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Biography

Ms. Carole Rovère is Senior Research Fellow at INSERM. She joined Dr. Jean-Louis Nahon's team at the IPMC in January 2002, before joining the team in January 2024 «"Epigenetics and Metabolism"» led by Dr. Romain Barrès. Within this team, she develops and funds her own research themes, while also supervising students and young researchers for many years.

She recently supervised the doctoral thesis of Ms. Clara Sanchez (defended in 2023), now a postdoctoral researcher at the Karolinska Institute (Stockholm), as well as that of a postdoctoral researcher, Ms. Selma Ben Fradj (2021–2023), now a lecturer in Nancy. She is currently supervising the doctoral thesis of Ms. Lou Ruffino, in joint supervision with Dr. Arnaud Droit (Université Laval, Quebec), which focuses on the impact of nanoplastics and phthalates from ultra-processed foods on brain disorders.

His recent works, published in 2024 in Brain, Immunity and Behavior These findings, widely reported in the media, have highlighted that a high imbalance in the omega-6/omega-3 ratio—particularly linked to high sunflower oil consumption—induces increased inflammation in several organs in mice, especially the liver and adipose tissue. These results contribute to understanding the mechanisms associated with the metabolic complications observed in humans with excess body fat.

In parallel, Carole Rovère is involved in numerous national and international research projects. She notably coordinates the ANR RANTES project (until 2026) and participates in the MicroFlamEAT project. She is also a partner in the European HORIZON program. PsyCoMed and has obtained several grants from the University of Côte d'Azur (IDEX).

Deeply involved in the scientific community, she actively participates in evaluation and governance bodies. She has been a member of the Inserm Neuroscience Committee (CSS4) since 2021, a member of the Scientific Council of Academy 3 at Université Côte d'Azur since 2023, and served on the EUR LIFE project monitoring committee (CoSP) from 2020 to 2024. Since January 2025, she has been the secretary of the French Society of Neuroendocrinology and was elected to its Board of Directors as the representative of the "Neuroendocrinology and Integrated Physiology" group for the 2025–2029 term.

She also provides more than 60 hours of teaching per year, notably in master's programs (University of Rouen, University Côte d'Azur), as well as at Polytech Nice in the teaching units of pharmacology and integrative biology.

Recognized for her scientific communication skills, she is regularly invited to present her work at national and international conferences and contributes to the organization of scientific events. In particular, she chaired the organizing committee of the 46th Symposium of the French Society of Neuroendocrinology, the first France-Canada symposium, held in Nice in September 2024. She also organized and moderated symposia at NeuroFrance 2025 in Montpellier and at the 10th Congress of the Mediterranean Neuroscience Society in 2025 in Chania, Crete.

Deeply committed to the dialogue between science and society, she actively participates in science outreach events such as the Science Festival and Brain Awareness Week, coordinating their activities on the French Riviera. She has chaired the organizing committee since 2009. In this capacity, she was awarded a grant of €150,000 in 2023 from the French National Research Agency (ANR) under the program "Science with and for Society – Innovative Ambitions," aimed at strengthening interactions between researchers and civil society and encouraging interdisciplinarity.

Her work has been recognized with several awards, including the Medisite Foundation Neuroscience Prize and the Benjamin Delessert Institute Research Prize in 2018, for her research on obesity, which she continues at the IPMC.


Award of Excellence

  • 2011 : Research Prize – French-speaking Society of Clinical Nutrition and Metabolism
  • 2015 : "Women in Science and Research" Award – La Tribune
  • 2017 : Neuroscience Research Prize – Medisite Foundation
  • 2018 : EDAB-FENS BAW Award of Excellence
  • 2018 : Benjamin Delessert Institute Research Prize

Main Funding Sources

Over the past ten years, Carole Rovère has secured and coordinated numerous competitive funding opportunities, including:

