Florian LESAGE

2026

Chatelain FC, de Oliveira BR, Grataloup G, Robert N, Alameh M, Thollet A, Montnach J, Feliciangeli S, Rio A, Bibault F, Bichet D, Bignucolo O, Extramiana F, Majumder R, Schott JJ, Probst V, Denjoy I, Lesage F, Loussouarn G, De Waard M, SPARC: a structural pathogenicity algorithm for risk classification of hERG variants., Europace 2026 Feb; 28(2): .

2024

Chatelain FC, Gilbert N, Bichet D, Jauch A, Feliciangeli S, Lesage F, Bignucolo O, Mechanistic basis of the dynamic response of TWIK1 ionic selectivity to pH., Nat Common 2024 May; 15(1): 3849.

2023

Oliveira-Mendes BBR, Alameh M, Montnach J, Ollivier B, Gibaud S, Feliciangeli S, Lesage F, Charpentier F, Loussouarn G, De Waard M, Baró I, Predicting hERG repolarization power at 37°C from recordings at room temperature. Clin Transl Med 2023 May; 13(5): e1266.

2023

Landra-Willm A, Karapurkar A, Duveau A, Chassot AA, Esnault L, Callejo G, Bied M, Häfner S, Lesage F, Wdziekonski B, Baron A, Fossat P, Marsollier L, Gasull X, Boué-Grabot E, Kienzler MA, Sandoz G, A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals. Nat Commun 2023 Mar;14(1):1160.

2023

Alameh M, Oliveira-Mendes BR, Kyndt F, Rivron J, Denjoy I, Lesage F, Schott JJ, De Waard M, Loussouarn G, A need for exhaustive and standardized characterization of ion channels activity. The case of KV11.1., Front Physiol 2023; 14(): 1132533.

2021

Barbara BR Oliveira‐mendes, Sylvain Feliciangeli, Mélissa Ménard, Frank Chatelain, Malak Alameh, Jérôme Montnach, Sébastien Nicolas, Béatrice Ollivier, Julien Barc, Isabelle Baró, Jean-Jacques Schott, Vincent Probst, Florence Kyndt, Isabelle Denjoy, Florian Lesage, Gildas Loussouarn, Michel de Waard, A standardized hERG phenotyping pipeline to evaluate KCNH2 genetic variant pathogenicity, Clinical and Translational Medicine, 2021, 11 (11), ⟨10.1002/ctm2.609⟩.

2021

Choveau FS, Ben Soussia I, Bichet D, Chatelain FC, Feliciangeli S, Lesage F, Corrigendum: Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels. Front Pharmacol 2021; 12():795920.

2021

Choveau FS, Ben Soussia I, Bichet D, Franck CC, Feliciangeli S, Lesage F, Convergence of Multiple Stimuli to a Single Gate in TREK1 and TRAAK Potassium Channels. Front Pharmacol 2021; 12(): 755826.

2020

Busserolles J, Ben Soussia I, Pouchol L, Marie N, Meleine M, Devilliers M, Judon C, Schopp J, Clémenceau L, Poupon L, Chapuy E, Richard S, Noble F, Lesage F, Ducki S, Eschalier A, Lolignier S, TREK1 channel activation as a new analgesic strategy void of opioid adverse effects. Br J Pharmacol 2020 Oct; 177(20): 4782-4795.

2020

Cooper A, Butto T, Hammer N, Jagannath S, Fend-Guella DL, Akhtar J, Radyushkin K, Lesage F, Winter J, Strand S, Roeper J, Zechner U, Schweiger S, Inhibition of histone deacetylation rescues phenotype in a mouse model of Birk-Barel intellectual disability syndrome. Nat Commun 2020 Jan;11(1):480.

2019

Ben Soussia I, El Mouridi S, Kang D, Leclercq-Blondel A, Khoubza L, Tardy P, Zariohi N, Gendrel M, Lesage F, Kim EJ, Bichet D, Andrini O, Boulin T, Mutation of a single residue promotes gating of vertebrate and invertebrate two-pore domain potassium channels. Nat Common 2019 Feb; 10(1): 787.

