Les protéines Arf : transport membranaire, morphologie épithéliale et cancer – IPMC

Recherche

Intranet

Thème

Transport de lipides : mécanismes moléculaires et rôle dans la pathogenèse

Métabolisme et fonctions des lipides membranaires

Membres

Frédéric LUTON

Chercheur INSERM

Sarah COGOLUEGNES

Laetitia DELLA-CROCE

Enseignant-chercheur UniCA

Isabelle MUS-VETEAU

Présentation

Schématiquement, la morphologie cellulaire repose sur la membrane plasmique qui forme une enveloppe lipidique à l’intérieur de laquelle le cytosquelette d’actine, un échafaudage moléculaire modulable, structure la forme des cellules. La morphologie cellulaire ainsi que l’arrangement intracellulaire des organelles et des cytosquelettes (actine, microtubules, filaments intermédiaires) sont adaptés au service des multiples fonctions cellulaires telles que le transport vésiculaire, la sécrétion, la phagocytose, l’adhésion, la migration, etc. Les cellules assemblent également des sous-structures membranaires de surface (cil, filopodes, lamellipodes, spicules, CDR, etc) qui leur confèrent des propriétés particulières. Ainsi, l’organisation coordonnée et dynamique de la membrane plasmique et du cytosquelette d’actine est un élément clé du bon fonctionnement des cellules de l’organisme.
La petite protéine G Arf6, ses régulateurs et ses effecteurs sont impliqués dans l’architecture cellulaire et dans de nombreux processus nécessitant un remodelage de la morphologie cellulaire. Ces dernières années nous avons focalisé nos recherches sur leur rôle dans l’organisation du cytosquelette d’actine et le trafic membranaire, la polarité épithéliale et le cancer, et enfin la recherche de drogues anti-cancéreuses.

Projets

Drogues anti-cancéreuses

Dans le laboratoire, nous développons deux types de drogues anti-cancéreuses : des inhibiteurs de l’invasion tumorale dépendante d’Arf6 et des […]

Polarité épithéliale et cancer

Les tissus épithéliaux tapissent la face interne des organes. Ils sont formés de cellules polarisées présentant un domaine apical ouvert […]

Transport membranaire et cytosquelette d’actine

► Les petites protéines G Arf sont impliquées dans le transport intracellulaire mais leur fonction exacte demeure encore mal définie. […]

Publications

Fukaya M, Ibuchi K, Sugawara T, Itakura M, Ito A, Shiroshima T, Hara Y, Okamoto H, Luton F, Sakagami H, EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells., Traffic 2024 May; 25(5): e12936.

Kovács D, Gay AS, Debayle D, Abélanet S, Patel A, Mesmin B, Luton F, Antonny B, Lipid exchange at ER-trans-Golgi contact sites governs polarized cargo sorting., J Cell Biol 2024 Jan; 223(1): .

Kovachka S, Malloci G, Simsir M, Ruggerone P, Azoulay S, Mus-Veteau I, Inhibition of the drug efflux activity of Ptch1 as a promising strategy to overcome chemotherapy resistance in cancer cells., Eur J Med Chem 2022 Jun; 236(): 114306.

Feliz Morel ÁJ, Hasanovic A, Morin A, Prunier C, Magnone V, Lebrigand K, Aouad A, Cogoluegnes S, Favier J, Pasquier C, Mus-Veteau I, Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched., Pharmaceutics 2022 May; 14(5): .

Braud V, Cazals F, Duca M, Mus-Veteau I, Pasquier C, Soriani O, [Highlights of the UCAncer 2021 symposium on multidisciplinary approaches to cancer research]., Bull Cancer 2022 Apr; 109(4): 505-509.

Kovachka S, Soule P, Mus-Veteau I, Microscale Thermophoresis to Evaluate the Functionality of Heterologously Overexpressed Membrane Proteins in Membrane Preparations., Methods Mol Biol 2022 ; 2507(): 445-461.

