Frédéric LUTON – IPMC

Recherche

Intranet

Thème

Inger LAURITZEN

Biographie pas encore disponible.

Projets

Drogues anti-cancéreuses

Dans le laboratoire, nous développons deux types de drogues anti-cancéreuses : des inhibiteurs de l’invasion tumorale dépendante d’Arf6 et des […]

Polarité épithéliale et cancer

Les tissus épithéliaux tapissent la face interne des organes. Ils sont formés de cellules polarisées présentant un domaine apical ouvert […]

Transport membranaire et cytosquelette d’actine

► Les petites protéines G Arf sont impliquées dans le transport intracellulaire mais leur fonction exacte demeure encore mal définie. […]

Publications

Fukaya M, Ibuchi K, Sugawara T, Itakura M, Ito A, Shiroshima T, Hara Y, Okamoto H, Luton F, Sakagami H, EFA6A, an Exchange Factor for Arf6, Regulates NGF-Dependent TrkA Recycling From Early Endosomes and Neurite Outgrowth in PC12 Cells., Traffic 2024 May; 25(5): e12936.

Kovács D, Gay AS, Debayle D, Abélanet S, Patel A, Mesmin B, Luton F, Antonny B, Lipid exchange at ER-trans-Golgi contact sites governs polarized cargo sorting., J Cell Biol 2024 Jan; 223(1): .

Macia E, Partisani M, Paleotti O, Luton F, Franco M, Arf6 negatively controls the rapid recycling of the β2 adrenergic receptor., J Cell Sci 2012 Sep; 125(Pt 17): 4026-35.

Su T, Bryant DM, Luton F, Vergés M, Ulrich SM, Hansen KC, Datta A, Eastburn DJ, Burlingame AL, Shokat KM, Mostov KE, A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor., Nat Cell Biol 2010 Dec; 12(12): 1143-53.

Théard D, Labarrade F, Partisani M, Milanini J, Sakagami H, Fon EA, Wood SA, Franco M, Luton F, USP9x-mediated deubiquitination of EFA6 regulates de novo tight junction assembly., EMBO J 2010 May; 29(9): 1499-509.

Luton F, Hexham MJ, Zhang M, Mostov KE, Identification of a cytoplasmic signal for apical transcytosis., Traffic 2009 Aug; 10(8): 1128-42.

Klein S, Partisani M, Franco M, Luton F, EFA6 facilitates the assembly of the tight junction by coordinating an Arf6-dependent and -independent pathway., J Biol Chem 2008 Oct; 283(44): 30129-38.

Macia E, Partisani M, Favard C, Mortier E, Zimmermann P, Carlier MF, Gounon P, Luton F, Franco M, The pleckstrin homology domain of the Arf6-specific exchange factor EFA6 localizes to the plasma membrane by interacting with phosphatidylinositol 4,5-bisphosphate and F-actin., J Biol Chem 2008 Jul; 283(28): 19836-44.

Yano H, Kobayashi I, Onodera Y, Luton F, Franco M, Mazaki Y, Hashimoto S, Iwai K, Ronai Z, Sabe H, Fbx8 makes Arf6 refractory to function via ubiquitination., Mol Biol Cell 2008 Mar; 19(3): 822-32.

Klein S, Franco M, Chardin P, Luton F, Role of the Arf6 GDP/GTP cycle and Arf6 GTPase-activating proteins in actin remodeling and intracellular transport., J Biol Chem 2006 May; 281(18): 12352-61.

Pauchet Y, Luton F, Castella C, Charles JF, Romey G, Pauron D, Effects of a mosquitocidal toxin on a mammalian epithelial cell line expressing its target receptor., Cell Microbiol 2005 Sep; 7(9): 1335-44.

Fournier HN, Dupé-Manet S, Bouvard D, Luton F, Degani S, Block MR, Retta SF, Albiges-Rizo C, Nuclear translocation of integrin cytoplasmic domain-associated protein 1 stimulates cellular proliferation., Mol Biol Cell 2005 Apr; 16(4): 1859-71.

Luton F, The role of EFA6, exchange factor for Arf6, for tight junction assembly, functions, and interaction with the actin cytoskeleton., Methods Enzymol 2005 ; 404(): 332-45.

Klein S, Franco M, Chardin P, Luton F, AlFx affects the formation of focal complexes by stabilizing the Arf-GAP ASAP1 in a complex with Arf1., FEBS Lett 2005 Oct; 579(25): 5741-5.

