Mécanismes de régulation de l’expression génique en physiopathologie – IPMC

Recherche

Intranet

Thème

Métabolisme et fonctions des lipides membranaires

Physiopathologie moléculaire des phospholipases A2 et de leurs médiateurs

Membres

Chercheur INSERM

Carmen RUGGIERO

Margaux RICHTER

Mabrouka DOGHMAN

Khattar KHATTAR

Présentation

Notre équipe est labellisée « Centre de Recherche d’Excellence » par l’ENS@T
(European Network for the Study of Adrenal Tumours)

Notre équipe de recherche utilise une approche intégrée pour l’investigation de questions biologiques revêtant une importance médicale particulière dans le domaine du développement, du fonctionnement et de la pathologie du cortex surrénal, associant des méthodes de biologie moléculaire et cellulaire, des outils génomiques, des modèles animaux, des études pharmacologiques et cliniques.

Exemples d’approches intégratives d’étude de la physiopathologie corticosurrénalienne utilisées dans notre équipe

Événements

E. LALLI invite le Dr Violaine MOREAU

Fascin-1 as a new target of oncogenic ß-catenin in pediatric liver cancers

E. LALLI invite le Dr Annarita PATRIZI

» Choroid plexus and non-cell autonomous brain regulation”

Projets

Découverte du rôle clé de la surexpression du facteur de transcription SF-1 et de ses gènes cibles dans la pathogenèse des tumeurs corticosurrénaliennes

NR5A1/SF-1 (Steroidogenic Factor-1), un facteur de transcription de la famille des récepteurs nucléaires, joue un rôle clé dans le développement […]

Découverte d’un réseau génique associé à l’hyperaldostéronisme primaire

La détection des formes secondaires d’hypertension artérielle (HT) est particulièrement importante car elle permet une gestion ciblée de la maladie […]

Recherche préclinique de nouveaux outils pharmacologiques pour le traitement du carcinome corticosurrénalien

L’ACC est une tumeur maligne rare avec un pronostic défavorable. Les traitements actuels pour les tumeurs en stade avancé sont […]

Caractérisation des profils génétiques et épidémiologie moléculaire des tumeurs corticosurrénaliennes de l’enfant

Nous avons identifié plusieurs altérations chromosomiques récurrentes dans les ACC des enfants (Letouzé et al., 2012). Cette étude a mis en […]

Offres d'emplois

Post Doctorant (H/F) : Étude des bases moléculaires du mécanisme d’action d’un nouvel inhibiteur de la voie de signalisation Wnt canonique

Publications

Delhaye S, Jarjat M, Boulksibat A, Sanchez C, Tempio A, Turtoi A, Giorgi M, Lacas-Gervais S, Baj G, Rovere C, Trezza V, Pellegrini M, Maurin T, Lalli E, Bardoni B, Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a., Neurobiol Dis 2024 Feb; 191(): 106393.

Figueiredo BC, Dupont F, Portelli G, Costa TEJ, Custódio G, Paraizo MM, Komechen H, Gascuel H, Bottau M, Callea E, Percicote AP, Telles LG, Jendoubi M, Lalli E, AI-guided identification of risk variants for adrenocortical tumours in TP53 p.R337H carrier children: a genetic association study., Lancet Reg Health Am 2024 Oct; 38(): 100863.

Lalli E, Immune checkpoint molecules in adrenocortical carcinoma: hope for immunotherapy., J Clin Endocrinol Metab 2024 May; (): .

Schneider G, Ruggiero C, Renault L, Doghman-Bouguerra M, Durand N, Hingrai G, Dijoud F, Plotton I, Lalli E, ACTH and prolactin synergistically and selectively regulate CYP17 expression and adrenal androgen production in human foetal adrenal organ cultures., Eur J Endocrinol 2023 Sep; 189(3): 327-335.