Kovachka S, Malloci G, Vargiu AV, Azoulay S, Mus-Veteau I, Ruggerone P, Molecular insights into the Patched1 drug efflux inhibitory activity of panicein A hydroquinone: a computational study., Phys Chem Chem Phys 2021 Apr; 23(13): 8013-8022.

Durand N, Simsir M, Signetti L, Labbal F, Ballotti R, Mus-Veteau I, Methiothepin Increases Chemotherapy Efficacy against Resistant Melanoma Cells., Molecules 2021 Mar; 26(7): .

Marcetteau J, Matusek T, Luton F, Thérond PP, Arf6 is necessary for senseless expression in response to wingless signalling during Drosophila wing development., Biol Open 2021 Dec; 10(12): .

Fayad R, Rojas MV, Partisani M, Finetti P, Dib S, Abelanet S, Virolle V, Farina A, Cabaud O, Lopez M, Birnbaum D, Bertucci F, Franco M, Luton F, EFA6B regulates a stop signal for collective invasion in breast cancer., Nat Commun 2021 Apr; 12(1): 2198.

Simsir M, Broutin I, Mus-Veteau I, Cazals F, Studying dynamics without explicit dynamics: A structure-based study of the export mechanism by AcrB., Proteins 2021 Mar; 89(3): 259-275.

Macia E, Vazquez-Rojas M, Robiolo A, Fayad R, Abélanet S, Mus-Veteau I, Fontaine-Vive F, Mehiri M, Luton F, Franco M, Chlortetracycline, a Novel Arf Inhibitor That Decreases the Arf6-Dependent Invasive Properties of Breast Cancer Cells., Molecules 2021 Feb; 26(4): .

Partisani M, Baron CL, Ghossoub R, Fayad R, Pagnotta S, Abélanet S, Macia E, Brau F, Lacas-Gervais S, Benmerah A, Luton F, Franco M, EFA6A, an exchange factor for Arf6, regulates early steps in ciliogenesis., J Cell Sci 2021 Jan; 134(2): .

Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Al..., Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1., Autophagy 2021 Jan; 17(1): 1-382.

Hasanovic A, Simsir M, Choveau FS, Lalli E, Mus-Veteau I, Astemizole Sensitizes Adrenocortical Carcinoma Cells to Doxorubicin by Inhibiting Patched Drug Efflux Activity., Biomedicines 2020 Jul; 8(8): .

Signetti L, Elizarov N, Simsir M, Paquet A, Douguet D, Labbal F, Debayle D, Di Giorgio A, Biou V, Girard C, Duca M, Bretillon L, Bertolotto C, Verrier B, Azoulay S, Mus-Veteau I, Inhibition of Patched Drug Efflux Increases Vemurafenib Effectiveness against Resistant BrafV600E Melanoma., Cancers (Basel) 2020 Jun; 12(6): .

Macia E, Partisani M, Wang H, Lacas-Gervais S, Le Clainche C, Luton F, Franco M, The C-terminal domain of EFA6A interacts directly with F-actin and assembles F-actin bundles., Sci Rep 2019 Dec; 9(1): 19209.

Zobel M, Disanza A, Senic-Matuglia F, Franco M, Colaluca IN, Confalonieri S, Bisi S, Barbieri E, Caldieri G, Sigismund S, Pece S, Chavrier P, Di Fiore PP, Scita G, A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility., J Cell Biol 2018 Sep; 217(9): 3161-3182.

Hasanovic A, Mus-Veteau I, Targeting the Multidrug Transporter Ptch1 Potentiates Chemotherapy Efficiency., Cells 2018 Aug; 7(8): .

Hasanovic A, Ruggiero C, Jung S, Rapa I, Signetti L, Ben Hadj M, Terzolo M, Beuschlein F, Volante M, Hantel C, Lalli E, Mus-Veteau I, Targeting the multidrug transporter Patched potentiates chemotherapy efficiency on adrenocortical carcinoma in vitro and in vivo., Int J Cancer 2018 Jul; 143(1): 199-211.

