Brice MARCET – IPMC

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For 20 years, Dr. Brice Marcet has dedicated his research to the genomic mechanisms involved in the regeneration of the epithelium of normal and pathological airways, within the "Genomic Physiology of Eukaryotes" team led by Dr. Barbry, today in the "Human Airway Biology" group led by Dr. Zaragosi, in the same team.
In 2003, he obtained his PhD on the pharmacology of the CFTR ion channel and P2Y nucleotide receptors from Aix-Marseille University. Between 2003 and 2006, he pursued postdoctoral studies at the Free University of Brussels, focusing on the role of extracellular nucleotides and P2Y receptors in the inflammatory response of normal and pathological airways.
In 2006, the researcher (a research fellow at the CNRS) joined the IPMC, then was awarded in 2007 for his work on cystic fibrosis with the research prize awarded by the French Cystic Fibrosis Society.
In 2012, he was awarded the CNRS and University of Nice-Sophia-Antipolis Bronze Medal for his discovery concerning the key role of microRNAs (small non-coding RNAs) of the miR-34/miR-449 family in the differentiation of multiciliated cells of the respiratory tract epithelium. In 2013, the researcher obtained his Habilitation à Diriger des Recherches (HDR) from a jury chaired by Professor Michel Lazdunski at the University of Côte d'Azur.
Since 2016, he has been a research director at the CNRS, and supervises several doctoral theses.
His research is based on ex vivo 3D differentiation models of primary cultures of human and murine respiratory cells as well as on the technical and methodological developments from the UCA-Genomix platform led by Dr. Barbry.

Events

Symposium of the Trans Mucus Network

Projects

The epithelium of the respiratory tract: a protective ecosystem

The airway epithelium lines the nose, trachea, and bronchi. It is made up of different types of cells […]

The study of the transcriptome at the single cell level

Since the beginning of 2015, our research on the epithelium of the airways has adopted a new approach allowing […]

Human Cell Atlas

The “Human Cell Atlas” is an international effort to create a reference atlas of all […]

Publications

Redman E, Fierville M, Cavard A, Plaisant M, Arguel MJ, Ruiz Garcia S, McAndrew EM, Girard-Riboulleau C, Lebrigand K, Magnone V, Ponzio G, Gras D, Chanez P, Abelanet S, Barbry P, Marcet B, Zaragosi LE, Cell Culture Differentiation and Proliferation Conditions Influence the In Vitro Regeneration of the Human Airway Epithelium., Am J Respir Cell Mol Biol 2024 Sep; 71(3): 267-281.

Zaragosi LE, Gouleau A, Delin M, Lebrigand K, Arguel MJ, Girard-Riboulleau C, Rios G, Redman E, Plaisant M, Waldmann R, Magnone V, Marcet B, Barbry P, Ponzio G, Combination of CRISPR-Cas9-RNP and Single-Cell RNAseq to Identify Cell State-Specific FOXJ1 Functions in the Human Airway Epithelium. Methods Mol Biol 2024; 2725(): 1-25.

Barbry P, Marcet B, Caballero I, Where Is the Cystic Fibrosis Transmembrane Conductance Regulator?, Am J Respir Crit Care Med 2021 May; 203(10): 1214-1216.

Giovannini-Chami L, Paquet A, Sanfiorenzo C, Pons N, Cazareth J, Magnone V, Lebrigand K, Chevalier B, Vallauri A, Julia V, Marquette CH, Marcet B, Leroy S, Barbry P, The «one airway, one disease» concept in light of Th2 inflammation., Eur Respir J 2018 Oct; 52(4): .

Mercey O, Popa A, Cavard A, Paquet A, Chevalier B, Pons N, Magnone V, Zangari J, Brest P, Zaragosi LE, Ponzio G, Lebrigand K, Barbry P, Marcet B, Characterizing isomiR variants within the microRNA-34/449 family. FEBS Lett 2017 Mar; 591(5): 693-705.