2019

Royal P, Andres-Bilbe A, Ávalos Prado P, Verkest C, Wdziekonski B, Schaub S, Baron A, Lesage F, Gasull X, Levitz J, Sandoz G, Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK. Neuron 2019 Jan; 101(2): 232-245.e6.

2019

Inoue M, Matsuoka H, Lesage F, Harada K, Lack of p11 expression facilitates acidity-sensing function of TASK1 channels in mouse adrenal medullary cells. FASEB J 2019 Jan; 33(1): 455-468.

2018

Soussia IB, Choveau FS, Blin S, Kim EJ, Feliciangeli S, Chatelain FC, Kang D, Bichet D, Lesage F, Antagonistic Effect of a Cytoplasmic Domain on the Basal Activity of Polymodal Potassium Channels. Front Mol Neurosci 2018; 11(): 301.

2017

Schwingshackl A, Lopez B, Teng B, Luellen C, Lesage F, Belperio J, Olcese R, Waters CM, Hyperoxia treatment of TREK-1/TREK-2/TRAAK-deficient mice is associated with a reduction in surfactant proteins. Am J Physiol Lung Cell Mol Physiol 2017 Dec; 313(6): L1030-L1046.

2017

Buehler PK, Bleiler D, Tegtmeier I, Heitzmann D, Both C, Georgieff M, Lesage F, Warth R, Thomas J, Abnormal respiration under hyperoxia in TASK-1/3 potassium channel double knockout mice. Respir Physiol Neurobiol 2017 Oct; 244(): 17-25.

2017

Vivier D, Soussia IB, Rodrigues N, Lolignier S, Devilliers M, Chatelain FC, Prival L, Chapuy E, Bourdier G, Bennis K, Lesage F, Eschalier A, Busserolles J, Ducki S, Development of the First Two-Pore Domain Potassium Channel TWIK-Related K+ Channel 1-Selective Agonist Possessing in Vivo Antinociceptive Activity. J Med Chem 2017 Feb; 60(3): 1076-1088.

2016

Christensen AH, Chatelain FC, Huttner IG, Olesen MS, Soka M, Feliciangeli S, Horvat C, Santiago CF, Vandenberg JI, Schmitt N, Olesen SP, Lesage F, Fatkin D, The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size. J Mol Cell Cardiol 2016 Aug; 97(): 24-35.

2016

Vivier D, Bennis K, Lesage F, Ducki S, Perspectives on the Two-Pore Domain Potassium Channel TREK-1 (TWIK-Related K(+) Channel 1). A Novel Therapeutic Target? J Med Chem 2016 Jun; 59(11): 5149-57.

2016

Ronjat M, Feng W, Dardevet L, Dong Y, Al Khoury S, Chatelain FC, Vialla V, Chahboun S, Lesage F, Darbon H, Pessah IN, De Waard M, In cellulo phosphorylation induces pharmacological reprogramming of maurocalcin, a cell-penetrating venom peptide. Proc Natl Acad Sci USA 2016 Apr; 113(17): E2460-8.

2015

Feliciangeli S, Chatelain FC, Bichet D, Lesage F, The family of K2P channels: salient structural and functional properties. J Physiol 2015 Jun; 593(12): 2587-603.

2015

Bichet D, Blin S, Feliciangeli S, Chatelain FC, Bobak N, Lesage F, Silent but not dumb: how cellular trafficking and pore gating modulate expression of TWIK1 and THIK2. Pflugers Arch 2015 May; 467(5): 1121-31.

2014

Pereira V, Busserolles J, Christin M, Devilliers M, Poupon L, Legha W, Alloui A, Aissouni Y, Bourinet E, Lesage F, Eschalier A, Lazdunski M, Noël J, Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception. Bread 2014 Dec; 155(12): 2534-2544.

2014

Comoglio Y, Levitz J, Kienzler MA, Lesage F, Isacoff EY, Sandoz G, Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid. Proc Natl Acad Sci USA 2014 Sep; 111(37): 13547-52.

2014

Xiao Z, Cilz NI, Kurada L, Hu B, Yang C, Wada E, Combs CK, Porter JE, Lesage F, Lei S, Activation of neurotensin receptor 1 facilitates neuronal excitability and spatial learning and memory in the entorhinal cortex: beneficial actions in an Alzheimer's disease model. J Neurosci 2014 May; 34(20): 7027-42.

