Épigénétique et métabolisme – IPMC

Recherche

Intranet

Thème

Physiologie génomique des eucaryotes

Mécanique cellulaire de l’échelle moléculaire á l’échelle tissulaire

Membres

Chercheur INSERM

Marie-Charlotte DUMARGNE

Coordinatrice de recherches

Clémentine PLACET

Jean-Louis NAHON

Chercheur émérite

Présentation

Notre compréhension de l’obésité a subi un changement de paradigme. La découverte récente selon laquelle les informations épigénétiques des gamètes sont sensibles à des facteurs alimentaires conforte l’idée selon laquelle le mode de vie avant la conception peut influencer la santé métabolique de la génération suivante.

Notre but est d’étudier les mécanismes cellulaires par lesquels les informations épigénétiques acquises et transférées via les gamètes peuvent influencer le développement et le métabolisme chez la progéniture et prédisposer la prochaine génération à l’obésité.

Actualités

Publication IPMC / Brain, Behavior, and Immunity / Équipe Barrès

La composition en acides gras de l’alimentation est à l’origine de la neuroinflammation et de l’altération du comportement dans l’obésité […]

Projets

Prise alimentaire et modifications épigénétiques des spermatozoïdes

Amélioration de la fertilité

Neuroinflammation et dérégulations du comportement alimentaire

Les projets développés dans ce second axe de recherche sont à l’interface entre la neuroimmunoendocrinologie, la nutrition et le métabolisme. […]

Impact de la nature des lipides sur la neuroinflammation et la réactivité gliale, associées au développement de l’obésité.

Mots-clés : Lipides, Neuroinflammation, Réactivité gliale et Obésité nutritionnelle Ce projet vise à comprendre les mécanismes impliqués dans la réponse […]

Régulation centrale des fonctions neuroendocriniennes, génomique et évolution

Implication du système MCH/MCHR1-MCHR2 dans la régulation des fonctions neuroendocriniennes Notre modèle de prédilection est celui du peptide MCH dont […]

Publications

Ni D, Tan J, Reyes J, Senior AM, Andrews C, Taitz J, Potier-Villette C, Wishart C, Spiteri A, Piccio L, King NJC, Barrès R, Raubenheimer D, Simpson SJ, Nanan R, Macia L, High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection., Adv Sci (Weinh) 2025 Jun; 12(22): e2412236.

Tuulari JJ, Bourgery M, Iversen J, Koefoed TG, Ahonen A, Ahmedani A, Kataja EL, Karlsson L, Barrès R, Karlsson H, Kotaja N, Exposure to childhood maltreatment is associated with specific epigenetic patterns in sperm., Mol Psychiatry 2025 Jun; 30(6): 2635-2644.

Agueda-Oyarzabal M, Isidor MS, Plucińska K, Ingerslev LR, Dmytriyeva O, Petersen PSS, Laftih S, Pontoppidan AB, Henningsen JB, Rupar K, Brown EL, Schwartz TW, Barrès R, Gerhart-Hines Z, Schéele CC, Emanuelli B, Transcriptomic signatures of cold acclimated adipocytes reveal CXCL12 as a Brown autocrine and paracrine chemokine., Mol Metab 2025 Mar; 93(): 102102.

Kornerup N, Danielsen JH, Sahl RE, Pico ML, Johansen MY, Knop FK, Bønnelykke K, Bergholt T, Kelstrup L, Foghsgaard S, Ghauri N, Grønlund E, Lund L, Vinter CA, Lyng Forman J, Barrès R, Kragelund Nielsen K, Andersen A, Torekov SS, Groth Grunnet L, Vilsbøll T, Healthy lifestyle before and during pregnancy to prevent childhood obesity: study protocol for a parallel group randomised trial – the PRE-STORK trial., BMJ Open 2025 Jan; 15(1): e087895.

Pinto A, Haytural H, Loss CM, Alvarez C, Ertas A, Curtis O, Williams AR, Murphy G, Salleng K, Gografe S, Altıntaş A, Kafri T, Barres R, Deshmukh AS, van Praag H, Muscle Cathepsin B treatment improves behavioral and neurogenic deficits in a mouse model of Alzheimer’s Disease., bioRxiv 2025 Jan; (): .