Ruggiero C, Tamburello M, Rossini E, Zini S, Durand N, Cantini G, Cioppi F, Hantel C, Kiseljak-Vassiliades K, Wierman ME, Landwehr LS, Weigand I, Kurlbaum M, Zizioli D, Turtoi A, Yang S, Berruti A, Luconi M, Sigala S, Lalli E, FSCN1 as a new druggable target in adrenocortical carcinoma., Int J Cancer 2023 Jul; 153(1): 210-223.

Richter M, Lalli E, Ruggiero C, Complex and pleiotropic signaling pathways regulated by the secreted protein augurin., Cell Commun Signal 2023 Apr; 21(1): 69.

Relav L, Doghman-Bouguerra M, Ruggiero C, Muzzi JCD, Figueiredo BC, Lalli E, Steroidogenic Factor 1, a Goldilocks Transcription Factor from Adrenocortical Organogenesis to Malignancy., Int J Mol Sci 2023 Feb; 24(4): .

Lalli E, A reappraisal of transcriptional regulation by NR5A1 and beta-catenin in adrenocortical carcinoma., Front Endocrinol (Lausanne) 2023 ; 14(): 1303332.

Lalli E, Figueiredo BC, Prolactin as an adrenocorticotropic hormone: Prolactin signalling is a conserved key regulator of sexually dimorphic adrenal gland function in health and disease., Bioessays 2022 Oct; 44(10): e2200109.

Gerber VKQ, Paraizo MM, Ibañez HC, Casali-da-Rocha JC, Pinto EM, Andrade DP, Ibañez MVC, Komechen H, Figueiredo MMO, Custódio G, Fiori CMCM, Balbinotti JHG, Nardin JM, Almeida TA, Beltrame OO, Yamada PA, de Fraga GS, de Brito LL, Martins J, Melanda VS, Licht OAB, Teixeira VZ, Pinho SKS, Bottini S, Lalli E, Zambetti GP, Figueiredo BC, Environmental Contaminants Modulate Breast Cancer Development and Outcome in TP53 p.R337H Carriers and Noncarriers., Cancers (Basel) 2022 Jun; 14(12): .

Altieri B, Lalli E, Faggiano A, Mitotane treatment in adrenocortical carcinoma: mechanisms of action and predictive markers of response to therapy., Minerva Endocrinol (Torino) 2022 Jun; 47(2): 203-214.

Ruggiero C, Doghman-Bouguerra M, Lalli E, How good are the current models of adrenocortical carcinoma for novel drug discovery?, Expert Opin Drug Discov 2022 Mar; 17(3): 211-213.

Carmen Ruggiero, Nelly Durand, Marielle Jarjat, Jacques Barhanin, Elena J Ghirardello, Michael R G Dack, Graham R Williams, J H Duncan Bassett, Enzo Lalli, The secreted protein augurin is a novel modulator of canonical Wnt signalling involved in osteoblast differentiation, Clinical and Translational Discovery, 2022, 2 (3), pp.e113. ⟨10.1002/ctd2.113⟩.

Ruggiero C, Altieri B, Arnold E, Siqueiros-Marquez L, Doghman-Bouguerra M, Detomas M, Durand N, Jarjat M, Kurlbaum M, Chatonnet F, Deutschbein T, Clapp C, Lalli E, Integrative genomic analysis reveals a conserved role for prolactin signalling in the regulation of adrenal function., Clin Transl Med 2021 Nov; 11(11): e630.

Lalli E, ‘You cannot expect miracles to happen overnight’: patience pays off when you wish to establish a new adrenocortical carcinoma cell line., Eur J Endocrinol 2021 Jul; 185(2): C9-C11.

Jeffers JR, Pinto EM, Rehg JE, Clay MR, Wang J, Neale G, Heath RJ, Lozano G, Lalli E, Figueiredo BC, Pappo AS, Rodriguez-Galindo C, Chen W, Pounds S, Ribeiro RC, Zambetti GP, The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model., Cancer Res 2021 May; 81(9): 2442-2456.

Ruggiero C, Lalli E, Targeting the cytoskeleton against metastatic dissemination., Cancer Metastasis Rev 2021 Mar; 40(1): 89-140.

Lalli E, Editorial – Chaperones in endocrinology., Mol Cell Endocrinol 2020 Aug; 514(): 110943.