2014

Rodrigues N, Bennis K, Vivier D, Pereira V, C Chatelain F, Chapuy E, Deokar H, Busserolles J, Lesage F, Eschalier A, Ducki S, Synthesis and structure-activity relationship study of substituted caffeate esters as antinociceptive agents modulating the TREK-1 channel., Eur J Med Chem 2014 Mar;75():391-402.

2014

Stebe S, Schellig K, Lesage F, Breer H, Fleischer J, The thermosensitive potassium channel TREK-1 contributes to coolness-evoked responses of Grueneberg ganglion neurons. Cell Mol Neurobiol 2014 Jan; 34(1): 113-22.

2013

Chatelain FC, Bichet D, Feliciangeli S, Larroque MM, Braud VM, Douguet D, Lesage F, Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relates on combined intracellular retention and low intrinsic activity at the plasma membrane. J Biol Chem 2013 Dec; 288(49): 35081-92.

2013

Wang S, Benamer N, Zanella S, Kumar NN, Shi Y, Bevengut M, Penton D, Guyenet PG, Lesage F, Gestreau C, Barhanin J, Bayliss DA, TASK-2 channels contribute to pH sensitivity of retrotrapezoid nucleus chemoreceptor neurons. J Neurosci 2013 Oct; 33(41): 16033-44.

2013

Bandulik S, Tauber P, Penton D, Schweda F, Tegtmeier I, Sterner C, Lalli E, Lesage F, Hartmann M, Barhanin J, Warth R, Severe hyperaldosteronism in neonatal Task3 potassium channel knockout mice is associated with activation of the intraadrenal renin-angiotensin system. Endocrinology 2013 Aug; 154(8): 2712-22.

2013

Hao J, Padilla F, Dandonneau M, Lavebratt C, Lesage F, Noël J, Delmas P, Kv1.1 channels act as mechanical brake in the senses of touch and pain., Neuron 2013 Mar; 77(5): 899-914.

2013

Wang W, Putra A, Schools GP, Ma B, Chen H, Kaczmarek LK, Barhanin J, Lesage F, Zhou M, The contribution of TWIK-1 channels to astrocyte K(+) current is limited by retention in intracellular compartments. Front Cell Neurosci 2013; 7(): 246.

2012

Penton D, Bandulik S, Schweda F, Haubs S, Tauber P, Reichold M, Cong LD, El Wakil A, Budde T, Lesage F, Lalli E, Zennaro MC, Warth R, Barhanin J, Task3 potassium channel gene invalidation causes low renin and salt-sensitive arterial hypertension. Endocrinology 2012 Oct; 153(10): 4740-8.

2012

Tadmouri A, Kiyonaka S, Barbado M, Rousset M, Fablet K, Sawamura S, Bahembera E, Pernet-Gallay K, Arnoult C, Miki T, Sadoul K, Gory-Faure S, Lambrecht C, Lesage F, Akiyama S, Khochbin S, Baulande S, Janssens V, Andrieux A, Dolmetsch R, Ronjat M, Mori Y, De Waard M, Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy. EMBO J 2012 Sep; 31(18): 3730-44.

2012

Chatelain FC, Bichet D, Douguet D, Feliciangeli S, Bendahhou S, Reichold M, Warth R, Barhanin J, Lesage F, TWIK1, a unique background channel with variable ion selectivity. Proc Natl Acad Sci USA 2012 Apr; 109(14): 5499-504.

2012

Peyronnet R, Sharif-Naeini R, Folgering JH, Arhatte M, Jodar M, El Boustany C, Gallian C, Tauc M, Duranton C, Rubera I, Lesage F, Pei Y, Peters DJ, Somlo S, Sachs F, Patel A , Honoré E, Duprat F, Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels. Cell Rep 2012 Mar; 1(3): 241-50.

2012

Mirkovic K, Palmersheim J, Lesage F, Wickman K, Behavioral characterization of mice lacking Trek channels. Front Behav Neurosci 2012; 6(): 60.

