Guillaume DRIN – IPMC

Recherche

Intranet

Thème

Emanuela MARTINUZZI

Présentation

Chef d’équipe

Événements

Thèse de Noha AL-QATABI

« Caractérisation de protéines atypiques à domaine BAR codées par Toxoplasma gondii« Directeur de Thèse :Dr. Guillaume DRIN, , Directeur de […]

Guillaume DRIN invite le Pr. Tim LEVINE (Keynote Seminar)

« The Great Unknown … and can we find lipid transfer proteins (LTPs) in Alphafold »

Guillaume Drin invite le Dr. Naresh YANDRAPALLI

« Engineering complex synthetic cells: A bottom-up platform for membrane biophysics«

Thèse d'Amazigh HAMAI

« Titre à venir ». Dir. de Thèse : Guillaume DRIN

Projets

Comprendre comment la phosphatidylsérine est distribuée dans les cellules eucaryotes

La phosphatidylsérine (PS) est un lipide anionique essentiel des cellules eucaryotes. Il est distribué de manière asymétrique dans la cellule […]

Décrypter les mécanismes moléculaires de la distribution du phosphatidylinositol

Le phosphatidylinositol (PI) est un lipide unique car il est le précurseur des phosphoinositides, comme le PI4P et PI(4,5)P2, qui […]

Identifier des molécules pour contrer STARD3 dans les cellules tumorales HER2+

STARD3 est un transporteur de stérol localisé à l’interface entre le réticulum endoplasmique et les endosomes. De façon intéressante et […]

Outils

Le lien suivant donne accès à HeliQuest, un outil bioinformatique permettant l’analyse d’hélices amphipatiques et de rechercher des séquences présentant […]

Publications

Fabbre A, Drin G, Lipid traffic: an enigmatic alliance between ORPs and a TMEM16-like protein at membrane contact sites., Biochem Soc Trans 2026 Jun; 54(6): 793-802.

Eichler J, Wendling C, Huver S, Zouiouich M, Hanss V, Cardinal A, Fimbel V, Birck C, McEwen AG, Knorr C, Fromental-Ramain C, Boutry M, Chenard MP, Drin G, Tomasetto C, Alpy F, STARD3 regulates lysosome positioning and contacts via a GSK3-controlled phosphorylation switch., EMBO J 2026 Feb; (): .

Eichler J, Tomasetto C, Drin G, Alpy F, In vitro methods for studying protein-lipid droplet interactions., Methods Enzymol 2026 ; 727(): 93-121.

Fabbre A, Syska C, Sebinelli HG, Cardinal A, Magdeleine M, Al-Qatabi N, D'Ambrosio JM, Montigny C, Lenoir G, Čopič A, Drin G, Ist2 promotes lipid transfer by Osh6 via its membrane tethering and lipid scramblase activities., Sci Adv 2025 Nov; 11(46): eadz2217.

Delfosse V, Drin G, Determining the Relative Affinity of ORPs for Lipid Ligands Using Fluorescence and Thermal Shift Assays., Methods Mol Biol 2025 ; 2888(): 259-280.

Hamaï A, Drin G, Specificity of lipid transfer proteins: An in vitro story., Biochimie 2024 Dec; 227(Pt B): 85-110.

Al-Qatabi N, Magdeleine M, Pagnotta S, Leforestier A, Degrouard J, Arteni AA, Lacas-Gervais S, Gautier R, Drin G, Characterization of atypical BAR domain-containing proteins coded by Toxoplasma gondii., J Biol Chem 2024 Oct; 300(12): 107923.

Fuggetta N, Rigolli N, Magdeleine M, Hamaï A, Seminara A, Drin G, Reconstitution of ORP-mediated lipid exchange coupled to PI4P metabolism., Proc Natl Acad Sci U S A 2024 Mar; 121(10): e2315493121.

