Épigénétique et métabolisme
Présentation
Notre compréhension de l’obésité a subi un changement de paradigme. La découverte récente selon laquelle les informations épigénétiques des gamètes sont sensibles à des facteurs alimentaires conforte l’idée selon laquelle le mode de vie avant la conception peut influencer la santé métabolique de la génération suivante.
Notre but est d’étudier les mécanismes cellulaires par lesquels les informations épigénétiques acquises et transférées via les gamètes peuvent influencer le développement et le métabolisme chez la progéniture et prédisposer la prochaine génération à l’obésité.
Création d’un Laboratoire International Associé dédié aux interactions cerveau-corps-environnement en santé métabolique et mentale dont la signature officielle a eu lieu le 23 Avril 2026.
Le LIA-SYNAPSE (Systèmes Neuroendocriniens : Adaptation, Plasticité, Signalisation et Environnement) est une initiative conjointe entre Université Côte d’Azur et l’Université Laval, visant à structurer une collaboration internationale d’excellence en neuroendocrinologie intégrative. Les co-directeurs sont Carole Rovère (IPMC/UniCA) et Alexandre Caron (IUCPQ/UL).
Les liens du compte LinkedIn : https://www.linkedin.com/company/LIA-SYNAPSE
Actualités
Publication
08
Sep
2025
Publication IPMC / Cell Metabolism / Equipe Barrès
Alimentation ultra-transformée : des risques pour la santé même sans excès calorique. La consommation d’aliments ultra-transformés est associée à un […]
Publication
01
Mar
2024
Publication IPMC / Brain, Behavior, and Immunity / Équipe Barrès
La composition en acides gras de l’alimentation est à l’origine de la neuroinflammation et de l’altération du comportement dans l’obésité […]
Autre
24
Mar
2026
Carole Rovere- France 3 Côte d'Azur est venu voir le spectacle musical "La mélodie des Neurones"
Le spectacle musical « La mélodie des Neurones » a fait salle comble lors de l’inauguration de la Semaine du Cerveau à […]
Autre
08
Avr
2026
Un article de Nice-Matin, signé Nancy Cattan, met en lumière les travaux de recherche de Romain Barrès (IPMC) sur les effets de l’alimentation sur la santé.
Autre
17
Avr
2026
🎓 Une nouvelle fierté pour l’IPMC !
Pour la deuxième année consécutive, une doctorante de l’IPMC est sélectionnée pour participer aux Lindau Nobel Laureate Meetings, un événement […]
Autre
05
Mai
2026
Création d'un Laboratoire International Associé dédié aux interactions cerveau-corps-environnement en santé métabolique et mentale dont la signature officielle a eu lieu le 23 Avril 2026.
Le LIA-SYNAPSE (Systèmes Neuroendocriniens : Adaptation, Plasticité, Signalisation et Environnement) est une initiative conjointe entre Université Côte d’Azur et l’Université […]
Projets
Projet
2025
Prise alimentaire et modifications épigénétiques des spermatozoïdes
Projet
2025
Amélioration de la fertilité
Projet
2026
Neuroinflammation et dérégulations du comportement alimentaire
Les projets développés dans ce second axe de recherche sont à l’interface entre la neuroimmunoendocrinologie, la nutrition et le métabolisme. […]
Projet
2024
Impact de la nature des lipides sur la neuroinflammation et la réactivité gliale, associées au développement de l’obésité.
Mots-clés : Lipides, Neuroinflammation, Réactivité gliale et Obésité nutritionnelle Ce projet vise à comprendre les mécanismes impliqués dans la réponse […]
Projet
2024
Régulation centrale des fonctions neuroendocriniennes, génomique et évolution
Implication du système MCH/MCHR1-MCHR2 dans la régulation des fonctions neuroendocriniennes Notre modèle de prédilection est celui du peptide MCH dont […]
Projet
2026
EXPOSURE: EXPOsome Signatures of Ultra-processed food pollutants: outcomes on brain Regulation
Key words: Pollutants, Phthalates, Plastics,Ultra-processed food, Exposome, Brain disorders. DESCRIPTION OF THE PROJECT EXPOSURE: EXPOsome Signatures of Ultra-processed food pollutants: outcomes on […]
Projet
2026
Impact de la nature des lipides sur la neuroinflammation et la réactivité gliale, associées au développement de l’obésité.
Présentation Mots-clés : Lipides, Neuroinflammation, Réactivité gliale, Obésité nutritionnelle Ce projet vise à comprendre les mécanismes impliqués dans la réponse […]
Publications
2026
EFA6A regulates retinal function through the control of photoreceptor cell activity and structure.,
iScience 2026 Apr; 29(4): 115179.
2025
Effect of ultra-processed food consumption on male reproductive and metabolic health.,
Cell Metab 2025 Aug; online ahead of print.
2025
The horse cardiac transcriptome: Moving towards a molecular understanding of atrial fibrillation,
Equine Veterinary Journal, 2025, ⟨10.1111/evj.70115⟩.
2025
Two-phase model of ageing in mice for improved identification of age-related and late life metabolic decline.,
BMC Biol 2025 Oct; 23(1): 318.
2025
Smurf Mice »: revolutionising our understanding of age-related and end-of-life animal physiology,
2025.
