Michel FRANCO – IPMC

Recherche

Intranet

Thème

Laetitia DELLA-CROCE

Présentation

/https://orcid.org/0000-0003-1853-8661

Projets

Drogues anti-cancéreuses

Dans le laboratoire, nous développons deux types de drogues anti-cancéreuses : des inhibiteurs de l’invasion tumorale dépendante d’Arf6 et des […]

Polarité épithéliale et cancer

Les tissus épithéliaux tapissent la face interne des organes. Ils sont formés de cellules polarisées présentant un domaine apical ouvert […]

Transport membranaire et cytosquelette d’actine

► Les petites protéines G Arf sont impliquées dans le transport intracellulaire mais leur fonction exacte demeure encore mal définie. […]

Publications

Zobel M, Disanza A, Senic-Matuglia F, Franco M, Colaluca IN, Confalonieri S, Bisi S, Barbieri E, Caldieri G, Sigismund S, Pece S, Chavrier P, Di Fiore PP, Scita G, A NUMB-EFA6B-ARF6 recycling route controls apically restricted cell protrusions and mesenchymal motility., J Cell Biol 2018 Sep; 217(9): 3161-3182.

Padovani D, Folly-Klan M, Labarde A, Boulakirba S, Campanacci V, Franco M, Zeghouf M, Cherfils J, EFA6 controls Arf1 and Arf6 activation through a negative feedback loop., Proc Natl Acad Sci U S A 2014 Aug; 111(34): 12378-83.

Montagnac G, Meas-Yedid V, Irondelle M, Castro-Castro A, Franco M, Shida T, Nachury MV, Benmerah A, Olivo-Marin JC, Chavrier P, αTAT1 catalyses microtubule acetylation at clathrin-coated pits., Nature 2013 Oct; 502(7472): 567-70.

Macia E, Partisani M, Paleotti O, Luton F, Franco M, Arf6 negatively controls the rapid recycling of the β2 adrenergic receptor., J Cell Sci 2012 Sep; 125(Pt 17): 4026-35.

Zhang Y, Franco M, Ducret A, Mignot T, A bacterial Ras-like small GTP-binding protein and its cognate GAP establish a dynamic spatial polarity axis to control directed motility., PLoS Biol 2010 Jul; 8(7): e1000430.

Théard D, Labarrade F, Partisani M, Milanini J, Sakagami H, Fon EA, Wood SA, Franco M, Luton F, USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly., EMBO J 2010 May; 29(9): 1499-509.

Isabet T, Montagnac G, Regazzoni K, Raynal B, El Khadali F, England P, Franco M, Chavrier P, Houdusse A, Ménétrey J, The structural basis of Arf effector specificity: the crystal structure of ARF6 in a complex with JIP4., EMBO J 2009 Sep; 28(18): 2835-45.

Klein S, Partisani M, Franco M, Luton F, EFA6 facilitates the assembly of the tight junction by coordinating an Arf6-dependent and -independent pathway., J Biol Chem 2008 Oct; 283(44): 30129-38.

Macia E, Partisani M, Favard C, Mortier E, Zimmermann P, Carlier MF, Gounon P, Luton F, Franco M, The pleckstrin homology domain of the Arf6-specific exchange factor EFA6 localizes to the plasma membrane by interacting with phosphatidylinositol 4,5-bisphosphate and F-actin., J Biol Chem 2008 Jul; 283(28): 19836-44.

Yano H, Kobayashi I, Onodera Y, Luton F, Franco M, Mazaki Y, Hashimoto S, Iwai K, Ronai Z, Sabe H, Fbx8 makes Arf6 refractory to function via ubiquitination., Mol Biol Cell 2008 Mar; 19(3): 822-32.

Heuvingh J, Franco M, Chavrier P, Sykes C, ARF1-mediated actin polymerization produces movement of artificial vesicles., Proc Natl Acad Sci U S A 2007 Oct; 104(43): 16928-33.

