Se connecter
Recherche
Intranet
Thème

Membres

Thomas BERTERO
Chef d'équipe
Chercheur CNRS
Stephan CLAVEL
Enseignant-chercheur UniCA
Keren FRAISSARD
PhD
Eirini FYTILI
PhD
Nesrine RACHEDI
Doctorant(e)
Chaima SBAI
ITA
Stephanie TORRINO
Chercheur CNRS
Lucille BARBAN
ITA
Cécilia COLSON
Post-doc.
Lara NASR
PhD
Blandine MADJI-HOUNOUM
Post-doc
Narji KRAIMI
Post-doc
Nathan GLISE
ITA
Pierre CABIROL
Post-doc

Événements

21
Mar
2024
2:00 pm
Thèse
Thèse de Nesrine Safia RACHEDI

« Rôle du remodelage de la matrice extracellulaire dans la reprogrammation des cellules vasculaires pulmonaires au cours de l’hypertension artérielle pulmonaire » […]

IPMC
28
Juin
2024
2:00 pm
Thèse
HDR Stéphanie TORRINO

« Les modifications post-traductionnelles au centre de la mécanobiologie » Président du jury : Christophe LAMAZE

IPMC
12
Juil
2024
Conférence
T. BERTERO invite le Dr Stephen Y CHAN

« Developing a precision medicine approach to vascular inflammation and pulmonary hypertension»

