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Leader

Events

19
Jun
2024
Thesis
Thesis by Noha AL-QATABI

«Characterization of atypical BAR domain proteins encoded by Toxoplasma gondii« Thesis Director: Dr. Guillaume DRIN, Director of […]

IPMC
05
Dec
2025
11:00 am
Conference
Guillaume DRIN invites Prof. Tim LEVINE (Keynote Seminar)

«The Great Unknown … and can we find lipid transfer proteins (LTPs) in Alphafold»

IPMC
08
Jun
2026
11:00 am
Conference
Guillaume Drin invites Dr. Naresh YANDRAPALLI

«Engineering complex synthetic cells: A bottom-up platform for membrane biophysics« 

IPMC

Projects

Project
2024
Understanding how phosphatidylserine is distributed in eukaryotic cells

Phosphatidylserine (PS) is an essential anionic lipid in eukaryotic cells. It is distributed asymmetrically in the cell […]
Project
2025
Deciphering the molecular mechanisms of phosphatidylinositol distribution

Phosphatidylinositol (PI) is a unique lipid because it is the precursor to phosphoinositides, such as PI4P and PI(4,5)P2, which […]
Project
2023
Identifying molecules to counter STARD3 in HER2+ tumor cells

STARD3 is a sterol transporter located at the interface between the endoplasmic reticulum and endosomes. Interestingly and […]

Tools

Tool
2024
HeliQuest

The following link provides access to HeliQuest, a bioinformatics tool allowing the analysis of amphipathic helices and searching for sequences presenting […]