Drozd M, Delhaye S, Maurin T, Castagnola S, Grossi M, Brau F, Jarjat M, Willemsen R, Capovilla M, Hukema RK, Lalli E, Bardoni B, Reduction of Fmr1 mRNA Levels Rescues Pathological Features in Cortical Neurons in a Model of FXTAS., Mol Ther Nucleic Acids 2019 Dec; 18(): 546-553.

Parise IZS, Parise GA, Noronha L, Surakhy M, Woiski TD, Silva DB, Costa TEB, Del-Valle MHCP, Komechen H, Rosati R, Ribeiro MG, Nascimento ML, Souza JA, Andrade DP, Paraizo MM, Galvão MMR, Barbosa JRS, Barbosa ML, Custódio GC, Figueiredo MMO, Fabro ALMR, Bond G, Volante M, Lalli E, Figueiredo BC, The Prognostic Role of CD8+ T Lymphocytes in Childhood Adrenocortical Carcinomas Compared to Ki-67, PD-1, PD-L1, and the Weiss Score., Cancers (Basel) 2019 Nov; 11(11): .

Poli G, Ruggiero C, Cantini G, Canu L, Baroni G, Armignacco R, Jouinot A, Santi R, Ercolino T, Ragazzon B, Assie G, Mannelli M, Nesi G, Lalli E, Luconi M, Fascin-1 Is a Novel Prognostic Biomarker Associated With Tumor Invasiveness in Adrenocortical Carcinoma., J Clin Endocrinol Metab 2019 May; 104(5): 1712-1724.

Doghman-Bouguerra M, Lalli E, ER-mitochondria interactions: Both strength and weakness within cancer cells., Biochim Biophys Acta Mol Cell Res 2019 Apr; 1866(4): 650-662.

Ibañez HC, Melanda VS, Gerber VKQ, Licht OAB, Ibañez MVC, Aguiar Júnior TR, Mello RG, Komechen H, Andrade DP, Picharski GL, Figueiredo DPG, Pianovski MAD, Figueiredo MMO, Custódio G, Parise IZS, Castilho LM, Paraizo MM, Edinger C, Fiori CMCM, Pedrini H, Kiesel Filho N, Fabro ALMR, Fachin RD, Ogradowski KRP, Parise GA, Saldiva PHN, Legal EF, Rosati R, Rodriguez-Galindo C, Ribeiro RC, Zambetti GP, Lalli E, Figueiredo BC, Spatial trends in congenital malformations and stream water chemistry in Southern Brazil., Sci Total Environ 2019 Feb; 650(Pt 1): 1278-1291.

Ruggiero C, Doghman-Bouguerra M, Ronco C, Benhida R, Rocchi S, Lalli E, The GRP78/BiP inhibitor HA15 synergizes with mitotane action against adrenocortical carcinoma cells through convergent activation of ER stress pathways., Mol Cell Endocrinol 2018 Oct; 474(): 57-64.

Hasanovic A, Ruggiero C, Jung S, Rapa I, Signetti L, Ben Hadj M, Terzolo M, Beuschlein F, Volante M, Hantel C, Lalli E, Mus-Veteau I, Targeting the multidrug transporter Patched potentiates chemotherapy efficiency on adrenocortical carcinoma in vitro and in vivo., Int J Cancer 2018 Jul; 143(1): 199-211.

Lalli E, Luconi M, The next step: mechanisms driving adrenocortical carcinoma metastasis., Endocr Relat Cancer 2018 Feb; 25(2): R31-R48.

Lalli E, Small non-coding RNAs in endocrinology., Mol Cell Endocrinol 2017 Nov; 456(): 1.

Ruggiero C, Lalli E, VAV2: a novel prognostic marker and a druggable target for adrenocortical carcinoma., Oncotarget 2017 Oct; 8(51): 88257-88258.