2010

Feliciangeli S, Tardy MP, Sandoz G, Chatelain FC, Warth R, Barhanin J, Bendahhou S, Lesage F, Potassium channel silencing by constitutive endocytosis and intracellular sequestration. J Biol Chem 2010 Feb; 285(7): 4798-805.

2010

Christian Gestreau, Dirk Heitzmann, Joerg Thomas, V. Dubreuil, Sascha Bandulik, Markus Reichold, Saïd Bendahhou, Patricia Pierson, Christina Sterner, Julie Peyronnet-Roux, Chérif Benfriha, Ines Tegtmeier, Hannah Ehnes, Michael Georgieff, Florian Lesage, Jean-Francois Brunet, Christo Goridis, Richard Warth, Jacques Barhanin, Task2 potassium channels set central respiratory CO 2 and O 2 sensitivity, Proceedings of the National Academy of Sciences of the United States of America, 2010, 107 (5), pp.2325-2330. ⟨10.1073/pnas.0910059107⟩.

2009

Guyon A, Tardy MP, Nahon JL, Barhanin J, Lesage F, Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels. J Neurosci 2009 Feb; 29(8): 2528-33.

2009

Sandoz G, Douguet D, Chatelain F, Lazdunski M, Lesage F, Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue. Proc Natl Acad Sci USA 2009 Aug; 106(34): 14628-33.

2008

Sandoz G, Tardy MP, Thümmler S, Feliciangeli S, Lazdunski M, Lesage F, Mtap2 is a constituent of the protein network that regulates twik-related K+ channel expression and trafficking. J Neurosci 2008 Aug; 28(34): 8545-52.

2008

Heitzmann D, Derand R, Jungbauer S, Bandulik S, Sterner C, Schweda F, El Wakil A, Lalli E, Guy N, Mengual R, Reichold M, Tegtmeier I, Bendahhou S, Gomez-Sanchez CE, Aller MI, Wisden W , Weber A, Lesage F, Warth R, Barhanin J, Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis. EMBO J 2008 Jan;27(1):179-87.

2008

Sandoz G, Lesage F, Protein complex analysis of native brain potassium channels by proteomics. Methods Mol Biol 2008; 491(): 113-23.

2007

Feliciangeli S, Bendahhou S, Sandoz G, Gounon P, Reichold M, Warth R, Lazdunski M, Barhanin J, Lesage F, Does sumoylation control K2P1/TWIK1 background K+ channels?, Cell 2007 Aug;130(3):563-9.

2006

Sandoz G, Thümmler S, Duprat F, Feliciangeli S, Vinh J, Escoubas P, Guy N, Lazdunski M, Lesage F, AKAP150, a switch to convert mechano-, pH- and arachidonic acid-sensitive TREK K(+) channels into open leak channels., EMBO J 2006 Dec; 25(24): 5864-72.

2006

Zanzouri M, Lauritzen I, Duprat F, Mazzuca M, Lesage F, Lazdunski M, Patel A, Membrane potential-regulated transcription of the resting K+ conductance TASK-3 via the calcineurin pathway. J Biol Chem 2006 Sep; 281(39): 28910-8.

2005

Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S, International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels. Pharmacol Rev 2005 Dec; 57(4): 527-40.

2005

Ebensperger G, Ebensperger R, Herrera EA, Riquelme RA, Sanhueza EM, Lesage F, Marengo JJ, Tejo RI, Llanos AJ, Reyes RV, Fetal brain hypometabolism during prolonged hypoxaemia in the llama. J Physiol 2005 Sep; 567(Pt 3): 963-75.

2005

Vamecq J, Vallée L, Lesage F, Gressens P, Stables JP, Antiepileptic popular ketogenic diet: emerging twists in an ancient story. Prog Neurobiol 2005 Jan; 75(1): 1-28.

2004

Decressac S, Franco M, Bendahhou S, Warth R, Knauer S, Barhanin J, Lazdunski M, Lesage F, ARF6-dependent interaction of the TWIK1 K+ channel with EFA6, a GDP/GTP exchange factor for ARF6. EMBO Rep 2004 Dec; 5(12): 1171-5.

