Fabrice DUPRAT

2024

Rusina E, Simonti M, Duprat F, Cestèle S, Mantegazza M, Voltage-gated sodium channels in genetic epilepsy: up and down of excitability., J Neurochem 2024 Dec; 168(12): 3872-3890.

2024

Smith J, Richerson G, Kouchi H, Duprat F, Mantegazza M, Bezin L, Rheims S, Are we there yet? A critical evaluation of sudden and unexpected death in epilepsy models., Epilepsia 2024 Jan; 65(1): 9-25.

2021

Chever O, Zerimech S, Scalmani P, Lemaire L, Pizzamiglio L, Loucif A, Ayrault M, Krupa M, Desroches M, Duprat F, Léna I, Cestèle S, Mantegazza M, Initiation of migraine-related cortical spreading depolarization by hyperactivity of GABAergic neurons and NaV1.1 channels., J Clin Invest 2021 Nov; 131(21): .

2021

Daniel Diaz-Arce, Anis Ghouma, Pierre Guetschel, Théodore Papadopoulo, Massimo Mantegazza, Fabrice Duprat, Tools for convulsive seizures and interictal spikes detection, Congrès Labex ICST, Nov 2021, Nantes, France.

2020

Falvey A, Duprat F, Simon T, Hugues-Ascery S, Conde SV, Glaichenhaus N, Blancou P, Electrostimulation of the carotid sinus nerve in mice attenuates inflammation via glucocorticoid receptor on myeloid immune cells., J Neuroinflammation 2020 Dec; 17(1): 368.

2020

Pierre Guetschel, Théodore Papadopoulo, Fabrice Duprat, EEG signal analysis for epileptic seizure genesis study, Soph.IA, Nov 2020, Sophia Antipolis, France.

2020

Zerimech S, Chever O, Scalmani P, Pizzamiglio L, Duprat F, Mantegazza M, Cholinergic modulation inhibits cortical spreading depression in mouse neocortex through activation of muscarinic receptors and decreased excitatory/inhibitory drive., Neuropharmacology 2020 Apr; 166(): 107951.

2019

Arhatte M, Gunaratne GS, El Boustany C, Kuo IY, Moro C, Duprat F, Plaisant M, Duval H, Li D, Picard N, Couvreux A, Duranton C, Rubera I, Pagnotta S, Lacas-Gervais S, Ehrlich BE, Marchant JS, Savage AM, van Eeden FJM, Wilkinson RN, Demolombe S, Honoré E, Patel A, TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells., Nat Commun 2019 May; 10(1): 2024.

2019

Salgueiro-Pereira AR, Duprat F, Pousinha PA, Loucif A, Douchamps V, Regondi C, Ayrault M, Eugie M, Stunault MI, Escayg A, Goutagny R, Gnatkovsky V, Frassoni C, Marie H, Bethus I, Mantegazza M, A two-hit story: Seizures and genetic mutation interaction sets phenotype severity in SCN1A epilepsies., Neurobiol Dis 2019 May; 125(): 31-44.

2018

Castagnola S, Delhaye S, Folci A, Paquet A, Brau F, Duprat F, Jarjat M, Grossi M, Béal M, Martin S, Mantegazza M, Bardoni B, Maurin T, New Insights Into the Role of Cav2 Protein Family in Calcium Flux Deregulation in Fmr1-KO Neurons., Front Mol Neurosci 2018 ; 11(): 342.

2017

Li Fraine S, Patel A, Duprat F, Sharif-Naeini R, Dynamic regulation of TREK1 gating by Polycystin 2 via a Filamin A-mediated cytoskeletal Mechanism., Sci Rep 2017 Dec; 7(1): 17403.

2017

Lacampagne A, Liu X, Reiken S, Bussiere R, Meli AC, Lauritzen I, Teich AF, Zalk R, Saint N, Arancio O, Bauer C, Duprat F, Briggs CA, Chakroborty S, Stutzmann GE, Shelanski ML, Checler F, Chami M, Marks AR, Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s disease-like pathologies and cognitive deficits., Acta Neuropathol 2017 Nov; 134(5): 749-767.

2016

Retailleau K, Arhatte M, Demolombe S, Jodar M, Baudrie V, Offermanns S, Feng Y, Patel A, Honoré E, Duprat F, Smooth muscle filamin A is a major determinant of conduit artery structure and function at the adult stage., Pflugers Arch 2016 Jul; 468(7): 1151-1160.

2016

Retailleau K, Arhatte M, Demolombe S, Peyronnet R, Baudrie V, Jodar M, Bourreau J, Henrion D, Offermanns S, Nakamura F, Feng Y, Patel A, Duprat F, Honoré E, Arterial Myogenic Activation through Smooth Muscle Filamin A., Cell Rep 2016 Mar; 14(9): 2050-2058.

