Thomas SIMON – IPMC

Recherche

Intranet

Thème

Philippe BLANCOU

Présentation

Expertise:

Immunology, Autoimmunity, Neuromodulation, Bioelectronic medicine, Electrostimulation

Événements

Thèse d'Alexandre BONDUE

« L’Électrostimulation du nerf splénique comme traitement de pathologies autoimmunes :Étude mécanistique appliquée à la Polyarthrite Rhumatoïde et la Sclérose en […]

Projets

Splenic nerve stimulation to reduce inflammation-driven Parkinson’sprogression and LRRK2 mutation-driven Parkinson’s risk

Study Rationale: Splenic nerve stimulation involves implanting a small device in the body that electrically stimulates the nerve going to […]

Stimulating splenic nerve to inhibit Rheumatoid Arthritis

Splenic Nerve Electrostimulation (SpNES) The autonomic nervous system innervates all lymphoid tissues including the spleen therefore providing a link between […]

Mucosal vaccine

A major goal of mucosal vaccines is to induce a local, rapid and effective immune response at the site of […]

Neural activity of splenic nerves as predictive biomarker of inflammatory arthritis relapses

Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting approximately 1% of the population, and is characterized by joint inflammation […]

Stimulating pancreatic nerve to inhibit type 1 diabetes

Type 1 Diabetes (T1D) is an autoimmune disease with selective destruction of the pancreas’ insulin-producing cells by the patient’s own […]

Publications

Canali MM, Guyot M, Simon T, Daoudlarian D, Chabry J, Panzolini C, Petit-Paitel A, Hypolite N, Nicolas S, Bourdely P, Schmid-Antomarchi H, Schmid-Alliana A, Soria J, Karimdjee Soilihi B, Hofman P, Prevost-Blondel A, Kato M, Mougneau E, Glaichenhaus N, Blancou P, Environmental signals perceived by the brain abate pro-metastatic monocytes by dampening glucocorticoids receptor signaling., Cancer Cell Int 2023 Feb; 23(1): 15.

Simon T, Kirk J, Dolezalova N, Guyot M, Panzolini C, Bondue A, Lavergne J, Hugues S, Hypolite N, Saeb-Parsy K, Perkins J, Macia E, Sridhar A, Vervoordeldonk MJ, Glaichenhaus N, Donegá M, Blancou P, The cholinergic anti-inflammatory pathway inhibits inflammation without lymphocyte relay., Front Neurosci 2023 ; 17(): 1125492.

Martinuzzi E, Benzaquen J, Guerin O, Leroy S, Simon T, Ilie M, Hofman V, Allegra M, Tanga V, Michel E, Boutros J, Maniel C, Sicard A, Glaichenhaus N, Czerkinsky C, Blancou P, Hofman P, Marquette CH, A Single Dose of BNT162b2 Messenger RNA Vaccine Induces Airway Immunity in Severe Acute Respiratory Syndrome Coronavirus 2 Naive and Recovered Coronavirus Disease 2019 Subjects., Clin Infect Dis 2022 Dec; 75(12): 2053-2059.

Saxena V, Piao W, Li L, Paluskievicz C, Xiong Y, Simon T, Lakhan R, Brinkman CC, Walden S, Hippen KL, WillsonShirkey M, Lee YS, Wagner C, Blazar BR, Bromberg JS, Treg tissue stability depends on lymphotoxin beta-receptor- and adenosine-receptor-driven lymphatic endothelial cell responses., Cell Rep 2022 Apr; 39(3): 110727.

Brinkman DJ, Simon T, Ten Hove AS, Zafeiropoulou K, Welting O, van Hamersveld PHP, Willemze RA, Yim AYFL, Verseijden C, Hakvoort TBM, Luyer MD, Vervoordeldonk MJ, Blancou P, de Jonge WJ, Electrical stimulation of the splenic nerve bundle ameliorates dextran sulfate sodium-induced colitis in mice., J Neuroinflammation 2022 Jun; 19(1): 155.

Bromberg JS, Hittle L, Xiong Y, Saxena V, Smyth EM, Li L, Zhang T, Wagner C, Fricke WF, Simon T, Brinkman CC, Mongodin EF, Gut microbiota-dependent modulation of innate immunity and lymph node remodeling affects cardiac allograft outcomes., JCI Insight 2020 Aug; 5(15): .