2025
High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection.,
Adv Sci (Weinh) 2025 Jun; 12(22): e2412236.
2025
Exposure to childhood maltreatment is associated with specific epigenetic patterns in sperm.,
Mol Psychiatry 2025 Jun; 30(6): 2635-2644.
2025
Computational detection, characterization, and clustering of microglial cells in a mouse model of fat-induced postprandial hypothalamic inflammation.,
Methods 2025 Apr; 236(): 28-38.
2025
Transcriptomic signatures of cold acclimated adipocytes reveal CXCL12 as a Brown autocrine and paracrine chemokine.,
Mol Metab 2025 Mar; 93(): 102102.
2025
Healthy lifestyle before and during pregnancy to prevent childhood obesity: study protocol for a parallel group randomised trial – the PRE-STORK trial.,
BMJ Open 2025 Jan; 15(1): e087895.
2025
Muscle Cathepsin B treatment improves behavioral and neurogenic deficits in a mouse model of Alzheimer’s Disease.,
bioRxiv 2025 Jan; (): .
2025
A Guinea Pig Model of Pediatric Metabolic Dysfunction-Associated Steatohepatitis: Poor Vitamin C Status May Advance Disease.,
Nutrients 2025 Jan; 17(2): .
2024
Lessons from paleoclimates for recent and future climate change: opportunities and insights,
Frontiers in Climate, 2024, 6, ⟨10.3389/fclim.2024.1511997⟩.
2024
Oncogenic GNAQ/11-induced remodeling of the IP3/Calcium signaling pathway protects Uveal Melanoma against Calcium-driven cell death,
2024.
2024
Using graph neural networks to reconstruct charged pion showers in the CMS High Granularity Calorimeter,
JINST, 2024, 19 (11), pp.P11025. ⟨10.1088/1748-0221/19/11/P11025⟩.
2024
Timing Performance of the CMS High Granularity Calorimeter Prototype,
JINST, 2024, 19 (04), pp.P04015. ⟨10.1088/1748-0221/19/04/P04015⟩.
2024
Evidence for the Higgs Boson Decay to a Z Boson and a Photon at the LHC,
Phys.Rev.Lett., 2024, 132 (2), pp.021803. ⟨10.1103/PhysRevLett.132.021803⟩.
2024
Effects of tire particles and associated-chemicals on the Pacific oyster (Magallana gigas) physiology, reproduction and next-generation,
Journal of Hazardous Materials, 2024, 480, pp.135742. ⟨10.1016/j.jhazmat.2024.135742⟩.
2024
Loss of atrial natriuretic peptide signaling causes insulin resistance, mitochondrial dysfunction, and low endurance capacity,
Science Advances , 2024, 10 (41), 18p.,eadl4374. ⟨10.1126/sciadv.adl4374⟩.
2024
Extracellular vesicles – small messengers with a wide range of applications?,
Dan Med J 2024 Jul; 71(8): .
2024
Epigenetics of the non-coding RNA nc886 across blood, adipose tissue and skeletal muscle in offspring exposed to diabetes in pregnancy,
Clinical Epigenetics, 2024, 16 (1), pp.61. ⟨10.1186/s13148-024-01673-3⟩.
2024
Paternal dietary macronutrient balance and energy intake drive metabolic and behavioral differences among offspring,
Nature Communications, 2024, 15 (1), pp.2982. ⟨10.1038/s41467-024-46782-y⟩.
2024
Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity.,
Brain Behav Immun 2024 Mar; 117(): 330-346.
2024
Dietary macronutrient composition impacts gene regulation in adipose tissue,
Communications Biology, 2024, 7 (1), pp.194. ⟨10.1038/s42003-024-05876-5⟩.
2024
Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a.,
Neurobiol Dis 2024 Feb; 191(): 106393.
2024
Acid-sensing ion channel 3 mediates pain hypersensitivity associated with high-fat diet consumption in mice.,
Pain 2024 Feb; 165(2): 470-486.
2024
Microgliosis: a double-edged sword in the control of food intake.,
FEBS J 2024 Feb; 291(4): 615-631.
2024
Evolution de l’architecture sédimentaire de la plaine maritime flamande depuis l’Antiquité : apport des données géoradar,
19e Congrès Français de Sédimentologie, Nov 2024, Lille, France.
2023
Composition and evolution of the gut microbiota of growing puppies is impacted by their birth weight,
Scientific Reports, 2023, 13 (1), pp.14717. ⟨10.1038/s41598-023-41422-9⟩.
2023
Coral reef structural complexity loss exposes coastlines to waves,
Scientific Reports, 2023, 13 (1), pp.1683. ⟨10.1038/s41598-023-28945-x⟩.
2023
L’uso del legno di quercia nell’architettura romana: l’apporto delle fonti testuali latine,
Terra, legno e materiali deperibili nell’architettura antica, Caterina Previato; Jacopo Bonetto, Jun 2021, Padova, France.
2023
Combination of inclusive top-quark pair production cross-section measurements using ATLAS and CMS data at $ \sqrt{s} $ = 7 and 8 TeV,
JHEP, 2023, 07, pp.213. ⟨10.1007/JHEP07(2023)213⟩.