  • 2017-2018 : Medisite Foundation Neuroscience Research Prize – €20,000 – Coordinator
  • 2017-2019 : NUTRIMORPH UniCA-IDEX Research Project / Academy 2 «Complex Systems» / Neuromod Institute – €11,000 – Coordinator
  • 2018-2019 : Master's degree in Environment IDEX-JEDI / Academy 4 "Complexity and Diversity of Life" – €24,000 – Co-coordinator with Dr. Eric Debreuve
  • 2018-2019 : Benjamin Delessert Institute Research Prize – €16,000 – Coordinator
  • 2019-2021 : IDEX-JEDI / Sentinel North research program (University Côte d'Azur – University Laval partnership) – €20,000/year (UniCA) + CAD 30,000/year (ULaval) – Coordinator
  • 2019-2021 : NUTRINEURO UCA-IDEX / Academy 3 research project «Space, environment, risks and resilience» – €35,000 – Coordinator
  • 2019-2021 : NUTRINEURO Université Côte d'Azur-IDEX / Académie 3 – Coordinator
  • 2020-2022 : PsyCoMed UCA-IDEX / Academy 3 research project «Space, environment, risks and resilience» – €25,000 – Co-coordinator with Professor Jacques Noël
  • 2021 : SFD-Roche Diabetes Care Grant – €15,000 – Coordinator
  • 2021 : SFD-Roche Diabetes Care – Coordinator
  • 2021-2026 : ANR Generic AAP 2020 – RANTES: Regulation of obesogenic neuroinflammation and energy and carbohydrate homeostasis – €280,560 for the team – Coordinator
  • 2021-2026 : ANR AAP Generic 2021 – MicroFlamEAT: Role of the postprandial microglial inflammatory response in the cerebral control of appetite – €90,000 for the team – Partner
  • 2023-2026 : European program HORIZON-MSCA-2021-SE-01-01 – PsyCoMed – €110,400 for the team – Partner
  • 2024-2026 : ANR «Science with and for Society» – Innovative Ambitions 2023 – €150,000 for the team – Coordinator
  • 2025-2028 : PLASTIC-BRAIN UCA-IDEX / Academy 3 research project «Space, environment, risks and resilience» – €50,000/year – Co-coordinator with Dr. Jacques Noël
  • 2026-2031 : SYNAPSE International Associated Laboratory (Université Côte d'Azur – Université Laval) – €20,000/year – Co-coordinator with Dr. Alexandre Caron

Science and Society

Carole Rovère is involved in original science communication initiatives. «"The melody of neurons"» A beautiful illustration of this is: a musical show that explores the brain by blending research, emotions and artistic creation.