2004

Nicolas MT, Lesage F, Reyes R, Barhanin J, Deprès D, Localization of TREK-1, a two-pore-domain K+ channel in the peripheral vestibular system of mouse and rat. Brain Res 2004 Aug; 1017(1-2): 46-52.

2004

Warth R, Barrière H, Meneton P, Bloch M, Thomas J, Tauc M, Heitzmann D, Romeo E, Verrey F, Mengual R, Guy N, Bendahhou S, Lesage F, Poujeol P, Barhanin J, Proximal renal tubular acidosis in TASK2 K+ channel-deficient mice reveals a mechanism for stabilizing bicarbonate transport. Proc Natl Acad Sci USA 2004 May; 101(21): 8215-20.

2004

Girard C, Lesage F, [Neuronal background two-P-domain potassium channels: molecular and functional aspects]. Med Sci (Paris) 2004 May; 20(5): 544-9.

2004

Lesage F, Hibino H, Hudspeth AJ, Association of beta-catenin with the alpha-subunit of neuronal large-conductance Ca2+-activated K+ channels. Proc Natl Acad Sci USA 2004 Jan; 101(2): 671-5.

2003

Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y , Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS, International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev 2003 Dec; 55(4): 583-6.

2003

Chemin J, Girard C, Duprat F, Lesage F, Romey G, Lazdunski M, Mechanisms underlying excitatory effects of group I metabotropic glutamate receptors via inhibition of 2P domain K+ channels., EMBO J 2003 Oct; 22(20): 5403-11.

2003

Barrière H, Belfodil R, Rubera I, Tauc M, Lesage F, Poujeol C, Guy N, Barhanin J, Poujeol P, Role of TASK2 potassium channels regarding volume regulation in primary cultures of mouse proximal tubules. J Gen Physiol 2003 Aug; 122(2): 177-90.

2003

Magloire H, Lesage F, Couble ML, Lazdunski M, Bleicher F, Expression and localization of TREK-1 K+ channels in human odontoblasts. J Dent Res 2003 Jul;82(7):542-5.

2003

Hibino H, Pironkova R, Onwumere O, Rousset M, Charnet P, Hudspeth AJ, Lesage F, Direct interaction with a nuclear protein and regulation of gene silencing by a variant of the Ca2+-channel beta 4 subunit., Proc Natl Acad Sci USA 2003 Jan; 100(1): 307-12.

2002

Hibino H, Pironkova R, Onwumere O, Vologodskaia M, Hudspeth AJ, Lesage F, RIM binding proteins (RBPs) couple Rab3-interacting molecules (RIMs) to voltage-gated Ca(2+) channels. Neuron 2002 Apr; 34(3): 411-23.

2001

Terrenoire C, Lauritzen I, Lesage F, Romey G, Lazdunski M, A TREK-1-like potassium channel in atrial cells inhibited by beta-adrenergic stimulation and activated by volatile anesthetics. Circ Res 2001 Aug; 89(4): 336-42.

2001

Girard C, Duprat F, Terrenoire C, Tinel N, Fosset M, Romey G, Lazdunski M, Lesage F, Genomic and functional characteristics of novel human pancreatic 2P domain K(+) channels., Biochem Biophys Res Commun 2001 Mar; 282(1): 249-56.

2000

Lesage F, Lazdunski M, Molecular and functional properties of two-pore-domain potassium channels. Am J Physiol Renal Physiol 2000 Nov; 279(5): F793-801.

2000

Lesage F, Terrenoire C, Romey G, Lazdunski M, Human TREK2, a 2P domain mechano-sensitive K+ channel with multiple regulations by polyunsaturated fatty acids, lysophospholipids, and Gs, Gi, and Gq protein-coupled receptors. J Biol Chem 2000 Sep; 275(37): 28398-405.

2000

Duprat F, Lesage F, Patel AJ, Fink M, Romey G, Lazdunski M, The neuroprotective agent riluzole activates the two P domain K(+) channels TREK-1 and TRAAK. Mol Pharmacol 2000 May; 57(5): 906-12.

2000

Lesage F, Maingret F, Lazdunski M, Cloning and expression of human TRAAK, a polyunsaturated fatty acids-activated and mechano-sensitive K(+) channel. FEBS Lett 2000 Apr; 471(2-3): 137-40.