2023
Splicing across adipocyte differentiation is highly dynamic and impacted by metabolic phenotype.,
Res Sq 2023 Oct; (): .
2023
Seasonal light hours modulate peripheral clocks and energy metabolism in mice,
Cell Metabolism, 2023, 35 (10), pp.1722-1735.e5. ⟨10.1016/j.cmet.2023.08.005⟩.
2023
Effect of CYP51 gene expression levels and haplotype diversity on resistance phenotypes of field isolates of cercospora beticola,
12th International Congress of Plant Pathology, Aug 2023, LYON, France. Poster.
2023
Beta cell dysfunction induced by bone morphogenetic protein (BMP)-2 is associated with histone modifications and decreased NeuroD1 chromatin binding,
Cell Death and Disease, 2023, 14 (7), pp.399. ⟨10.1038/s41419-023-05906-w⟩.
2023
Male reproductive traits are differentially affected by dietary macronutrient balance but unrelated to adiposity,
Nature Communications, 2023, 14 (1), pp.2566. ⟨10.1038/s41467-023-38314-x⟩.
2023
Physical Activity and Insulin Sensitivity Independently Attenuate the Effect of FTO rs9939609 on Obesity,
Diabetes Care, 2023, 46 (5), pp.985-992. ⟨10.2337/dc22-2078⟩.
2023
NAMPT-dependent NAD + biosynthesis controls circadian metabolism in a tissue-specific manner,
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (14), ⟨10.1073/pnas.2220102120⟩.
2023
Palmitate impairs circadian transcriptomics in muscle cells through histone modification of enhancers,
Life Science Alliance, 2023, 6 (1), pp.e202201598. ⟨10.26508/lsa.202201598⟩.
2023
Two phases model of ageing in mice: towards a better identification of age-related and late-life metabolic decline [Registered Report Stage 1 Protocol],
2023.
2022
Role of cerium addition in enhancing the oxidation resistance of austenitic Fe-Mn-Si-Cr-Ni shape memory stainless steels at 800 °C: Microstructure and oxidation mechanism,
Corrosion Science, 2022, 209, pp.110788. ⟨10.1016/j.corsci.2022.110788⟩.
2022
Including environmental variables in genomic models for carcass traits in Hanwoo beef cattle,
12th World Congress on Genetics Applied to Livestock Production, Jul 2022, Rotterdam, Netherlands.
2022
The International Bathymetric Chart of the Southern Ocean Version 2,
Scientific Data , 2022, 9 (1), 275 (13p.). ⟨10.1038/s41597-022-01366-7⟩.
2022
Response of a CMS HGCAL silicon-pad electromagnetic calorimeter prototype to 20–300 GeV positrons,
JINST, 2022, 17 (05), pp.P05022. ⟨10.1088/1748-0221/17/05/P05022⟩.
2022
One-year mental health outcomes in a cohort of COVID-19 survivors,
Journal of Psychiatric Research, 2022, 145, pp.118 - 124. ⟨10.1016/j.jpsychires.2021.11.031⟩.
2022
Association of apolipoprotein M and sphingosine-1-phosphate with brown adipose tissue after cold exposure in humans,
Scientific Reports, 2022, 12 (1), pp.18753. ⟨10.1038/s41598-022-21938-2⟩.
2022
MicroRNAs in non-alcoholic fatty liver disease: Progress and perspectives,
Molecular metabolism, 2022, 65, pp.101581. ⟨10.1016/j.molmet.2022.101581⟩.
2022
Comparative analysis of sperm DNA methylation supports evolutionary acquired epigenetic plasticity for organ speciation,
Epigenomics, 2022, 14 (21), pp.1305-1324. ⟨10.2217/epi-2022-0168⟩.
2022
Butyrate inhibits IL-1β-induced inflammatory gene expression by suppression of NF-κB activity in pancreatic beta cells,
Journal of Biological Chemistry, 2022, 298 (9), pp.102312. ⟨10.1016/j.jbc.2022.102312⟩.
2022
Evidence for Constitutive Microbiota-Dependent Short-Term Control of Food Intake in Mice: Is There a Link with Inflammation, Oxidative Stress, Endotoxemia, and GLP-1?,
Antioxid Redox Signal 2022 Aug; 37(4-6): 349-369.
2022
Sperm count is increased by diet-induced weight loss and maintained by exercise or GLP-1 analogue treatment: a randomized controlled trial,
Human Reproduction, 2022, 37 (7), pp.1414-1422. ⟨10.1093/humrep/deac096⟩.
2022
Transforming growth factor β1 impairs the transcriptomic response to contraction in myotubes from women with polycystic ovary syndrome,
The Journal of Physiology, 2022, 600 (14), pp.3313-3330. ⟨10.1113/JP282954⟩.
2022
DNA Methylation and Gene Expression in Blood and Adipose Tissue of Adult Offspring of Women with Diabetes in Pregnancy—A Validation Study of DNA Methylation Changes Identified in Adolescent Offspring,
Biomedicines, 2022, 10 (6), pp.1244. ⟨10.3390/biomedicines10061244⟩.
2022
Comparative analysis of oral and intraperitoneal glucose tolerance tests in mice,
Molecular metabolism, 2022, 57, pp.101440. ⟨10.1016/j.molmet.2022.101440⟩.