Pedersen K, Poojari A, Colberg SF, Mechernsee SM, Iversen JF, Barrès R, Lykkesfeldt J, Tveden-Nyborg P, A Guinea Pig Model of Pediatric Metabolic Dysfunction-Associated Steatohepatitis: Poor Vitamin C Status May Advance Disease., Nutrients 2025 Jan; 17(2): .

Sanchez C, Colson C, Gautier N, Noser P, Salvi J, Villet M, Fleuriot L, Peltier C, Schlich P, Brau F, Sharif A, Altintas A, Amri EZ, Nahon JL, Blondeau N, Benani A, Barrès R, Rovère C, Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity., Brain Behav Immun 2024 Mar; 117(): 330-346.

Carper D, Lac M, Coue M, Labour A, Märtens A, Banda JAA, Mazeyrie L, Mechta M, Ingerslev LR, Elhadad M, Petit JV, Maslo C, Monbrun L, Del Carmine P, Sainte-Marie Y, Bourlier V, Laurens C, Mithieux G, Joanisse DR, Coudray C, Feillet-Coudray C, Montastier E, Viguerie N, Tavernier G, Waldenberger M, Peters A, Wang-Sattler R, Adamski J, Suhre K, Gieger C, Kastenmüller G, Illig T, Lichtinghagen R, Seissler J, Mounier R, Hiller K, Jordan J, Barrès R, Kuhn M, Pesta D, Moro C, Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity., Sci Adv 2024 Oct; 10(41): eadl4374.

Hufnagel A, Barrès R, Extracellular vesicles – small messengers with a wide range of applications?, Dan Med J 2024 Jul; 71(8): .

Hjort L, Bredgaard SS, Manitta E, Marques I, Sørensen AE, Martino D, Grunnet LG, Kelstrup L, Houshmand-Oeregaard A, Clausen TD, Mathiesen ER, Olsen SF, Saffery R, Barrès R, Damm P, Vaag AA, Dalgaard LT, Epigenetics of the non-coding RNA nc886 across blood, adipose tissue and skeletal muscle in offspring exposed to diabetes in pregnancy., Clin Epigenetics 2024 May; 16(1): 61.

Crean AJ, Senior AM, Freire T, Clark TD, Mackay F, Austin G, Pulpitel TJ, Nobrega MA, Barrès R, Simpson SJ, Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring., Nat Commun 2024 Apr; 15(1): 2982.

Farris KM, Senior AM, Sobreira DR, Mitchell RM, Weber ZT, Ingerslev LR, Barrès R, Simpson SJ, Crean AJ, Nobrega MA, Dietary macronutrient composition impacts gene regulation in adipose tissue., Commun Biol 2024 Feb; 7(1): 194.

Dollet L, Lundell LS, Chibalin AV, Pendergrast LA, Pillon NJ, Lansbury EL, Elmastas M, Frendo-Cumbo S, Jalkanen J, de Castro Barbosa T, Cervone DT, Caidahl K, Dmytriyeva O, Deshmukh AS, Barrès R, Rydén M, Wallberg-Henriksson H, Zierath JR, Krook A, Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M., Cell Rep Med 2024 Jan; 5(1): 101348.

Nobrega M, Farris K, Andersen E, Donkin I, Versteyhe S, Kristiansen VB, Simpson S, Barres R, Splicing across adipocyte differentiation is highly dynamic and impacted by metabolic phenotype., Res Sq 2023 Oct; (): .

Small L, Lundell LS, Iversen J, Ehrlich AM, Dall M, Basse AL, Dalbram E, Hansen AN, Treebak JT, Barrès R, Zierath JR, Seasonal light hours modulate peripheral clocks and energy metabolism in mice., Cell Metab 2023 Oct; 35(10): 1722-1735.e5.

Adriana Ibarra Urizar, Michala Prause, Lars Roed Ingerslev, Matthew Wortham, Yinghui Sui, Maike Sander, Kristine Williams, Romain Barrès, Martin Larsen, Gitte Lund Christensen, Nils Billestrup, Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding, Cell Death and Disease, 2023, 14 (7), pp.399. ⟨10.1038/s41419-023-05906-w⟩.

A. Crean, S. Afrin, H. Niranjan, T. Pulpitel, G. Ahmad, A. Senior, T. Freire, F. Mackay, M. Nobrega, R. Barrès, S. Simpson, T. Pini, Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity, Nature Communications, 2023, 14 (1), pp.2566. ⟨10.1038/s41467-023-38314-x⟩.