Ménétrey J, Perderiset M, Cicolari J, Dubois T, Elkhatib N, El Khadali F, Franco M, Chavrier P, Houdusse A, Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes., EMBO J 2007 Apr; 26(7): 1953-62.

Li M, Ng SS, Wang J, Lai L, Leung SY, Franco M, Peng Y, He ML, Kung HF, Lin MC, EFA6A enhances glioma cell invasion through ADP ribosylation factor 6/extracellular signal-regulated kinase signaling., Cancer Res 2006 Feb; 66(3): 1583-90.

Klein S, Franco M, Chardin P, Luton F, Role of the Arf6 GDP/GTP cycle and Arf6 GTPase-activating proteins in actin remodeling and intracellular transport., J Biol Chem 2006 May; 281(18): 12352-61.

Dubois T, Paléotti O, Mironov AA, Fraisier V, Stradal TE, De Matteis MA, Franco M, Chavrier P, Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics., Nat Cell Biol 2005 Apr; 7(4): 353-64.

Franco M, Albano L, Kacso I, Gaïd H, Jaeger P, An uncommon cause of foot pain: the cuboid insufficiency stress fracture., Joint Bone Spine 2005 Jan; 72(1): 76-8.

Franco M, Albano L, Gaid H, Gigante M, Barrillon D, Jaeger P, Resolution of tumoral calcinosis in a hemodialysis patient using low calcium dialysate., Joint Bone Spine 2005 Jan; 72(1): 95-7.

Klein S, Franco M, Chardin P, Luton F, AlFx affects the formation of focal complexes by stabilizing the Arf-GAP ASAP1 in a complex with Arf1., FEBS Lett 2005 Oct; 579(25): 5741-5.

Paleotti O, Macia E, Luton F, Klein S, Partisani M, Chardin P, Kirchhausen T, Franco M, The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes., J Biol Chem 2005 Jun; 280(22): 21661-6.

Franco M, Albano L, Blaimont A, Barrillon D, Bracco J, Spontaneous fracture of the lower angle of scapula. Possible role of cough., Joint Bone Spine 2004 Nov; 71(6): 580-2.

Franco M, Blaimont A, Albano L, Bendini C, Cassuto E, Jaeger P, Tacrolimus pain syndrome in renal transplant patients: report of two cases., Joint Bone Spine 2004 Mar; 71(2): 157-9.

Franco M, Puch JM, Carayon MJ, Bortolotti D, Albano L, Lallemand A, Lipoma arborescens of the knee: report of a case managed by arthroscopic synovectomy., Joint Bone Spine 2004 Jan; 71(1): 73-5.

Decressac S, Franco M, Bendahhou S, Warth R, Knauer S, Barhanin J, Lazdunski M, Lesage F, ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6., EMBO Rep 2004 Dec; 5(12): 1171-5.

Macia E, Luton F, Partisani M, Cherfils J, Chardin P, Franco M, The GDP-bound form of Arf6 is located at the plasma membrane., J Cell Sci 2004 May; 117(Pt 11): 2389-98.

Franco M, Bendini JC, Blaimont A, Albano L, Cassuto E, Jaeger P, Longitudinal bone insufficiency fracture of the tibia in a renal transplant recipient., Joint Bone Spine 2003 Aug; 70(4): 296-9.

Franco M, Bendini JC, Blaimont A, Albano L, Dray G, Barrillon D, Jaeger P, Distal phalangeal brachydactyly and osteosclerosis in a case of secondary hyperparathyroidism., Joint Bone Spine 2003 Mar; 70(2): 143-5.

Derrien V, Couillault C, Franco M, Martineau S, Montcourrier P, Houlgatte R, Chavrier P, A conserved C-terminal domain of EFA6-family ARF6-guanine nucleotide exchange factors induces lengthening of microvilli-like membrane protrusions., J Cell Sci 2002 Jul; 115(Pt 14): 2867-79.