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Publications
2022
Inhibition of the drug efflux activity of Ptch1 as a promising strategy to overcome chemotherapy resistance in cancer cells.,
Eur J Med Chem 2022 Jun; 236(): 114306.
2022
Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched.,
Pharmaceutics 2022 May; 14(5): .
2022
Microscale Thermophoresis to Evaluate the Functionality of Heterologously Overexpressed Membrane Proteins in Membrane Preparations.,
Methods Mol Biol 2022 ; 2507(): 445-461.
2021
Molecular insights into the Patched1 drug efflux inhibitory activity of panicein A hydroquinone: a computational study.,
Phys Chem Chem Phys 2021 Apr; 23(13): 8013-8022.
2021
Methiothepin Increases Chemotherapy Efficacy against Resistant Melanoma Cells.,
Molecules 2021 Mar; 26(7): .
2021
Studying dynamics without explicit dynamics: A structure-based study of the export mechanism by AcrB.,
Proteins 2021 Mar; 89(3): 259-275.
2020
Astemizole Sensitizes Adrenocortical Carcinoma Cells to Doxorubicin by Inhibiting Patched Drug Efflux Activity.,
Biomedicines 2020 Jul; 8(8): .
2018
Targeting the Multidrug Transporter Ptch1 Potentiates Chemotherapy Efficiency.,
Cells 2018 Aug; 7(8): .
2018
Targeting the multidrug transporter Patched potentiates chemotherapy efficiency on adrenocortical carcinoma in vitro and in vivo.,
Int J Cancer 2018 Jul; 143(1): 199-211.
2016
Method to Screen Multidrug Transport Inhibitors Using Yeast Overexpressing a Human MDR Transporter.,
Methods Mol Biol 2016 ; 1432(): 303-18.
2015
Natural paniceins from mediterranean sponge inhibit the multidrug resistance activity of Patched and increase chemotherapy efficiency on melanoma cells.,
Oncotarget 2015 Sep; 6(26): 22282-97.
2015
Lung fibroblasts share mesenchymal stem cell features which are altered in chronic obstructive pulmonary disease via the overactivation of the Hedgehog signaling pathway.,
PLoS One 2015 ; 10(3): e0121579.
2014
Special issue: from membranes to pathologies.,
Biochimie 2014 Dec; 107 Pt A(): 1-2.
2012
The Hedgehog receptor patched functions in multidrug transport and chemotherapy resistance.,
Mol Cancer Res 2012 Nov; 10(11): 1496-508.
2011
A class of mild surfactants that keep integral membrane proteins water-soluble for functional studies and crystallization.,
Mol Membr Biol 2011 Apr; 28(3): 171-81.
2011
The hedgehog receptor patched is involved in cholesterol transport.,
PLoS One 2011 ; 6(9): e23834.
2010
Proteins of the Hedgehog signaling pathway as therapeutic targets against cancer.,
Expert Rev Proteomics 2010 Aug; 7(4): 601-12.
2010
Stability study of the human G-protein coupled receptor, Smoothened.,
Biochim Biophys Acta 2010 Jun; 1798(6): 1100-10.
2010
Heterologous expression of human membrane receptors in the yeast Saccharomyces cerevisiae.,
Methods Mol Biol 2010 ; 601(): 87-103.
2010
Heterologous expression of membrane proteins for structural analysis.,
Methods Mol Biol 2010 ; 601(): 1-16.
2009
Functional studies of membrane-bound and purified human Hedgehog receptor Patched expressed in yeast.,
Biochim Biophys Acta 2009 Sep; 1788(9): 1813-21.
2006
Human receptors patched and smoothened partially transduce hedgehog signal when expressed in Drosophila cells.,
J Biol Chem 2006 Sep; 281(39): 28584-95.
2005
Mouse myodulin, a new potential angiogenic factor, functionally expressed in yeast.,
Biochem Biophys Res Commun 2005 Jun; 331(2): 552-6.
2005
Human receptor Smoothened, a mediator of Hedgehog signalling, expressed in its native conformation in yeast.,
FEBS Lett 2005 Feb; 579(6): 1529-33.
2002
Heterologous expression and purification systems for structural proteomics of mammalian membrane proteins.,
Comp Funct Genomics 2002 ; 3(6): 511-7.
2000
Secondary structure components and properties of the melibiose permease from Escherichia coli: a fourier transform infrared spectroscopy analysis.,
Biophys J 2000 Aug; 79(2): 747-55.
2000
Evidence for a role of helix IV in connecting cation- and sugar-binding sites of Escherichia coli melibiose permease.,
Biochemistry 2000 Apr; 39(15): 4493-9.
1998
Structural studies of the melibiose permease of Escherichia coli by fluorescence resonance energy transfer. II. Identification of the tryptophan residues acting as energy donors.,
J Biol Chem 1998 Dec; 273(50): 33198-202.
1998
Structural studies of the melibiose permease of Escherichia coli by fluorescence resonance energy transfer. I. Evidence for ion-induced conformational change.,
J Biol Chem 1998 Dec; 273(50): 33192-7.
1996
Melibiose permease of Escherichia coli: structural organization of cosubstrate binding sites as deduced from tryptophan fluorescence analyses.,
Biochemistry 1996 Sep; 35(37): 12053-60.
1996
Cation and sugar selectivity determinants in a novel family of transport proteins.,
Mol Microbiol 1996 Mar; 19(5): 911-22.
1995
Melibiose permease of Escherichia coli: substrate-induced conformational changes monitored by tryptophan fluorescence spectroscopy.,
Biochemistry 1995 May; 34(20): 6775-83.
1994
Involvement of histidine residues in the catalytic mechanism of hydrogenases.,
Biochem Biophys Res Commun 1994 May; 201(1): 128-34.
1992
Site-directed mutagenesis of tetraheme cytochrome c3. Modification of oxidoreduction potentials after heme axial ligand replacement.,
J Biol Chem 1992 Aug; 267(24): 16851-8.