Sbiera S, Sbiera I, Ruggiero C, Doghman-Bouguerra M, Korpershoek E, de Krijger RR, Ettaieb H, Haak H, Volante M, Papotti M, Reimondo G, Terzolo M, Luconi M, Nesi G, Mannelli M, Libé R, Ragazzon B, Assié G, Bertherat J, Altieri B, Fadda G, Rogowski-Lehmann N, Reincke M, Beuschlein F, Fassnacht M, Lalli E, Assessment of VAV2 Expression Refines Prognostic Prediction in Adrenocortical Carcinoma., J Clin Endocrinol Metab 2017 Sep; 102(9): 3491-3498.

Morin A, Ruggiero C, Robidel E, Doghman-Bouguerra M, Das AT, Castellano R, Josselin E, Favier J, Lalli E, Establishment of a mouse xenograft model of metastatic adrenocortical carcinoma., Oncotarget 2017 Aug; 8(31): 51050-51057.

Ruggiero C, Doghman-Bouguerra M, Sbiera S, Sbiera I, Parsons M, Ragazzon B, Morin A, Robidel E, Favier J, Bertherat J, Fassnacht M, Lalli E, Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion., Sci Signal 2017 Mar; 10(469): .

Doghman-Bouguerra M, Lalli E, The ER-mitochondria couple: In life and death from steroidogenesis to tumorigenesis., Mol Cell Endocrinol 2017 Feb; 441(): 176-184.

Bardoni B, Capovilla M, Lalli E, Modeling Fragile X syndrome in neurogenesis: An unexpected phenotype and a novel tool for future therapies., Neurogenesis (Austin) 2017 ; 4(1): e1270384.

Doghman-Bouguerra M, Lalli E, ER-mitochondria contacts find their FATE., Cell Cycle 2016 Dec; 15(23): 3159-3160.

Doghman-Bouguerra M, Granatiero V, Sbiera S, Sbiera I, Lacas-Gervais S, Brau F, Fassnacht M, Rizzuto R, Lalli E, FATE1 antagonizes calcium- and drug-induced apoptosis by uncoupling ER and mitochondria., EMBO Rep 2016 Sep; 17(9): 1264-80.

Lalli E, Barhanin J, Zennaro MC, Warth R, Local Control of Aldosterone Production and Primary Aldosteronism., Trends Endocrinol Metab 2016 Mar; 27(3): 123-131.

Lalli E, Special issue on animal models in endocrine neoplasia., Mol Cell Endocrinol 2016 Feb; 421(): 1.

Lalli E, Sasano H, 5th International ACC Symposium: An Outlook to Current and Future Research on the Biology of Adrenocortical Carcinoma: Diagnostic and Therapeutic Applications., Horm Cancer 2016 Feb; 7(1): 44-8.

Ruggiero C, Lalli E, Impact of ACTH Signaling on Transcriptional Regulation of Steroidogenic Genes., Front Endocrinol (Lausanne) 2016 ; 7(): 24.

Lalli E, Mitotane Revisited: A New Target for an Old Drug., Endocrinology 2015 Nov; 156(11): 3873-5.

Fiorini L, Tribalat MA, Sauvard L, Cazareth J, Lalli E, Broutin I, Thomas OP, Mus-Veteau I, Natural paniceins from mediterranean sponge inhibit the multidrug resistance activity of Patched and increase chemotherapy efficiency on melanoma cells., Oncotarget 2015 Sep; 6(26): 22282-97.

Ruggiero C, Doghman M, Lalli E, How genomic studies have improved our understanding of the mechanisms of transcriptional regulation by NR5A nuclear receptors., Mol Cell Endocrinol 2015 Jun; 408(): 138-44.

Bertoin F, Letouzé E, Grignani P, Patey M, Rossignol S, Libé R, Pasqual C, Lardière-Deguelte S, Hoeffel-Fornes C, Gaillard D, Previderè C, Delemer B, Lalli E, Genome-wide paternal uniparental disomy as a cause of Beckwith-Wiedemann syndrome associated with recurrent virilizing adrenocortical tumors., Horm Metab Res 2015 Jun; 47(7): 497-503.