IPMC

Publications

2024
Alotaibi M, Harvey LD, Nichols WC, Pauciulo MW, Hemnes A, Long T, Watrous JD, Begzati A, Tuomilehto J, Havulinna AS, Niiranen TJ, Jousilahti P, Salomaa V, Bertero T, Kim NH, Desai AA, Malhotra A, Yuan JX, Cheng S, Chan SY, Jain M, Pulmonary primary oxysterol and bile acid synthesis as a predictor of outcomes in pulmonary arterial hypertension., bioRxiv 2024 Jan; (): .
2024
Tai YY, Yu Q, Tang Y, Sun W, Kelly NJ, Okawa S, Zhao J, Schwantes-An TH, Lacoux C, Torrino S, Al Aaraj Y, El Khoury W, Negi V, Liu M, Corey CG, Belmonte F, Vargas SO, Schwartz B, Bhat B, Chau BN, Karnes JH, Satoh T, Barndt RJ, Wu H, Parikh VN, Wang J, Zhang Y, McNamara D, Li G, Speyer G, Wang B, Shiva S, Kaufman B, Kim S, Gomez D, Mari B, Cho MH, Boueiz A, Pauciulo MW, Southgate L, Trembath RC, Sitbon O, Humbert M, Graf S, Morrell NW, Rhodes CJ, Wilkins MR, Nouraie M, Nichols WC, Desai AA, Berte..., Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension., Sci Transl Med 2024 Jan; 16(729): eadd2029.
2024
Murcy F, Borowczyk C, Gourion-Arsiquaud S, Torrino S, Ouahrouche N, Barouillet T, Dussaud S, Couralet M, Vaillant N, Merlin J, Berquand A, Kaikkonen MU, McClelland RL, Tressel W, Stein J, Thorp EB, Bertero T, Barbry P, Bailly-Maitre B, Gautier EL, Karjalainen MK, Kettunen J, Duca L, Shea S, Yvan-Charvet L, GLS2 links glutamine metabolism and atherosclerosis by remodeling artery walls., Nat Cardiovasc Res 2024 Nov; (): .
2024
Torrino S, Oldham WM, Tejedor AR, Burgos IS, Nasr L, Rachedi N, Fraissard K, Chauvet C, Sbai C, O'Hara BP, Abélanet S, Brau F, Favard C, Clavel S, Collepardo-Guevara R, Espinosa JR, Ben-Sahra I, Bertero T, Mechano-dependent sorbitol accumulation supports biomolecular condensate., Cell 2024 Nov; (): .
2024
Rachedi NS, Tang Y, Tai YY, Zhao J, Chauvet C, Grynblat J, Akoumia KKF, Estephan L, Torrino S, Sbai C, Ait-Mouffok A, Latoche JD, Al Aaraj Y, Brau F, Abélanet S, Clavel S, Zhang Y, Guillermier C, Kumar NVG, Tavakoli S, Mercier O, Risbano MG, Yao ZK, Yang G, Ouerfelli O, Lewis JS, Montani D, Humbert M, Steinhauser ML, Anderson CJ, Oldham WM, Perros F, Bertero T, Chan SY, Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness., Cell Metab 2024 Jun; 36(6): 1335-1350.e8.
2023
Buñay J, Kossai M, Damon-Soubeyrant C, De Haze A, Saru JP, Trousson A, de Joussineau C, Bouchareb E, Kocer A, Vialat M, Dallel S, Degoul F, Bost F, Clavel S, Penault-Llorca F, Valli MP, Guy L, Matthews J, Renaud Y, Ittmann M, Jones J, Morel L, Lobaccaro JM, Baron S, Persistent organic pollutants promote aggressiveness in prostate cancer., Oncogene 2023 Sep; 42(38): 2854-2867.
2023
Culley MK, Rao RJ, Mehta M, Zhao J, El Khoury W, Harvey LD, Perk D, Tai YY, Tang Y, Shiva S, Rabinovitch M, Gu M, Bertero T, Chan SY, Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function., Vascul Pharmacol 2023 Aug; 151(): 107181.
2023
Hafeez N, Kirillova A, Yue Y, Rao RJ, Kelly NJ, El Khoury W, Al Aaraj Y, Tai YY, Handen A, Tang Y, Jiang D, Wu T, Zhang Y, McNamara D, Kudryashova TV, Goncharova EA, Goncharov D, Bertero T, Nouraie M, Li G, Sun W, Chan SY, Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4-Human Leukocyte Antigen-DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension., J Am Heart Assoc 2023 Apr; 12(7): e027894.
2022
Torrino S, Bertero T, Metabo-reciprocity in cell mechanics: feeling the demands/feeding the demand., Trends Cell Biol 2022 Jul; 32(7): 624-636.
2021
