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Publications
2025
Presenilins as hub proteins controlling the endocytic and autophagic pathways and small extracellular vesicle secretion.,
J Extracell Vesicles 2025 Jan; 14(1): e70019.
2023
Correction to: Intraneuronal aggregation of the β‑CTF fragment of APP (C99) induces Aβ‑independent lysosomal-autophagic pathology.,
Acta Neuropathol 2023 Oct; 146(4): 659-660.
2023
The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aβ production.,
Cell Mol Life Sci 2023 Mar; 80(4): 97.
2021
Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology.,
Autophagy 2021 Dec; 17(12): 4363-4385.
2021
Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains.,
Acta Neuropathol 2021 Jan; 141(1): 39-65.
2021
Is γ-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?,
J Biol Chem 2021 ; 296(): 100489.
2020
The Transcription Factor EB Reduces the Intraneuronal Accumulation of the Beta-Secretase-Derived APP Fragment C99 in Cellular and Mouse Alzheimer’s Disease Models.,
Cells 2020 May; 9(5): .
2019
Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models.,
Transl Neurodegener 2019 ; 8(): 35.
2019
Does Intraneuronal Accumulation of Carboxyl-terminal Fragments of the Amyloid Precursor Protein Trigger Early Neurotoxicity in Alzheimer’s Disease?,
Curr Alzheimer Res 2019 ; 16(5): 453-457.
2019
Chronic fornix deep brain stimulation in a transgenic Alzheimer’s rat model reduces amyloid burden, inflammation, and neuronal loss.,
Brain Struct Funct 2019 Jan; 224(1): 363-372.
2018
Intraneuronal accumulation of C99 contributes to synaptic alterations, apathy-like behavior, and spatial learning deficits in 3×TgAD and 2×TgAD mice.,
Neurobiol Aging 2018 Nov; 71(): 21-31.
2018
Nuclear p53-mediated repression of autophagy involves PINK1 transcriptional down-regulation.,
Cell Death Differ 2018 May; 25(5): 873-884.
2018
β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models.,
Biol Psychiatry 2018 Mar; 83(5): 416-427.
2017
Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s disease-like pathologies and cognitive deficits.,
Acta Neuropathol 2017 Nov; 134(5): 749-767.
2017
The transcription factor XBP1s restores hippocampal synaptic plasticity and memory by control of the Kalirin-7 pathway in Alzheimer model.,
Mol Psychiatry 2017 Nov; 22(11): 1562-1575.
2016
Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology.,
Acta Neuropathol 2016 Aug; 132(2): 257-276.
2016
Influence of Genetic Background on Apathy-Like Behavior in Triple Transgenic AD Mice.,
Curr Alzheimer Res 2016 ; 13(8): 942-9.
2014
Study on Aβ34 biology and detection in transgenic mice brains.,
Neurobiol Aging 2014 Jul; 35(7): 1570-81.
2012
The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.,
J Neurosci 2012 Nov; 32(46): 16243-1655a.
2012
Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease.,
J Neurosci 2012 Aug; 32(34): 11820-34.
2012
Evidence that the amyloid-β protein precursor intracellular domain, AICD, derives from β-secretase-generated C-terminal fragment.,
J Alzheimers Dis 2012 ; 30(1): 145-53.
2011
Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension.,
Lab Invest 2011 Jan; 91(1): 24-32.
2009
Polycystin-1 and -2 dosage regulates pressure sensing.,
Cell 2009 Oct; 139(3): 587-96.
2007
The TASK background K2P channels: chemo- and nutrient sensors.,
Trends Neurosci 2007 Nov; 30(11): 573-80.
2006
The background K(+) channel TASK-3 is regulated at both the transcriptional and post-transcriptional levels.,
Biochem Biophys Res Commun 2006 Oct; 348(4): 1350-7.
2006
Membrane potential-regulated transcription of the resting K+ conductance TASK-3 via the calcineurin pathway.,
J Biol Chem 2006 Sep; 281(39): 28910-8.
