MapPIng PI inside cells brings new light to polyphosphoinositide biology.

Recherche

Intranet

Thème

Molecular and cellular dissection of the oxysterol-binding protein cycle through a fluorescent inhibitor.

Using single-cell RNA sequencing to unravel cell lineage relationships in the respiratory tract.

Présentation

It is unclear how phosphatidylinositol (PI), the precursor of polyphosphoinositides, is distributed within cell membranes. Pemberton et al. (2020. J. Cell. Biol.https://doi.org/10.1083/jcb.201906130) and Zewe et al. (2020. J. Cell. Biol.https://doi.org/10.1083/jcb.201906127) describe new approaches to map the subcellular PI abundance and clarify how polyphosphoinositide metabolism relates to PI distribution.