.1046/j.1460-9568.2002.02168.x⟩.

2002

Cornet V, Bichet D, Sandoz G, Marty I, Brocard J, Bourinet E, Mori Y, Villaz M, De Waard M, Multiple determinants in voltage-dependent P/Q calcium channels control their retention in the endoplasmic reticulum., Eur J Neurosci 2002 Sep; 16(5): 883-95.

2002

Geib S, Sandoz G, Cornet V, Mabrouk K, Fund-Saunier O, Bichet D, Villaz M, Hoshi T, Sabatier JM, De Waard M, The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a beta -dependent manner., J Biol Chem 2002 Mar; 277(12): 10003-13.

2002

Sandrine Geib, Guillaume Sandoz, Véronique Cornet, Kamel Mabrouk, Odile Fund-Saunier, Delphine Bichet, Michel Villaz, Toshinori Hoshi, Jean-Marc Sabatier, Michel de Waard, The Interaction between the I-II Loop and the III-IV Loop of Cav2.1 Contributes to Voltage-dependent Inactivation in a β-Dependent Manner, Journal of Biological Chemistry, 2002, 277 (12), pp.10003-10013. ⟨10.1074/jbc.M106231200⟩.

2001

Guillaume Sandoz, Delphine Bichet, Veronique Cornet, Yasuo Mori, Ricardo Felix, Michel de Waard, Distinct properties and differential β subunit regulation of two C-terminal isoforms of the P/Q-type Ca 2+ -channel α 1A subunit, European Journal of Neuroscience, 2001, 14 (6), pp.987-997. ⟨10.1046/j.0953-816x.2001.01728.x⟩.

2000

Delphine Bichet, Catherine Lecomte, Jean-Marc Sabatier, Ricardo Felix, Michel de Waard, Reversibility of the Ca2+ Channel α1–β Subunit Interaction, Biochemical and Biophysical Research Communications, 2000, 277 (3), pp.729-735. ⟨10.1006/bbrc.2000.3750⟩.

2000

Ziad Fajloun, Edmond Carlier, Catherine Lecomte, Sandrine Geib, Eric Di Luccio, Delphine Bichet, Kamel Mabrouk, Hervé Rochat, Michel de Waard, Jean-Marc Sabatier, Chemical synthesis and characterization of Pi1, a scorpion toxin from Pandinus imperator active on K+ channels, European Journal of Biochemistry, 2000, 267 (16), pp.5149-5155. ⟨10.1046/j.1432-1327.2000.01577.x⟩.

2000

Andrew Escayg, Michel de Waard, David Lee, Delphine Bichet, Peter Wolf, Thomas Mayer, Janine Johnston, Robert Baloh, Thomas Sander, Miriam Meisler, Coding and Noncoding Variation of the Human Calcium-Channel β4-Subunit Gene CACNB4 in Patients with Idiopathic Generalized Epilepsy and Episodic Ataxia, American Journal of Human Genetics, 2000, 66 (5), pp.1531-1539. ⟨10.1086/302909⟩.

2000

Z. Fajloun, R. Kharrat, Lin Chen, C. Lecomte, E. Di Luccio, D. Bichet, M. El Ayeb, H. Rochat, P Danny Allen, I.N. Pessah, M. de Waard, J.M Sabatier, Chemical synthesis and characterization of maurocalcine, a scorpion toxin that activates Ca 2+ release channel/ryanodine receptors, FEBS Letters, 2000, 469 (2-3), pp.179-185. ⟨10.1016/S0014-5793(00)01239-4⟩.

2000

Delphine Bichet, Véronique Cornet, Sandrine Geib, Edmond Carlier, Stephen Volsen, Toshi Hoshi, Yasuo Mori, Michel de Waard, The I-II Loop of the Ca 2+ Channel α 1 Subunit Contains an Endoplasmic Reticulum Retention Signal Antagonized by the β Subunit, Neuron, 2000, 25 (1), pp.177-190. ⟨10.1016/s0896-6273(00)80881-8⟩.

1999

Denise Walker, Delphine Bichet, Sandrine Geib, Emiko Mori, Véronique Cornet, Terry Snutch, Yasuo Mori, Michel de Waard, A New β Subtype-specific Interaction in α1ASubunit Controls P/Q-type Ca2+ Channel Activation, Journal of Biological Chemistry, 1999, 274 (18), pp.12383-12390. ⟨10.1074/jbc.274.18.12383⟩.

1999

Cécile Raymond, Bichet Delphine, Iborra Cecile, Martin-Moutot Nicole, Seagar Machael, Michel Dewaard, Antibodies against the beta subunit of voltage-dependent calcium channels in Lambert-Eaton myasthenic syndrome, Neuroscience, 1999, 90 (1), pp.269-277.

1998

Denise Walker, Delphine Bichet, Kevin Campbell, Michel de Waard, A β4 Isoform-specific Interaction Site in the Carboxyl-terminal Region of the Voltage-dependent Ca2+ Channel α1A Subunit, Journal of Biological Chemistry, 1998, 273 (4), pp.2361-2367. ⟨10.1074/jbc.273.4.2361⟩.