Milanini J, Fayad R, Partisani M, Lecine P, Borg JP, Franco M, Luton F, EFA6 proteins regulate lumen formation through α-actinin 1., J Cell Sci 2018 Feb; 131(3): .

Fiorini L, Mus-Veteau I, Method to Screen Multidrug Transport Inhibitors Using Yeast Overexpressing a Human MDR Transporter., Methods Mol Biol 2016 ; 1432(): 303-18.

Fiorini L, Tribalat MA, Sauvard L, Cazareth J, Lalli E, Broutin I, Thomas OP, Mus-Veteau I, Natural paniceins from mediterranean sponge inhibit the multidrug resistance activity of Patched and increase chemotherapy efficiency on melanoma cells., Oncotarget 2015 Sep; 6(26): 22282-97.

Figeac F, Dagouassat M, Mahrouf-Yorgov M, Le Gouvello S, Trébeau C, Sayed A, Stern JB, Validire P, Dubois-Randé JL, Boczkowski J, Mus-Veteau I, Rodriguez AM, Lung fibroblasts share mesenchymal stem cell features which are altered in chronic obstructive pulmonary disease via the overactivation of the Hedgehog signaling pathway., PLoS One 2015 ; 10(3): e0121579.

Treuner-Lange A, Macia E, Guzzo M, Hot E, Faure LM, Jakobczak B, Espinosa L, Alcor D, Ducret A, Keilberg D, Castaing JP, Lacas Gervais S, Franco M, Søgaard-Andersen L, Mignot T, The small G-protein MglA connects to the MreB actin cytoskeleton at bacterial focal adhesions., J Cell Biol 2015 Jul; 210(2): 243-56.

Mus-Veteau I, Lambeau G, Special issue: from membranes to pathologies., Biochimie 2014 Dec; 107 Pt A(): 1-2.

Padovani D, Folly-Klan M, Labarde A, Boulakirba S, Campanacci V, Franco M, Zeghouf M, Cherfils J, EFA6 controls Arf1 and Arf6 activation through a negative feedback loop., Proc Natl Acad Sci U S A 2014 Aug; 111(34): 12378-83.

Zangari J, Partisani M, Bertucci F, Milanini J, Bidaut G, Berruyer-Pouyet C, Finetti P, Long E, Brau F, Cabaud O, Chetaille B, Birnbaum D, Lopez M, Hofman P, Franco M, Luton F, EFA6B antagonizes breast cancer., Cancer Res 2014 Oct; 74(19): 5493-506.

Boulakirba S, Macia E, Partisani M, Lacas-Gervais S, Brau F, Luton F, Franco M, Arf6 exchange factor EFA6 and endophilin directly interact at the plasma membrane to control clathrin-mediated endocytosis., Proc Natl Acad Sci U S A 2014 Jul; 111(26): 9473-8.

Montagnac G, Meas-Yedid V, Irondelle M, Castro-Castro A, Franco M, Shida T, Nachury MV, Benmerah A, Olivo-Marin JC, Chavrier P, αTAT1 catalyses microtubule acetylation at clathrin-coated pits., Nature 2013 Oct; 502(7472): 567-70.

Lalli E, Doghman M, Latre de Late P, El Wakil A, Mus-Veteau I, Beyond steroidogenesis: novel target genes for SF-1 discovered by genomics., Mol Cell Endocrinol 2013 May; 371(1-2): 154-9.

Bidet M, Tomico A, Martin P, Guizouarn H, Mollat P, Mus-Veteau I, The Hedgehog receptor patched functions in multidrug transport and chemotherapy resistance., Mol Cancer Res 2012 Nov; 10(11): 1496-508.

Macia E, Partisani M, Paleotti O, Luton F, Franco M, Arf6 negatively controls the rapid recycling of the β2 adrenergic receptor., J Cell Sci 2012 Sep; 125(Pt 17): 4026-35.

Bidet M, Joubert O, Lacombe B, Ciantar M, Nehmé R, Mollat P, Brétillon L, Faure H, Bittman R, Ruat M, Mus-Veteau I, The hedgehog receptor patched is involved in cholesterol transport., PLoS One 2011 ; 6(9): e23834.