Zouiouich M, Di Mattia T, Martinet A, Eichler J, Wendling C, Tomishige N, Grandgirard E, Fuggetta N, Fromental-Ramain C, Mizzon G, Dumesnil C, Carpentier M, Reina-San-Martin B, Mathelin C, Schwab Y, Thiam AR, Kobayashi T, Drin G, Tomasetto C, Alpy F, MOSPD2 is an endoplasmic reticulum-lipid droplet tether functioning in LD homeostasis., J Cell Biol 2022 Jun; 221(6): .

Vanessa Delfosse, William Bourguet, Guillaume Drin, Structural and Functional Specialization of OSBP-Related Proteins, Contact 2020;3. doi:10.1177/2515256420946627.

Di Mattia T, Martinet A, Ikhlef S, McEwen AG, Nominé Y, Wendling C, Poussin-Courmontagne P, Voilquin L, Eberling P, Ruffenach F, Cavarelli J, Slee J, Levine TP, Drin G, Tomasetto C, Alpy F, FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts., EMBO J 2020 Dec; 39(23): e104369.

D'Ambrosio JM, Albanèse V, Lipp NF, Fleuriot L, Debayle D, Drin G, Čopič A, Osh6 requires Ist2 for localization to ER-PM contacts and efficient phosphatidylserine transport in budding yeast., J Cell Sci 2020 Jun; 133(11): .

Drin G, MapPIng PI inside cells brings new light to polyphosphoinositide biology., J Cell Biol 2020 Mar; 219(3): .

Lipp NF, Ikhlef S, Milanini J, Drin G, Lipid Exchangers: Cellular Functions and Mechanistic Links With Phosphoinositide Metabolism., Front Cell Dev Biol 2020 ; 8(): 663.

Di Mattia T, Wilhelm LP, Ikhlef S, Wendling C, Spehner D, Nominé Y, Giordano F, Mathelin C, Drin G, Tomasetto C, Alpy F, Identification of MOSPD2, a novel scaffold for endoplasmic reticulum membrane contact sites., EMBO Rep 2018 Jul; 19(7): .

Huang J, Mousley CJ, Dacquay L, Maitra N, Drin G, He C, Ridgway ND, Tripathi A, Kennedy M, Kennedy BK, Liu W, Baetz K, Polymenis M, Bankaitis VA, A Lipid Transfer Protein Signaling Axis Exerts Dual Control of Cell-Cycle and Membrane Trafficking Systems., Dev Cell 2018 Feb; 44(3): 378-391.e5.

Wilhelm LP, Wendling C, Védie B, Kobayashi T, Chenard MP, Tomasetto C, Drin G, Alpy F, STARD3 mediates endoplasmic reticulum-to-endosome cholesterol transport at membrane contact sites., EMBO J 2017 May; 36(10): 1412-1433.

Moser von Filseck J, Vanni S, Mesmin B, Antonny B, Drin G, A phosphatidylinositol-4-phosphate powered exchange mechanism to create a lipid gradient between membranes., Nat Commun 2015 Apr; 6(): 6671.

Strating JR, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L, Leyssen P, van der Schaar HM, Lanke KH, Thibaut HJ, Ulferts R, Drin G, Schlinck N, Wubbolts RW, Sever N, Head SA, Liu JO, Beachy PA, De Matteis MA, Shair MD, Olkkonen VM, Neyts J, van Kuppeveld FJ, Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein., Cell Rep 2015 Feb; 10(4): 600-15.

Moser von Filseck J, Mesmin B, Bigay J, Antonny B, Drin G, Building lipid ‘PIPelines’ throughout the cell by ORP/Osh proteins., Biochem Soc Trans 2014 Oct; 42(5): 1465-70.

Mesmin B, Bigay J, Moser von Filseck J, Lacas-Gervais S, Drin G, Antonny B, A four-step cycle driven by PI(4)P hydrolysis directs sterol/PI(4)P exchange by the ER-Golgi tether OSBP., Cell 2013 Nov; 155(4): 830-43.

