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Thème

Présentation

Notre équipe s’intéresse à la modulation de la plasticité neuronale dans les conditions physiologiques et pathologiques. Une solide expertise au sein de l’équipe en électrophysiologie in vitro (field et patch clamp sur tranche) et en comportement nous permet une approche transversale des mécanismes moléculaires à la sortie comportementale.  Pour manipuler les mécanismes cellulaires impliqués dans les diverses pathologies, nous utilisons une approche virale pour l’expression de protéines in vivo ainsi que des lignées de souris transgéniques. Actuellement, nous développons aussi des outils biochimiques et imagerie cellulaire pour compléter notre approche transversale. Nous collaborons aussi avec des équipes nationales et internationales pour des analyses biochimiques et neurocomputationelles de la fonction neuronale.

Publications

2025
Thomas Contesse, Joana Gomes-Ribeiro, Lea Royon, Hugo Fofo, Anaelle Braine, Christelle Glangetas, Shiliang Zhang, M Flavia Barbano, Mariano Soiza-Reilly, François Georges, Jacques Barik, Sebastian P Fernandez, Social stress increases anxiety by GluA1-dependent synaptic strengthening of ventral tegmental area inputs to the basolateral amygdala, Biol Psychiatry . 2025 Apr 15:S0006-3223(25)01121-7.
2024
Lauren M. Reynolds, Aylin Gulmez, Sophie L. Fayad, Renan Costa Campos, Daiana Rigoni, Claire Nguyen, Tinaïg Le Borgne, Thomas Topilko, Domitille Rajot, Clara Franco, Fabio Marti, Nicolas Heck, Alexandre Mourot, Nicolas Renier, Jacques Barik, and Philippe Faure, Transient nicotine exposure in early adolescent male mice freezes their dopamine circuits in an immature state, Nat Commun . 2024 Oct 18;15(1):9017.
2024
Dorian Battivelli, Cécile Vernochet, Estelle Conabady, Claire Nguyen, Abdallah Zayed, Ashley Lebel, Aura Carole Meirsman, Sarah Messaoudene, Alexandre Fieggen, Gautier Dreux, Daiana Rigoni, Tinaïg Le Borgne, Fabio Marti, Thomas Contesse, Jacques Barik, Jean-Pol Tassin, Philippe Faure, Sébastien Parnaudeau, François Tronche, Dopamine Neuron Activity and Stress Signaling as Links Between Social Hierarchy and Psychopathology Vulnerability, Biol Psychiatry . 2024 Apr 15;95(8):774-784..
2024
Dunot J, Moreno S, Gandin C, Pousinha PA, Amici M, Dupuis J, Anisimova M, Winschel A, Uriot M, Petshow SJ, Mensch M, Bethus I, Giudici C, Hampel H, Wefers B, Wurst W, Naumann R, Ashby MC, Laube B, Zito K, Mellor JR, Groc L, Willem M, Marie H, APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors., Neuron 2024 Aug; 112(16): 2708-2720.e9.
2024
2023
Dunot J, Ribera A, Pousinha PA, Marie H, Spatiotemporal insights of APP function., Curr Opin Neurobiol 2023 Oct; 82(): 102754.
2023
Rodrigues YE, Tigaret CM, Marie H, O'Donnell C, Veltz R, A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics., Elife 2023 Aug; 12(): .
2023
Rajão-Saraiva J, Dunot J, Ribera A, Temido-Ferreira M, Coelho JE, König S, Moreno S, Enguita FJ, Willem M, Kins S, Marie H, Lopes LV, Pousinha PA, Age-dependent NMDA receptor function is regulated by the amyloid precursor protein., Aging Cell 2023 Mar; 22(3): e13778.
2023
Dainauskas JJ, Vitale P, Moreno S, Marie H, Migliore M, Saudargiene A, Altered synaptic plasticity at hippocampal CA1-CA3 synapses in Alzheimer’s disease: integration of amyloid precursor protein intracellular domain and amyloid beta effects into computational models., Front Comput Neurosci 2023 ; 17(): 1305169.
2023
Dainauskas JJ, Marie H, Migliore M, Saudargiene A, GluN2B-NMDAR subunit contribution on synaptic plasticity: A phenomenological model for CA3-CA1 synapses., Front Synaptic Neurosci 2023 ; 15(): 1113957.
