Philippe BLANCOU – IPMC

Recherche

Intranet

Thème

Biographie pas encore disponible.

Événements

Thèse d'Alexandre BONDUE

« L’Électrostimulation du nerf splénique comme traitement de pathologies autoimmunes :Étude mécanistique appliquée à la Polyarthrite Rhumatoïde et la Sclérose en […]

Projets

Mucosal vaccine

A major goal of mucosal vaccines is to induce a local, rapid and effective immune response at the site of […]

Neural activity of splenic nerves as predictive biomarker of inflammatory arthritis relapses

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting approximately 1% of the population, and is characterized by joint inflammation […]

Stimulating pancreatic nerve to inhibit type 1 diabetes

Type 1 Diabetes (T1D) is an autoimmune disease with selective destruction of the pancreas’ insulin-producing cells by the patient’s own […]

Publications

Canali MM, Guyot M, Simon T, Daoudlarian D, Chabry J, Panzolini C, Petit-Paitel A, Hypolite N, Nicolas S, Bourdely P, Schmid-Antomarchi H, Schmid-Alliana A, Soria J, Karimdjee Soilihi B, Hofman P, Prevost-Blondel A, Kato M, Mougneau E, Glaichenhaus N, Blancou P, Environmental signals perceived by the brain abate pro-metastatic monocytes by dampening glucocorticoids receptor signaling., Cancer Cell Int 2023 Feb; 23(1): 15.

Simon T, Kirk J, Dolezalova N, Guyot M, Panzolini C, Bondue A, Lavergne J, Hugues S, Hypolite N, Saeb-Parsy K, Perkins J, Macia E, Sridhar A, Vervoordeldonk MJ, Glaichenhaus N, Donegá M, Blancou P, The cholinergic anti-inflammatory pathway inhibits inflammation without lymphocyte relay., Front Neurosci 2023 ; 17(): 1125492.

Martinuzzi E, Benzaquen J, Guerin O, Leroy S, Simon T, Ilie M, Hofman V, Allegra M, Tanga V, Michel E, Boutros J, Maniel C, Sicard A, Glaichenhaus N, Czerkinsky C, Blancou P, Hofman P, Marquette CH, A Single Dose of BNT162b2 Messenger RNA Vaccine Induces Airway Immunity in Severe Acute Respiratory Syndrome Coronavirus 2 Naive and Recovered Coronavirus Disease 2019 Subjects., Clin Infect Dis 2022 Dec; 75(12): 2053-2059.

Brinkman DJ, Simon T, Ten Hove AS, Zafeiropoulou K, Welting O, van Hamersveld PHP, Willemze RA, Yim AYFL, Verseijden C, Hakvoort TBM, Luyer MD, Vervoordeldonk MJ, Blancou P, de Jonge WJ, Electrical stimulation of the splenic nerve bundle ameliorates dextran sulfate sodium-induced colitis in mice., J Neuroinflammation 2022 Jun; 19(1): 155.

Massa F, Cremoni M, Gérard A, Grabsi H, Rogier L, Blois M, Couzin C, Hassen NB, Rouleau M, Barbosa S, Martinuzzi E, Fayada J, Bernard G, Favre G, Hofman P, Esnault VLM, Czerkinsky C, Seitz-Polski B, Glaichenhaus N, Sicard A, Safety and cross-variant immunogenicity of a three-dose COVID-19 mRNA vaccine regimen in kidney transplant recipients., EBioMedicine 2021 Nov; 73(): 103679.

Falvey A, Duprat F, Simon T, Hugues-Ascery S, Conde SV, Glaichenhaus N, Blancou P, Electrostimulation of the carotid sinus nerve in mice attenuates inflammation via glucocorticoid receptor on myeloid immune cells., J Neuroinflammation 2020 Dec; 17(1): 368.

Guyot M, Simon T, Ceppo F, Panzolini C, Guyon A, Lavergne J, Murris E, Daoudlarian D, Brusini R, Zarif H, Abélanet S, Hugues-Ascery S, Divoux JL, Lewis SJ, Sridhar A, Glaichenhaus N, Blancou P, Pancreatic nerve electrostimulation inhibits recent-onset autoimmune diabetes., Nat Biotechnol 2019 Dec; 37(12): 1446-1451.