Mesmin B, Antonny B, Drin G, Insights into the mechanisms of sterol transport between organelles., Cell Mol Life Sci 2013 Sep; 70(18): 3405-21.

Vanni S, Vamparys L, Gautier R, Drin G, Etchebest C, Fuchs PF, Antonny B, Amphipathic lipid packing sensor motifs: probing bilayer defects with hydrophobic residues., Biophys J 2013 Feb; 104(3): 575-84.

Manneville JB, Leduc C, Sorre B, Drin G, Studying in vitro membrane curvature recognition by proteins and its role in vesicular trafficking., Methods Cell Biol 2012 ; 108(): 47-71.

de Saint-Jean M, Delfosse V, Douguet D, Chicanne G, Payrastre B, Bourguet W, Antonny B, Drin G, Osh4p exchanges sterols for phosphatidylinositol 4-phosphate between lipid bilayers., J Cell Biol 2011 Dec; 195(6): 965-78.

Drin G, Scarlata S, Stimulation of phospholipase Cbeta by membrane interactions, interdomain movement, and G protein binding–how many ways can you activate an enzyme?, Cell Signal 2007 Jul; 19(7): 1383-92.

Mesmin B, Drin G, Levi S, Rawet M, Cassel D, Bigay J, Antonny B, Two lipid-packing sensor motifs contribute to the sensitivity of ArfGAP1 to membrane curvature., Biochemistry 2007 Feb; 46(7): 1779-90.

Drin G, Casella JF, Gautier R, Boehmer T, Schwartz TU, Antonny B, A general amphipathic alpha-helical motif for sensing membrane curvature., Nat Struct Mol Biol 2007 Feb; 14(2): 138-46.

Drin G, Douguet D, Scarlata S, The pleckstrin homology domain of phospholipase Cbeta transmits enzymatic activation through modulation of the membrane-domain orientation., Biochemistry 2006 May; 45(18): 5712-24.

Drin G, Antonny B, Cell biology: helices sculpt membrane., Nature 2005 Oct; 437(7063): 1247-9.

Bigay J, Casella JF, Drin G, Mesmin B, Antonny B, ArfGAP1 responds to membrane curvature through the folding of a lipid packing sensor motif., EMBO J 2005 Jul; 24(13): 2244-53.

Feng J, Roberts MF, Drin G, Scarlata S, Dissection of the steps of phospholipase C beta 2 activity that are enhanced by G beta gamma subunits., Biochemistry 2005 Feb; 44(7): 2577-84.

Drin G, Cottin S, Blanc E, Rees AR, Temsamani J, Studies on the internalization mechanism of cationic cell-penetrating peptides., J Biol Chem 2003 Aug; 278(33): 31192-201.

Drin G, Temsamani J, Translocation of protegrin I through phospholipid membranes: role of peptide folding., Biochim Biophys Acta 2002 Feb; 1559(2): 160-70.

Drin G, Rousselle C, Scherrmann JM, Rees AR, Temsamani J, Peptide delivery to the brain via adsorptive-mediated endocytosis: advances with SynB vectors., AAPS PharmSci 2002 ; 4(4): E26.

Drin G, Mazel M, Clair P, Mathieu D, Kaczorek M, Temsamani J, Physico-chemical requirements for cellular uptake of pAntp peptide. Role of lipid-binding affinity., Eur J Biochem 2001 Mar; 268(5): 1304-14.

Drin G, Déméné H, Temsamani J, Brasseur R, Translocation of the pAntp peptide and its amphipathic analogue AP-2AL., Biochemistry 2001 Feb; 40(6): 1824-34.

Cregut D, Drin G, Liautard JP, Chiche L, Hinge-bending motions in annexins: molecular dynamics and essential dynamics of apo-annexin V and of calcium bound annexin V and I., Protein Eng 1998 Oct; 11(10): 891-900.