Long-lasting astrocyte remodeling in Dravet Syndrome Scn1a+/– mouse model – IPMC

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Intranet

Thème

Dietary supplementation of alpha-linolenic acid in an enriched rapeseed oil diet protects from stroke.

Peripheral alterations of mitochondrial function and mitophagy in Alzheimer’s disease: from fundamental research to clinical perspectives

Présentation

Key points

Astrocytes remodel in Scn1a⁺/⁻ mice from early seizures to long-term DS stabilization without detectable tissue damage.
In the long term, the astrocyte network expands with increased Cx30/Cx43 expression and hemichannel impairment.
Histologically, microglial cells are not activated in the long term.

https://onlinelibrary.wiley.com/doi/10.1002/epi.70185