2022
Atlas of exercise metabolism reveals time-dependent signatures of metabolic homeostasis,
Cell Metabolism, 2022, 34 (2), pp.329-345.e8. ⟨10.1016/j.cmet.2021.12.016⟩.
2021
Genome-wide and comparative phylogenetic analysis of senescence-associated NAC transcription factors in sunflower (Helianthus annuus),
BMC Genomics, 2021, 22 (1), ⟨10.1186/s12864-021-08199-5⟩.
2021
X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19,
Science Immunology, 2021, 6 (62), ⟨10.1126/sciimmunol.abl4348⟩.
2021
GPS Coordinates for Modelling Correlated Herd Effects in Genomic Prediction Models Applied to Hanwoo Beef Cattle,
Animals, 2021, 11 (7), pp.2050. ⟨10.3390/ani11072050⟩.
2021
Climate pacing of millennial sea-level change variability in the central and western Mediterranean,
Nature Communications, 2021, 12 (1), pp.4013. ⟨10.1038/s41467-021-24250-1⟩.
2021
The DAQ system of the 12,000 channel CMS high granularity calorimeter prototype,
JINST, 2021, 16 (04), pp.T04001. ⟨10.1088/1748-0221/16/04/T04001⟩.
2021
Construction and commissioning of CMS CE prototype silicon modules,
JINST, 2021, 16 (04), pp.T04002. ⟨10.1088/1748-0221/16/04/T04002⟩.
2021
Probing effective field theory operators in the associated production of top quarks with a Z boson in multilepton final states at $ \sqrt{s} $ = 13 TeV,
JHEP, 2021, 12, pp.083. ⟨10.1007/JHEP12(2021)083⟩.
2021
Endurance Training in Humans Modulates the Bacterial DNA Signature of Skeletal Muscle,
Biomedicines, 2021, 10 (1), pp.64. ⟨10.3390/biomedicines10010064⟩.
2021
The exercise-induced long noncoding RNA CYTOR promotes fast-twitch myogenesis in aging,
Science Translational Medicine, 2021, 13 (623), ⟨10.1126/scitranslmed.abc7367⟩.
2021
Non-cell autonomous mechanisms control mitochondrial gene dysregulation in polycystic ovary syndrome.,
J Mol Endocrinol 2021 Dec; 68(1): 63-76.
2021
Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes.,
J Biol Chem 2021 Dec; 297(6): 101388.
2021
Insulin resistance rewires the metabolic gene program and glucose utilization in human white adipocytes,
International Journal of Obesity, 2021, 46 (3), pp.535-543. ⟨10.1038/s41366-021-01021-y⟩.
2021
Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in whole-body function and human health.,
Mol Metab 2021 Nov; 53(): 101290.
2021
Nampt controls skeletal muscle development by maintaining Ca2+ homeostasis and mitochondrial integrity.,
Mol Metab 2021 Nov; 53(): 101271.
2021
Disrupted circadian oscillations in type 2 diabetes are linked to altered rhythmic mitochondrial metabolism in skeletal muscle.,
Sci Adv 2021 Oct; 7(43): eabi9654.
2021
Endurance exercise training-responsive miR-19b-3p improves skeletal muscle glucose metabolism.,
Nat Commun 2021 Oct; 12(1): 5948.
2021
Exploring the Mechanisms of Recovery in Anorexia Nervosa through a Translational Approach: From Original Ecological Measurements in Human to Brain Tissue Analyses in Mice.,
Nutrients 2021 Aug; 13(8): .
2021
Perinatal exposure to nicotine alters spermatozoal DNA methylation near genes controlling nicotine action.,
FASEB J 2021 Jul; 35(7): e21702.
2021
Cold-induction of afadin in brown fat supports its thermogenic capacity.,
Sci Rep 2021 May; 11(1): 9794.
2021
Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway.,
Pharmacol Res 2021 May; 167(): 105539.
2021
Structured supervised exercise training or motivational counselling during pregnancy on physical activity level and health of mother and offspring: FitMum study protocol.,
BMJ Open 2021 Mar; 11(3): e043671.
2021
Exercise during pregnancy mitigates negative effects of parental obesity on metabolic function in adult mouse offspring.,
J Appl Physiol (1985) 2021 Mar; 130(3): 605-616.
2021
White adipose remodeling during browning in mice involves YBX1 to drive thermogenic commitment.,
Mol Metab 2021 Feb; 44(): 101137.
2021
Ablation of DNA-methyltransferase 3A in skeletal muscle does not affect energy metabolism or exercise capacity,
PLoS Genetics, 2021, 17 (1), pp.e1009325. ⟨10.1371/journal.pgen.1009325⟩.
2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition),
Autophagy, 2021, 17 (1), pp.1-382. ⟨10.1080/15548627.2020.1797280⟩.
2021
Dietary fat exacerbates postprandial hypothalamic inflammation involving glial fibrillary acidic protein-positive cells and microglia in male mice.,
Glia 2021 Jan; 69(1): 42-60.
2020
Assessing the efficacy of nourishment of a Mediterranean beach using bimodal fluvial sediments and a specific placement design,
Geo-Marine Letters, 2020, 40 (5), pp.687-698. ⟨10.1007/s00367-020-00664-6⟩.
