Laure-Emmanuelle ZARAGOSI – IPMC

Recherche

Intranet

Thème

Maria CAPOVILLA

Présentation

Laure-Emmanuelle ZARAGOSI is a Senior Research Scientist (Chargée de recherche hors classe) at Inserm, specializing in cellular and molecular biology. Her scientific career has been marked by significant advances in the understanding of microRNAs, particularly their roles in various differentiation processes and their functional complementarity with host genes.

Her current research focuses on the cellular and molecular mechanisms that govern the regeneration of the human airway epithelium. She is an active member of the international Human Lung Cell Atlas consortium, which aims to create a comprehensive molecular map of all cell types in the human lung. In this context, she contributed to the development of the first cellular atlas of the human airways using biopsies from healthy donors and single-cell RNA sequencing technologies.

Her recent work investigates the molecular mechanisms underlying secretory cell hyperplasia, a pathological feature observed in chronic respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), and cystic fibrosis.

https://scienceazur.univ-cotedazur.fr/portraits/laure-emanuelle-zaragosi

Événements

Symposium of the Trans Mucus Network

Actualités

SFBBM - Prix Maurice Nicloux 2025

Le prix Maurice Nicloux est attribué à Laure-Emmanuelle Zaragosi Lien vers la SFBBM

Prix d'excellence Université Côte d'Azur 2025

Université Côte d’Azur met à l’honneur chercheurs et étudiants qui ont été récompensé.e.s par des prix prestigieux pour leur contribution […]

Publications

Serizay J, Khoury Damaa M, Boudjema AR, Balagué R, Faucourt M, Delgehyr N, Noûs C, Zaragosi LE, Barbry P, Spassky N, Koszul R, Meunier A, Cyclin switch tailors a cell cycle variant to orchestrate multiciliogenesis., Cell Rep 2025 Jan; 44(1): 115103.

Khoury Damaa M, Serizay J, Balagué R, Boudjema AR, Faucourt M, Delgehyr N, Goh KJ, Lu H, Tan EK, James CT, Faucon C, Mitri R, Bracht DC, Bingle CD, Dunn NR, Arnold SJ, Zaragosi LE, Barbry P, Koszul R, Omran H, Gil-Gómez G, Escudier E, Legendre M, Roy S, Spassky N, Meunier A, Cyclin O controls entry into the cell-cycle variant required for multiciliated cell differentiation., Cell Rep 2025 Jan; 44(1): 115117.

Redman E, Fierville M, Cavard A, Plaisant M, Arguel MJ, Ruiz Garcia S, McAndrew EM, Girard-Riboulleau C, Lebrigand K, Magnone V, Ponzio G, Gras D, Chanez P, Abelanet S, Barbry P, Marcet B, Zaragosi LE, Cell Culture Differentiation and Proliferation Conditions Influence the In Vitro Regeneration of the Human Airway Epithelium., Am J Respir Cell Mol Biol 2024 Sep; 71(3): 267-281.

Dougherty GW, Ostrowski LE, Nöthe-Menchen T, Raidt J, Schramm A, Olbrich H, Yin W, Sears PR, Dang H, Smith AJ, Beule AG, Hjeij R, Rutjes N, Haarman EG, Maas SM, Ferkol TW, Noone PG, Olivier KN, Bracht DC, Barbry P, Zaragosi LE, Fierville M, Kliesch S, Wohlgemuth K, König J, George S, Loges NT, Ceppe A, Markovetz MR, Luo H, Guo T, Rizk H, Eldesoky T, Dahlke K, Boldt K, Ueffing M, Hill DB, Pang YP, Knowles MR, Zariwala MA, Omran H, Recessively Inherited Deficiency of Secreted WFDC2 (HE4) Causes Nasal Polyposis and Bronchiectasis., Am J Respir Crit Care Med 2024 Jul; 210(1): 63-76.

Zaragosi LE, Gouleau A, Delin M, Lebrigand K, Arguel MJ, Girard-Riboulleau C, Rios G, Redman E, Plaisant M, Waldmann R, Magnone V, Marcet B, Barbry P, Ponzio G, Combination of CRISPR-Cas9-RNP and Single-Cell RNAseq to Identify Cell State-Specific FOXJ1 Functions in the Human Airway Epithelium., Methods Mol Biol 2024 ; 2725(): 1-25.

Sikkema L, Ramírez-Suástegui C, Strobl DC, Gillett TE, Zappia L, Madissoon E, Markov NS, Zaragosi LE, Ji Y, Ansari M, Arguel MJ, Apperloo L, Banchero M, Bécavin C, Berg M, Chichelnitskiy E, Chung MI, Collin A, Gay ACA, Gote-Schniering J, Hooshiar Kashani B, Inecik K, Jain M, Kapellos TS, Kole TM, Leroy S, Mayr CH, Oliver AJ, von Papen M, Peter L, Taylor CJ, Walzthoeni T, Xu C, Bui LT, De Donno C, Dony L, Faiz A, Guo M, Gutierrez AJ, Heumos L, Huang N, Ibarra IL, Jackson ND, Kadur Lakshminaras..., An integrated cell atlas of the lung in health and disease., Nat Med 2023 Jun; 29(6): 1563-1577.