YouTube link: Excerpts from The Melody of Neurons – YouTube

Publications

2026
Abélanet S, Pagnotta S, Brau F, Péquignot M, Scheuermann V, Lacas-Gervais S, Rovere C, Corinus A, Della-Croce L, Delettre C, Luton F, Franco M, EFA6A regulates retinal function through the control of photoreceptor cell activity and structure., iScience 2026 Apr; 29(4): 115179.
2025
Cansell C, Goepp V, Bain F, Todd N, Douard V, Monnoye M, Zane F, Sanchez C, Pietrancosta N, Rovere C, Denis RGP, Luquet S, Rera M, Two-phase model of aging in mice for improved identification of age-related and late life metabolic decline., BMC Biol 2025 Oct; 23(1): 318.
2025
Céline Cansell, Vivien Goepp, Fanny Bain, Nicolas Todd, Veronique Douard, Magali Monnoye, Flaminia Zane, Clara Sanchez, Nicolas Pietrancosta, Carole Rovere, Raphaël Gp Denis, Serge Luquet, Michael Rera, Smurf Mice»: revolutionizing our understanding of age-related and end-of-life animal physiology, 2025.
2025
Sanchez C, Nadal M, Cansell C, Laroui S, Descombes X, Rovère C, Debreuve É, Computational detection, characterization, and clustering of microglial cells in a mouse model of fat-induced postprandial hypothalamic inflammation., Methods 2025 Apr; 236(): 28-38.
2024
Ilaria Bernardini, Kevin Tallec, Ika Paul-Pont, Luca Peruzza, Giulia Dalla Rovere, Matthias Huber, Carole Di Poi, Hugo Koechlin, Claudie Quéré, Virgile Quillien, Jacqueline Le Grand, Nelly Le Goïc, Christophe Lambert, Fabienne Lagarde, Camille Détrée, Rafael Trevisan, Charlotte Corporeau, Tomaso Patarnello, Massimo Milan, Arnaud Huvet, Effects of tire particles and associated-chemicals on the Pacific oyster (Magallana gigas) physiology, reproduction and next-generation, Journal of Hazardous Materials, 2024, 480, pp.135742. ⟨10.1016/j.jhazmat.2024.135742⟩.
2024
Sanchez C, Colson C, Gautier N, Noser P, Salvi J, Villet M, Fleuriot L, Peltier C, Schlich P, Brau F, Sharif A, Altintas A, Amri EZ, Nahon JL, Blondeau N, Benani A, Barrès R , Rovere C, Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity. Brain Behav Immune 2024 Mar; 117(): 330-346.
2024
Delhaye S, Jarjat M, Boulksibat A, Sanchez C, Tempio A, Turtoi A, Giorgi M, Lacas-Gervais S, Baj G, Rovere C, Trezza V, Pellegrini M, Maurin T, Lalli E, Bardoni B, Defects in AMPAR trafficking and microglia activation underlie socio-cognitive deficits associated to decreased expression of phosphodiesterase 2 a., Neurobiol Dis 2024 Feb; 191(): 106393.
2024
Negm A, Stobbe K, Ben Fradj S, Sanchez C, Landra-Willm A, Richter M, Fleuriot L, Debayle D, Deval E, Lingueglia E, Rovere C, Noel J, Acid-sensing ion channel 3 mediates pain hypersensitivity associated with high-fat diet consumption in mice. Bread 2024 Feb; 165(2): 470-486.
2024
Salvi J, Andreoletti P, Audinat E, Balland E, Ben Fradj S, Cherkaoui-Malki M, Heurtaux T, Liénard F, Nédélec E, Rovère C, Savary S, Véjux A, Trompier D, Benani A, Microgliosis: a double-edged sword in the control of food intake., FEBS J 2024 Feb; 291(4): 615-631.
2023
Céline Cansell, Vivien Goepp, Fanny Bain, Nicolas Todd, Véronique Douard, Magali Monnoye, Clara Sanchez, Nicolas Pietrancosta, Carole Rovere, Raphael Gp Denis, Serge Luquet, Michael Rera, Two phases model of aging in mice: towards a better identification of age-related and late-life metabolic decline [Registered Report Stage 1 Protocol], 2023.
2022
Ben Fradj S, Nédélec E, Salvi J, Fouesnard M, Huillet M, Pallot G, Cansell C, Sanchez C, Philippe C, Gigot V, Lemoine A, Trompier D, Henry T, Petrilli V, Py BF, Guillou H, Loiseau N, Ellero-Simatos S, Nahon JL, Rovère C, Grober J, Boudry G, Douard V, Benani A, Evidence for Constitutive Microbiota-Dependent Short-Term Control of Food Intake in Mice: Is There a Link with Inflammation, Oxidative Stress, Endotoxemia, and GLP-1?, Antioxid Redox Signal 2022 Aug; 37(4-6): 349-369.