2000

Maingret F, Patel AJ, Lesage F, Lazdunski M, Honoré E, Lysophospholipids open the two-pore domain mechano-gated K(+) channels TREK-1 and TRAAK., J Biol Chem 2000 Apr; 275(14): 10128-33.

2000

Bearzatto B, Lesage F, Reyes R, Lazdunski M, Laduron PM, Axonal transport of TREK and TRAAK potassium channels in rat sciatic nerves. Neuroreport 2000 Apr; 11(5): 927-30.

2000

Reyes R, Lauritzen I, Lesage F, Ettaiche M, Fosset M, Lazdunski M, Immunolocalization of the arachidonic acid and mechanosensitive baseline traak potassium channel in the nervous system. Neuroscience 2000; 95(3): 893-901.

1999

Maingret F, Patel AJ, Lesage F, Lazdunski M, Honoré E, Mechano- or acid stimulation, two interactive modes of activation of the TREK-1 potassium channel. J Biol Chem 1999 Sep; 274(38): 26691-6.

1999

Patel AJ, Honoré E, Lesage F, Fink M, Romey G, Lazdunski M, Inhalational anesthetics activate two-pore-domain background K+ channels., Nat Neurosci 1999 May; 2(5): 422-6.

1999

Salinas M, Reyes R, Lesage F, Fosset M, Heurteaux C, Romey G, Lazdunski M, Cloning of a new mouse two-P domain channel subunit and a human homolog with a unique pore structure. J Biol Chem 1999 Apr; 274(17): 11751-60.

1999

Maingret F, Fosset M, Lesage F, Lazdunski M, Honoré E, TRAAK is a mammalian neuronal mechano-gated K+ channel. J Biol Chem 1999 Jan;274(3):1381-7.

1998

Cluzeaud F, Reyes R, Escoubet B, Fay M, Lazdunski M, Bonvalet JP, Lesage F, Farman N, Expression of TWIK-1, a novel weakly inward rectifying potassium channel in rat kidney. Am J Physiol 1998 Dec; 275(6): C1602-9.

1998

Reyes R, Duprat F, Lesage F, Fink M, Salinas M, Farman N, Lazdunski M, Cloning and expression of a novel pH-sensitive two pore domain K+ channel from human kidney. J Biol Chem 1998 Nov; 273(47): 30863-9.

1998

Patel AJ, Honoré E, Maingret F, Lesage F, Fink M, Duprat F, Lazdunski M, A mammalian two pore domain mechano-gated S-like K+ channel. EMBO J 1998 Aug; 17(15): 4283-90.

1998

Lesage F, Lazdunski M, Mapping of human potassium channel genes TREK-1 (KCNK2) and TASK (KCNK3) to chromosomes 1q41 and 2p23. Genomics 1998 Aug; 51(3): 478-9.

1998

Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M, A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids. EMBO J 1998 Jun; 17(12): 3297-308.

1997

Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M, TASK, a human background K+ channel to sense external pH variations near physiological pH., EMBO J 1997 Sep; 16(17): 5464-71.

1997

Murer G, Adelbrecht C, Lauritzen I, Lesage F, Lazdunski M, Agid Y, Raisman-Vozari R, An immunocytochemical study on the distribution of two G-protein-gated inward rectifier potassium channels (GIRK2 and GIRK4) in the adult rat brain. Neuroscience 1997 Sep; 80(2): 345-57.

1997

Lauritzen I, De Weille J, Adelbrecht C, Lesage F, Murer G, Raisman-Vozari R, Lazdunski M, Comparative expression of the inward rectifier K+ channel GIRK2 in the cerebellum of normal and weaver mutant mice., Brain Res 1997 Apr; 753(1): 8-17.

1997

Salinas M, de Weille J, Guillemare E, Lazdunski M, Hugnot JP, Modes of regulation of shab K+ channel activity by the Kv8.1 subunit., J Biol Chem 1997 Mar;272(13):8774-80.

