Présentation
Directeur
Événements
19
Avr
2024
11:00 am
Conférence
F. LESAGE invite le Dr Eric RÖTTINGER
« Marine-related Science at UniCA: The Research Federation MARRES & Nematostella vectensis, a sea anemone to study stress-response, regeneration & longevity«
IPMC
24
Avr
2025
Conférence
F. LESAGE invite le Dr. Vincent DUSASTRE
« Publishing in High Impact Journals »
IPMC
Publications
2024
Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH.,
Nat Commun 2024 May; 15(1): 3849.
2023
Predicting hERG repolarization power at 37°C from recordings at room temperature.,
Clin Transl Med 2023 May; 13(5): e1266.
2023
A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals.,
Nat Commun 2023 Mar; 14(1): 1160.
2023
A need for exhaustive and standardized characterization of ion channels activity. The case of KV11.1.,
Front Physiol 2023 ; 14(): 1132533.
2021
A standardised hERG phenotyping pipeline to evaluate KCNH2 genetic variant pathogenicity,
Clinical and Translational Medicine, 2021, 11 (11), ⟨10.1002/ctm2.609⟩.
2021
Corrigendum: Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels.,
Front Pharmacol 2021 ; 12(): 795920.
2021
Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels.,
Front Pharmacol 2021 ; 12(): 755826.
2020
TREK1 channel activation as a new analgesic strategy devoid of opioid adverse effects.,
Br J Pharmacol 2020 Oct; 177(20): 4782-4795.
2020
Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome.,
Nat Commun 2020 Jan; 11(1): 480.
2019
Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels.,
Nat Commun 2019 Feb; 10(1): 787.
2019
Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK.,
Neuron 2019 Jan; 101(2): 232-245.e6.
2019
Lack of p11 expression facilitates acidity-sensing function of TASK1 channels in mouse adrenal medullary cells.,
FASEB J 2019 Jan; 33(1): 455-468.
2018
Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels,
Frontiers in Molecular Neuroscience, 2018, 11, ⟨10.3389/fnmol.2018.00301⟩.
2017
Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins.,
Am J Physiol Lung Cell Mol Physiol 2017 Dec; 313(6): L1030-L1046.
2017
Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice.,
Respir Physiol Neurobiol 2017 Oct; 244(): 17-25.
2017
Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity.,
J Med Chem 2017 Feb; 60(3): 1076-1088.
2016
The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size.,
J Mol Cell Cardiol 2016 Aug; 97(): 24-35.
2016
Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target?,
J Med Chem 2016 Jun; 59(11): 5149-57.
2016
In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide.,
Proc Natl Acad Sci U S A 2016 Apr; 113(17): E2460-8.
2015
The family of K2P channels: salient structural and functional properties.,
J Physiol 2015 Jun; 593(12): 2587-603.
2015
Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2.,
Pflugers Arch 2015 May; 467(5): 1121-31.
2014
Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.,
Pain 2014 Dec; 155(12): 2534-2544.
2014
Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.,
Proc Natl Acad Sci U S A 2014 Sep; 111(37): 13547-52.
2014
Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer’s disease model.,
J Neurosci 2014 May; 34(20): 7027-42.
2014
Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel.,
Eur J Med Chem 2014 Mar; 75(): 391-402.
2014
The thermosensitive potassium channel TREK-1 contributes to coolness-evoked responses of Grueneberg ganglion neurons.,
Cell Mol Neurobiol 2014 Jan; 34(1): 113-22.
2013
Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane.,
J Biol Chem 2013 Dec; 288(49): 35081-92.
2013
TASK-2 channels contribute to pH sensitivity of retrotrapezoid nucleus chemoreceptor neurons.,
J Neurosci 2013 Oct; 33(41): 16033-44.
2013
Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system.,
Endocrinology 2013 Aug; 154(8): 2712-22.
2013
Kv1.1 channels act as mechanical brake in the senses of touch and pain.,
Neuron 2013 Mar; 77(5): 899-914.
2013
The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartments.,
Front Cell Neurosci 2013 ; 7(): 246.
2012
Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension.,
Endocrinology 2012 Oct; 153(10): 4740-8.
2012
Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy.,
EMBO J 2012 Sep; 31(18): 3730-44.
2012
TWIK1, a unique background channel with variable ion selectivity.,
Proc Natl Acad Sci U S A 2012 Apr; 109(14): 5499-504.
2012
Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels.,
Cell Rep 2012 Mar; 1(3): 241-50.
2012
Behavioral characterization of mice lacking Trek channels.,
Front Behav Neurosci 2012 ; 6(): 60.
2010
Potassium channel silencing by constitutive endocytosis and intracellular sequestration.,
J Biol Chem 2010 Feb; 285(7): 4798-805.