2021
Duriez P, Nilsson IAK, Le Thuc O, Alexandre D, Chartrel N, Rovere C, Chauveau C, Gorwood P, Tolle V, Viltart O, Exploring the Mechanisms of Recovery in Anorexia Nervosa through a Translational Approach: From Original Ecological Measurements in Human to Brain Tissue Analyzes in Mice., Nutrients 2021 Aug; 13(8): .
2021
Daziano G, Blondeau N, Béraud-Dufour S, Abderrahmani A, Rovère C, Heurteaux C, Mazella J, Lebrun P, Coppola T, Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway., Pharmacol Res 2021 May; 167(): 105539.
2021
Daniel Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, Iannis Adamopoulos, Khosrow Adeli, Timon Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat Aggarwal, Maria Agnello, Patrizia Agostinis, Javed Agrewala, Alexander Agrotis, Patricia Aguilar, S. Tariq Ahmad, Zubair Ahmed, Ulises Ahumada-Castro, Sonja Aits, Shu Aizawa, Yunus Akkoc, To..., Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition), Autophagy, 2021, 17 (1), pp.1-382. ⟨10.1080/15548627.2020.1797280⟩.
2021
Cansell C, Stobbe K, Sanchez C, Le Thuc O, Mosser CA, Ben-Fradj S, Leredde J, Lebeaupin C, Debayle D, Fleuriot L, Brau F, Devaux N, Benani A, Audinat E, Blondeau N, Nahon JL, Rovère C, Dietary fat exacerbates postprandial hypothalamic inflammation involving glial fibrillary acidic protein-positive cells and microglia in male mice., Glia 2021 Jan; 69(1): 42-60.
2020
Nuzzaci D, Cansell C, Liénard F, Nédélec E, Ben Fradj S, Castel J, Foppen E, Denis R, Grouselle D, Laderrière A, Lemoine A, Mathou A, Tolle V, Heurtaux T, Fioramonti X, Audinat E, Pénicaud L, Nahon JL, Rovère C, Benani A, Postprandial Hyperglycemia Stimulates Neuroglial Plasticity in Hypothalamic POMC Neurons after a Balanced Meal., Cell Rep 2020 Mar; 30(9): 3067-3078.e5.
2017
Fournier M, d'Arripe-Longueville F, Rovere C, Easthope CS, Schwabe L, El Methni J, Radel R, Effects of circadian cortisol on the development of a health habit., Health Psychol 2017 Nov; 36(11): 1059-1064.
2017
Thuc OL, Noël J, Rovère C, An ex vivo Perifusion Method for Quantitative Determination of Neuropeptide Release from Mouse Hypothalamic Explants., Bio Protoc 2017 Aug; 7(16): e2521.
2017
Le Thuc O, Stobbe K, Cansell C, Nahon JL, Blondeau N, Rovère C, Hypothalamic Inflammation and Energy Balance Disruptions: Spotlight on Chemokines., Front Endocrinol (Lausanne) 2017; 8(): 197.
2017
Méquinion M, Le Thuc O, Zgheib S, Alexandre D, Chartrel N, Rovère C, Hardouin P, Viltart O, Chauveau C, Long-Term Energy Deficit in Mice Causes Long-Lasting Hypothalamic Alterations after Recovery., Neuroendocrinology 2017; 105(4): 372-383.
2016
Le Thuc O, Cansell C, Bourourou M, Denis RG, Stobbe K, Devaux N, Guyon A, Cazareth J, Heurteaux C, Rostène W, Luquet S, Blondeau N, Nahon JL, Rovère C, Central CCL2 signaling onto MCH neurons mediates metabolic and behavioral adaptation to inflammation. EMBO Rep 2016 Dec; 17(12): 1738-1752.
2016
Gorwood P, Blanchet-Collet C, Chartrel N, Duclos J, Dechelotte P, Hanachi M, Fetissov S, Godart N, Melchior JC, Ramoz N, Rovere-Jovene C, Tolle V, Viltart O, Epelbaum J, New Insights in Anorexia Nervosa., Front Neurosci 2016; 10(): 256.
2016
Le Thuc O, Rovère C, [Hypothalamic inflammation and energy balance deregulations: focus on chemokines.]., Biol Aujourd'hui 2016; 210(4): 211-225.
2015
Le Thuc O, Blondeau N, Nahon JL, Rovère C, The complex contribution of chemokines to neuroinflammation: switching from beneficial to detrimental effects., Ann NY Acad Sci 2015 Sep; 1351(): 127-40.
2014
Schneck AS, Iannelli A, Patouraux S, Rousseau D, Bonnafous S, Bailly-Maitre B, Le Thuc O, Rovere C, Panaia-Ferrari P, Anty R, Tran A, Gual P, Gugenheim J, Effects of sleeve gastrectomy in high fat diet-induced obese mice: respective role of reduced caloric intake, white adipose tissue inflammation and changes in adipose tissue and ectopic fat deposits., Surg Endosc 2014 Feb; 28(2): 592-602.