Negi V, Yang J, Speyer G, Pulgarin A, Handen A, Zhao J, Tai YY, Tang Y, Culley MK, Yu Q, Forsythe P, Gorelova A, Watson AM, Al Aaraj Y, Satoh T, Sharifi-Sanjani M, Rajaratnam A, Sembrat J, Provencher S, Yin X, Vargas SO, Rojas M, Bonnet S, Torrino S, Wagner BK, Schreiber SL, Dai M, Bertero T, Al Ghouleh I, Kim S, Chan SY, Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension., Sci Adv 2021 Oct; 7(43): eabh3794.
2021
Gallerand A, Stunault MI, Merlin J, Luehmann HP, Sultan DH, Firulyova MM, Magnone V, Khedher N, Jalil A, Dolfi B, Castiglione A, Dumont A, Ayrault M, Vaillant N, Gilleron J, Barbry P, Dombrowicz D, Mack M, Masson D, Bertero T, Becher B, Williams JW, Zaitsev K, Liu Y, Guinamard RR, Yvan-Charvet L, Ivanov S, Brown adipose tissue monocytes support tissue expansion., Nat Commun 2021 Sep; 12(1): 5255.
2021
Torrino S, Grasset EM, Audebert S, Belhadj I, Lacoux C, Haynes M, Pisano S, Abélanet S, Brau F, Chan SY, Mari B, Oldham WM, Ewald AJ, Bertero T, Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis., Cell Metab 2021 Jul; 33(7): 1342-1357.e10.
2021
Acharya AP, Tang Y, Bertero T, Tai YY, Harvey LD, Woodcock CC, Sun W, Pineda R, Mitash N, Königshoff M, Little SR, Chan SY, Simultaneous Pharmacologic Inhibition of Yes-Associated Protein 1 and Glutaminase 1 via Inhaled Poly(Lactic-co-Glycolic) Acid-Encapsulated Microparticles Improves Pulmonary Hypertension., J Am Heart Assoc 2021 Jun; 10(12): e019091.
2021
Culley MK, Zhao J, Tai YY, Tang Y, Perk D, Negi V, Yu Q, Woodcock CC, Handen A, Speyer G, Kim S, Lai YC, Satoh T, Watson AM, Aaraj YA, Sembrat J, Rojas M, Goncharov D, Goncharova EA, Khan OF, Anderson DG, Dahlman JE, Gurkar AU, Lafyatis R, Fayyaz AU, Redfield MM, Gladwin MT, Rabinovitch M, Gu M, Bertero T, Chan SY, Frataxin deficiency promotes endothelial senescence in pulmonary hypertension., J Clin Invest 2021 Jun; 131(11): .
2021
Woodcock CC, Hafeez N, Handen A, Tang Y, Harvey LD, Estephan LE, Speyer G, Kim S, Bertero T, Chan SY, Matrix stiffening induces a pathogenic QKI-miR-7-SRSF1 signaling axis in pulmonary arterial endothelial cells., Am J Physiol Lung Cell Mol Physiol 2021 May; 320(5): L726-L738.
2021
Torrino S, Tiroille V, Dolfi B, Dufies M, Hinault C, Bonesso L, Dagnino S, Uhler J, Irondelle M, Gay AS, Fleuriot L, Debayle D, Lacas-Gervais S, Cormont M, Bertero T, Bost F, Gilleron J, Clavel S, UBTD1 regulates ceramide balance and endolysosomal positioning to coordinate EGFR signaling., Elife 2021 Apr; 10(): .
2020
Zhao J, Florentin J, Tai YY, Torrino S, Ohayon L, Brzoska T, Tang Y, Yang J, Negi V, Woodcock CC, Risbano MG, Nouraie SM, Sundd P, Bertero T, Dutta P, Chan SY, Long Range Endocrine Delivery of Circulating miR-210 to Endothelium Promotes Pulmonary Hypertension., Circ Res 2020 Aug; 127(5): 677-692.
2019
Lambert M, Capuano V, Boet A, Tesson L, Bertero T, Nakhleh MK, Remy S, Anegon I, Pechoux C, Hautefort A, Rucker-Martin C, Manoury B, Domergue V, Mercier O, Girerd B, Montani D, Perros F, Humbert M, Antigny F, Characterization of Kcnk3-Mutated Rat, a Novel Model of Pulmonary Hypertension., Circ Res 2019 Sep; 125(7): 678-695.
2019
Bourgeois A, Bonnet S, Breuils-Bonnet S, Habbout K, Paradis R, Tremblay E, Lampron MC, Orcholski ME, Potus F, Bertero T, Peterlini T, Chan SY, Norris KA, Paulin R, Provencher S, Boucherat O, Inhibition of CHK 1 (Checkpoint Kinase 1) Elicits Therapeutic Effects in Pulmonary Arterial Hypertension., Arterioscler Thromb Vasc Biol 2019 Aug; 39(8): 1667-1681.
2019
Bertero T, Perk D, Chan SY, The molecular rationale for therapeutic targeting of glutamine metabolism in pulmonary hypertension., Expert Opin Ther Targets 2019 Jun; 23(6): 511-524.
2019