Bandulik S, Tauber P, Lalli E, Barhanin J, Warth R, Two-pore domain potassium channels in the adrenal cortex., Pflugers Arch 2015 May; 467(5): 1027-42.

Lalli E, Figueiredo BC, Pediatric adrenocortical tumors: what they can tell us on adrenal development and comparison with adult adrenal tumors., Front Endocrinol (Lausanne) 2015 ; 6(): 23.

Virgone C, Lalli E, Bisogno G, Lazzari E, Roma J, Zin A, Poli E, Cecchetto G, Dall'Igna P, Alaggio R, DAX-1 Expression in Pediatric Rhabdomyosarcomas: Another Immunohistochemical Marker Useful in the Diagnosis of Translocation Positive Alveolar Rhabdomyosarcoma., PLoS One 2015 ; 10(7): e0133019.

Latre de Late P, El Wakil A, Jarjat M, de Krijger RR, Heckert LL, Naquet P, Lalli E, Vanin-1 inactivation antagonizes the development of adrenocortical neoplasia in Sf-1 transgenic mice., Endocrinology 2014 Jul; 155(7): 2349-54.

Lalli E, Methodological pitfalls in the study of DAX-1 function., Cell Death Dis 2014 Jan; 5(1): e977.

Doghman M, Lalli E, Lack of long-lasting effects of mitotane adjuvant therapy in a mouse xenograft model of adrenocortical carcinoma., Mol Cell Endocrinol 2013 Dec; 381(1-2): 66-9.

El Wakil A, Mari B, Barhanin J, Lalli E, Genomic analysis of sexual dimorphism of gene expression in the mouse adrenal gland., Horm Metab Res 2013 Nov; 45(12): 870-3.

Doghman M, Figueiredo BC, Volante M, Papotti M, Lalli E, Integrative analysis of SF-1 transcription factor dosage impact on genome-wide binding and gene expression regulation., Nucleic Acids Res 2013 Oct; 41(19): 8896-907.

Bandulik S, Tauber P, Penton D, Schweda F, Tegtmeier I, Sterner C, Lalli E, Lesage F, Hartmann M, Barhanin J, Warth R, Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system., Endocrinology 2013 Aug; 154(8): 2712-22.

Custódio G, Parise GA, Kiesel Filho N, Komechen H, Sabbaga CC, Rosati R, Grisa L, Parise IZ, Pianovski MA, Fiori CM, Ledesma JA, Barbosa JR, Figueiredo FR, Sade ER, Ibañez H, Arram SB, Stinghen ST, Mengarelli LR, Figueiredo MM, Carvalho DC, Avilla SG, Woiski TD, Poncio LC, Lima GF, Pontarolo R, Lalli E, Zhou Y, Zambetti GP, Ribeiro RC, Figueiredo BC, Impact of neonatal screening and surveillance for the TP53 R337H mutation on early detection of childhood adrenocortical tumors., J Clin Oncol 2013 Jul; 31(20): 2619-26.

Lalli E, Doghman M, Latre de Late P, El Wakil A, Mus-Veteau I, Beyond steroidogenesis: novel target genes for SF-1 discovered by genomics., Mol Cell Endocrinol 2013 May; 371(1-2): 154-9.

Duregon E, Volante M, Giorcelli J, Terzolo M, Lalli E, Papotti M, Diagnostic and prognostic role of steroidogenic factor 1 in adrenocortical carcinoma: a validation study focusing on clinical and pathologic correlates., Hum Pathol 2013 May; 44(5): 822-8.

Singh P, Soon PS, Feige JJ, Chabre O, Zhao JT, Cherradi N, Lalli E, Sidhu SB, Dysregulation of microRNAs in adrenocortical tumors., Mol Cell Endocrinol 2012 Mar; 351(1): 118-28.

Hammer GD, Fassnacht M, Lalli E, Adrenal cancer: scientific advances., Mol Cell Endocrinol 2012 Mar; 351(1): 1.

Hammer GD, Fassnacht M, Lalli E, Adrenal cancer: clinical advances., Horm Cancer 2011 Dec; 2(6): 323.