2020
APOL1 C-Terminal Variants May Trigger Kidney Disease through Interference with APOL3 Control of Actomyosin,
Cell Reports, 2020, 30 (11), pp.3821-3836.e13. ⟨10.1016/j.celrep.2020.02.064⟩.
2020
Insights into high-temperature oxidation of Fe-Mn-Si-Cr-Ni shape memory stainless steels and its relationship to alloy chemical composition
Oxydation à haute température des aciers inoxydables à mémoire de forme Fe-Mn-Si-Cr-Ni et relation avec la composition chimique de l’alliage,
Corrosion Science, 2020, 163, pp.108269. ⟨10.1016/j.corsci.2019.108269⟩.
2020
Community composition predicts photogrammetry-based structural complexity on coral reefs,
Coral Reefs, 2020, 39, pp.967-975. ⟨10.1007/s00338-020-01916-8⟩.
2020
Contraction influences Per2 gene expression in skeletal muscle through a calcium-dependent pathway.,
J Physiol 2020 Dec; 598(24): 5739-5752.
2020
Insulin-induced serine 22 phosphorylation of retinoid X receptor alpha is dispensable for adipogenesis in brown adipocytes.,
Adipocyte 2020 Dec; 9(1): 142-152.
2020
Author Correction: Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression.,
Nat Commun 2020 Oct; 11(1): 5142.
2020
Time-restricted feeding alters lipid and amino acid metabolite rhythmicity without perturbing clock gene expression,
Nature Communications, 2020, 11 (1), pp.4643. ⟨10.1038/s41467-020-18412-w⟩.
2020
Skeletal muscle enhancer interactions identify genes controlling whole-body metabolism.,
Nat Commun 2020 Jun; 11(1): 2695.
2020
Transcriptomic and epigenomics atlas of myotubes reveals insight into the circadian control of metabolism and development.,
Epigenomics 2020 Apr; 12(8): 701-713.
2020
Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal.,
Cell Rep 2020 Mar; 30(9): 3067-3078.e5.
2020
Nicotinamide riboside does not alter mitochondrial respiration, content or morphology in skeletal muscle from obese and insulin-resistant men.,
J Physiol 2020 Feb; 598(4): 731-754.
2020
OBEDIS Core Variables Project: European Expert Guidelines on a Minimal Core Set of Variables to Include in Randomized, Controlled Clinical Trials of Obesity Interventions,
Obesity Facts, 2020, 13 (1), pp.1-28. ⟨10.1159/000505342⟩.
2019
HIV-1 Vpr mediates the depletion of the cellular repressor CTIP2 to counteract viral gene silencing,
Scientific Reports, 2019, 9 (1), ⟨10.1038/s41598-019-48689-x⟩.
2019
Epigenetic and Transcriptomic Characterization of Pure Adipocyte Fractions From Obese Pigs Identifies Candidate Pathways Controlling Metabolism,
Frontiers in Genetics, 2019, 10, ⟨10.3389/fgene.2019.01268⟩.
2019
Identification of two microRNA nodes as potential cooperative modulators of liver metabolism.,
Hepatol Res 2019 Dec; 49(12): 1451-1465.
2019
Epigenetic Reprogramming of Immune Cells in Women With PCOS Impact Genes Controlling Reproductive Function.,
J Clin Endocrinol Metab 2019 Dec; 104(12): 6155-6170.
2019
Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue.,
EMBO Rep 2019 Aug; 20(8): e48216.
2019
Time of Exercise Specifies the Impact on Muscle Metabolic Pathways and Systemic Energy Homeostasis.,
Cell Metab 2019 Jul; 30(1): 92-110.e4.
2019
Epigenetic changes in healthy human skeletal muscle following exercise- a systematic review.,
Epigenetics 2019 Jul; 14(7): 633-648.
2019
Environmental factors influence the epigenetic signature of newborns from mothers with gestational diabetes.,
Epigenomics 2019 Jun; 11(8): 861-873.
2019
Paternal high-fat diet transgenerationally impacts hepatic immunometabolism.,
FASEB J 2019 May; 33(5): 6269-6280.
2019
Preadipocytes from obese humans with type 2 diabetes are epigenetically reprogrammed at genes controlling adipose tissue function.,
Int J Obes (Lond) 2019 Feb; 43(2): 306-318.
2019
Genes controlling the activation of natural killer lymphocytes are epigenetically remodeled in intestinal cells from germ-free mice.,
FASEB J 2019 Feb; 33(2): 2719-2731.
2018
Safety classification of mechanical components for fusion application,
Fusion Engineering and Design, 2018, 136, pp.1237-1241. ⟨10.1016/j.fusengdes.2018.04.108⟩.
2018
Palaeoclimate constraints on the impact of 2 °C anthropogenic warming and beyond,
Nature Geoscience, 2018, 11 (7), pp.474 - 485. ⟨10.1038/s41561-018-0146-0⟩.
2018
Coral reef structural complexity provides important coastal protection from waves under rising sea levels,
Science Advances , 2018, 4 (2), ⟨10.1126/sciadv.aao4350⟩.