Publications

2026
Eichler J, Wendling C, Huver S, Zouiouich M, Hanss V, Cardinal A, Fimbel V, Birck C, McEwen AG, Knorr C, Fromental-Ramain C, Boutry M, Chenard MP, Drin G, Tomasetto C, Alpy F, STARD3 regulates lysosome positioning and contacts via a GSK3-controlled phosphorylation switch., EMBO J 2026 Feb; (): .
2026
Eichler J, Tomasetto C, Drin G, Alpy F, In vitro methods for studying protein-lipid droplet interactions., Methods Enzymol 2026; 727(): 93-121.
2025
Fabbre A, Syska C, Sebinelli HG, Cardinal A, Magdeleine M, Al-Qatabi N, D'Ambrosio JM, Montigny C, Lenoir G, Čopič A, Drin G, Ist2 promotes lipid transfer by Osh6 via its membrane tethering and lipid scramblase activities., Sci Adv 2025 Nov; 11(46): eadz2217.
2025
Delfosse V, Drin G, Determining the Relative Affinity of ORPs for Lipid Ligands Using Fluorescence and Thermal Shift Assays. Methods Mol Biol 2025; 2888(): 259-280.
2024
Hamaï A, Drin G, Specificity of lipid transfer proteins: An in vitro story. Biochemistry 2024 Dec; 227(Pt B): 85-110.
2024
Al-Qatabi N, Magdeleine M, Pagnotta S, Leforestier A, Degrouard J, Arteni AA, Lacas-Gervais S, Gautier R, Drin G, Characterization of a BAR domain-containing proteins coded by Toxoplasma gondii. J Biol Chem 2024 Oct; 300(12): 107923.
2024
Fuggetta N, Rigolli N, Magdeleine M, Hamaï A, Seminara A, Drin G, Reconstitution of ORP-mediated lipid exchange coupled to PI4P metabolism. Proc Natl Acad Sci USA 2024 Mar; 121(10): e2315493121.
2022
Zouiouich M, Di Mattia T, Martinet A, Eichler J, Wendling C, Tomishige N, Grandgirard E, Fuggetta N, Fromental-Ramain C, Mizzon G, Dumesnil C, Carpentier M, Reina-San-Martin B, Mathelin C, Schwab Y, Thiam AR, Kobayashi T, Drin G, Tomasetto C, Alpy F, MOSPD2 is an endoplasmic reticulum-lipid droplet tether functioning in LD homeostasis. J Cell Biol 2022 Jun; 221(6): .
2020
Vanessa Delfosse, William Bourguet, Guillaume Drin, Structural and Functional Specialization of OSBP-Related Proteins, Contact 2020;3. doi:10.1177/2515256420946627.
2020
Di Mattia T, Martinet A, Ikhlef S, McEwen AG, Nominé Y, Wendling C, Poussin-Courmontagne P, Voilquin L, Eberling P, Ruffenach F, Cavarelli J, Slee J, Levine TP, Drin G, Tomasetto C, Alpy F , FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts. EMBO J 2020 Dec; 39(23): e104369.
2020
D'Ambrosio JM, Albanese V, Lipp NF, Fleuriot L, Debayle D, Drin G, Čopič A, Osh6 requires Ist2 for localization to ER-PM contacts and efficient phosphatidylserine transport in budding yeast. J Cell Sci 2020 Jun; 133(11): .
2020
Drin G, MapPIng PI inside cells brings new light to polyphosphoinositide biology. J Cell Biol 2020 Mar; 219(3): .
2020
Lipp NF, Ikhlef S, Milanini J, Drin G, Lipid Exchangers: Cellular Functions and Mechanistic Links With Phosphoinositide Metabolism. Front Cell Dev Biol 2020; 8(): 663.
2018
Di Mattia T, Wilhelm LP, Ikhlef S, Wendling C, Spehner D, Nominé Y, Giordano F, Mathelin C, Drin G, Tomasetto C, Alpy F, Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites. EMBO Rep 2018 Jul; 19(7): .
2018
Huang J, Mousley CJ, Dacquay L, Maitra N, Drin G, He C, Ridgway ND, Tripathi A, Kennedy M, Kennedy BK, Liu W, Baetz K, Polymenis M, Bankaitis VA, A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems. Dev Cell 2018 Feb; 44(3): 378-391.e5.
2017
Wilhelm LP, Wendling C, Védie B, Kobayashi T, Chenard MP, Tomasetto C, Drin G, Alpy F, STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites. EMBO J 2017 May; 36(10): 1412-1433.
2015
Moser von Filseck J, Vanni S, Mesmin B, Antonny B, Drin G, A phosphatidylinositol-4-phosphate powered exchange mechanism to create a lipid gradient between membranes. Nat Commun 2015 Apr;6():6671.
2015
Strating JR, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L, Leyssen P, van der Schaar HM, Lanke KH, Thibaut HJ, Ulferts R, Drin G, Schlinck N, Wubbolts RW, Sever N, Head SA, Liu JO, Beachy PA, De Matteis MA, Shair MD, Olkkonen VM, Neyts J, van Kuppeveld FJ, Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein. Cell Rep 2015 Feb; 10(4): 600-15.
2014
Moser von Filseck J, Mesmin B, Bigay J, Antonny B, Drin G, Building lipid 'PIPelines' throughout the cell by ORP/Osh proteins. Biochem Soc Trans 2014 Oct; 42(5): 1465-70.
2013
Mesmin B, Bigay J, Moser von Filseck J, Lacas-Gervais S, Drin G, Antonny B, A four-step cycle driven by PI(4)P hydrolysis direct sterol/PI(4)P exchange by the ER-Golgi tether OSBP., Cell 2013 Nov; 155(4): 830-43.
2013
Mesmin B, Antonny B, Drin G, Insights into the mechanisms of sterol transport between organelles. Cell Mol Life Sci 2013 Sep; 70(18): 3405-21.
2013
Vanni S, Vamparys L, Gautier R, Drin G, Etchebest C, Fuchs PF, Antonny B, Amphipathic lipid packing sensor motifs: probing bilayer defects with hydrophobic residues. Biophys J 2013 Feb; 104(3): 575-84.
2012
Manneville JB, Leduc C, Sorre B, Drin G, Studying in vitro membrane curvature recognition by proteins and its role in vesicular trafficking. Methods Cell Biol 2012; 108(): 47-71.
2011
de Saint-Jean M, Delfosse V, Douguet D, Chicanne G, Payrastre B, Bourguet W, Antonny B, Drin G, Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers. J Cell Biol 2011 Dec; 195(6): 965-78.
2007
Drin G, Scarlata S, Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding–how many ways can you activate an enzyme? Cell Signal 2007 Jul; 19(7): 1383-92.
2007
Mesmin B, Drin G, Levi S, Rawet M, Cassel D, Bigay J, Antonny B, Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature. Biochemistry 2007 Feb; 46(7): 1779-90.
2007
Drin G, Casella JF, Gautier R, Boehmer T, Schwartz TU, Antonny B, A general amphipathic alpha-helical motif for sensing membrane curvature. Nat Struct Mol Biol 2007 Feb; 14(2): 138-46.
2006
Drin G, Douguet D, Scarlata S, The pleckstrin homology domain of phospholipase Cbeta transmits enzymatic activation through modulation of the membrane-domain orientation. Biochemistry 2006 May; 45(18): 5712-24.
2005
Drin G, Antonny B, Cell biology: helices sculpt membrane. Nature 2005 Oct; 437(7063): 1247-9.
2005
Bigay J, Casella JF, Drin G, Mesmin B, Antonny B, ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif. EMBO J 2005 Jul; 24(13): 2244-53.
2005
Feng J, Roberts MF, Drin G, Scarlata S, Dissection of the steps of phospholipase C beta 2 activity that are enhanced by G beta gamma subunits. Biochemistry 2005 Feb; 44(7): 2577-84.
2003
Drin G, Cottin S, Blanc E, Rees AR, Temsamani J, Studies on the internalization mechanism of cationic cell-penetrating peptides. J Biol Chem 2003 Aug; 278(33): 31192-201.
2002
Drin G, Temsamani J, Translocation of protegrin I through phospholipid membranes: role of peptide folding. Biochim Biophys Acta 2002 Feb; 1559(2): 160-70.
2002
Drin G, Rousselle C, Scherrmann JM, Rees AR, Temsamani J, Peptide delivery to the brain via adsorptive-mediated endocytosis: advances with SynB vectors. AAPS PharmSci 2002; 4(4): E26.
2001
Drin G, Mazel M, Clair P, Mathieu D, Kaczorek M, Temsamani J, Physico-chemical requirements for cellular uptake of pAntp peptide. Role of lipid-binding affinity. Eur J Biochem 2001 Mar;268(5):1304-14.
2001
Drin G, Déméné H, Temsamani J, Brasseur R, Translocation of the pAntp peptide and its amphipathic analogue AP-2AL. Biochemistry 2001 Feb; 40(6): 1824-34.
1998
Cregut D, Drin G, Liautard JP, Chiche L, Hinge-bending motions in annexins: molecular dynamics and essential dynamics of apo-annexin V and of calcium bound annexin V and I., Protein Eng 1998 Oct; 11(10): 891-900.