1997

Lesage F, Lauritzen I, Duprat F, Reyes R, Fink M, Heurteaux C, Lazdunski M, The structure, function and distribution of the mouse TWIK-1 K+ channel., FEBS Lett 1997 Jan; 402(1): 28-32.

1996

Fink M, Duprat F, Lesage F, Reyes R, Romey G, Heurteaux C, Lazdunski M, Cloning, functional expression and brain localization of a novel unconventional outward rectifier K+ channel. EMBO J 1996 Dec; 15(24): 6854-62.

1996

Lesage F, Reyes R, Fink M, Duprat F, Guillemare E, Lazdunski M, Dimerization of TWIK-1 K+ channel subunits via a disulfide bridge. EMBO J 1996 Dec; 15(23): 6400-7.

1996

Vetter DE, Mann JR, Wangemann P, Liu J, McLaughlin KJ, Lesage F, Marcus DC, Lazdunski M, Heinemann SF, Barhanin J, Inner ear defects induced by null mutation of the isk gene. Neuron 1996 Dec; 17(6): 1251-64.

1996

Barhanin J, Lesage F, Guillemare E, Fink M, Lazdunski M, Romey G, K(V)LQT1 and lsK (minK) proteins associate to form the I(Ks) cardiac potassium current., Nature 1996 Nov; 384(6604): 78-80.

1996

Fink M, Duprat F, Lesage F, Heurteaux C, Romey G, Barhanin J, Lazdunski M, A new K+ channel beta subunit to specifically enhance Kv2.2 (CDRK) expression. J Biol Chem 1996 Oct; 271(42): 26341-8.

1996

Hugnot JP, Salinas M, Lesage F, Guillemare E, de Weille J, Heurteaux C, Mattéi MG, Lazdunski M, Kv8.1, a new neuronal potassium channel subunit with specific inhibitory properties towards Shab and Shaw channels. EMBO J 1996 Jul; 15(13): 3322-31.

1996

Lesage F, Mattéi M, Fink M, Barhanin J, Lazdunski M, Assignment of the human weak inward rectifier K+ channel TWIK-1 gene to chromosome 1q42-q43. Genomics 1996 May; 34(1): 153-5.

1996

Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J, TWIK-1, a ubiquitous human weakly inward rectifying K+ channel with a novel structure. EMBO J 1996 Mar; 15(5): 1004-11.

1996

Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romey G, Barhanin J, A pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel gating properties. J Biol Chem 1996 Feb; 271(8): 4183-7.

1996

Fink M, Duprat F, Heurteaux C, Lesage F, Romey G, Barhanin J, Lazdunski M, Dominant negative chimeras provide evidence for homo and heteromultimeric assembly of inward rectifier K+ channel proteins via their N-terminal end., FEBS Lett 1996 Jan; 378(1): 64-8.

1995

Duprat F, Guillemare E, Romey G, Fink M, Lesage F, Lazdunski M, Honore E, Susceptibility of cloned K+ channels to reactive oxygen species. Proc Natl Acad Sci USA 1995 Dec; 92(25): 11796-800.

1995

Lesage F, Guillemare E, Fink M, Duprat F, Heurteaux C, Fosset M, Romey G, Barhanin J, Lazdunski M, Molecular properties of neuronal G-protein-activated inwardly rectifying K+ channels. J Biol Chem 1995 Dec; 270(48): 28660-7.

1995

Lesage F, Fink M, Barhanin J, Lazdunski M, Mattéi MG, Assignment of human G-protein-coupled inward rectifier K+ channel homolog GIRK3 gene to chromosome 1q21-q23. Genomics 1995 Oct; 29(3): 808-9.

1995

Duprat F, Lesage F, Guillemare E, Fink M, Hugnot JP, Bigay J, Lazdunski M, Romey G, Barhanin J, Heterologous multimeric assembly is essential for K+ channel activity of neuronal and cardiac G-protein-activated inward rectifiers. Biochem Biophys Res Commun 1995 Jul; 212(2): 657-63.

1994

Lesage F, Duprat F, Fink M, Guillemare E, Coppola T, Lazdunski M, Hugnot JP, Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. FEBS Lett 1994 Oct; 353(1): 37-42.