2023
Lecca S, Congiu M, Royon L, Restivo L, Girard B, Mazaré N, Bellone C, Telley L, Mameli M, A neural substrate for negative affect dictates female parental behavior., Neuron 2023 Apr; 111(7): 1094-1103.e8.
2022
Andry Andrianarivelo, Pierre Trifilieff, Jacques Barik, Peter Vanhoutte, Interaction between dopamine and glutamate receptors: A therapeutic target against addiction?, Med Sci (Paris) . 2022 Aug-Sep;38(8-9):623-626..
2022
Bianchi D, Migliore R, Vitale P, Garad M, Pousinha PA, Marie H, Lessmann V, Migliore M, Membrane electrical properties of mouse hippocampal CA1 pyramidal neurons during strong inputs., Biophys J 2022 Feb; 121(4): 644-657.
2022
Broussot L, Contesse T, Costa-Campos R, Glangetas C, Royon L, Fofo H, Lorivel T, Georges F, Fernandez SP, Barik J, A non-canonical GABAergic pathway to the VTA promotes unconditioned freezing., Mol Psychiatry 2022 Dec; 27(12): 4905-4917.
2022
Ortiz V, Costa Campos R, Fofo H, Fernandez SP, Barik J, Nicotinic receptors promote susceptibility to social stress in female mice linked with neuroadaptations within VTA dopamine neurons., Neuropsychopharmacology 2022 Aug; 47(9): 1587-1596.
2022
Zayed A, Baranowski C, Compagnion AC, Vernochet C, Karaki S, Cuttoli RD, Saint-Jour E, Bhattacharya S, Marti F, Vanhoutte P, Yaniv M, Faure P, Barik J, Amar L, Tronche F, Parnaudeau S, SWI/SNF chromatin remodeler complex within the reward pathway is required for behavioral adaptations to stress., Nat Commun 2022 Apr; 13(1): 1807.
2021
Marie-Charlotte Allichon, Vanesa Ortiz, Paula Pousinha, Andry Andrianarivelo, Anna Petitbon, Nicolas Heck, Pierre Trifilieff , Jacques Barik, Peter Vanhoutte, Cell-Type-Specific Adaptions in Striatal Medium-Sized Spiny Neurons and Their Roles in Behavioral Responses to Drugs of Abuse, Front Synaptic Neurosci . 2021 Dec 14:13:799274. .
2021
Brigas HC, Ribeiro M, Coelho JE, Gomes R, Gomez-Murcia V, Carvalho K, Faivre E, Costa-Pereira S, Darrigues J, de Almeida AA, Buée L, Dunot J, Marie H, Pousinha PA, Blum D, Silva-Santos B, Lopes LV, Ribot JC, IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer’s disease., Cell Rep 2021 Aug; 36(9): 109574.
2021
Mensch M, Dunot J, Yishan SM, Harris SS, Blistein A, Avdiu A, Pousinha PA, Giudici C, Busche MA, Jedlicka P, Willem M, Marie H, Aη-α and Aη-β peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo., Alzheimers Res Ther 2021 Jul; 13(1): 125.
2021
Vitale P, Salgueiro-Pereira AR, Lupascu CA, Willem M, Migliore R, Migliore M, Marie H, Analysis of Age-Dependent Alterations in Excitability Properties of CA1 Pyramidal Neurons in an APPPS1 Model of Alzheimer’s Disease., Front Aging Neurosci 2021 ; 13(): 668948.
2021
Bermudez-Martin P, Becker JAJ, Caramello N, Fernandez SP, Costa-Campos R, Canaguier J, Barbosa S, Martinez-Gili L, Myridakis A, Dumas ME, Bruneau A, Cherbuy C, Langella P, Callebert J, Launay JM, Chabry J, Barik J, Le Merrer J, Glaichenhaus N, Davidovic L, The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota., Microbiome 2021 Jul; 9(1): 157.
2021
Contesse T, Broussot L, Fofo H, Vanhoutte P, Fernandez SP, Barik J, Dopamine and glutamate receptors control social stress-induced striatal ERK1/2 activation., Neuropharmacology 2021 Jun; 190(): 108534.
2020
Kartalou GI, Salgueiro-Pereira AR, Endres T, Lesnikova A, Casarotto P, Pousinha P, Delanoe K, Edelmann E, Castrén E, Gottmann K, Marie H, Lessmann V, Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model., Int J Mol Sci 2020 Nov; 21(23): .