2005
Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton.,
EMBO Rep 2005 Jul; 6(7): 642-8.
2005
A phospholipid sensor controls mechanogating of the K+ channel TREK-1.,
EMBO J 2005 Jan; 24(1): 44-53.
2003
K+-dependent cerebellar granule neuron apoptosis. Role of task leak K+ channels.,
J Biol Chem 2003 Aug; 278(34): 32068-76.
2002
A potent protective role of lysophospholipids against global cerebral ischemia and glutamate excitotoxicity in neuronal cultures.,
J Cereb Blood Flow Metab 2002 Jul; 22(7): 821-34.
2001
A TREK-1-like potassium channel in atrial cells inhibited by beta-adrenergic stimulation and activated by volatile anesthetics.,
Circ Res 2001 Aug; 89(4): 336-42.
2000
M-type KCNQ2-KCNQ3 potassium channels are modulated by the KCNE2 subunit.,
FEBS Lett 2000 Sep; 480(2-3): 137-41.
2000
TREK-1 is a heat-activated background K(+) channel.,
EMBO J 2000 Jun; 19(11): 2483-91.
2000
Polyunsaturated fatty acids are potent neuroprotectors.,
EMBO J 2000 Apr; 19(8): 1784-93.
2000
Immunolocalization of the arachidonic acid and mechanosensitive baseline traak potassium channel in the nervous system.,
Neuroscience 2000 ; 95(3): 893-901.
1998
The KCNQ2 potassium channel: splice variants, functional and developmental expression. Brain localization and comparison with KCNQ3.,
FEBS Lett 1998 Nov; 438(3): 171-6.
1998
Disruption of mitochondrial respiration inhibits volume-regulated anion channels and provokes neuronal cell swelling.,
J Neurosci 1998 May; 18(9): 3117-23.
1998
A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion.,
J Cell Biol 1998 Apr; 141(1): 187-97.
1997
The potassium channel opener (-)-cromakalim prevents glutamate-induced cell death in hippocampal neurons.,
J Neurochem 1997 Oct; 69(4): 1570-9.
1997
An immunocytochemical study on the distribution of two G-protein-gated inward rectifier potassium channels (GIRK2 and GIRK4) in the adult rat brain.,
Neuroscience 1997 Sep; 80(2): 345-57.
1997
Comparative expression of the inward rectifier K+ channel GIRK2 in the cerebellum of normal and weaver mutant mice.,
Brain Res 1997 Apr; 753(1): 8-17.
1997
An immunocytochemical study of a G-protein-gated inward rectifier K+ channel (GIRK2) in the weaver mouse mesencephalon.,
Neuroreport 1997 Mar; 8(4): 969-74.
1997
The structure, function and distribution of the mouse TWIK-1 K+ channel.,
FEBS Lett 1997 Jan; 402(1): 28-32.
1996
The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans.,
J Biol Chem 1996 May; 271(18): 10433-6.
1995
Essential role of adenosine, adenosine A1 receptors, and ATP-sensitive K+ channels in cerebral ischemic preconditioning.,
Proc Natl Acad Sci U S A 1995 May; 92(10): 4666-70.
1994
Glutamate-induced overexpression of NMDA receptor messenger RNAs and protein triggered by activation of AMPA/kainate receptors in rat hippocampus following forebrain ischemia.,
Brain Res 1994 Oct; 659(1-2): 67-74.
1994
Expression of group II phospholipase A2 in rat brain after severe forebrain ischemia and in endotoxic shock.,
Brain Res 1994 Jul; 651(1-2): 353-6.
1991
DNA cytophotometry in adrenocortical tumours: a clinicomorphological study of 66 cases.,
Virchows Arch A Pathol Anat Histopathol 1991 ; 419(3): 167-70.
1990
[Histology, immunocytochemistry and DNA cytophotometry of adrenocortical tumors–a clinicomorphological study of 72 tumors].,
Verh Dtsch Ges Pathol 1990 ; 74(): 284-8.