Mercey O, Kodjabachian L, Barbry P, Marcet B, MicroRNAs as key regulators of GTPase-mediated apical actin reorganization in multiciliated epithelia. Small GTPases 2016 Apr; 7(2): 54-8.

O. Mercey, L. Kodjabachian, P. Barbry, B. Marcet, MicroRNAs as key regulators of GTPase-mediated apical actin reorganization in multiciliated epithelia, Small GTPases, 2016, 7 (2), pp.54-8. ⟨10.1080/21541248.2016.1151099.Epub2016May4⟩.

Mercey O, Chevalier B, Kodjabachian L, Barbry P, Marcet B, [MicroRNAs pull the strings of motile cilia]., Med Sci (Paris) 2015 Dec; 31(12): 1078-80.

Chevalier B, Adamiok A, Mercey O, Revinski DR, Zaragosi LE, Pasini A, Kodjabachian L, Barbry P, Marcet B, miR-34/449 controls apical actin network formation during multiciliogenesis through small GTPase pathways. Nat Commun 2015 Sep; 6(): 8386.

Cibois M, Luxardi G, Chevalier B, Thomé V, Mercey O, Zaragosi LE, Barbry P, Pasini A, Marcet B, Kodjabachian L, BMP signaling controls the construction of vertebrate mucociliary epithelia. Development 2015 Jul; 142(13): 2352-63.

Lino Cardenas CL, Henaoui IS, Courcot E, Roderburg C, Cauffiez C, Aubert S, Copin MC, Wallaert B, Glowacki F, Dewaeles E, Milosevic J, Maurizio J, Tedrow J, Marcet B, Lo-Guidice JM, Kaminski N, Barbry P, Luedde T, Perrais M, Mari B, Pottier N, miR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1., PLoS Genet 2013; 9(2): e1003291.

Giovannini-Chami L, Marcet B, Moreilhon C, Chevalier B, Illie MI, Lebrigand K, Robbe-Sermesant K, Bourrier T, Michiels JF, Mari B, Crénesse D, Hofman P, de Blic J, Castillo L, Albertini M, Barbry P, Distinct epithelial gene expression phenotypes in childhood respiratory allergy., Eur Respir J 2012 May; 39(5): 1197-205.

Marcet B, Chevalier B, Coraux C, Kodjabachian L, Barbry P, MicroRNA-based silencing of Delta/Notch signaling promotes multiple cilia formation. Cell Cycle 2011 Sep; 10(17): 2858-64.

Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi LE, Cibois M, Robbe-Sermesant K, Jolly T, Cardinaud B, Moreilhon C, Giovannini-Chami L, Nawrocki-Raby B, Birembaut P, Waldmann R, Kodjabachian L, Barbry P, Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway., Nat Cell Biol 2011 Jun; 13(6): 693-9.

Chevalier B, Kodjabachian L, Coraux C, Barbry P, Marcet B, [MicroRNA controls biosynthesis of motile cilia in vertebrates]., Med Sci (Paris) 2011; 27(6-7): 671-3.

Cardinaud B, Moreilhon C, Marcet B, Robbe-Sermesant K, LeBrigand K, Mari B, Eclache V, Cymbalista F, Raynaud S, Barbry P, miR-34b/miR-34c: a regulator of TCL1 expression in 11q-chronic lymphocytic leukaemia?, Leukemia 2009 Nov; 23(11): 2174-7.

Pottier N, Maurin T, Chevalier B, Puisségur MP, Lebrigand K, Robbe-Sermesant K, Bertero T, Lino Cardenas CL, Courcot E, Rios G, Fourre S, Lo-Guidice JM, Marcet B, Cardinaud B, Barbry P, Mari B, Identification of keratinocyte growth factor as a target of microRNA-155 in lung fibroblasts: implication in epithelial-mesenchymal interactions., PLoS One 2009 Aug; 4(8): e6718.

Relvas LJ, Bouffioux C, Marcet B, Communi D, Makhoul M, Horckmans M, Blero D, Bruyns C, Caspers L, Boeynaems JM, Willermain F, Extracellular nucleotides and interleukin-8 production by ARPE cells: potential role of danger signals in blood-retinal barrier activation., Invest Ophthalmol Vis Sci 2009 Mar; 50(3): 1241-6.