Yu Q, Tai YY, Tang Y, Zhao J, Negi V, Culley MK, Pilli J, Sun W, Brugger K, Mayr J, Saggar R, Saggar R, Wallace WD, Ross DJ, Waxman AB, Wendell SG, Mullett SJ, Sembrat J, Rojas M, Khan OF, Dahlman JE, Sugahara M, Kagiyama N, Satoh T, Zhang M, Feng N, Gorcsan J, Vargas SO, Haley KJ, Kumar R, Graham BB, Langer R, Anderson DG, Wang B, Shiva S, Bertero T, Chan SY, BOLA (BolA Family Member 3) Deficiency Controls Endothelial Metabolism and Glycine Homeostasis in Pulmonary Hypertension., Circulation 2019 May; 139(19): 2238-2255.
2019
Torrino S, Roustan FR, Kaminski L, Bertero T, Pisano S, Ambrosetti D, Dufies M, Uhler JP, Lemichez E, Mettouchi A, Gesson M, Laurent K, Gaggioli C, Michiels JF, Lamaze C, Bost F, Clavel S, UBTD1 is a mechano-regulator controlling cancer aggressiveness., EMBO Rep 2019 Apr; 20(4): .
2019
Hautefort A, Mendes-Ferreira P, Sabourin J, Manaud G, Bertero T, Rucker-Martin C, Riou M, Adão R, Manoury B, Lambert M, Boet A, Lecerf F, Domergue V, Brás-Silva C, Gomez AM, Montani D, Girerd B, Humbert M, Antigny F, Perros F, Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension., Circulation 2019 Feb; 139(7): 932-948.
2019
Bertero T, Oldham WM, Grasset EM, Bourget I, Boulter E, Pisano S, Hofman P, Bellvert F, Meneguzzi G, Bulavin DV, Estrach S, Feral CC, Chan SY, Bozec A, Gaggioli C, Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy., Cell Metab 2019 Jan; 29(1): 124-140.e10.
2019
Bertero T, Gaggioli C, Mechanical forces rewire metabolism in the tumor niche., Mol Cell Oncol 2019 ; 6(3): 1592945.
2018
Tarantelli RA, Schweitzer F, Simon MA, Vanderpool RR, Christman I, Rayens E, Kling HM, Zullo T, Carney JP, Lopresti BJ, Bertero T, Chan SY, Norris KA, Longitudinal Evaluation of Pulmonary Arterial Hypertension in a Rhesus Macaque (Macaca mulatta) Model of HIV Infection., Comp Med 2018 Dec; 68(6): 461-473.
2018
Grasset EM, Bertero T, Bozec A, Friard J, Bourget I, Pisano S, Lecacheur M, Maiel M, Bailleux C, Emelyanov A, Ilie M, Hofman P, Meneguzzi G, Duranton C, Bulavin DV, Gaggioli C, Matrix Stiffening and EGFR Cooperate to Promote the Collective Invasion of Cancer Cells., Cancer Res 2018 Sep; 78(18): 5229-5242.
2018
Bertero T, Handen AL, Chan SY, Factors Associated with Heritable Pulmonary Arterial Hypertension Exert Convergent Actions on the miR-130/301-Vascular Matrix Feedback Loop., Int J Mol Sci 2018 Aug; 19(8): .
2017
Bonan S, Albrengues J, Grasset E, Kuzet SE, Nottet N, Bourget I, Bertero T, Mari B, Meneguzzi G, Gaggioli C, Membrane-bound ICAM-1 contributes to the onset of proinvasive tumor stroma by controlling acto-myosin contractility in carcinoma-associated fibroblasts., Oncotarget 2017 Jan; 8(1): 1304-1320.
2017
Bertero T, Rezzonico R, Pottier N, Mari B, Impact of MicroRNAs in the Cellular Response to Hypoxia., Int Rev Cell Mol Biol 2017 ; 333(): 91-158.
2016
Brichkina A, Bertero T, Loh HM, Nguyen NT, Emelyanov A, Rigade S, Ilie M, Hofman P, Gaggioli C, Bulavin DV, p38MAPK builds a hyaluronan cancer niche to drive lung tumorigenesis., Genes Dev 2016 Dec; 30(23): 2623-2636.
2016
Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan J, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, Waxman AB, Parikh VN, De Marco T, Hsue PY, Morris A, Simon MA, Norris KA, Gaggioli C, Loscalzo J, Fessel J, Chan SY, Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension., J Clin Invest 2016 Sep; 126(9): 3313-35.
2015
Albrengues J, Bertero T, Grasset E, Bonan S, Maiel M, Bourget I, Philippe C, Herraiz Serrano C, Benamar S, Croce O, Sanz-Moreno V, Meneguzzi G, Feral CC, Cristofari G, Gaggioli C, Epigenetic switch drives the conversion of fibroblasts into proinvasive cancer-associated fibroblasts., Nat Commun 2015 Dec; 6(): 10204.
2015
