Présentation
Chef d’équipe
Projets
Projet
2024
Comprendre comment la phosphatidylsérine est distribuée dans les cellules eucaryotes
La phosphatidylsérine (PS) est un lipide anionique essentiel des cellules eucaryotes. Il est distribué de manière asymétrique dans la cellule […]
Projet
2025
Décrypter les mécanismes moléculaires de la distribution du phosphatidylinositol
Le phosphatidylinositol (PI) est un lipide unique car il est le précurseur des phosphoinositides, comme le PI4P et PI(4,5)P2, qui […]
Projet
2023
Identifier des molécules pour contrer STARD3 dans les cellules tumorales HER2+
STARD3 est un transporteur de stérol localisé à l’interface entre le réticulum endoplasmique et les endosomes. De façon intéressante et […]
Publications
2025
Determining the Relative Affinity of ORPs for Lipid Ligands Using Fluorescence and Thermal Shift Assays.,
Methods Mol Biol 2025 ; 2888(): 259-280.
2024
Specificity of lipid transfer proteins: An in vitro story.,
Biochimie 2024 Dec; 227(Pt B): 85-110.
2024
Characterization of atypical BAR domain-containing proteins coded by Toxoplasma gondii.,
J Biol Chem 2024 Oct; 300(12): 107923.
2024
Reconstitution of ORP-mediated lipid exchange coupled to PI4P metabolism.,
Proc Natl Acad Sci U S A 2024 Mar; 121(10): e2315493121.
2022
MOSPD2 is an endoplasmic reticulum-lipid droplet tether functioning in LD homeostasis.,
J Cell Biol 2022 Jun; 221(6): .
2020
Structural and Functional Specialization of OSBP-Related Proteins,
Contact 2020;3. doi:10.1177/2515256420946627.
2020
FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts.,
EMBO J 2020 Dec; 39(23): e104369.
2020
Osh6 requires Ist2 for localization to ER-PM contacts and efficient phosphatidylserine transport in budding yeast.,
J Cell Sci 2020 Jun; 133(11): .
2020
MapPIng PI inside cells brings new light to polyphosphoinositide biology.,
J Cell Biol 2020 Mar; 219(3): .
2020
Lipid Exchangers: Cellular Functions and Mechanistic Links With Phosphoinositide Metabolism.,
Front Cell Dev Biol 2020 ; 8(): 663.
2018
Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites.,
EMBO Rep 2018 Jul; 19(7): .
2018
A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems.,
Dev Cell 2018 Feb; 44(3): 378-391.e5.
2017
STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites.,
EMBO J 2017 May; 36(10): 1412-1433.
2015
A phosphatidylinositol-4-phosphate powered exchange mechanism to create a lipid gradient between membranes.,
Nat Commun 2015 Apr; 6(): 6671.
2015
Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.,
Cell Rep 2015 Feb; 10(4): 600-15.
2014
Building lipid ‘PIPelines’ throughout the cell by ORP/Osh proteins.,
Biochem Soc Trans 2014 Oct; 42(5): 1465-70.
2013
A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP.,
Cell 2013 Nov; 155(4): 830-43.
2013
Insights into the mechanisms of sterol transport between organelles.,
Cell Mol Life Sci 2013 Sep; 70(18): 3405-21.
2013
Amphipathic lipid packing sensor motifs: probing bilayer defects with hydrophobic residues.,
Biophys J 2013 Feb; 104(3): 575-84.
2012
Studying in vitro membrane curvature recognition by proteins and its role in vesicular trafficking.,
Methods Cell Biol 2012 ; 108(): 47-71.
2011
Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers.,
J Cell Biol 2011 Dec; 195(6): 965-78.
2007
Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding–how many ways can you activate an enzyme?,
Cell Signal 2007 Jul; 19(7): 1383-92.
2007
Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature.,
Biochemistry 2007 Feb; 46(7): 1779-90.
2007
A general amphipathic alpha-helical motif for sensing membrane curvature.,
Nat Struct Mol Biol 2007 Feb; 14(2): 138-46.
2006
The pleckstrin homology domain of phospholipase Cbeta transmits enzymatic activation through modulation of the membrane-domain orientation.,
Biochemistry 2006 May; 45(18): 5712-24.
2005
Cell biology: helices sculpt membrane.,
Nature 2005 Oct; 437(7063): 1247-9.
2005
ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif.,
EMBO J 2005 Jul; 24(13): 2244-53.
2005
Dissection of the steps of phospholipase C beta 2 activity that are enhanced by G beta gamma subunits.,
Biochemistry 2005 Feb; 44(7): 2577-84.
2003
Studies on the internalization mechanism of cationic cell-penetrating peptides.,
J Biol Chem 2003 Aug; 278(33): 31192-201.
2002
Translocation of protegrin I through phospholipid membranes: role of peptide folding.,
Biochim Biophys Acta 2002 Feb; 1559(2): 160-70.
2002
Peptide delivery to the brain via adsorptive-mediated endocytosis: advances with SynB vectors.,
AAPS PharmSci 2002 ; 4(4): E26.
2001
Physico-chemical requirements for cellular uptake of pAntp peptide. Role of lipid-binding affinity.,
Eur J Biochem 2001 Mar; 268(5): 1304-14.
2001
Translocation of the pAntp peptide and its amphipathic analogue AP-2AL.,
Biochemistry 2001 Feb; 40(6): 1824-34.
1998
Hinge-bending motions in annexins: molecular dynamics and essential dynamics of apo-annexin V and of calcium bound annexin V and I.,
Protein Eng 1998 Oct; 11(10): 891-900.