Frédéric LUTON – IPMC

Recherche

Intranet

Thème

Biographie pas encore disponible.

Projets

Drogues anti-cancéreuses

Dans le laboratoire, nous développons deux types de drogues anti-cancéreuses : des inhibiteurs de l’invasion tumorale dépendante d’Arf6 et des […]

Polarité épithéliale et cancer

Les tissus épithéliaux tapissent la face interne des organes. Ils sont formés de cellules polarisées présentant un domaine apical ouvert […]

Transport membranaire et cytosquelette d’actine

► Les petites protéines G Arf sont impliquées dans le transport intracellulaire mais leur fonction exacte demeure encore mal définie. […]

Publications

Kovachka S, Malloci G, Simsir M, Ruggerone P, Azoulay S, Mus-Veteau I, Inhibition of the drug efflux activity of Ptch1 as a promising strategy to overcome chemotherapy resistance in cancer cells., Eur J Med Chem 2022 Jun; 236(): 114306.

Álvaro Javier Feliz Morel, Anida Hasanovic, Aurélie Morin, Chloé Prunier, Virginie Magnone, Kevin Lebrigand, Amaury Aouad, Sarah Cogoluegnes, Judith Favier, Claude Pasquier, Isabelle Mus-Veteau, Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched, Pharmaceutics, 2022, 14 (5), pp.988. ⟨10.3390/pharmaceutics14050988⟩.

Feliz Morel ÁJ, Hasanovic A, Morin A, Prunier C, Magnone V, Lebrigand K, Aouad A, Cogoluegnes S, Favier J, Pasquier C, Mus-Veteau I, Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched., Pharmaceutics 2022 May; 14(5): .

Álvaro Javier Feliz Morel, Anida Hasanovic, Aurélie Morin, Chloé Prunier, Virginie Magnone, Kevin Lebrigand, Amaury Aouad, Sarah Cogoluegnes, Judith Favier, Claude Pasquier, Isabelle Mus-Veteau, Persistent Properties of a Subpopulation of Cancer Cells Overexpressing the Hedgehog Receptor Patched, Pharmaceutics, 2022, 14 (5), pp.988. ⟨10.3390/pharmaceutics14050988⟩.

Kovachka S, Soule P, Mus-Veteau I, Microscale Thermophoresis to Evaluate the Functionality of Heterologously Overexpressed Membrane Proteins in Membrane Preparations., Methods Mol Biol 2022 ; 2507(): 445-461.

Kovachka S, Malloci G, Vargiu AV, Azoulay S, Mus-Veteau I, Ruggerone P, Molecular insights into the Patched1 drug efflux inhibitory activity of panicein A hydroquinone: a computational study., Phys Chem Chem Phys 2021 Apr; 23(13): 8013-8022.

Durand N, Simsir M, Signetti L, Labbal F, Ballotti R, Mus-Veteau I, Methiothepin Increases Chemotherapy Efficacy against Resistant Melanoma Cells., Molecules 2021 Mar; 26(7): .

Simsir M, Broutin I, Mus-Veteau I, Cazals F, Studying dynamics without explicit dynamics: A structure-based study of the export mechanism by AcrB., Proteins 2021 Mar; 89(3): 259-275.

Hasanovic A, Simsir M, Choveau FS, Lalli E, Mus-Veteau I, Astemizole Sensitizes Adrenocortical Carcinoma Cells to Doxorubicin by Inhibiting Patched Drug Efflux Activity., Biomedicines 2020 Jul; 8(8): .

Hasanovic A, Mus-Veteau I, Targeting the Multidrug Transporter Ptch1 Potentiates Chemotherapy Efficiency., Cells 2018 Aug; 7(8): .

Hasanovic A, Ruggiero C, Jung S, Rapa I, Signetti L, Ben Hadj M, Terzolo M, Beuschlein F, Volante M, Hantel C, Lalli E, Mus-Veteau I, Targeting the multidrug transporter Patched potentiates chemotherapy efficiency on adrenocortical carcinoma in vitro and in vivo., Int J Cancer 2018 Jul; 143(1): 199-211.

Fiorini L, Tribalat MA, Sauvard L, Cazareth J, Lalli E, Broutin I, Thomas OP, Mus-Veteau I, Natural paniceins from mediterranean sponge inhibit the multidrug resistance activity of Patched and increase chemotherapy efficiency on melanoma cells., Oncotarget 2015 Sep; 6(26): 22282-97.