Guyot M, Simon T, Panzolini C, Ceppo F, Daoudlarian D, Murris E, Macia E, Abélanet S, Sridhar A, Vervoordeldonk MJ, Glaichenhaus N, Blancou P, Apical splenic nerve electrical stimulation discloses an anti-inflammatory pathway relying on adrenergic and nicotinic receptors in myeloid cells., Brain Behav Immun 2019 Aug; 80(): 238-246.

Pogu J, Tzima S, Kollias G, Anegon I, Blancou P, Simon T, Genetic Restoration of Heme Oxygenase-1 Expression Protects from Type 1 Diabetes in NOD Mice., Int J Mol Sci 2019 Apr; 20(7): .

Paul Hofman, Nicholas Ayache, Pascal Barbry, Michel Barlaud, Audrey Bel, Philippe Blancou, Frédéric Checler, Sylvie Chevillard, Gael Cristofari, Mathilde Demory, Vincent Esnault, Claire Falandry, Eric Gilson, Olivier Guerin, Nicolas Glaichenhaus, Joël Guigay, Marius I. Ilie, Bernard Mari, Charles-Hugo Marquette, Véronique Paquis-Flucklinger, Frédéric Prate, Pierre Saintigny, Barbara Seitz-Polsky, Taycir Skhiri, Ellen van Obberghen-Schilling, Emmanuel Van Obberghen, Laurent Yvan-Charvet, The OncoAge Consortium: Linking Aging and Oncology from Bench to Bedside and Back Again, Cancers, 2019, 11 (2), pp.1-11. ⟨10.3390/cancers11020250⟩.

Willemze RA, Welting O, van Hamersveld P, Verseijden C, Nijhuis LE, Hilbers FW, Meijer SL, Heesters BA, Folgering JHA, Darwinkel H, Blancou P, Vervoordeldonk MJ, Seppen J, Heinsbroek SEM, de Jonge WJ, Loss of intestinal sympathetic innervation elicits an innate immune driven colitis., Mol Med 2019 Jan; 25(1): 1.

Simon T, Pogu J, Rémy S, Brau F, Pogu S, Maquigneau M, Fonteneau JF, Poirier N, Vanhove B, Blancho G, Piaggio E, Anegon I, Blancou P, Inhibition of effector antigen-specific T cells by intradermal administration of heme oxygenase-1 inducers., J Autoimmun 2017 Jul; 81(): 44-55.

Espinoza JA, León MA, Céspedes PF, Gómez RS, Canedo-Marroquín G, Riquelme SA, Salazar-Echegarai FJ, Blancou P, Simon T, Anegon I, Lay MK, González PA, Riedel CA, Bueno SM, Kalergis AM, Heme Oxygenase-1 Modulates Human Respiratory Syncytial Virus Replication and Lung Pathogenesis during Infection., J Immunol 2017 Jul; 199(1): 212-223.

White R, Chenciner N, Bonello G, Salas M, Blancou P, Gauduin MC, Epithelial stem cells as mucosal antigen-delivering cells: A novel AIDS vaccine approach., Vaccine 2015 Nov; 33(48): 6914-21.

Tardif V, Riquelme SA, Remy S, Carreño LJ, Cortés CM, Simon T, Hill M, Louvet C, Riedel CA, Blancou P, Bach JM, Chauveau C, Bueno SM, Anegon I, Kalergis AM, Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells., Eur J Immunol 2013 Nov; 43(11): 2832-44.

Hervé J, Dubreil L, Tardif V, Terme M, Pogu S, Anegon I, Rozec B, Gauthier C, Bach JM, Blancou P, β2-Adrenoreceptor agonist inhibits antigen cross-presentation by dendritic cells., J Immunol 2013 Apr; 190(7): 3163-71.

Simon T, Pogu S, Tardif V, Rigaud K, Rémy S, Piaggio E, Bach JM, Anegon I, Blancou P, Carbon monoxide-treated dendritic cells decrease β1-integrin induction on CD8⁺ T cells and protect from type 1 diabetes., Eur J Immunol 2013 Jan; 43(1): 209-18.