Li L, Shirkey MW, Zhang T, Xiong Y, Piao W, Saxena V, Paluskievicz C, Lee Y, Toney N, Cerel BM, Li Q, Simon T, Smith KD, Hippen KL, Blazar BR, Abdi R, Bromberg JS, The lymph node stromal laminin α5 shapes alloimmunity., J Clin Invest 2020 May; 130(5): 2602-2619.

Falvey A, Duprat F, Simon T, Hugues-Ascery S, Conde SV, Glaichenhaus N, Blancou P, Electrostimulation of the carotid sinus nerve in mice attenuates inflammation via glucocorticoid receptor on myeloid immune cells., J Neuroinflammation 2020 Dec; 17(1): 368.

Simon T, Li L, Wagner C, Zhang T, Saxena V, Brinkman CC, Tostanoski LH, Ostrand-Rosenberg S, Jewell C, Shea-Donohue T, Hippen K, Blazar B, Abdi R, Bromberg JS, Differential Regulation of T-cell Immunity and Tolerance by Stromal Laminin Expressed in the Lymph Node., Transplantation 2019 Oct; 103(10): 2075-2089.

Guyot M, Simon T, Ceppo F, Panzolini C, Guyon A, Lavergne J, Murris E, Daoudlarian D, Brusini R, Zarif H, Abélanet S, Hugues-Ascery S, Divoux JL, Lewis SJ, Sridhar A, Glaichenhaus N, Blancou P, Pancreatic nerve electrostimulation inhibits recent-onset autoimmune diabetes., Nat Biotechnol 2019 Dec; 37(12): 1446-1451.

Guyot M, Simon T, Panzolini C, Ceppo F, Daoudlarian D, Murris E, Macia E, Abélanet S, Sridhar A, Vervoordeldonk MJ, Glaichenhaus N, Blancou P, Apical splenic nerve electrical stimulation discloses an anti-inflammatory pathway relying on adrenergic and nicotinic receptors in myeloid cells., Brain Behav Immun 2019 Aug; 80(): 238-246.

Pogu J, Tzima S, Kollias G, Anegon I, Blancou P, Simon T, Genetic Restoration of Heme Oxygenase-1 Expression Protects from Type 1 Diabetes in NOD Mice., Int J Mol Sci 2019 Apr; 20(7): .

Piao W, Xiong Y, Famulski K, Brinkman CC, Li L, Toney N, Wagner C, Saxena V, Simon T, Bromberg JS, Regulation of T cell afferent lymphatic migration by targeting LTβR-mediated non-classical NFκB signaling., Nat Commun 2018 Aug; 9(1): 3020.

Ashari N, Pang HW, Simon T, Xiong Y, Coburn JM, Bromberg JS, Kaplan DL, McLenithan J, Fontaine MJ, Silk fibroin preserves beta cell function under inflammatory stress while stimulating islet cell surface GLUT2 expression., Cell Immunol 2018 Jul; 329(): 10-16.

Casaos J, Huq S, Lott T, Felder R, Choi J, Gorelick N, Peters M, Xia Y, Maxwell R, Zhao T, Ji C, Simon T, Sesen J, Scotland SJ, Kast RE, Rubens J, Raabe E, Eberhart CG, Jackson EM, Brem H, Tyler B, Skuli N, Ribavirin as a potential therapeutic for atypical teratoid/rhabdoid tumors., Oncotarget 2018 Jan; 9(8): 8054-8067.

Simon T, Bromberg JS, Regulation of the Immune System by Laminins., Trends Immunol 2017 Nov; 38(11): 858-871.

Simon T, Pogu J, Rémy S, Brau F, Pogu S, Maquigneau M, Fonteneau JF, Poirier N, Vanhove B, Blancho G, Piaggio E, Anegon I, Blancou P, Inhibition of effector antigen-specific T cells by intradermal administration of heme oxygenase-1 inducers., J Autoimmun 2017 Jul; 81(): 44-55.