Boulkroun S, Samson-Couterie B, Golib-Dzib JF, Amar L, Plouin PF, Sibony M, Lefebvre H, Louiset E, Jeunemaitre X, Meatchi T, Benecke A, Lalli E, Zennaro MC, Aldosterone-producing adenoma formation in the adrenal cortex involves expression of stem/progenitor cell markers., Endocrinology 2011 Dec; 152(12): 4753-63.

El Wakil A, Doghman M, Latre De Late P, Zambetti GP, Figueiredo BC, Lalli E, Genetics and genomics of childhood adrenocortical tumors., Mol Cell Endocrinol 2011 Apr; 336(1-2): 169-73.

Custodio G, Taques GR, Figueiredo BC, Gugelmin ES, Oliveira Figueiredo MM, Watanabe F, Pontarolo R, Lalli E, Torres LF, Increased incidence of choroid plexus carcinoma due to the germline TP53 R337H mutation in southern Brazil., PLoS One 2011 Mar; 6(3): e18015.

Darcan S, Goksen D, Ozen S, Ozkinay F, Durmaz B, Lalli E, Gonadotropin-dependent precocious puberty in a patient with X-linked adrenal hypoplasia congenita caused by a novel DAX-1 mutation., Horm Res Paediatr 2011 Feb; 75(2): 153-6.

El Wakil A, Lalli E, The Wnt/beta-catenin pathway in adrenocortical development and cancer., Mol Cell Endocrinol 2011 Jan; 332(1-2): 32-7.

Maluf DF, de Oliveira BH, Lalli E, Therapy of adrenocortical cancer: present and future., Am J Cancer Res 2011 ; 1(2): 222-232.

Doghman M, Axelson M, Lalli E, Potent inhibitory effect of the cyclolignan picropodophyllin (PPP) on human adrenocortical carcinoma cells proliferation., Am J Cancer Res 2011 ; 1(3): 356-361.

Lalli E, Adrenal cortex ontogenesis., Best Pract Res Clin Endocrinol Metab 2010 Dec; 24(6): 853-64.

Boulkroun S, Samson-Couterie B, Dzib JF, Lefebvre H, Louiset E, Amar L, Plouin PF, Lalli E, Jeunemaitre X, Benecke A, Meatchi T, Zennaro MC, Adrenal cortex remodeling and functional zona glomerulosa hyperplasia in primary aldosteronism., Hypertension 2010 Nov; 56(5): 885-92.

Lalli E, Adrenocortical development and cancer: focus on SF-1., J Mol Endocrinol 2010 Jun; 44(6): 301-7.

Doghman M, El Wakil A, Cardinaud B, Thomas E, Wang J, Zhao W, Peralta-Del Valle MH, Figueiredo BC, Zambetti GP, Lalli E, Regulation of insulin-like growth factor-mammalian target of rapamycin signaling by microRNA in childhood adrenocortical tumors., Cancer Res 2010 Jun; 70(11): 4666-75.

De Moura J, Kavalec FL, Doghman M, Rosati R, Custodio G, Lalli E, Cavallari GM, Santa Maria J, Figueiredo BC, Heterozygous TP53stop146/R72P fibroblasts from a Li-Fraumeni syndrome patient with impaired response to DNA damage., Int J Oncol 2010 Apr; 36(4): 983-90.

Lalli E, Alonso J, Targeting DAX-1 in embryonic stem cells and cancer., Expert Opin Ther Targets 2010 Feb; 14(2): 169-77.

Doghman M, Madoux F, Hodder P, Lalli E, Identification and characterization of steroidogenic factor-1 inverse agonists., Methods Enzymol 2010 ; 485(): 3-23.

Khalfallah O, Rouleau M, Barbry P, Bardoni B, Lalli E, Dax-1 knockdown in mouse embryonic stem cells induces loss of pluripotency and multilineage differentiation., Stem Cells 2009 Jul; 27(7): 1529-37.

Doghman M, Cazareth J, Douguet D, Madoux F, Hodder P, Lalli E, Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists., J Clin Endocrinol Metab 2009 Jun; 94(6): 2178-83.