Andersen MK, Ängquist L, Bork-Jensen J, Jonsson AE, Stinson SE, Sandholt CH, Thodberg M, Pikkupeura LM, Ongstad EL, Grarup N, Astrup A, Pedersen O, Williams K, Barrès R, Sørensen TIA, Linneberg A, Grimsby J, Rhodes CJ, Hansen T, Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity., Diabetes Care 2023 May; 46(5): 985-992.

Astrid L. Basse, Karen N. Nielsen, Iuliia Karavaeva, Lars R. Ingerslev, Tao Ma, Jesper F. Havelund, Thomas S. Nielsen, Mikkel Frost, Julia Peics, Emilie Dalbram, Morten Dall, Juleen R. Zierath, Romain Barrès, Nils J. Færgeman, Jonas T. Treebak, Zachary Gerhart-Hines, NAMPT-dependent NAD + biosynthesis controls circadian metabolism in a tissue-specific manner, Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (14), ⟨10.1073/pnas.2220102120⟩.

Pillon NJ, Sardón Puig L, Altıntaş A, Kamble PG, Casaní-Galdón S, Gabriel BM, Barrès R, Conesa A, Chibalin AV, Näslund E, Krook A, Zierath JR, Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers., Life Sci Alliance 2023 Jan; 6(1): .

Borup A, Donkin I, Boon MR, Frydland M, Martinez-Tellez B, Loft A, Keller SH, Kjaer A, Kjaergaard J, Hassager C, Barrès R, Rensen PCN, Christoffersen C, Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans., Sci Rep 2022 Nov; 12(1): 18753.

Hochreuter MY, Dall M, Treebak JT, Barrès R, MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives., Mol Metab 2022 Nov; 65(): 101581.

Moharrek F, Ingerslev LR, Altıntaş A, Lundell L, Hansen AN, Small L, Workman CT, Barrès R, Comparative analysis of sperm DNA methylation supports evolutionary acquired epigenetic plasticity for organ speciation., Epigenomics 2022 Nov; 14(21): 1305-1324.

Pedersen SS, Prause M, Williams K, Barrès R, Billestrup N, Butyrate inhibits IL-1β-induced inflammatory gene expression by suppression of NF-κB activity in pancreatic beta cells., J Biol Chem 2022 Sep; 298(9): 102312.

McIlvenna LC, Altıntaş A, Patten RK, McAinch AJ, Rodgers RJ, Stepto NK, Barrès R, Moreno-Asso A, Transforming growth factor β1 impairs the transcriptomic response to contraction in myotubes from women with polycystic ovary syndrome., J Physiol 2022 Jul; 600(14): 3313-3330.

Andersen E, Juhl CR, Kjøller ET, Lundgren JR, Janus C, Dehestani Y, Saupstad M, Ingerslev LR, Duun OM, Jensen SBK, Holst JJ, Stallknecht BM, Madsbad S, Torekov SS, Barrès R, Sperm count is increased by diet-induced weight loss and maintained by exercise or GLP-1 analogue treatment: a randomized controlled trial., Hum Reprod 2022 Jun; 37(7): 1414-1422.

Manitta E, Fontes Marques IC, Stokholm Bredgaard S, Kelstrup L, Houshmand-Oeregaard A, Dalsgaard Clausen T, Groth Grunnet L, Reinhardt Mathiesen E, Torp Dalgaard L, Barrès R, Vaag AA, Damm P, Hjort L, DNA Methylation and Gene Expression in Blood and Adipose Tissue of Adult Offspring of Women with Diabetes in Pregnancy-A Validation Study of DNA Methylation Changes Identified in Adolescent Offspring., Biomedicines 2022 May; 10(6): .

Small L, Ehrlich A, Iversen J, Ashcroft SP, Trošt K, Moritz T, Hartmann B, Holst JJ, Treebak JT, Zierath JR, Barrès R, Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice., Mol Metab 2022 Mar; 57(): 101440.

Isidor MS, Dong W, Servin-Uribe RI, Villarroel J, Altıntaş A, Ayala-Sumuano JT, Varela-Echavarría A, Barrès R, Stephanopoulos G, Macotela Y, Emanuelli B, Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes., Int J Obes (Lond) 2022 Mar; 46(3): 535-543.