Hovers J, Potschies M, Polidori A, Pucci B, Raynal S, Bonneté F, Serrano-Vega MJ, Tate CG, Picot D, Pierre Y, Popot JL, Nehmé R, Bidet M, Mus-Veteau I, Busskamp H, Jung KH, Marx A, Timmins PA, Welte W, A class of mild surfactants that keep integral membrane proteins water-soluble for functional studies and crystallization., Mol Membr Biol 2011 Apr; 28(3): 171-81.

Su T, Bryant DM, Luton F, Vergés M, Ulrich SM, Hansen KC, Datta A, Eastburn DJ, Burlingame AL, Shokat KM, Mostov KE, A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor., Nat Cell Biol 2010 Dec; 12(12): 1143-53.

Nehmé R, Mus-Veteau I, Proteins of the Hedgehog signaling pathway as therapeutic targets against cancer., Expert Rev Proteomics 2010 Aug; 7(4): 601-12.

Zhang Y, Franco M, Ducret A, Mignot T, A bacterial Ras-like small GTP-binding protein and its cognate GAP establish a dynamic spatial polarity axis to control directed motility., PLoS Biol 2010 Jul; 8(7): e1000430.

Nehmé R, Joubert O, Bidet M, Lacombe B, Polidori A, Pucci B, Mus-Veteau I, Stability study of the human G-protein coupled receptor, Smoothened., Biochim Biophys Acta 2010 Jun; 1798(6): 1100-10.

Joubert O, Nehmé R, Bidet M, Mus-Veteau I, Heterologous expression of human membrane receptors in the yeast Saccharomyces cerevisiae., Methods Mol Biol 2010 ; 601(): 87-103.

Mus-Veteau I, Heterologous expression of membrane proteins for structural analysis., Methods Mol Biol 2010 ; 601(): 1-16.

Théard D, Labarrade F, Partisani M, Milanini J, Sakagami H, Fon EA, Wood SA, Franco M, Luton F, USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly., EMBO J 2010 May; 29(9): 1499-509.

Isabet T, Montagnac G, Regazzoni K, Raynal B, El Khadali F, England P, Franco M, Chavrier P, Houdusse A, Ménétrey J, The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4., EMBO J 2009 Sep; 28(18): 2835-45.

Joubert O, Nehmé R, Fleury D, De Rivoyre M, Bidet M, Polidori A, Ruat M, Pucci B, Mollat P, Mus-Veteau I, Functional studies of membrane-bound and purified human Hedgehog receptor Patched expressed in yeast., Biochim Biophys Acta 2009 Sep; 1788(9): 1813-21.

Luton F, Hexham MJ, Zhang M, Mostov KE, Identification of a cytoplasmic signal for apical transcytosis., Traffic 2009 Aug; 10(8): 1128-42.

Klein S, Partisani M, Franco M, Luton F, EFA6 facilitates the assembly of the tight junction by coordinating an Arf6-dependent and -independent pathway., J Biol Chem 2008 Oct; 283(44): 30129-38.

Macia E, Partisani M, Favard C, Mortier E, Zimmermann P, Carlier MF, Gounon P, Luton F, Franco M, The pleckstrin homology domain of the Arf6-specific exchange factor EFA6 localizes to the plasma membrane by interacting with phosphatidylinositol 4,5-bisphosphate and F-actin., J Biol Chem 2008 Jul; 283(28): 19836-44.

Yano H, Kobayashi I, Onodera Y, Luton F, Franco M, Mazaki Y, Hashimoto S, Iwai K, Ronai Z, Sabe H, Fbx8 makes Arf6 refractory to function via ubiquitination., Mol Biol Cell 2008 Mar; 19(3): 822-32.

Heuvingh J, Franco M, Chavrier P, Sykes C, ARF1-mediated actin polymerization produces movement of artificial vesicles., Proc Natl Acad Sci U S A 2007 Oct; 104(43): 16928-33.