Figeac F, Dagouassat M, Mahrouf-Yorgov M, Le Gouvello S, Trébeau C, Sayed A, Stern JB, Validire P, Dubois-Randé JL, Boczkowski J, Mus-Veteau I, Rodriguez AM, Lung fibroblasts share mesenchymal stem cell features which are altered in chronic obstructive pulmonary disease via the overactivation of the Hedgehog signaling pathway., PLoS One 2015 ; 10(3): e0121579.

Mus-Veteau I, Lambeau G, Special issue: from membranes to pathologies., Biochimie 2014 Dec; 107 Pt A(): 1-2.

Bidet M, Tomico A, Martin P, Guizouarn H, Mollat P, Mus-Veteau I, The Hedgehog receptor patched functions in multidrug transport and chemotherapy resistance., Mol Cancer Res 2012 Nov; 10(11): 1496-508.

Hovers J, Potschies M, Polidori A, Pucci B, Raynal S, Bonneté F, Serrano-Vega MJ, Tate CG, Picot D, Pierre Y, Popot JL, Nehmé R, Bidet M, Mus-Veteau I, Busskamp H, Jung KH, Marx A, Timmins PA, Welte W, A class of mild surfactants that keep integral membrane proteins water-soluble for functional studies and crystallization., Mol Membr Biol 2011 Apr; 28(3): 171-81.

Bidet M, Joubert O, Lacombe B, Ciantar M, Nehmé R, Mollat P, Brétillon L, Faure H, Bittman R, Ruat M, Mus-Veteau I, The hedgehog receptor patched is involved in cholesterol transport., PLoS One 2011 ; 6(9): e23834.

Nehmé R, Mus-Veteau I, Proteins of the Hedgehog signaling pathway as therapeutic targets against cancer., Expert Rev Proteomics 2010 Aug; 7(4): 601-12.

Nehmé R, Joubert O, Bidet M, Lacombe B, Polidori A, Pucci B, Mus-Veteau I, Stability study of the human G-protein coupled receptor, Smoothened., Biochim Biophys Acta 2010 Jun; 1798(6): 1100-10.

Joubert O, Nehmé R, Bidet M, Mus-Veteau I, Heterologous expression of human membrane receptors in the yeast Saccharomyces cerevisiae., Methods Mol Biol 2010 ; 601(): 87-103.

Mus-Veteau I, Heterologous expression of membrane proteins for structural analysis., Methods Mol Biol 2010 ; 601(): 1-16.

Joubert O, Nehmé R, Fleury D, De Rivoyre M, Bidet M, Polidori A, Ruat M, Pucci B, Mollat P, Mus-Veteau I, Functional studies of membrane-bound and purified human Hedgehog receptor Patched expressed in yeast., Biochim Biophys Acta 2009 Sep; 1788(9): 1813-21.

Mus-Veteau I, Heterologous expression and purification systems for structural proteomics of mammalian membrane proteins., Comp Funct Genomics 2002 ; 3(6): 511-7.

I. Mus-Veteau, A. Dolla, F. Guerlesquin, F. Payan, M. Czjzek, R. Haser, P. Bianco, J. Haladjian, Bj Rapp-Giles, Jd Wall, Site-directed mutagenesis of tetraheme cytochrome c3. Modification of oxidoreduction potentials after heme axial ligand replacement., Journal of Biological Chemistry, 1992, 267, pp.16851-16858.

I. Mus-Veteau, G. Chottard, O. Lexa, Françoise Guerlesquin, Mireille Bruschi, Cytochrome c3-heteropolytungstate complex, a model for the interaction of the tetrahemic cytochrome with its redox partners: ferredoxin and rubredoxin, BBA - Biochimica et Biophysica Acta, 1992, 1102, pp.353.

I. Mus-Veteau, A. Dolla, Françoise Guerlesquin, F. Payan, M. Czjzek, R. Haser, P. Bianco, J. Haladjian, B. Rapp-Giles, B. Wall, G. Voordoum, Mireille Bruschi, Site directed mutagenesis of tetraheme cytochrome c3: modification of redox potentials after heme axial ligand replacement, Journal of Biological Chemistry, 1992, 267, pp.16851.