Sato S, Dyar KA, Treebak JT, Jepsen SL, Ehrlich AM, Ashcroft SP, Trost K, Kunzke T, Prade VM, Small L, Basse AL, Schönke M, Chen S, Samad M, Baldi P, Barrès R, Walch A, Moritz T, Holst JJ, Lutter D, Zierath JR, Sassone-Corsi P, Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis., Cell Metab 2022 Feb; 34(2): 329-345.e8.

Villarroel J, Donkin I, Champion C, Burcelin R, Barrès R, Endurance Training in Humans Modulates the Bacterial DNA Signature of Skeletal Muscle., Biomedicines 2021 Dec; 10(1): .

Wohlwend M, Laurila PP, Williams K, Romani M, Lima T, Pattawaran P, Benegiamo G, Salonen M, Schneider BL, Lahti J, Eriksson JG, Barrès R, Wisløff U, Moreira JBN, Auwerx J, The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging., Sci Transl Med 2021 Dec; 13(623): eabc7367.

Moreno-Asso A, Altıntaş A, McIlvenna LC, Patten RK, Botella J, McAinch AJ, Rodgers RJ, Barrès R, Stepto NK, Non-cell autonomous mechanisms control mitochondrial gene dysregulation in polycystic ovary syndrome., J Mol Endocrinol 2021 Dec; 68(1): 63-76.

Dall M, Hassing AS, Niu L, Nielsen TS, Ingerslev LR, Sulek K, Trammell SAJ, Gillum MP, Barrès R, Larsen S, Poulsen SS, Mann M, Ørskov C, Treebak JT, Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes., J Biol Chem 2021 Dec; 297(6): 101388.

Williams K, Carrasquilla GD, Ingerslev LR, Hochreuter MY, Hansson S, Pillon NJ, Donkin I, Versteyhe S, Zierath JR, Kilpeläinen TO, Barrès R, Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health., Mol Metab 2021 Nov; 53(): 101290.

Basse AL, Agerholm M, Farup J, Dalbram E, Nielsen J, Ørtenblad N, Altıntaş A, Ehrlich AM, Krag T, Bruzzone S, Dall M, de Guia RM, Jensen JB, Møller AB, Karlsen A, Kjær M, Barrès R, Vissing J, Larsen S, Jessen N, Treebak JT, Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity., Mol Metab 2021 Nov; 53(): 101271.

Gabriel BM, Altıntaş A, Smith JAB, Sardon-Puig L, Zhang X, Basse AL, Laker RC, Gao H, Liu Z, Dollet L, Treebak JT, Zorzano A, Huo Z, Rydén M, Lanner JT, Esser KA, Barrès R, Pillon NJ, Krook A, Zierath JR, Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle., Sci Adv 2021 Oct; 7(43): eabi9654.

Massart J, Sjögren RJO, Egan B, Garde C, Lindgren M, Gu W, Ferreira DMS, Katayama M, Ruas JL, Barrès R, O'Gorman DJ, Zierath JR, Krook A, Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism., Nat Commun 2021 Oct; 12(1): 5948.

Altıntaş A, Liu J, Fabre O, Chuang TD, Wang Y, Sakurai R, Chehabi GN, Barrès R, Rehan VK, Perinatal exposure to nicotine alters spermatozoal DNA methylation near genes controlling nicotine action., FASEB J 2021 Jul; 35(7): e21702.

Lundh M, Altıntaş A, Tozzi M, Fabre O, Ma T, Shamsi F, Gerhart-Hines Z, Barrès R, Tseng YH, Emanuelli B, Cold-induction of afadin in brown fat supports its thermogenic capacity., Sci Rep 2021 May; 11(1): 9794.

Roland CB, Knudsen SP, Alomairah SA, Andersen AD, Bendix J, Clausen TD, Molsted S, Jensen AK, Teilmann G, Jespersen AP, Larsen JE, Hall GV, Andersen E, Barrès R, Mortensen OH, Maindal HT, Tarnow L, Løkkegaard ECL, Stallknecht B, Structured supervised exercise training or motivational counselling during pregnancy on physical activity level and health of mother and offspring: FitMum study protocol., BMJ Open 2021 Mar; 11(3): e043671.