2010
Task2 potassium channels set central respiratory CO 2 and O 2 sensitivity,
Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (5), pp.2325-2330. ⟨10.1073/pnas.0910059107⟩.
2009
Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue.,
Proc Natl Acad Sci U S A 2009 Aug; 106(34): 14628-33.
2009
Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels.,
J Neurosci 2009 Feb; 29(8): 2528-33.
2008
Mtap2 is a constituent of the protein network that regulates twik-related K+ channel expression and trafficking.,
J Neurosci 2008 Aug; 28(34): 8545-52.
2008
Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis.,
EMBO J 2008 Jan; 27(1): 179-87.
2008
Protein complex analysis of native brain potassium channels by proteomics.,
Methods Mol Biol 2008 ; 491(): 113-23.
2007
Does sumoylation control K2P1/TWIK1 background K+ channels?,
Cell 2007 Aug; 130(3): 563-9.
2006
AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels.,
EMBO J 2006 Dec; 25(24): 5864-72.
2006
Membrane potential-regulated transcription of the resting K+ conductance TASK-3 via the calcineurin pathway.,
J Biol Chem 2006 Sep; 281(39): 28910-8.
2005
International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels.,
Pharmacol Rev 2005 Dec; 57(4): 527-40.
2005
Fetal brain hypometabolism during prolonged hypoxaemia in the llama.,
J Physiol 2005 Sep; 567(Pt 3): 963-75.
2005
Antiepileptic popular ketogenic diet: emerging twists in an ancient story.,
Prog Neurobiol 2005 Jan; 75(1): 1-28.
2004
ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6.,
EMBO Rep 2004 Dec; 5(12): 1171-5.
2004
Localization of TREK-1, a two-pore-domain K+ channel in the peripheral vestibular system of mouse and rat.,
Brain Res 2004 Aug; 1017(1-2): 46-52.
2004
Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport.,
Proc Natl Acad Sci U S A 2004 May; 101(21): 8215-20.
2004
[Neuronal background two-P-domain potassium channels: molecular and functional aspects].,
Med Sci (Paris) 2004 May; 20(5): 544-9.
2004
Association of beta-catenin with the alpha-subunit of neuronal large-conductance Ca2+-activated K+ channels.,
Proc Natl Acad Sci U S A 2004 Jan; 101(2): 671-5.
2003
International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels.,
Pharmacol Rev 2003 Dec; 55(4): 583-6.
2003
Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels.,
EMBO J 2003 Oct; 22(20): 5403-11.
2003
Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules.,
J Gen Physiol 2003 Aug; 122(2): 177-90.
2003
Expression and localization of TREK-1 K+ channels in human odontoblasts.,
J Dent Res 2003 Jul; 82(7): 542-5.
2003
Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit.,
Proc Natl Acad Sci U S A 2003 Jan; 100(1): 307-12.
2002
RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels.,
Neuron 2002 Apr; 34(3): 411-23.
2001
A TREK-1-like potassium channel in atrial cells inhibited by beta-adrenergic stimulation and activated by volatile anesthetics.,
Circ Res 2001 Aug; 89(4): 336-42.
2001
Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels.,
Biochem Biophys Res Commun 2001 Mar; 282(1): 249-56.
2000
Molecular and functional properties of two-pore-domain potassium channels.,
Am J Physiol Renal Physiol 2000 Nov; 279(5): F793-801.
2000
Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors.,
J Biol Chem 2000 Sep; 275(37): 28398-405.
2000
The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK.,
Mol Pharmacol 2000 May; 57(5): 906-12.
2000
Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel.,
FEBS Lett 2000 Apr; 471(2-3): 137-40.
2000
Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK.,
J Biol Chem 2000 Apr; 275(14): 10128-33.
2000
Axonal transport of TREK and TRAAK potassium channels in rat sciatic nerves.,
Neuroreport 2000 Apr; 11(5): 927-30.
2000
Immunolocalization of the arachidonic acid and mechanosensitive baseline traak potassium channel in the nervous system.,
Neuroscience 2000 ; 95(3): 893-901.
1999
Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel.,
J Biol Chem 1999 Sep; 274(38): 26691-6.
1999
Inhalational anesthetics activate two-pore-domain background K+ channels.,
Nat Neurosci 1999 May; 2(5): 422-6.
1999
Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure.,
J Biol Chem 1999 Apr; 274(17): 11751-60.
1999
TRAAK is a mammalian neuronal mechano-gated K+ channel.,
J Biol Chem 1999 Jan; 274(3): 1381-7.
1998
Expression of TWIK-1, a novel weakly inward rectifying potassium channel in rat kidney.,
Am J Physiol 1998 Dec; 275(6): C1602-9.
1998
Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney.,
J Biol Chem 1998 Nov; 273(47): 30863-9.
1998
A mammalian two pore domain mechano-gated S-like K+ channel.,
EMBO J 1998 Aug; 17(15): 4283-90.