2018
Very high resolution mapping of coral reef state using airborne bathymetric LiDAR surface-intensity and drone imagery,
International Journal of Remote Sensing, 2018, 39 (17), pp.5676-5688. ⟨10.1080/01431161.2018.1500072⟩.
2018
T cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors.,
Clin Epigenetics 2018 Nov; 10(1): 138.
2018
[The importance of sperm epigenetics for conception and embryology].,
Ugeskr Laeger 2018 Aug; 180(34): .
2018
Exercise training alters the genomic response to acute exercise in human adipose tissue.,
Epigenomics 2018 Aug; 10(8): 1033-1050.
2018
Sperm epigenetics and influence of environmental factors.,
Mol Metab 2018 Aug; 14(): 1-11.
2018
Methodology for Accurate Detection of Mitochondrial DNA Methylation.,
J Vis Exp 2018 May; (135): .
2018
Endurance training remodels sperm-borne small RNA expression and methylation at neurological gene hotspots.,
Clin Epigenetics 2018 ; 10(): 12.
2017
Active tectonics of the Calabrian subduction revealed by new multi-beam bathymetric data and high-resolution seismic profiles in the Ionian Sea (Central Mediterranean),
Earth and Planetary Science Letters, 2017, 461, pp.61 - 72. ⟨10.1016/j.epsl.2016.12.020⟩.
2017
Social Value of Mitigation Action, an anchor for new forms of carbon pricing?,
2017.
2017
In Situ Fixation Redefines Quiescence and Early Activation of Skeletal Muscle Stem Cells,
Cell Reports, 2017, 21 (7), pp.1982-1993. ⟨10.1016/j.celrep.2017.10.080⟩.
2017
Effects of circadian cortisol on the development of a health habit.,
Health Psychol 2017 Nov; 36(11): 1059-1064.
2017
An ex vivo Perifusion Method for Quantitative Determination of Neuropeptide Release from Mouse Hypothalamic Explants.,
Bio Protoc 2017 Aug; 7(16): e2521.
2017
Grandpaternal-induced transgenerational dietary reprogramming of the unfolded protein response in skeletal muscle.,
Mol Metab 2017 Jul; 6(7): 621-630.
2017
Evidence Suggesting Absence of Mitochondrial DNA Methylation.,
Front Genet 2017 ; 8(): 166.
2017
The Microbiota and Epigenetic Regulation of T Helper 17/Regulatory T Cells: In Search of a Balanced Immune System.,
Front Immunol 2017 ; 8(): 417.
2017
Hypothalamic Inflammation and Energy Balance Disruptions: Spotlight on Chemokines.,
Front Endocrinol (Lausanne) 2017 ; 8(): 197.
2017
Long-Term Energy Deficit in Mice Causes Long-Lasting Hypothalamic Alterations after Recovery.,
Neuroendocrinology 2017 ; 105(4): 372-383.
2016
Mapping coral reefs using consumer-grade drones and structure from motion photogrammetry techniques,
Coral Reefs, 2016, ⟨10.1007/s00338-016-1522-0⟩.
2016
Central CCL2 signaling onto MCH neurons mediates metabolic and behavioral adaptation to inflammation.,
EMBO Rep 2016 Dec; 17(12): 1738-1752.
2016
Ionizing Radiation Potentiates High-Fat Diet-Induced Insulin Resistance and Reprograms Skeletal Muscle and Adipose Progenitor Cells.,
Diabetes 2016 Dec; 65(12): 3573-3584.
2016
The Emerging Role of Epigenetics in Inflammation and Immunometabolism.,
Trends Endocrinol Metab 2016 Nov; 27(11): 782-795.
2016
[Epigenetic influence on embryonic development].,
Ugeskr Laeger 2016 Sep; 178(37): .
2016
The role of diet and exercise in the transgenerational epigenetic landscape of T2DM.,
Nat Rev Endocrinol 2016 Aug; 12(8): 441-51.
2016
Altered DNA methylation of glycolytic and lipogenic genes in liver from obese and type 2 diabetic patients.,
Mol Metab 2016 Mar; 5(3): 171-183.
2016
High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring.,
Mol Metab 2016 Mar; 5(3): 184-197.
2016
Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans.,
Cell Metab 2016 Feb; 23(2): 369-78.
2016
Altered Methylation Profile of Lymphocytes Is Concordant with Perturbation of Lipids Metabolism and Inflammatory Response in Obesity,
Journal of diabetes research, 2016, 2016, pp.8539057. ⟨10.1155/2016/8539057⟩.
2016
Muscle Contraction Induces Acute Hydroxymethylation of the Exercise-Responsive Gene Nr4a3.,
Front Endocrinol (Lausanne) 2016 ; 7(): 165.
2016
New Insights in Anorexia Nervosa.,
Front Neurosci 2016 ; 10(): 256.
2016
[Hypothalamic inflammation and energy balance deregulations: focus on chemokines.].,
Biol Aujourdhui 2016 ; 210(4): 211-225.
2015
ER stress induces NLRP3 inflammasome activation and hepatocyte death,
Cell Death and Disease, 2015, 6 (9), pp.e1879-e1879. ⟨10.1038/cddis.2015.248⟩.
2015
Through bleaching and tsunami: Coral reef recovery in the Maldives,
Marine Pollution Bulletin, 2015, 98 (1-2), ⟨10.1016/j.marpolbul.2015.06.050⟩.