Laker RC, Altıntaş A, Lillard TS, Zhang M, Connelly JJ, Sabik OL, Onengut S, Rich SS, Farber CR, Barrès R, Yan Z, Exercise during pregnancy mitigates negative effects of parental obesity on metabolic function in adult mouse offspring., J Appl Physiol (1985) 2021 Mar; 130(3): 605-616.

Rabiee A, Plucińska K, Isidor MS, Brown EL, Tozzi M, Sidoli S, Petersen PSS, Agueda-Oyarzabal M, Torsetnes SB, Chehabi GN, Lundh M, Altıntaş A, Barrès R, Jensen ON, Gerhart-Hines Z, Emanuelli B, White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment., Mol Metab 2021 Feb; 44(): 101137.

Small L, Ingerslev LR, Manitta E, Laker RC, Hansen AN, Deeney B, Carrié A, Couvert P, Barrès R, Ablation of DNA-methyltransferase 3A in skeletal muscle does not affect energy metabolism or exercise capacity., PLoS Genet 2021 Jan; 17(1): e1009325.

Small L, Altıntaş A, Laker RC, Ehrlich A, Pattamaprapanont P, Villarroel J, Pillon NJ, Zierath JR, Barrès R, Contraction influences Per2 gene expression in skeletal muscle through a calcium-dependent pathway., J Physiol 2020 Dec; 598(24): 5739-5752.

Ardenkjær-Larsen J, Rupar K, Sinkevičiūtė G, Petersen PSS, Villarroel J, Lundh M, Barrès R, Rabiee A, Emanuelli B, Insulin-induced serine 22 phosphorylation of retinoid X receptor alpha is dispensable for adipogenesis in brown adipocytes., Adipocyte 2020 Dec; 9(1): 142-152.

Lundell LS, Parr EB, Devlin BL, Ingerslev LR, Altıntaş A, Sato S, Sassone-Corsi P, Barrès R, Zierath JR, Hawley JA, Author Correction: Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression., Nat Commun 2020 Oct; 11(1): 5142.

Leonidas S Lundell, Evelyn B Parr, Brooke L Devlin, Lars R Ingerslev, Ali Altintaş, Shogo Sato, Paolo Sassone-Corsi, Romain Barrès, Juleen R Zierath, John A Hawley, Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression, Nature Communications, 2020, 11 (1), pp.4643. ⟨10.1038/s41467-020-18412-w⟩.

Williams K, Ingerslev LR, Bork-Jensen J, Wohlwend M, Hansen AN, Small L, Ribel-Madsen R, Astrup A, Pedersen O, Auwerx J, Workman CT, Grarup N, Hansen T, Barrès R, Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism., Nat Commun 2020 Jun; 11(1): 2695.

Altıntaş A, Laker RC, Garde C, Barrès R, Zierath JR, Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development., Epigenomics 2020 Apr; 12(8): 701-713.

Dollerup OL, Chubanava S, Agerholm M, Søndergård SD, Altıntaş A, Møller AB, Høyer KF, Ringgaard S, Stødkilde-Jørgensen H, Lavery GG, Barrès R, Larsen S, Prats C, Jessen N, Treebak JT, Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men., J Physiol 2020 Feb; 598(4): 731-754.

Alligier M, Barrès R, Blaak EE, Boirie Y, Bouwman J, Brunault P, Campbell K, Clément K, Farooqi IS, Farpour-Lambert NJ, Frühbeck G, Goossens GH, Hager J, Halford JCG, Hauner H, Jacobi D, Julia C, Langin D, Natali A, Neovius M, Oppert JM, Pagotto U, Palmeira AL, Roche H, Rydén M, Scheen AJ, Simon C, Sorensen TIA, Tappy L, Yki-Järvinen H, Ziegler O, Laville M, OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions., Obes Facts 2020 ; 13(1): 1-28.

Hochreuter MY, Altıntaş A, Garde C, Emanuelli B, Kahn CR, Zierath JR, Vienberg S, Barrès R, Identification of two microRNA nodes as potential cooperative modulators of liver metabolism., Hepatol Res 2019 Dec; 49(12): 1451-1465.