Espinoza JA, León MA, Céspedes PF, Gómez RS, Canedo-Marroquín G, Riquelme SA, Salazar-Echegarai FJ, Blancou P, Simon T, Anegon I, Lay MK, González PA, Riedel CA, Bueno SM, Kalergis AM, Heme Oxygenase-1 Modulates Human Respiratory Syncytial Virus Replication and Lung Pathogenesis during Infection., J Immunol 2017 Jul; 199(1): 212-223.

Simon T, Bromberg JS, BTLA+ Dendritic Cells: The Regulatory T Cell Force Awakens., Immunity 2016 Nov; 45(5): 956-958.

Tostanoski LH, Chiu YC, Gammon JM, Simon T, Andorko JI, Bromberg JS, Jewell CM, Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific., Cell Rep 2016 Sep; 16(11): 2940-2952.

Brinkman CC, Iwami D, Hritzo MK, Xiong Y, Ahmad S, Simon T, Hippen KL, Blazar BR, Bromberg JS, Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration., Nat Commun 2016 Jun; 7(): 12021.

Bromberg JS, Fricke WF, Brinkman CC, Simon T, Mongodin EF, Microbiota—implications for immunity and transplantation., Nat Rev Nephrol 2015 Jun; 11(6): 342-53.

Mackern-Oberti JP, Riquelme SA, Llanos C, Schmidt CB, Simon T, Anegon I, Jara E, Riedel CA, Bueno SM, Kalergis AM, Heme oxygenase-1 as a target for the design of gene and pharmaceutical therapies for autoimmune diseases., Curr Gene Ther 2014 ; 14(3): 218-35.

Simon T, Fonteneau JF, Grégoire M, Requirement of tumor-associated antigen-specific CD4+ T cells for an efficient dendritic cell vaccine in antitumor immunotherapy., Immunotherapy 2013 Jun; 5(6): 565-7.

Tardif V, Riquelme SA, Remy S, Carreño LJ, Cortés CM, Simon T, Hill M, Louvet C, Riedel CA, Blancou P, Bach JM, Chauveau C, Bueno SM, Anegon I, Kalergis AM, Carbon monoxide decreases endosome-lysosome fusion and inhibits soluble antigen presentation by dendritic cells to T cells., Eur J Immunol 2013 Nov; 43(11): 2832-44.

Simon T, Pogu S, Tardif V, Rigaud K, Rémy S, Piaggio E, Bach JM, Anegon I, Blancou P, Carbon monoxide-treated dendritic cells decrease β1-integrin induction on CD8⁺ T cells and protect from type 1 diabetes., Eur J Immunol 2013 Jan; 43(1): 209-18.

Frikeche J, Simon T, Brissot E, Grégoire M, Gaugler B, Mohty M, Impact of valproic acid on dendritic cells function., Immunobiology 2012 Jul; 217(7): 704-10.

Simon T, Tanguy-Royer S, Royer PJ, Boisgerault N, Frikeche J, Fonteneau JF, Grégoire M, Human dendritic cells sequentially matured with CD4(+) T cells as a secondary signal favor CTL and long-term T memory cell responses., Biol Res 2012 ; 45(1): 33-43.

Simon T, Anegon I, Blancou P, Heme oxygenase and carbon monoxide as an immunotherapeutic approach in transplantation and cancer., Immunotherapy 2011 Apr; 3(4 Suppl): 15-8.

Blancou P, Tardif V, Simon T, Rémy S, Carreño L, Kalergis A, Anegon I, Immunoregulatory properties of heme oxygenase-1., Methods Mol Biol 2011 ; 677(): 247-68.

Simon T, Fonteneau JF, Grégoire M, Dendritic cell preparation for immunotherapeutic interventions., Immunotherapy 2009 Mar; 1(2): 289-302.

Royer PJ, Bougras G, Ebstein F, Leveque L, Tanguy-Royer S, Simon T, Juge-Morineau N, Chevallier P, Harousseau JL, Gregoire M, Efficient monocyte-derived dendritic cell generation in patients with acute myeloid leukemia after chemotherapy treatment: application to active immunotherapy., Exp Hematol 2008 Mar; 36(3): 329-39.

Royer PJ, Tanguy-Royer S, Ebstein F, Sapede C, Simon T, Barbieux I, Oger R, Gregoire M, Culture medium and protein supplementation in the generation and maturation of dendritic cells., Scand J Immunol 2006 Jun; 63(6): 401-9.