2015
The complex contribution of chemokines to neuroinflammation: switching from beneficial to detrimental effects.,
Ann N Y Acad Sci 2015 Sep; 1351(): 127-40.
2015
Chronic erythropoietin treatment improves diet-induced glucose intolerance in rats,
Journal of Endocrinology, 2015, 225 (2), pp.77 - 88. ⟨10.1530/JOE-15-0010⟩.
2014
Search for massive resonances in dijet systems containing jets tagged as W or Z boson decays in pp collisions at $ \sqrt{s} $ = 8 TeV,
JHEP, 2014, 08, pp.173. ⟨10.1007/JHEP08(2014)173⟩.
2014
Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.,
Cell 2014 Sep; 159(1): 33-45.
2014
DNA methylation is altered in B and NK lymphocytes in obese and type 2 diabetic human.,
Metabolism 2014 Sep; 63(9): 1188-97.
2014
Dynamic epigenetic responses to muscle contraction.,
Drug Discov Today 2014 Jul; 19(7): 1010-4.
2014
Effects of sleeve gastrectomy in high fat diet-induced obese mice: respective role of reduced caloric intake, white adipose tissue inflammation and changes in adipose tissue and ectopic fat depots.,
Surg Endosc 2014 Feb; 28(2): 592-602.
2014
Altered promoter methylation of PDK4, IL1 B, IL6, and TNF after Roux-en Y gastric bypass.,
Surg Obes Relat Dis 2014 ; 10(4): 671-8.
2013
New unabated coal is not compatible with keeping global warming below 2°C Statement by leading climate and energy scientists,
2013.
2013
Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume.,
Nat Neurosci 2013 Jul; 16(7): 845-7.
2013
Weight loss after gastric bypass surgery in human obesity remodels promoter methylation.,
Cell Rep 2013 Apr; 3(4): 1020-7.
2012
Acute exercise remodels promoter methylation in human skeletal muscle.,
Cell Metab 2012 Mar; 15(3): 405-11.
2011
Evidence for non-CpG methylation in mammals.,
Exp Cell Res 2011 Nov; 317(18): 2555-61.
2011
Variations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reduction.,
Am J Clin Nutr 2011 Aug; 94(2): 450-8.
2011
Nutritional status affects the epigenomic profile of peripheral blood cells.,
Epigenomics 2011 Jun; 3(3): 259-60.
2011
DNA methylation in metabolic disorders.,
Am J Clin Nutr 2011 Apr; 93(4): 897S-900.
2011
Chemokines and chemokine receptors: New actors in neuroendocrine regulations,
Frontiers in Neuroendocrinology, 2011, 32 (1), pp.10-24.
2011
Strenuous physical exercise adversely affects monocyte chemotaxis.,
Thromb Haemost 2011 Jan; 105(1): 122-30.
2011
C-peptide increases Na,K-ATPase expression via PKC- and MAP kinase-dependent activation of transcription factor ZEB in human renal tubular cells.,
PLoS One 2011 ; 6(12): e28294.
2011
Chemokines and chemokine receptors: new actors in neuroendocrine regulations.,
Front Neuroendocrinol 2011 Jan; 32(1): 10-24.
2010
Dietary supplementation of alpha-linolenic acid in an enriched rapeseed oil diet protects from stroke.,
Pharmacological Research, 2010, 61 (3), pp.226-33. ⟨10.1016/j.phrs.2009.12.007⟩.
2010
Performance of the CMS Drift-Tube Local Trigger with Cosmic Rays,
Journal of Instrumentation, 2010, 5, pp.T03003. ⟨10.1088/1748-0221/5/03/T03003⟩.
2010
Use of magnetically oriented orthogonal collagen scaffolds for hemi-corneal reconstruction and regeneration,
Biomaterials, 2010, 31 (32), pp.8313-8322. ⟨10.1016/j.biomaterials.2010.07.066⟩.
2010
Chronic high-fat diet in fathers programs β-cell dysfunction in female rat offspring.,
Nature 2010 Oct; 467(7318): 963-6.
2010
The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases.,
J Neuroimmunol 2010 Jul; 224(1-2): 93-100.
2009
Long term exposure to the chemokine CCL2 activates the nigrostriatal dopamine system: a novel mechanism for the control of dopamine release.,
Neuroscience, 2009, 162 (4), pp.1072-80. ⟨10.1016/j.neuroscience.2009.05.048⟩.
2009
ZBED6, a novel transcription factor derived from a domesticated DNA transposon regulates IGF2 expression and muscle growth.,
PLoS Biol 2009 Dec; 7(12): e1000256.
2009
Melanin-concentrating hormone induces neurite outgrowth in human neuroblastoma SH-SY5Y cells through p53 and MAPKinase signaling pathways.,
Peptides 2009 Nov; 30(11): 2014-24.
2009
Melanin-concentrating hormone producing neurons: Activities and modulations.,
Peptides 2009 Nov; 30(11): 2031-9.
2009
Non-CpG methylation of the PGC-1alpha promoter through DNMT3B controls mitochondrial density.,
Cell Metab 2009 Sep; 10(3): 189-98.