Hiam D, Simar D, Laker R, Altıntaş A, Gibson-Helm M, Fletcher E, Moreno-Asso A, Trewin AJ, Barres R, Stepto NK, Epigenetic Reprogramming of Immune Cells in Women With PCOS Impact Genes Controlling Reproductive Function., J Clin Endocrinol Metab 2019 Dec; 104(12): 6155-6170.

Lundh M, Petersen PS, Isidor MS, Kazoka-Sørensen DN, Plucińska K, Shamsi F, Ørskov C, Tozzi M, Brown EL, Andersen E, Ma T, Müller U, Barrès R, Kristiansen VB, Gerhart-Hines Z, Tseng YH, Emanuelli B, Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue., EMBO Rep 2019 Aug; 20(8): e48216.

Sato S, Basse AL, Schönke M, Chen S, Samad M, Altıntaş A, Laker RC, Dalbram E, Barrès R, Baldi P, Treebak JT, Zierath JR, Sassone-Corsi P, Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis., Cell Metab 2019 Jul; 30(1): 92-110.e4.

Jacques M, Hiam D, Craig J, Barrès R, Eynon N, Voisin S, Epigenetic changes in healthy human skeletal muscle following exercise- a systematic review., Epigenetics 2019 Jul; 14(7): 633-648.

Andersen E, Altıntaş A, Andersson-Hall U, Holmäng A, Barrès R, Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes., Epigenomics 2019 Jun; 11(8): 861-873.

de Castro Barbosa T, Alm PS, Krook A, Barrès R, Zierath JR, Paternal high-fat diet transgenerationally impacts hepatic immunometabolism., FASEB J 2019 May; 33(5): 6269-6280.

Andersen E, Ingerslev LR, Fabre O, Donkin I, Altıntaş A, Versteyhe S, Bisgaard T, Kristiansen VB, Simar D, Barrès R, Preadipocytes from obese humans with type 2 diabetes are epigenetically reprogrammed at genes controlling adipose tissue function., Int J Obes (Lond) 2019 Feb; 43(2): 306-318.

Poupeau A, Garde C, Sulek K, Citirikkaya K, Treebak JT, Arumugam M, Simar D, Olofsson LE, Bäckhed F, Barrès R, Genes controlling the activation of natural killer lymphocytes are epigenetically remodeled in intestinal cells from germ-free mice., FASEB J 2019 Feb; 33(2): 2719-2731.

Jacobsen MJ, Havgaard JH, Anthon C, Mentzel CMJ, Cirera S, Krogh PM, Pundhir S, Karlskov-Mortensen P, Bruun CS, Lesnik P, Guerin M, Gorodkin J, Jørgensen CB, Fredholm M, Barrès R, Epigenetic and Transcriptomic Characterization of Pure Adipocyte Fractions From Obese Pigs Identifies Candidate Pathways Controlling Metabolism., Front Genet 2019 ; 10(): 1268.

Daniel S, Nylander V, Ingerslev LR, Zhong L, Fabre O, Clifford B, Johnston K, Cohn RJ, Barres R, Simar D, T cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors., Clin Epigenetics 2018 Nov; 10(1): 138.

Saupstad M, Andersen E, Barrès R, [The importance of sperm epigenetics for conception and embryology]., Ugeskr Laeger 2018 Aug; 180(34): .

Fabre O, Ingerslev LR, Garde C, Donkin I, Simar D, Barrès R, Exercise training alters the genomic response to acute exercise in human adipose tissue., Epigenomics 2018 Aug; 10(8): 1033-1050.

Donkin I, Barrès R, Sperm epigenetics and influence of environmental factors., Mol Metab 2018 Aug; 14(): 1-11.

Mechta M, Ingerslev LR, Barrès R, Methodology for Accurate Detection of Mitochondrial DNA Methylation., J Vis Exp 2018 May; (135): .

Ingerslev LR, Donkin I, Fabre O, Versteyhe S, Mechta M, Pattamaprapanont P, Mortensen B, Krarup NT, Barrès R, Endurance training remodels sperm-borne small RNA expression and methylation at neurological gene hotspots., Clin Epigenetics 2018 ; 10(): 12.

Machado L, Esteves de Lima J, Fabre O, Proux C, Legendre R, Szegedi A, Varet H, Ingerslev LR, Barrès R, Relaix F, Mourikis P, In Situ Fixation Redefines Quiescence and Early Activation of Skeletal Muscle Stem Cells., Cell Rep 2017 Nov; 21(7): 1982-1993.