Simon T, Anegon I, Blancou P, Heme oxygenase and carbon monoxide as an immunotherapeutic approach in transplantation and cancer., Immunotherapy 2011 Apr; 3(4 Suppl): 15-8.

Blancou P, Tardif V, Simon T, Rémy S, Carreño L, Kalergis A, Anegon I, Immunoregulatory properties of heme oxygenase-1., Methods Mol Biol 2011 ; 677(): 247-68.

Hill M, Deghmane AE, Segovia M, Zarantonelli ML, Tilly G, Blancou P, Bériou G, Josien R, Anegon I, Hong E, Ruckly C, Antignac A, El Ghachi M, Boneca IG, Taha MK, Cuturi MC, Penicillin binding proteins as danger signals: meningococcal penicillin binding protein 2 activates dendritic cells through Toll-like receptor 4., PLoS One 2011 ; 6(10): e23995.

Blancou P, Anegon I, Editorial: Heme oxygenase-1 and dendritic cells: what else?, J Leukoc Biol 2010 Feb; 87(2): 185-7.

Rémy S, Blancou P, Tesson L, Tardif V, Brion R, Royer PJ, Motterlini R, Foresti R, Painchaut M, Pogu S, Gregoire M, Bach JM, Anegon I, Chauveau C, Carbon monoxide inhibits TLR-induced dendritic cell immunogenicity., J Immunol 2009 Feb; 182(4): 1877-84.

Martinuzzi E, Novelli G, Scotto M, Blancou P, Bach JM, Chaillous L, Bruno G, Chatenoud L, van Endert P, Mallone R, The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment., Diabetes 2008 May; 57(5): 1312-20.

Enée E, Martinuzzi E, Blancou P, Bach JM, Mallone R, van Endert P, Equivalent specificity of peripheral blood and islet-infiltrating CD8+ T lymphocytes in spontaneously diabetic HLA-A2 transgenic NOD mice., J Immunol 2008 Apr; 180(8): 5430-8.

Blancou P, Mallone R, Martinuzzi E, Sévère S, Pogu S, Novelli G, Bruno G, Charbonnel B, Dolz M, Chaillous L, van Endert P, Bach JM, Immunization of HLA class I transgenic mice identifies autoantigenic epitopes eliciting dominant responses in type 1 diabetes patients., J Immunol 2007 Jun; 178(11): 7458-66.

Mallone R, Martinuzzi E, Blancou P, Novelli G, Afonso G, Dolz M, Bruno G, Chaillous L, Chatenoud L, Bach JM, van Endert P, CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes., Diabetes 2007 Mar; 56(3): 613-21.

Philippe Blancou, R Mallone, E Martinuzzi, Sabine Sévère, Sylvie Pogu, Karine Haurogné, P van Endert, Jean-Marie Bach, HLA-A2-restricted islet-reactive CD8+ T-cells in type 1 diabetes, ECI, 2006, Paris, France. pp.Inconnu.

van Endert P, Hassainya Y, Lindo V, Bach JM, Blancou P, Lemonnier F, Mallone R, HLA class I epitope discovery in type 1 diabetes., Ann N Y Acad Sci 2006 Oct; 1079(): 190-7.

Blancou P, Evans DT, Desrosiers RC, PRA1 co-localizes with envelope but does not influence primate lentivirus production, infectivity or envelope incorporation., J Gen Virol 2005 Jun; 86(Pt 6): 1785-1790.

Blancou P, Chenciner N, Ho Tsong Fang R, Monceaux V, Cumont MC, Guétard D, Hurtrel B, Wain-Hobson S, Simian immunodeficiency virus promoter exchange results in a highly attenuated strain that protects against uncloned challenge virus., J Virol 2004 Feb; 78(3): 1080-92.

Blancou P, Chenciner N, Cumont MC, Wain-Hobson S, Hurtrel B, Cheynier R, The infiltration kinetics of simian immunodeficiency virus-specific T cells drawn to sites of high antigenic stimulation determines local in vivo viral escape., Proc Natl Acad Sci U S A 2001 Nov; 98(23): 13237-42.

Blancou P, Vartanian JP, Christopherson C, Chenciner N, Basilico C, Kwok S, Wain-Hobson S, Polio vaccine samples not linked to AIDS., Nature 2001 Apr; 410(6832): 1045-6.