2015

Retailleau K, Duprat F, Arhatte M, Ranade SS, Peyronnet R, Martins JR, Jodar M, Moro C, Offermanns S, Feng Y, Demolombe S, Patel A, Honoré E, Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling., Cell Rep 2015 Nov; 13(6): 1161-1171.

2014

Retailleau K, Duprat F, Polycystins and partners: proposed role in mechanosensitivity., J Physiol 2014 Jun; 592(12): 2453-71.

2013

Peyronnet R, Martins JR, Duprat F, Demolombe S, Arhatte M, Jodar M, Tauc M, Duranton C, Paulais M, Teulon J, Honoré E, Patel A, Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells., EMBO Rep 2013 Dec; 14(12): 1143-8.

2013

Demolombe S, Duprat F, Honoré E, Patel A, Slower Piezo1 inactivation in dehydrated hereditary stomatocytosis (xerocytosis)., Biophys J 2013 Aug; 105(4): 833-4.

2013

2012

Peyronnet R, Sharif-Naeini R, Folgering JH, Arhatte M, Jodar M, El Boustany C, Gallian C, Tauc M, Duranton C, Rubera I, Lesage F, Pei Y, Peters DJ, Somlo S, Sachs F, Patel A, Honoré E, Duprat F, Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels., Cell Rep 2012 Mar; 1(3): 241-50.

2011

Hassane S, Claij N, Jodar M, Dedman A, Lauritzen I, Duprat F, Koenderman JS, van der Wal A, Breuning MH, de Heer E, Honore E, DeRuiter MC, Peters DJ, Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension., Lab Invest 2011 Jan; 91(1): 24-32.

2010

Patel A, Sharif-Naeini R, Folgering JR, Bichet D, Duprat F, Honoré E, Canonical TRP channels and mechanotransduction: from physiology to disease states., Pflugers Arch 2010 Aug; 460(3): 571-81.

2010

Sharif-Naeini R, Folgering JH, Bichet D, Duprat F, Delmas P, Patel A, Honoré E, Sensing pressure in the cardiovascular system: Gq-coupled mechanoreceptors and TRP channels., J Mol Cell Cardiol 2010 Jan; 48(1): 83-9.

2009

Sharif-Naeini R, Folgering JH, Bichet D, Duprat F, Lauritzen I, Arhatte M, Jodar M, Dedman A, Chatelain FC, Schulte U, Retailleau K, Loufrani L, Patel A, Sachs F, Delmas P, Peters DJ, Honoré E, Polycystin-1 and -2 dosage regulates pressure sensing., Cell 2009 Oct; 139(3): 587-96.

2009

Dedman A, Sharif-Naeini R, Folgering JH, Duprat F, Patel A, Honoré E, The mechano-gated K(2P) channel TREK-1., Eur Biophys J 2009 Mar; 38(3): 293-303.

2008

Sharif-Naeini R, Dedman A, Folgering JH, Duprat F, Patel A, Nilius B, Honoré E, TRP channels and mechanosensory transduction: insights into the arterial myogenic response., Pflugers Arch 2008 Jun; 456(3): 529-40.

2007

Duprat F, Lauritzen I, Patel A, Honoré E, The TASK background K2P channels: chemo- and nutrient sensors., Trends Neurosci 2007 Nov; 30(11): 573-80.

2007

2007

Thümmler S, Duprat F, Lazdunski M, Antipsychotics inhibit TREK but not TRAAK channels., Biochem Biophys Res Commun 2007 Mar; 354(1): 284-9.

2006

Sandoz G, Thümmler S, Duprat F, Feliciangeli S, Vinh J, Escoubas P, Guy N, Lazdunski M, Lesage F, AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels., EMBO J 2006 Dec; 25(24): 5864-72.

2006

Zanzouri M, Lauritzen I, Duprat F, Mazzuca M, Lesage F, Lazdunski M, Patel A, Membrane potential-regulated transcription of the resting K+ conductance TASK-3 via the calcineurin pathway., J Biol Chem 2006 Sep; 281(39): 28910-8.

2006

A. Alloui, K. Zimmermann, J. Mamet, Frederic Duprat, J. Noël, J. Chemin, N. Guy, N. Blondeau, N. Voilley, C. Rubat-Couderc, M. Borsotto, G. Romey, C. Heurteaux, P. Reeh, A. Eschalier, M. Lazdunski, TREK-1, a K+ channel involved in polymodal pain perception., EMBO Journal, 2006, 25, pp.2368-2376.

2005

Chemin J, Patel A, Duprat F, Zanzouri M, Lazdunski M, Honoré E, Lysophosphatidic acid-operated K+ channels., J Biol Chem 2005 Feb; 280(6): 4415-21.

2005

Chemin J, Patel AJ, Duprat F, Lauritzen I, Lazdunski M, Honoré E, A phospholipid sensor controls mechanogating of the K+ channel TREK-1., EMBO J 2005 Jan; 24(1): 44-53.

2005

Kindler CH, Yost CS, Two-pore domain potassium channels: new sites of local anesthetic action and toxicity., Reg Anesth Pain Med 2005 ; 30(3): 260-74.