Alm PS, de Castro Barbosa T, Barrès R, Krook A, Zierath JR, Grandpaternal-induced transgenerational dietary reprogramming of the unfolded protein response in skeletal muscle., Mol Metab 2017 Jul; 6(7): 621-630.

Mechta M, Ingerslev LR, Fabre O, Picard M, Barrès R, Evidence Suggesting Absence of Mitochondrial DNA Methylation., Front Genet 2017 ; 8(): 166.

Luo A, Leach ST, Barres R, Hesson LB, Grimm MC, Simar D, The Microbiota and Epigenetic Regulation of T Helper 17/Regulatory T Cells: In Search of a Balanced Immune System., Front Immunol 2017 ; 8(): 417.

Le Thuc O, Cansell C, Bourourou M, Denis RG, Stobbe K, Devaux N, Guyon A, Cazareth J, Heurteaux C, Rostène W, Luquet S, Blondeau N, Nahon JL, Rovère C, Central CCL2 signaling onto MCH neurons mediates metabolic and behavioral adaptation to inflammation., EMBO Rep 2016 Dec; 17(12): 1738-1752.

Nylander V, Ingerslev LR, Andersen E, Fabre O, Garde C, Rasmussen M, Citirikkaya K, Bæk J, Christensen GL, Aznar M, Specht L, Simar D, Barrès R, Ionizing Radiation Potentiates High-Fat Diet-Induced Insulin Resistance and Reprograms Skeletal Muscle and Adipose Progenitor Cells., Diabetes 2016 Dec; 65(12): 3573-3584.

Raghuraman S, Donkin I, Versteyhe S, Barrès R, Simar D, The Emerging Role of Epigenetics in Inflammation and Immunometabolism., Trends Endocrinol Metab 2016 Nov; 27(11): 782-795.

Donkin I, Barrès R, Pinborg A, [Epigenetic influence on embryonic development]., Ugeskr Laeger 2016 Sep; 178(37): .

Barrès R, Zierath JR, The role of diet and exercise in the transgenerational epigenetic landscape of T2DM., Nat Rev Endocrinol 2016 Aug; 12(8): 441-51.

Kirchner H, Sinha I, Gao H, Ruby MA, Schönke M, Lindvall JM, Barrès R, Krook A, Näslund E, Dahlman-Wright K, Zierath JR, Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients., Mol Metab 2016 Mar; 5(3): 171-183.

de Castro Barbosa T, Ingerslev LR, Alm PS, Versteyhe S, Massart J, Rasmussen M, Donkin I, Sjögren R, Mudry JM, Vetterli L, Gupta S, Krook A, Zierath JR, Barrès R, High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring., Mol Metab 2016 Mar; 5(3): 184-197.

Donkin I, Versteyhe S, Ingerslev LR, Qian K, Mechta M, Nordkap L, Mortensen B, Appel EV, Jørgensen N, Kristiansen VB, Hansen T, Workman CT, Zierath JR, Barrès R, Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans., Cell Metab 2016 Feb; 23(2): 369-78.

Pattamaprapanont P, Garde C, Fabre O, Barrès R, Muscle Contraction Induces Acute Hydroxymethylation of the Exercise-Responsive Gene Nr4a3., Front Endocrinol (Lausanne) 2016 ; 7(): 165.

Jacobsen MJ, Mentzel CM, Olesen AS, Huby T, Jørgensen CB, Barrès R, Fredholm M, Simar D, Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity., J Diabetes Res 2016 ; 2016(): 8539057.

Corinne. Caillaud, M. Mechta, H. Ainge, A. Madsen, P. Ruell, Eric Mas, Catherine Bisbal, Jacques Mercier, S. Twigg, T. Mori, D. Simar, R. Barres, Chronic erythropoietin treatment improves diet-induced glucose intolerance in rats, Journal of Endocrinology, 2015, 225 (2), pp.77 - 88. ⟨10.1530/JOE-15-0010⟩.

Agudelo LZ, Femenía T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, Correia JC, Izadi M, Bhat M, Schuppe-Koistinen I, Pettersson AT, Ferreira DMS, Krook A, Barres R, Zierath JR, Erhardt S, Lindskog M, Ruas JL, Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression., Cell 2014 Sep; 159(1): 33-45.