Ménétrey J, Perderiset M, Cicolari J, Dubois T, Elkhatib N, El Khadali F, Franco M, Chavrier P, Houdusse A, Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes., EMBO J 2007 Apr; 26(7): 1953-62.

Li M, Ng SS, Wang J, Lai L, Leung SY, Franco M, Peng Y, He ML, Kung HF, Lin MC, EFA6A enhances glioma cell invasion through ADP ribosylation factor 6/extracellular signal-regulated kinase signaling., Cancer Res 2006 Feb; 66(3): 1583-90.

De Rivoyre M, Ruel L, Varjosalo M, Loubat A, Bidet M, Thérond P, Mus-Veteau I, Human receptors patched and smoothened partially transduce hedgehog signal when expressed in Drosophila cells., J Biol Chem 2006 Sep; 281(39): 28584-95.

Klein S, Franco M, Chardin P, Luton F, Role of the Arf6 GDP/GTP cycle and Arf6 GTPase-activating proteins in actin remodeling and intracellular transport., J Biol Chem 2006 May; 281(18): 12352-61.

Pauchet Y, Luton F, Castella C, Charles JF, Romey G, Pauron D, Effects of a mosquitocidal toxin on a mammalian epithelial cell line expressing its target receptor., Cell Microbiol 2005 Sep; 7(9): 1335-44.

Fournier HN, Dupé-Manet S, Bouvard D, Luton F, Degani S, Block MR, Retta SF, Albiges-Rizo C, Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation., Mol Biol Cell 2005 Apr; 16(4): 1859-71.

Dubois T, Paléotti O, Mironov AA, Fraisier V, Stradal TE, De Matteis MA, Franco M, Chavrier P, Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics., Nat Cell Biol 2005 Apr; 7(4): 353-64.

Luton F, The role of EFA6, exchange factor for Arf6, for tight junction assembly, functions, and interaction with the actin cytoskeleton., Methods Enzymol 2005 ; 404(): 332-45.

Franco M, Albano L, Kacso I, Gaïd H, Jaeger P, An uncommon cause of foot pain: the cuboid insufficiency stress fracture., Joint Bone Spine 2005 Jan; 72(1): 76-8.

Franco M, Albano L, Gaid H, Gigante M, Barrillon D, Jaeger P, Resolution of tumoral calcinosis in a hemodialysis patient using low calcium dialysate., Joint Bone Spine 2005 Jan; 72(1): 95-7.

Klein S, Franco M, Chardin P, Luton F, AlFx affects the formation of focal complexes by stabilizing the Arf-GAP ASAP1 in a complex with Arf1., FEBS Lett 2005 Oct; 579(25): 5741-5.

Pisani DF, Rivoyre MD, Ruel L, Bonino F, Bidet M, Dechesne CA, Mus-Veteau I, Mouse myodulin, a new potential angiogenic factor, functionally expressed in yeast., Biochem Biophys Res Commun 2005 Jun; 331(2): 552-6.

Paleotti O, Macia E, Luton F, Klein S, Partisani M, Chardin P, Kirchhausen T, Franco M, The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes., J Biol Chem 2005 Jun; 280(22): 21661-6.

De Rivoyre M, Bonino F, Ruel L, Bidet M, Thérond P, Mus-Veteau I, Human receptor Smoothened, a mediator of Hedgehog signalling, expressed in its native conformation in yeast., FEBS Lett 2005 Feb; 579(6): 1529-33.

Mesmin B, Robbe K, Geny B, Luton F, Brandolin G, Popoff MR, Antonny B, A phosphatidylserine-binding site in the cytosolic fragment of Clostridium sordellii lethal toxin facilitates glucosylation of membrane-bound Rac and is required for cytotoxicity., J Biol Chem 2004 Nov; 279(48): 49876-82.

Franco M, Albano L, Blaimont A, Barrillon D, Bracco J, Spontaneous fracture of the lower angle of scapula. Possible role of cough., Joint Bone Spine 2004 Nov; 71(6): 580-2.