2020
Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, Baqi Y, Müller CE, Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV, Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors., Mol Psychiatry 2020 Aug; 25(8): 1876-1900.
2019
Pousinha PA, Mouska X, Bianchi D, Temido-Ferreira M, Rajão-Saraiva J, Gomes R, Fernandez SP, Salgueiro-Pereira AR, Gandin C, Raymond EF, Barik J, Goutagny R, Bethus I, Lopes LV, Migliore M, Marie H, The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding., Cell Rep 2019 Oct; 29(2): 317-331.e5.
2019
Costa-Pereira JT, Ribeiro J, Martins I, Tavares I, Role of Spinal Cord α2-Adrenoreceptors in Noradrenergic Inhibition of Nociceptive Transmission During Chemotherapy-Induced Peripheral Neuropathy., Front Neurosci 2019 ; 13(): 1413.
2018
Fernandez SP, Broussot L, Marti F, Contesse T, Mouska X, Soiza-Reilly M, Marie H, Faure P, Barik J, Mesopontine cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors., Nat Commun 2018 Oct; 9(1): 4449.
2018
Kootar S, Frandemiche ML, Dhib G, Mouska X, Lorivel T, Poupon-Silvestre G, Hunt H, Tronche F, Bethus I, Barik J, Marie H, Identification of an acute functional cross-talk between amyloid-β and glucocorticoid receptors at hippocampal excitatory synapses., Neurobiol Dis 2018 Oct; 118(): 117-128.
2018
Morel C, Fernandez SP, Pantouli F, Meye FJ, Marti F, Tolu S, Parnaudeau S, Marie H, Tronche F, Maskos U, Moretti M, Gotti C, Han MH, Bailey A, Mameli M, Barik J, Faure P, Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells’ activity., Mol Psychiatry 2018 Jul; 23(7): 1597-1605.
2018
Belmer A, Quentin E, Diaz SL, Guiard BP, Fernandez SP, Doly S, Banas SM, Pitychoutis PM, Moutkine I, Muzerelle A, Tchenio A, Roumier A, Mameli M, Maroteaux L, Positive regulation of raphe serotonin neurons by serotonin 2B receptors., Neuropsychopharmacology 2018 Jun; 43(7): 1623-1632.
2017
Fernandez SP, Muzerelle A, Scotto-Lomassese S, Barik J, Gruart A, Delgado-García JM, Gaspar P, Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity., Neuropsychopharmacology 2017 Jan; 42(2): 512-523.
2016
Fernandez SP, Cauli B, Cabezas C, Muzerelle A, Poncer JC, Gaspar P, Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain., Brain Struct Funct 2016 Nov; 221(8): 4007-4025.
2015
Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C, η-Secretase processing of APP inhibits neuronal activity in the hippocampus., Nature 2015 Oct; 526(7573): 443-7.
2015
Lanté F, Chafai M, Raymond EF, Pereira AR, Mouska X, Kootar S, Barik J, Bethus I, Marie H, Subchronic glucocorticoid receptor inhibition rescues early episodic memory and synaptic plasticity deficits in a mouse model of Alzheimer’s disease., Neuropsychopharmacology 2015 Jun; 40(7): 1772-81.
2014
Middei S, Ammassari-Teule M, Marie H, Synaptic plasticity under learning challenge., Neurobiol Learn Mem 2014 Nov; 115(): 108-15.
2014
Marcantoni A, Raymond EF, Carbone E, Marie H, Firing properties of entorhinal cortex neurons and early alterations in an Alzheimer’s disease transgenic model., Pflugers Arch 2014 Jul; 466(7): 1437-50.
2014
Sébastien Parnaudeau, Marie-Louise Dongelmans, Marc Turiault, Frédéric Ambroggi, Anne-Sophie Delbes, Céline Cansell, Serge Luquet, Pier-Vincenzo Piazza, François Tronche, Jacques Barik, Glucocorticoid receptor gene inactivation in dopamine-innervated areas selectively decreases behavioral responses to amphetamine, Front Behav Neurosci . 2014 Feb 12:8:35..
2013
Jacques Barik, Fabio Marti, Carole Morel, Sebastian P Fernandez, Christophe Lanteri, Gérard Godeheu, Jean-Pol Tassin, Cédric Mombereau, Philippe Faure, François Tronche, Chronic stress triggers social aversion via glucocorticoid receptor in dopaminoceptive neurons, Science . 2013 Jan 18;339(6117):332-5..