Simar D, Versteyhe S, Donkin I, Liu J, Hesson L, Nylander V, Fossum A, Barrès R, DNA methylation is altered in B and NK lymphocytes in obese and type 2 diabetic human., Metabolism 2014 Sep; 63(9): 1188-97.

Rasmussen M, Zierath JR, Barrès R, Dynamic epigenetic responses to muscle contraction., Drug Discov Today 2014 Jul; 19(7): 1010-4.

Kirchner H, Nylen C, Laber S, Barrès R, Yan J, Krook A, Zierath JR, Näslund E, Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass., Surg Obes Relat Dis 2014 ; 10(4): 671-8.

Barres R, Kirchner H, Rasmussen M, Yan J, Kantor FR, Krook A, Näslund E, Zierath JR, Weight loss after gastric bypass surgery in human obesity remodels promoter methylation., Cell Rep 2013 Apr; 3(4): 1020-7.

Barrès R, Yan J, Egan B, Treebak JT, Rasmussen M, Fritz T, Caidahl K, Krook A, O'Gorman DJ, Zierath JR, Acute exercise remodels promoter methylation in human skeletal muscle., Cell Metab 2012 Mar; 15(3): 405-11.

Yan J, Zierath JR, Barrès R, Evidence for non-CpG methylation in mammals., Exp Cell Res 2011 Nov; 317(18): 2555-61.

Zierath JR, Barrès RE, Nutritional status affects the epigenomic profile of peripheral blood cells., Epigenomics 2011 Jun; 3(3): 259-60.

Barres R, Zierath JR, DNA methylation in metabolic disorders., Am J Clin Nutr 2011 Apr; 93(4): 897S-900.

Czepluch FS, Barrès R, Caidahl K, Olieslagers S, Krook A, Rickenlund A, Zierath JR, Waltenberger J, Strenuous physical exercise adversely affects monocyte chemotaxis., Thromb Haemost 2011 Jan; 105(1): 122-30.

Galuska D, Pirkmajer S, Barrès R, Ekberg K, Wahren J, Chibalin AV, C-peptide increases Na,K-ATPase expression via PKC- and MAP kinase-dependent activation of transcription factor ZEB in human renal tubular cells., PLoS One 2011 ; 6(12): e28294.

Ng SF, Lin RC, Laybutt DR, Barres R, Owens JA, Morris MJ, Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring., Nature 2010 Oct; 467(7318): 963-6.

Markljung E, Jiang L, Jaffe JD, Mikkelsen TS, Wallerman O, Larhammar M, Zhang X, Wang L, Saenz-Vash V, Gnirke A, Lindroth AM, Barrés R, Yan J, Strömberg S, De S, Pontén F, Lander ES, Carr SA, Zierath JR, Kullander K, Wadelius C, Lindblad-Toh K, Andersson G, Hjälm G, Andersson L, ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth., PLoS Biol 2009 Dec; 7(12): e1000256.

Barrès R, Osler ME, Yan J, Rune A, Fritz T, Caidahl K, Krook A, Zierath JR, Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density., Cell Metab 2009 Sep; 10(3): 189-98.

Galuska D, Kotova O, Barrès R, Chibalina D, Benziane B, Chibalin AV, Altered expression and insulin-induced trafficking of Na+-K+-ATPase in rat skeletal muscle: effects of high-fat diet and exercise., Am J Physiol Endocrinol Metab 2009 Jul; 297(1): E38-49.

Glund S, Treebak JT, Long YC, Barres R, Viollet B, Wojtaszewski JF, Zierath JR, Role of adenosine 5′-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle., Endocrinology 2009 Feb; 150(2): 600-6.

Barrès R, Grémeaux T, Gual P, Gonzalez T, Gugenheim J, Tran A, Le Marchand-Brustel Y, Tanti JF, Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation., Mol Endocrinol 2006 Nov; 20(11): 2864-75.

Barrès R, Gonzalez T, Le Marchand-Brustel Y, Tanti JF, The interaction between the adaptor protein APS and Enigma is involved in actin organisation., Exp Cell Res 2005 Aug; 308(2): 334-44.

Gual P, Gonzalez T, Grémeaux T, Barres R, Le Marchand-Brustel Y, Tanti JF, Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes., J Biol Chem 2003 Jul; 278(29): 26550-7.