2009
Altered expression and insulin-induced trafficking of Na+-K+-ATPase in rat skeletal muscle: effects of high-fat diet and exercise.,
Am J Physiol Endocrinol Metab 2009 Jul; 297(1): E38-49.
2009
Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels.,
J Neurosci 2009 Feb; 29(8): 2528-33.
2009
Role of adenosine 5′-monophosphate-activated protein kinase in interleukin-6 release from isolated mouse skeletal muscle.,
Endocrinology 2009 Feb; 150(2): 600-6.
2008
Crecimiento y asignación de recursos en Berberis serrato-dentata, un arbusto del bosque de Nothofagus pumilio. 1era y segunda parte,
Patagonia Forestal, 2008, 14 (1-2), pp.19-20.
2008
Crecimento y asignacion de recursos en berberis serrato-dentata, un arbusto del bosque de Nothofagus Pumilio,
Segunda Reunión sobre nothofagus en la Patagonia, Apr 2008, Esquel, Argentina.
2008
How cytokines can influence the brain: a role for chemokines?,
J Neuroimmunol 2008 Jul; 198(1-2): 46-55.
2007
The chemokine stromal cell-derived factor-1/CXCL12 activates the nigrostriatal dopamine system.,
Journal of Neurochemistry, 2007, 102 (4), pp.1175-83. ⟨10.1111/j.1471-4159.2007.04639.x⟩.
2007
Issues related to mitigation in the long term context,
Metz, B. and Davidson, O.R. and Bosch, P.R. and Dave, R. and Meyer, L.A. Climate Change 2007: Mitigation. Contribution of Working Group III to the Fourth Assessment Report of the InterGovernmental Panel on Climate Change, Cambridge University Press, pp.82, 2007.
2007
CMS Physics Technical Design Report, Volume II: Physics Performance,
Journal of Physics G: Nuclear and Particle Physics, 2007, 34, pp.995-1579. ⟨10.1088/0954-3899/34/6/S01⟩.
2006
Appetite boosting property of pro-MCH131-165 (NEI-MCH) is associated with proteolytic resistance,
2006.
2006
The SUCIMA project: A status report on high granularity dosimetry and proton beam monitoring,
13th International Workshop on Vertex Detectors - VERTEX 2004, Sep 2004, Menaggio - Como, Italy. pp.153-157, ⟨10.1016/j.nima.2005.11.219⟩.
2006
Workshop Bariloche « Understanding biodiversity loss: A worshop on forest fragmentation in South America,
Understanding biodiversity loss: A worshop on forest fragmentation in South America,San Carlos de Bariloche, ARG, 26-30 june 2006, 2006, 2006.
2006
Enigma interacts with adaptor protein with PH and SH2 domains to control insulin-induced actin cytoskeleton remodeling and glucose transporter 4 translocation.,
Mol Endocrinol, 2006, 20 (11), pp.2864-75. ⟨10.1210/me.2005-0455⟩.
2005
Complex effects of stromal cell-derived factor-1a on melanin-concentrating hormone neuron excitability,
European Journal of Neuroscience, 2005, 21, pp.701-710.
2005
Stromal cell-derived factor-1a directly modulates voltage-dependent currents of the action potential in mammalian neuronal cells,
Journal of Neurochemistry, 2005, 93, pp.963-973.
2005
The interaction between the adaptor protein APS and Enigma is involved in actin organisation.,
Exp Cell Res, 2005, 308, pp.334-44. ⟨10.1016/j.yexcr.2005.05.008⟩.
2003
The Arg617-Arg618 cleavage site in the C-terminal domain of PC1 plays a major role in the processing and targeting of the enzyme within the regulated secretory pathway.,
J Neurochem 2003 Jun; 85(6): 1592-603.
2003
Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes.,
Journal of Biological Chemistry, 2003, 278, pp.26550-7. ⟨10.1074/jbc.M212273200⟩.
2002
SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor,
Biochemical and Biophysical Research Communications, 2002, 295, pp.841-848.
2002
Appetite-boosting property of pro-melanin-concentrating hormone(131-165) (neuropeptide-glutamic acid-isoleucine) is associated with proteolytic resistance.,
J Pharmacol Exp Ther 2002 Aug; 302(2): 766-73.
2002
SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor.,
Biochem Biophys Res Commun 2002 Jul; 295(4): 841-8.
2002
Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity.,
Biochem Biophys Res Commun 2002 Feb; 290(4): 1161-8.
1994
Post-translational processing of the neurotensin/neuromedin N precursor in the central nervous system of the rat. 1.Biochemical characterization of maturation products,
Neuroscience, 1994, 60 (1), pp.159-166.
1993
Immunological and biochemical characterization of processing products from the neurotensin/neuromedin N precursor in the rat medullary thyroid carcinoma 6-23 cell line,
Biochemical Journal, 1993, 291, pp.225-233.
1993
Biosynthesis and posttranslational processing of the neurotensin/neuromedin N precursor in the rat medullary thyroid carcinoma 6-23 cell line. Effect of dexamethasone,
Endocrinology, 1993, 132 (4), pp.1614-1620.
1993
PC12 cells can be induced to produce, but do not process, the neurotensin/neuromedin N precursor,
Peptides, 1993, 14 (5), pp.983-989.