Paleotti O, Macia E, Luton F, Klein S, Partisani M, Chardin P, Kirchhausen T, Franco M, The small G-protein Arf6GTP recruits the AP-2 adaptor complex to membranes., J Biol Chem 2005 Jun; 280(22): 21661-6.

Mesmin B, Robbe K, Geny B, Luton F, Brandolin G, Popoff MR, Antonny B, A phosphatidylserine-binding site in the cytosolic fragment of Clostridium sordellii lethal toxin facilitates glucosylation of membrane-bound Rac and is required for cytotoxicity., J Biol Chem 2004 Nov; 279(48): 49876-82.

Vergés M, Luton F, Gruber C, Tiemann F, Reinders LG, Huang L, Burlingame AL, Haft CR, Mostov KE, The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor., Nat Cell Biol 2004 Aug; 6(8): 763-9.

Macia E, Luton F, Partisani M, Cherfils J, Chardin P, Franco M, The GDP-bound form of Arf6 is located at the plasma membrane., J Cell Sci 2004 May; 117(Pt 11): 2389-98.

Luton F, Vergés M, Vaerman JP, Sudol M, Mostov KE, The SRC family protein tyrosine kinase p62yes controls polymeric IgA transcytosis in vivo., Mol Cell 1999 Oct; 4(4): 627-32.

Luton F, Mostov KE, Transduction of basolateral-to-apical signals across epithelial cells: ligand-stimulated transcytosis of the polymeric immunoglobulin receptor requires two signals., Mol Biol Cell 1999 May; 10(5): 1409-27.

Malmborg AC, Shultz DB, Luton F, Mostov KE, Richly E, Leung PS, Benson GD, Ansari AA, Coppel RL, Gershwin ME, Van de Water J, Penetration and co-localization in MDCK cell mitochondria of IgA derived from patients with primary biliary cirrhosis., J Autoimmun 1998 Oct; 11(5): 573-80.

Luton F, Cardone MH, Zhang M, Mostov KE, Role of tyrosine phosphorylation in ligand-induced regulation of transcytosis of the polymeric Ig receptor., Mol Biol Cell 1998 Jul; 9(7): 1787-802.

Luton F, Buferne M, Legendre V, Chauvet E, Boyer C, Schmitt-Verhulst AM, Role of CD3gamma and CD3delta cytoplasmic domains in cytolytic T lymphocyte functions and TCR/CD3 down-modulation., J Immunol 1997 May; 158(9): 4162-70.

Luton F, Legendre V, Gorvel JP, Schmitt-Verhulst AM, Boyer C, Tyrosine and serine protein kinase activities associated with ligand-induced internalized TCR/CD3 complexes., J Immunol 1997 Apr; 158(7): 3140-7.

Mostov KE, Altschuler Y, Chapin SJ, Enrich C, Low SH, Luton F, Richman-Eisenstat J, Singer KL, Tang K, Weimbs T, Regulation of protein traffic in polarized epithelial cells: the polymeric immunoglobulin receptor model., Cold Spring Harb Symp Quant Biol 1995 ; 60(): 775-81.

Luton F, Buferne M, Davoust J, Schmitt-Verhulst AM, Boyer C, Evidence for protein tyrosine kinase involvement in ligand-induced TCR/CD3 internalization and surface redistribution., J Immunol 1994 Jul; 153(1): 63-72.

Luton F, Buferne M, Schmitt-Verhulst AM, Boyer C, Developmental control of T-cell receptor internalization., Thymus 1994 ; 23(1): 15-25.

Buferne M, Luton F, Letourneur F, Hoeveler A, Couez D, Barad M, Malissen B, Schmitt-Verhulst AM, Boyer C, Role of CD3 delta in surface expression of the TCR/CD3 complex and in activation for killing analyzed with a CD3 delta-negative cytotoxic T lymphocyte variant., J Immunol 1992 Feb; 148(3): 657-64.

Wegener AM, Letourneur F, Hoeveler A, Brocker T, Luton F, Malissen B, The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules., Cell 1992 Jan; 68(1): 83-95.

Boyer C, Auphan N, Luton F, Malburet JM, Barad M, Bizozzero JP, Reggio H, Schmitt-Verhulst AM, T cell receptor/CD3 complex internalization following activation of a cytolytic T cell clone: evidence for a protein kinase C-independent staurosporine-sensitive step., Eur J Immunol 1991 Jul; 21(7): 1623-34.