1994

Lesage F, Hugnot JP, Amri EZ, Grimaldi P, Barhanin J, Lazdunski M, Expression cloning in K+ transport defective yeast and distribution of HBP1, a new putative HMG transcriptional regulator. Nucleic Acids Res 1994 Sep; 22(18): 3685-8.

1994

Honoré E, Guillemare E, Lesage F, Barhanin J, Lazdunski M, Injection of a K+ channel (Kv1.3) cRNA in fertilized eggs leads to functional expression in cultured myotomal muscle cells from Xenopus embryos. FEBS Lett 1994 Jul; 348(3): 259-62.

1994

Honoré E, Barhanin J, Attali B, Lesage F, Lazdunski M, External blockade of the major cardiac delayed-rectifier K+ channel (Kv1.5) by polyunsaturated fatty acids. Proc Natl Acad Sci USA 1994 Mar; 91(5): 1937-41.

1993

Attali B, Lesage F, Ziliani P, Guillemare E, Honoré E, Waldmann R, Hugnot JP, Mattéi MG, Lazdunski M, Barhanin J, Multiple mRNA isoforms encoding the mouse cardiac Kv1-5 delayed rectifier K+ channel. J Biol Chem 1993 Nov; 268(32): 24283-9.

1993

Attali B, Guillemare E, Lesage F, Honoré E, Romey G, Lazdunski M, Barhanin J, The protein IsK is a dual activator of K+ and Cl- channels. Nature 1993 Oct; 365(6449): 850-2.

1993

Chevillard C, Attali B, Lesage F, Fontes M, Barhanin J, Lazdunski M, Mattei MG, Localization of a potassium channel gene (KCNE1) to 21q22.1-q22.2 by in situ hybridization and somatic cell hybridization. Genomics 1993 Jan; 15(1): 243-5.

1993

Lesage F, Attali B, Lakey J, Honoré E, Romey G, Faurobert E, Lazdunski M, Barhanin J, Are Xenopus oocytes unique in displaying functional IsK channel heterologous expression? Recept Channels 1993; 1(2): 143-52.

1992

Guillemare E, Honoré E, Pradier L, Lesage F, Schweitz H, Attali B, Barhanin J, Lazdunski M, Effects of the level of mRNA expression on biophysical properties, sensitivity to neurotoxins, and regulation of the brain delayed-rectifier K+ channels Kv1.2., Biochemistry 1992 Dec; 31(49): 12463-8.

1992

Lesage F, Attali B, Lazdunski M, Barhanin J, Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells. FEBS Lett 1992 Sep; 310(2): 162-6.

1992

Honoré E, Attali B, Romey G, Lesage F, Barhanin J, Lazdunski M, Different types of K+ channel current are generated by different levels of a single mRNA. EMBO J 1992 Jul; 11(7): 2465-71.

1992

Attali B, Honoré E, Lesage F, Lazdunski M, Barhanin J, Regulation of a major cloned voltage-gated K+ channel from human T lymphocytes. FEBS Lett 1992 Jun; 303(2-3): 229-32.

1992

Honore E, Attali B, Lesage F, Barhanin J, Lazdunski M, Receptor-mediated regulation of IsK, a very slowly activating, voltage-dependent K+ channel in Xenopus oocytes. Biochem Biophys Res Commun 1992 May; 184(3): 1135-41.

1992

Attali B, Romey G, Honoré E, Schmid-Alliana A, Mattéi MG, Lesage F, Ricard P, Barhanin J, Lazdunski M, Cloning, functional expression, and regulation of two K+ channels in human T lymphocytes. J Biol Chem 1992 Apr; 267(12): 8650-7.

1992

Lesage F, Attali B, Lazdunski M, Barhanin J, ISK, a slowly activating voltage-sensitive K+ channel. Characterization of multiple cDNAs and gene organization in the mouse. FEBS Lett 1992 Apr; 301(2): 168-72.

1991

Honoré E, Attali B, Romey G, Heurteaux C, Ricard P, Lesage F, Lazdunski M, Barhanin J, Cloning, expression, pharmacology and regulation of a delayed rectifier K+ channel in mouse heart. EMBO J 1991 Oct; 10(10): 2805-11.