Vergés M, Luton F, Gruber C, Tiemann F, Reinders LG, Huang L, Burlingame AL, Haft CR, Mostov KE, The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor., Nat Cell Biol 2004 Aug; 6(8): 763-9.

Franco M, Blaimont A, Albano L, Bendini C, Cassuto E, Jaeger P, Tacrolimus pain syndrome in renal transplant patients: report of two cases., Joint Bone Spine 2004 Mar; 71(2): 157-9.

Franco M, Puch JM, Carayon MJ, Bortolotti D, Albano L, Lallemand A, Lipoma arborescens of the knee: report of a case managed by arthroscopic synovectomy., Joint Bone Spine 2004 Jan; 71(1): 73-5.

Decressac S, Franco M, Bendahhou S, Warth R, Knauer S, Barhanin J, Lazdunski M, Lesage F, ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6., EMBO Rep 2004 Dec; 5(12): 1171-5.

Macia E, Luton F, Partisani M, Cherfils J, Chardin P, Franco M, The GDP-bound form of Arf6 is located at the plasma membrane., J Cell Sci 2004 May; 117(Pt 11): 2389-98.

Luton F, Klein S, Chauvin JP, Le Bivic A, Bourgoin S, Franco M, Chardin P, EFA6, exchange factor for ARF6, regulates the actin cytoskeleton and associated tight junction in response to E-cadherin engagement., Mol Biol Cell 2004 Mar; 15(3): 1134-45.

Franco M, Bendini JC, Blaimont A, Albano L, Cassuto E, Jaeger P, Longitudinal bone insufficiency fracture of the tibia in a renal transplant recipient., Joint Bone Spine 2003 Aug; 70(4): 296-9.

Franco M, Bendini JC, Blaimont A, Albano L, Dray G, Barrillon D, Jaeger P, Distal phalangeal brachydactyly and osteosclerosis in a case of secondary hyperparathyroidism., Joint Bone Spine 2003 Mar; 70(2): 143-5.

Derrien V, Couillault C, Franco M, Martineau S, Montcourrier P, Houlgatte R, Chavrier P, A conserved C-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions., J Cell Sci 2002 Jul; 115(Pt 14): 2867-79.

Mus-Veteau I, Heterologous expression and purification systems for structural proteomics of mammalian membrane proteins., Comp Funct Genomics 2002 ; 3(6): 511-7.

Dave N, Troullier A, Mus-Veteau I, Duñach M, Leblanc G, Padrós E, Secondary structure components and properties of the melibiose permease from Escherichia coli: a fourier transform infrared spectroscopy analysis., Biophys J 2000 Aug; 79(2): 747-55.

Cordat E, Leblanc G, Mus-Veteau I, Evidence for a role of helix IV in connecting cation- and sugar-binding sites of Escherichia coli melibiose permease., Biochemistry 2000 Apr; 39(15): 4493-9.

Luton F, Vergés M, Vaerman JP, Sudol M, Mostov KE, The SRC family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo., Mol Cell 1999 Oct; 4(4): 627-32.

Luton F, Mostov KE, Transduction of basolateral-to-apical signals across epithelial cells: ligand-stimulated transcytosis of the polymeric immunoglobulin receptor requires two signals., Mol Biol Cell 1999 May; 10(5): 1409-27.

Malmborg AC, Shultz DB, Luton F, Mostov KE, Richly E, Leung PS, Benson GD, Ansari AA, Coppel RL, Gershwin ME, Van de Water J, Penetration and co-localization in MDCK cell mitochondria of IgA derived from patients with primary biliary cirrhosis., J Autoimmun 1998 Oct; 11(5): 573-80.

Luton F, Cardone MH, Zhang M, Mostov KE, Role of tyrosine phosphorylation in ligand-induced regulation of transcytosis of the polymeric Ig receptor., Mol Biol Cell 1998 Jul; 9(7): 1787-802.