Doghman M, Lalli E, A matter of dosage: SF-1 in adrenocortical development and cancer., Ann Endocrinol (Paris) 2009 Jun; 70(3): 148-52.

Ehrlund A, Anthonisen EH, Gustafsson N, Venteclef N, Robertson Remen K, Damdimopoulos AE, Galeeva A, Pelto-Huikko M, Lalli E, Steffensen KR, Gustafsson JA, Treuter E, E3 ubiquitin ligase RNF31 cooperates with DAX-1 in transcriptional repression of steroidogenesis., Mol Cell Biol 2009 Apr; 29(8): 2230-42.

Bensaid M, Melko M, Bechara EG, Davidovic L, Berretta A, Catania MV, Gecz J, Lalli E, Bardoni B, FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure., Nucleic Acids Res 2009 Mar; 37(4): 1269-79.

Ye P, Nakamura Y, Lalli E, Rainey WE, Differential effects of high and low steroidogenic factor-1 expression on CYP11B2 expression and aldosterone production in adrenocortical cells., Endocrinology 2009 Mar; 150(3): 1303-9.

García-Aragoncillo E, Carrillo J, Lalli E, Agra N, Gómez-López G, Pestaña A, Alonso J, DAX1, a direct target of EWS/FLI1 oncoprotein, is a principal regulator of cell-cycle progression in Ewing’s tumor cells., Oncogene 2008 Oct; 27(46): 6034-43.

Rosati R, Cerrato F, Doghman M, Pianovski MA, Parise GA, Custódio G, Zambetti GP, Ribeiro RC, Riccio A, Figueiredo BC, Lalli E, High frequency of loss of heterozygosity at 11p15 and IGF2 overexpression are not related to clinical outcome in childhood adrenocortical tumors positive for the R337H TP53 mutation., Cancer Genet Cytogenet 2008 Oct; 186(1): 19-24.

Doghman M, Cazareth J, Lalli E, The T cell factor/beta-catenin antagonist PKF115-584 inhibits proliferation of adrenocortical carcinoma cells., J Clin Endocrinol Metab 2008 Aug; 93(8): 3222-5.

Heitzmann D, Derand R, Jungbauer S, Bandulik S, Sterner C, Schweda F, El Wakil A, Lalli E, Guy N, Mengual R, Reichold M, Tegtmeier I, Bendahhou S, Gomez-Sanchez CE, Aller MI, Wisden W, Weber A, Lesage F, Warth R, Barhanin J, Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis., EMBO J 2008 Jan; 27(1): 179-87.

Bechara E, Davidovic L, Melko M, Bensaid M, Tremblay S, Grosgeorge J, Khandjian EW, Lalli E, Bardoni B, Fragile X related protein 1 isoforms differentially modulate the affinity of fragile X mental retardation protein for G-quartet RNA structure., Nucleic Acids Res 2007 ; 35(1): 299-306.

Laissue P, Copelli S, Bergada I, Bergada C, Barrio G, Karaboga S, Wurtz JM, Fellous M, Lalli E, Veitia RA, Partial defects in transcriptional activity of two novel DAX-1 mutations in childhood-onset adrenal hypoplasia congenita., Clin Endocrinol (Oxf) 2006 Nov; 65(5): 681-6.

Gautier-Stein A, Zitoun C, Lalli E, Mithieux G, Rajas F, Transcriptional regulation of the glucose-6-phosphatase gene by cAMP/vasoactive intestinal peptide in the intestine. Role of HNF4alpha, CREM, HNF1alpha, and C/EBPalpha., J Biol Chem 2006 Oct; 281(42): 31268-78.

Pianovski MA, Cavalli LR, Figueiredo BC, Santos SC, Doghman M, Ribeiro RC, Oliveira AG, Michalkiewicz E, Rodrigues GA, Zambetti G, Haddad BR, Lalli E, SF-1 overexpression in childhood adrenocortical tumours., Eur J Cancer 2006 May; 42(8): 1040-3.