2005

Duprat F, Girard C, Jarretou G, Lazdunski M, Pancreatic two P domain K+ channels TALK-1 and TALK-2 are activated by nitric oxide and reactive oxygen species., J Physiol 2005 Jan; 562(Pt 1): 235-44.

2004

Heurteaux C, Guy N, Laigle C, Blondeau N, Duprat F, Mazzuca M, Lang-Lazdunski L, Widmann C, Zanzouri M, Romey G, Lazdunski M, TREK-1, a K+ channel involved in neuroprotection and general anesthesia., EMBO J 2004 Jul; 23(13): 2684-95.

2003

Chemin J, Girard C, Duprat F, Lesage F, Romey G, Lazdunski M, Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels., EMBO J 2003 Oct; 22(20): 5403-11.

2003

Lauritzen I, Zanzouri M, Honoré E, Duprat F, Ehrengruber MU, Lazdunski M, Patel AJ, K+-dependent cerebellar granule neuron apoptosis. Role of task leak K+ channels., J Biol Chem 2003 Aug; 278(34): 32068-76.

2003

Duprat F, Daw M, Lim W, Collingridge G, Isaac J, GluR2 protein-protein interactions and the regulation of AMPA receptors during synaptic plasticity., Philos Trans R Soc Lond B Biol Sci 2003 Apr; 358(1432): 715-20.

2001

Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F, Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels., Biochem Biophys Res Commun 2001 Mar; 282(1): 249-56.

2000

Duprat F, Lesage F, Patel AJ, Fink M, Romey G, Lazdunski M, The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK., Mol Pharmacol 2000 May; 57(5): 906-12.

2000

Maingret F, Patel AJ, Lesage F, Lazdunski M, Honoré E, Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK., J Biol Chem 2000 Apr; 275(14): 10128-33.

1998

Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M, Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney., J Biol Chem 1998 Nov; 273(47): 30863-9.

1998

Patel AJ, Honoré E, Maingret F, Lesage F, Fink M, Duprat F, Lazdunski M, A mammalian two pore domain mechano-gated S-like K+ channel., EMBO J 1998 Aug; 17(15): 4283-90.

1998

Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M, A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids., EMBO J 1998 Jun; 17(12): 3297-308.

1997

Salinas M, Duprat F, Heurteaux C, Hugnot JP, Lazdunski M, New modulatory alpha subunits for mammalian Shab K+ channels., J Biol Chem 1997 Sep; 272(39): 24371-9.

1997

Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M, TASK, a human background K+ channel to sense external pH variations near physiological pH., EMBO J 1997 Sep; 16(17): 5464-71.

1997

Lesage F, Lauritzen I, Duprat F, Reyes R, Fink M, Heurteaux C, Lazdunski M, The structure, function and distribution of the mouse TWIK-1 K+ channel., FEBS Lett 1997 Jan; 402(1): 28-32.

1996

Fink M, Duprat F, Lesage F, Reyes R, Romey G, Heurteaux C, Lazdunski M, Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel., EMBO J 1996 Dec; 15(24): 6854-62.

1996

Lesage F, Reyes R, Fink M, Duprat F, Guillemare E, Lazdunski M, Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge., EMBO J 1996 Dec; 15(23): 6400-7.

1996

Fink M, Duprat F, Lesage F, Heurteaux C, Romey G, Barhanin J, Lazdunski M, A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression., J Biol Chem 1996 Oct; 271(42): 26341-8.

1996

Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J, TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure., EMBO J 1996 Mar; 15(5): 1004-11.

1996

Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J, A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties., J Biol Chem 1996 Feb; 271(8): 4183-7.

1996

Fink M, Duprat F, Heurteaux C, Lesage F, Romey G, Barhanin J, Lazdunski M, Dominant negative chimeras provide evidence for homo and heteromultimeric assembly of inward rectifier K+ channel proteins via their N-terminal end., FEBS Lett 1996 Jan; 378(1): 64-8.

1995

Duprat F, Guillemare E, Romey G, Fink M, Lesage F, Lazdunski M, Honore E, Susceptibility of cloned K+ channels to reactive oxygen species., Proc Natl Acad Sci U S A 1995 Dec; 92(25): 11796-800.

1995

Lesage F, Guillemare E, Fink M, Duprat F, Heurteaux C, Fosset M, Romey G, Barhanin J, Lazdunski M, Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels., J Biol Chem 1995 Dec; 270(48): 28660-7.

1995

Duprat F, Lesage F, Guillemare E, Fink M, Hugnot JP, Bigay J, Lazdunski M, Romey G, Barhanin J, Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers., Biochem Biophys Res Commun 1995 Jul; 212(2): 657-63.

1994

Lesage F, Duprat F, Fink M, Guillemare E, Coppola T, Lazdunski M, Hugnot JP, Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain., FEBS Lett 1994 Oct; 353(1): 37-42.