Cordat E, Mus-Veteau I, Leblanc G, Structural studies of the melibiose permease of Escherichia coli by fluorescence resonance energy transfer. II. Identification of the tryptophan residues acting as energy donors., J Biol Chem 1998 Dec; 273(50): 33198-202.

Maehrel C, Cordat E, Mus-Veteau I, Leblanc G, Structural studies of the melibiose permease of Escherichia coli by fluorescence resonance energy transfer. I. Evidence for ion-induced conformational change., J Biol Chem 1998 Dec; 273(50): 33192-7.

Luton F, Buferne M, Legendre V, Chauvet E, Boyer C, Schmitt-Verhulst AM, Role of CD3gamma and CD3delta cytoplasmic domains in cytolytic T lymphocyte functions and TCR/CD3 down-modulation., J Immunol 1997 May; 158(9): 4162-70.

Luton F, Legendre V, Gorvel JP, Schmitt-Verhulst AM, Boyer C, Tyrosine and serine protein kinase activities associated with ligand-induced internalized TCR/CD3 complexes., J Immunol 1997 Apr; 158(7): 3140-7.

Mus-Veteau I, Leblanc G, Melibiose permease of Escherichia coli: structural organization of cosubstrate binding sites as deduced from tryptophan fluorescence analyses., Biochemistry 1996 Sep; 35(37): 12053-60.

Poolman B, Knol J, van der Does C, Henderson PJ, Liang WJ, Leblanc G, Pourcher T, Mus-Veteau I, Cation and sugar selectivity determinants in a novel family of transport proteins., Mol Microbiol 1996 Mar; 19(5): 911-22.

Mostov KE, Altschuler Y, Chapin SJ, Enrich C, Low SH, Luton F, Richman-Eisenstat J, Singer KL, Tang K, Weimbs T, Regulation of protein traffic in polarized epithelial cells: the polymeric immunoglobulin receptor model., Cold Spring Harb Symp Quant Biol 1995 ; 60(): 775-81.

Mus-Veteau I, Pourcher T, Leblanc G, Melibiose permease of Escherichia coli: substrate-induced conformational changes monitored by tryptophan fluorescence spectroscopy., Biochemistry 1995 May; 34(20): 6775-83.

Luton F, Buferne M, Davoust J, Schmitt-Verhulst AM, Boyer C, Evidence for protein tyrosine kinase involvement in ligand-induced TCR/CD3 internalization and surface redistribution., J Immunol 1994 Jul; 153(1): 63-72.

Luton F, Buferne M, Schmitt-Verhulst AM, Boyer C, Developmental control of T-cell receptor internalization., Thymus 1994 ; 23(1): 15-25.

Mus-Veteau I, Guerlesquin F, Involvement of histidine residues in the catalytic mechanism of hydrogenases., Biochem Biophys Res Commun 1994 May; 201(1): 128-34.

Buferne M, Luton F, Letourneur F, Hoeveler A, Couez D, Barad M, Malissen B, Schmitt-Verhulst AM, Boyer C, Role of CD3 delta in surface expression of the TCR/CD3 complex and in activation for killing analyzed with a CD3 delta-negative cytotoxic T lymphocyte variant., J Immunol 1992 Feb; 148(3): 657-64.

Wegener AM, Letourneur F, Hoeveler A, Brocker T, Luton F, Malissen B, The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules., Cell 1992 Jan; 68(1): 83-95.

Mus-Veteau I, Dolla A, Guerlesquin F, Payan F, Czjzek M, Haser R, Bianco P, Haladjian J, Rapp-Giles BJ, Wall JD, Site-directed mutagenesis of tetraheme cytochrome c3. Modification of oxidoreduction potentials after heme axial ligand replacement., J Biol Chem 1992 Aug; 267(24): 16851-8.

Boyer C, Auphan N, Luton F, Malburet JM, Barad M, Bizozzero JP, Reggio H, Schmitt-Verhulst AM, T cell receptor/CD3 complex internalization following activation of a cytolytic T cell clone: evidence for a protein kinase C-independent staurosporine-sensitive step., Eur J Immunol 1991 Jul; 21(7): 1623-34.