Mendiola M, Carrillo J, García E, Lalli E, Hernández T, de Alava E, Tirode F, Delattre O, García-Miguel P, López-Barea F, Pestaña A, Alonso J, The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors., Int J Cancer 2006 Mar; 118(6): 1381-9.

Mazziotti G, Amato G, Sorvillo F, Piscopo M, Rizzo MR, Lalli E, Iride L, Cioffi M, Molinari AM, Paolisso G, Carella C, Increased serum osteoprotegerin values in long-lived subjects: different effects of inflammation and bone metabolism., Eur J Endocrinol 2006 Mar; 154(3): 373-7.

Stinghen ST, Moura JF, Zancanella P, Rodrigues GA, Pianovski MA, Lalli E, Arnold DL, Minozzo JC, Callefe LG, Ribeiro RC, Figueiredo BC, Specific immunoassays for placental alkaline phosphatase as a tumor marker., J Biomed Biotechnol 2006 ; 2006(5): 56087.

Bardoni B, Willemsen R, Weiler IJ, Schenck A, Severijnen LA, Hindelang C, Lalli E, Mandel JL, NUFIP1 (nuclear FMRP interacting protein 1) is a nucleocytoplasmic shuttling protein associated with active synaptoneurosomes., Exp Cell Res 2003 Sep; 289(1): 95-107.

Lalli E, Sassone-Corsi P, DAX-1, an unusual orphan receptor at the crossroads of steroidogenic function and sexual differentiation., Mol Endocrinol 2003 Aug; 17(8): 1445-53.

Manna PR, Eubank DW, Lalli E, Sassone-Corsi P, Stocco DM, Transcriptional regulation of the mouse steroidogenic acute regulatory protein gene by the cAMP response-element binding protein and steroidogenic factor 1., J Mol Endocrinol 2003 Jun; 30(3): 381-97.

Amato G, Conte M, Mazziotti G, Lalli E, Vitolo G, Tucker AT, Bellastella A, Carella C, Izzo A, Serum and follicular fluid cytokines in polycystic ovary syndrome during stimulated cycles., Obstet Gynecol 2003 Jun; 101(6): 1177-82.

Lehmann SG, Wurtz JM, Renaud JP, Sassone-Corsi P, Lalli E, Structure-function analysis reveals the molecular determinants of the impaired biological function of DAX-1 mutants in AHC patients., Hum Mol Genet 2003 May; 12(9): 1063-72.

Gévry NY, Lalli E, Sassone-Corsi P, Murphy BD, Regulation of niemann-pick c1 gene expression by the 3’5′-cyclic adenosine monophosphate pathway in steroidogenic cells., Mol Endocrinol 2003 Apr; 17(4): 704-15.

Lalli E, Ohe K, Latorre E, Bianchi ME, Sassone-Corsi P, Sexy splicing: regulatory interplays governing sex determination from Drosophila to mammals., J Cell Sci 2003 Feb; 116(Pt 3): 441-5.

Amato G, Lalli E, Mazziotti G, De Felice G, Rotondi M, Vitolo G, Saggese A, Livrea A, Bellastella A, Carella C, Eight parathyroid glands incidentally discovered during a surgical intervention for secondary hyperparathyroidism: an unusual clinical finding., J Endocrinol Invest 2002 Oct; 25(9): 800-3.

Lehmann SG, Lalli E, Sassone-Corsi P, X-linked adrenal hypoplasia congenita is caused by abnormal nuclear localization of the DAX-1 protein., Proc Natl Acad Sci U S A 2002 Jun; 99(12): 8225-30.

Ohe K, Lalli E, Sassone-Corsi P, A direct role of SRY and SOX proteins in pre-mRNA splicing., Proc Natl Acad Sci U S A 2002 Feb; 99(3): 1146-51.

Manna PR, Dyson MT, Eubank DW, Clark BJ, Lalli E, Sassone-Corsi P, Zeleznik AJ, Stocco DM, Regulation of steroidogenesis and the steroidogenic acute regulatory protein by a member of the cAMP response-element binding protein family., Mol Endocrinol 2002 Jan; 16(1): 184-99.