2013
Conductier G, Brau F, Viola A, Langlet F, Ramkumar N, Dehouck B, Lemaire T, Chapot R, Lucas L, Rovère C, Maitre P, Hosseiny S, Petit-Paitel A, Adamantidis A, Lakaye B, Risold PY, Prévot V, Meste O, Nahon JL, Guyon A, Melanin-concentrating hormone regulates beat frequency of ependymal cilia and ventricular volume., Nat Neurosci 2013 Jul; 16(7): 845-7.
2011
Dalmas E, Rouault C, Abdennour M, Rovere C, Rizkalla S, Bar-Hen A, Nahon JL, Bouillot JL, Guerre-Millo M, Clément K, Poitou C, Variations in circulating inflammatory factors are related to changes in calorie and carbohydrate intakes early in the course of surgery-induced weight reduction., Am J Clin Nutr 2011 Aug; 94(2): 450-8.
2011
William Rostène, Alice Guyon, Lara Kular, David Godefroy, Federica Barbieri, Adriana Bajetto, Ghazal Banisadr, Céline Callewaere, Grégory Conductier, Carole Rovère, Chemokines and chemokine receptors: New actors in neuroendocrine regulations, Frontiers in Neuroendocrinology, 2011, 32 (1), pp.10-24.
2011
Rostène W, Guyon A, Kular L, Godefroy D, Barbieri F, Bajetto A, Banisadr G, Callewaere C, Conductier G, Rovère C, Mélik-Parsadaniantz S, Florio T, Chemokines and chemokine receptors: new actors in neuroendocrine regulations., Front Neuroendocrinol 2011 Jan; 32(1): 10-24.
2010
Nicolas Builles, Hélène Janin-Manificat, Marilyne Malbouyres, Virginie Justin, Marie-Rose Rovère, Graziella Pellegrini, Jim Torbet, David JS Hulmes, Carole Burillon, Odile Damour, Florence Ruggiero, Use of magnetically oriented orthogonal collagen scaffolds for hemi-corneal reconstruction and regeneration, Biomaterials, 2010, 31 (32), pp.8313-8322. ⟨10.1016/j.biomaterials.2010.07.066⟩.
2010
Conductier G, Blondeau N, Guyon A, Nahon JL, Rovère C, The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases., J Neuroimmunol 2010 Jul; 224(1-2): 93-100.
2009
Cotta-Grand N, Rovere C, Guyon A, Cervantes A, Brau F, Nahon JL, Melanin-concentrating hormone induces neurite outgrowth in human neuroblastoma SH-SY5Y cells through p53 and MAPKinase signaling pathways., Peptides 2009 Nov; 30(11): 2014-24.
2009
Guyon A, Conductier G, Rovere C, Enfissi A, Nahon JL, Melanin-concentrating hormone producing neurons: Activities and modulations., Peptides 2009 Nov; 30(11): 2031-9.
2009
Guyon A, Tardy MP, Rovère C, Nahon JL, Barhanin J, Lesage F, Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels. J Neurosci 2009 Feb; 29(8): 2528-33.
2008
Guyon A, Massa F, Rovere C, Nahon JL, How cytokines can influence the brain: a role for chemokines?, J Neuroimmunol 2008 Jul; 198(1-2): 46-55.
2003
Bernard N, Kitabgi P, Rovere-Jovene C, The Arg617-Arg618 cleavage site in the C-terminal domain of PC1 plays a major role in the processing and targeting of the enzyme within the regulated secretory pathway., J Neurochem 2003 Jun; 85(6): 1592-603.
2002
Maulon-Feraille L, Della Zuana O, Suply T, Rovere-Jovene C, Audinot V, Levens N, Boutin JA, Duhault J, Nahon JL, Appetite-boosting property of pro-melanin-concentrating hormone(131-165) (neuropeptide-glutamic acid-isoleucine) is associated with proteolytic resistance., J Pharmacol Exp Ther 2002 Aug; 302(2): 766-73.
2002
Audinot V, Lahaye C, Suply T, Rovère-Jovène C, Rodriguez M, Nicolas JP, Beauverger P, Cardinaud B, Galizzi JP, Fauchère JL, Nahon JL, Boutin JA, SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor., Biochem Biophys Res Commun 2002 Jul; 295(4): 841-8.
2002
Friry C, Feliciangeli S, Richard F, Kitabgi P, Rovere C, Production of recombinant large proneurotensin/neuromedin N-derived peptides and characterization of their binding and biological activity., Biochem Biophys Res Commun 2002 Feb; 290(4): 1161-8.