1998
Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23.,
Genomics 1998 Aug; 51(3): 478-9.
1998
A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids.,
EMBO J 1998 Jun; 17(12): 3297-308.
1997
TASK, a human background K+ channel to sense external pH variations near physiological pH.,
EMBO J 1997 Sep; 16(17): 5464-71.
1997
An immunocytochemical study on the distribution of two G-protein-gated inward rectifier potassium channels (GIRK2 and GIRK4) in the adult rat brain.,
Neuroscience 1997 Sep; 80(2): 345-57.
1997
Comparative expression of the inward rectifier K+ channel GIRK2 in the cerebellum of normal and weaver mutant mice.,
Brain Res 1997 Apr; 753(1): 8-17.
1997
Modes of regulation of shab K+ channel activity by the Kv8.1 subunit.,
J Biol Chem 1997 Mar; 272(13): 8774-80.
1997
The structure, function and distribution of the mouse TWIK-1 K+ channel.,
FEBS Lett 1997 Jan; 402(1): 28-32.
1996
Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel.,
EMBO J 1996 Dec; 15(24): 6854-62.
1996
Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge.,
EMBO J 1996 Dec; 15(23): 6400-7.
1996
Inner ear defects induced by null mutation of the isk gene.,
Neuron 1996 Dec; 17(6): 1251-64.
1996
K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current.,
Nature 1996 Nov; 384(6604): 78-80.
1996
A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression.,
J Biol Chem 1996 Oct; 271(42): 26341-8.
1996
Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels.,
EMBO J 1996 Jul; 15(13): 3322-31.
1996
Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43.,
Genomics 1996 May; 34(1): 153-5.
1996
TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure.,
EMBO J 1996 Mar; 15(5): 1004-11.
1996
A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties.,
J Biol Chem 1996 Feb; 271(8): 4183-7.
1996
Dominant negative chimeras provide evidence for homo and heteromultimeric assembly of inward rectifier K+ channel proteins via their N-terminal end.,
FEBS Lett 1996 Jan; 378(1): 64-8.
1995
Susceptibility of cloned K+ channels to reactive oxygen species.,
Proc Natl Acad Sci U S A 1995 Dec; 92(25): 11796-800.
1995
Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels.,
J Biol Chem 1995 Dec; 270(48): 28660-7.
1995
Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23.,
Genomics 1995 Oct; 29(3): 808-9.
1995
Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers.,
Biochem Biophys Res Commun 1995 Jul; 212(2): 657-63.
1994
Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain.,
FEBS Lett 1994 Oct; 353(1): 37-42.
1994
Expression cloning in K+ transport defective yeast and distribution of HBP1, a new putative HMG transcriptional regulator.,
Nucleic Acids Res 1994 Sep; 22(18): 3685-8.
1994
Injection of a K+ channel (Kv1.3) cRNA in fertilized eggs leads to functional expression in cultured myotomal muscle cells from Xenopus embryos.,
FEBS Lett 1994 Jul; 348(3): 259-62.
1994
External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids.,
Proc Natl Acad Sci U S A 1994 Mar; 91(5): 1937-41.
1993
Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel.,
J Biol Chem 1993 Nov; 268(32): 24283-9.
1993
The protein IsK is a dual activator of K+ and Cl- channels.,
Nature 1993 Oct; 365(6449): 850-2.
1993
Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in situ hybridization and somatic cell hybridization.,
Genomics 1993 Jan; 15(1): 243-5.
1993
Are Xenopus oocytes unique in displaying functional IsK channel heterologous expression?,
Recept Channels 1993 ; 1(2): 143-52.
1992
Effects of the level of mRNA expression on biophysical properties, sensitivity to neurotoxins, and regulation of the brain delayed-rectifier K+ channels Kv1.2.,
Biochemistry 1992 Dec; 31(49): 12463-8.
1992
Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells.,
FEBS Lett 1992 Sep; 310(2): 162-6.
1992
Different types of K+ channel current are generated by different levels of a single mRNA.,
EMBO J 1992 Jul; 11(7): 2465-71.
1992
Regulation of a major cloned voltage-gated K+ channel from human T lymphocytes.,
FEBS Lett 1992 Jun; 303(2-3): 229-32.
1992
Receptor-mediated regulation of IsK, a very slowly activating, voltage-dependent K+ channel in Xenopus oocytes.,
Biochem Biophys Res Commun 1992 May; 184(3): 1135-41.
1992
Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes.,
J Biol Chem 1992 Apr; 267(12): 8650-7.
1992
ISK, a slowly activating voltage-sensitive K+ channel. Characterization of multiple cDNAs and gene organization in the mouse.,
FEBS Lett 1992 Apr; 301(2): 168-72.
1991
Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart.,
EMBO J 1991 Oct; 10(10): 2805-11.