Bertero T, Cottrill KA, Annis S, Bhat B, Gochuico BR, Osorio JC, Rosas I, Haley KJ, Corey KE, Chung RT, Nelson Chau B, Chan SY, A YAP/TAZ-miR-130/301 molecular circuit exerts systems-level control of fibrosis in a network of human diseases and physiologic conditions., Sci Rep 2015 Dec; 5(): 18277.
2015
Bertero T, Cottrill KA, Lu Y, Haeger CM, Dieffenbach P, Annis S, Hale A, Bhat B, Kaimal V, Zhang YY, Graham BB, Kumar R, Saggar R, Saggar R, Wallace WD, Ross DJ, Black SM, Fratz S, Fineman JR, Vargas SO, Haley KJ, Waxman AB, Chau BN, Fredenburgh LE, Chan SY, Matrix Remodeling Promotes Pulmonary Hypertension through Feedback Mechanoactivation of the YAP/TAZ-miR-130/301 Circuit., Cell Rep 2015 Nov; 13(5): 1016-32.
2015
Bertero T, Cottrill K, Krauszman A, Lu Y, Annis S, Hale A, Bhat B, Waxman AB, Chau BN, Kuebler WM, Chan SY, The microRNA-130/301 family controls vasoconstriction in pulmonary hypertension., J Biol Chem 2015 Jan; 290(4): 2069-85.
2014
Bertero T, Robbe-Sermesant K, Le Brigand K, Ponzio G, Pottier N, Rezzonico R, Mazure NM, Barbry P, Mari B, MicroRNA target identification: lessons from hypoxamiRs., Antioxid Redox Signal 2014 Sep; 21(8): 1249-68.
2014
Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY, Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension., J Clin Invest 2014 Aug; 124(8): 3514-28.
2014
Gastaldi C, Bertero T, Xu N, Bourget-Ponzio I, Lebrigand K, Fourre S, Popa A, Cardot-Leccia N, Meneguzzi G, Sonkoly E, Pivarcsi A, Mari B, Barbry P, Ponzio G, Rezzonico R, miR-193b/365a cluster controls progression of epidermal squamous cell carcinoma., Carcinogenesis 2014 May; 35(5): 1110-20.
2013
Bertero T, Bourget-Ponzio I, Puissant A, Loubat A, Mari B, Meneguzzi G, Auberger P, Barbry P, Ponzio G, Rezzonico R, Tumor suppressor function of miR-483-3p on squamous cell carcinomas due to its pro-apoptotic properties., Cell Cycle 2013 Jul; 12(14): 2183-93.
2013
Bertero T, Gastaldi C, Bourget-Ponzio I, Mari B, Meneguzzi G, Barbry P, Ponzio G, Rezzonico R, CDC25A targeting by miR-483-3p decreases CCND-CDK4/6 assembly and contributes to cell cycle arrest., Cell Death Differ 2013 Jun; 20(6): 800-11.
2013
Grosso S, Doyen J, Parks SK, Bertero T, Paye A, Cardinaud B, Gounon P, Lacas-Gervais S, Noël A, Pouysségur J, Barbry P, Mazure NM, Mari B, MiR-210 promotes a hypoxic phenotype and increases radioresistance in human lung cancer cell lines., Cell Death Dis 2013 Mar; 4(3): e544.
2012
Bertero T, Grosso S, Robbe-Sermesant K, Lebrigand K, Hénaoui IS, Puisségur MP, Fourre S, Zaragosi LE, Mazure NM, Ponzio G, Cardinaud B, Barbry P, Rezzonico R, Mari B, « Seed-Milarity » confers to hsa-miR-210 and hsa-miR-147b similar functional activity., PLoS One 2012 ; 7(9): e44919.
2011
Bertero T, Gastaldi C, Bourget-Ponzio I, Imbert V, Loubat A, Selva E, Busca R, Mari B, Hofman P, Barbry P, Meneguzzi G, Ponzio G, Rezzonico R, miR-483-3p controls proliferation in wounded epithelial cells., FASEB J 2011 Sep; 25(9): 3092-105.
2011
Puisségur MP, Mazure NM, Bertero T, Pradelli L, Grosso S, Robbe-Sermesant K, Maurin T, Lebrigand K, Cardinaud B, Hofman V, Fourre S, Magnone V, Ricci JE, Pouysségur J, Gounon P, Hofman P, Barbry P, Mari B, miR-210 is overexpressed in late stages of lung cancer and mediates mitochondrial alterations associated with modulation of HIF-1 activity., Cell Death Differ 2011 Mar; 18(3): 465-78.
2009
Pottier N, Maurin T, Chevalier B, Puisségur MP, Lebrigand K, Robbe-Sermesant K, Bertero T, Lino Cardenas CL, Courcot E, Rios G, Fourre S, Lo-Guidice JM, Marcet B, Cardinaud B, Barbry P, Mari B, Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial-mesenchymal interactions., PLoS One 2009 Aug; 4(8): e6718.