Marcet B, Libert F, Boeynaems JM, Communi D, Extracellular nucleotides induce COX-2 up-regulation and prostaglandin E2 production in human A549 alveolar type II epithelial cells., Eur J Pharmacol 2007 Jul; 566(1-3): 167-71.

Marcet B, Horckmans M, Libert F, Hassid S, Boeynaems JM, Communi D, Extracellular nucleotides regulate CCL20 release from human primary airway epithelial cells, monocytes and monocyte-derived dendritic cells., J Cell Physiol 2007 Jun; 211(3): 716-27.

Marcet B, Boeynaems JM, Relationships between cystic fibrosis transmembrane conductance regulator, extracellular nucleotides and cystic fibrosis., Pharmacol Ther 2006 Dec; 112(3): 719-32.

Horckmans M, Marcet B, Marteau F, Bulté F, Maho A, Parmentier M, Boeynaems JM, Communi D, Extracellular adenine nucleotides inhibit the release of major monocyte recruiters by human monocyte-derived dendritic cells., FEBS Lett 2006 Feb; 580(3): 747-54.

Matarazzo V, Clot-Faybesse O, Marcet B, Guiraudie-Capraz G, Atanasova B, Devauchelle G, Cerutti M, Etiévant P, Ronin C, Functional characterization of two human olfactory receptors expressed in the baculovirus Sf9 insect cell system., Chem Senses 2005 Mar; 30(3): 195-207.

V. Matarazzo, Olivier Clot-Faybesse, B. Marcet, Gaelle Guiraudie-Capraz, B. Atanasova, G. Devauchelle, M. Cerutti, P. Etiévant, Catherine Ronin, Functional characterization of two human olfactory receptors expressed in the baculovirus Sf9 insect cell system, Chemical Senses, 2005, 30, pp.195-207.

V. Matarazzo, Olivier Clot-Faybesse, B. Marcet, Gaelle Guiraudie-Capraz, Boriana Atanasova, O. Devauchelle, M. Cerutti, Patrick Etiévant, C. Ronin, Functional characterization of two human olfactory receptors expressed in the baculovirus Sf9 insect cell system, Chemical Senses, 2005, 30, pp.195-207.

Olivier Clos-Faybesse, V. Matarazzo, B. Marcet, G. Guiraudie-Capraz, G. Devauchelle, P. Etievant, M. Cerutti, C. Ronin, Functional expression of two olfactory receptors in the Baculovirus/insect system, Chemical Senses, 2005, 30, pp.195-207.

Marcet B, Chappe V, Delmas P, Verrier B, Pharmacological and signaling properties of endogenous P2Y1 receptors in cystic fibrosis transmembrane conductance regulator-expressing Chinese hamster ovary cells., J Pharmacol Exp Ther 2004 May; 309(2): 533-9.

Marcet B, Becq F, Norez C, Delmas P, Verrier B, General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels., Br J Pharmacol 2004 Mar; 141(6): 905-14.

B. Marcet, F. Becq, C. Norez, P. Delmas, Bernard Verrier, General anesthetic octanol and related compounds activate wild-type and delF508 cystic fibrosis chloride channels., British Journal of Pharmacology, 2004, 919, pp.919.

B. Marcet, V. Chappe, P. Delmas, Bernard Verrier, Pharmacological and signaling properties of endogenous P2Y1 receptors in cystic fibrosis transmembrane conductance regulator-expressing Chinese hamster overgrowth cells., Journal of Pharmacology and Experimental Therapeutics, 2004, pp.542.

Roubertoux PL, Sluyter F, Carlier M, Marcet B, Maarouf-Veray F, Chérif C, Marican C, Arrechi P, Godin F, Jamon M, Verrier B, Cohen-Salmon C, Mitochondrial DNA modifies cognition in interaction with the nuclear genome and age in mice., Nat Genet 2003 Sep; 35(1): 65-9.