Luecken MD, Zaragosi LE, Madissoon E, Sikkema L, Firsova AB, De Domenico E, Kümmerle L, Saglam A, Berg M, Gay ACA, Schniering J, Mayr CH, Abalo XM, Larsson L, Sountoulidis A, Teichmann SA, van Eunen K, Koppelman GH, Saeb-Parsy K, Leroy S, Powell P, Sarkans U, Timens W, Lundeberg J, van den Berge M, Nilsson M, Horváth P, Denning J, Papatheodorou I, Schultze JL, Schiller HB, Barbry P, Petoukhov I, Misharin AV, Adcock IM, von Papen M, Theis FJ, Samakovlis C, Meyer KB, Nawijn MC, The discovAIR project: a roadmap towards the Human Lung Cell Atlas., Eur Respir J 2022 Aug; 60(2): .

Bui LT, Winters NI, Chung MI, Joseph C, Gutierrez AJ, Habermann AC, Adams TS, Schupp JC, Poli S, Peter LM, Taylor CJ, Blackburn JB, Richmond BW, Nicholson AG, Rassl D, Wallace WA, Rosas IO, Jenkins RG, Kaminski N, Kropski JA, Banovich NE, Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity., Nat Commun 2021 Jul; 12(1): 4314.

Legendre M, Zaragosi LE, Mitchison HM, Motile cilia and airway disease., Semin Cell Dev Biol 2021 Feb; 110(): 19-33.

Bui LT, Winters NI, Chung MI, Joseph C, Gutierrez AJ, Habermann AC, Adams TS, Schupp JC, Poli S, Peter LM, Taylor CJ, Blackburn JB, Richmond BW, Nicholson AG, Rassl D, Wallace WA, Rosas IO, Jenkins RG, Kaminski N, Kropski JA, Banovich NE, Chronic lung diseases are associated with gene expression programs favoring SARS-CoV-2 entry and severity., bioRxiv 2021 Jan; (): .

Bernardes JP, Mishra N, Tran F, Bahmer T, Best L, Blase JI, Bordoni D, Franzenburg J, Geisen U, Josephs-Spaulding J, Köhler P, Künstner A, Rosati E, Aschenbrenner AC, Bacher P, Baran N, Boysen T, Brandt B, Bruse N, Dörr J, Dräger A, Elke G, Ellinghaus D, Fischer J, Forster M, Franke A, Franzenburg S, Frey N, Friedrichs A, Fuß J, Glück A, Hamm J, Hinrichsen F, Hoeppner MP, Imm S, Junker R, Kaiser S, Kan YH, Knoll R, Lange C, Laue G, Lier C, Lindner M, Marinos G, Markewitz R, Nattermann J, N..., Longitudinal Multi-omics Analyses Identify Responses of Megakaryocytes, Erythroid Cells, and Plasmablasts as Hallmarks of Severe COVID-19., Immunity 2020 Dec; 53(6): 1296-1314.e9.

Deprez M, Zaragosi LE, Truchi M, Becavin C, Ruiz García S, Arguel MJ, Plaisant M, Magnone V, Lebrigand K, Abelanet S, Brau F, Paquet A, Pe'er D, Marquette CH, Leroy S, Barbry P, A Single-Cell Atlas of the Human Healthy Airways., Am J Respir Crit Care Med 2020 Dec; 202(12): 1636-1645.

Tucker NR, Chaffin M, Bedi KC, Papangeli I, Akkad AD, Arduini A, Hayat S, Eraslan G, Muus C, Bhattacharyya RP, Stegmann CM, , Margulies KB, Ellinor PT, Myocyte-Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2-Mediated Myocarditis., Circulation 2020 Aug; 142(7): 708-710.

Bottini S, Hamouda-Tekaya N, Mategot R, Zaragosi LE, Audebert S, Pisano S, Grandjean V, Mauduit C, Benahmed M, Barbry P, Repetto E, Trabucchi M, Post-transcriptional gene silencing mediated by microRNAs is controlled by nucleoplasmic Sfpq., Nat Commun 2017 Oct; 8(1): 1189.

Pousinha PA, Mouska X, Raymond EF, Gwizdek C, Dhib G, Poupon G, Zaragosi LE, Giudici C, Bethus I, Pacary E, Willem M, Marie H, Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein., Elife 2017 Jul; 6(): .

Bottini S, Hamouda-Tekaya N, Tanasa B, Zaragosi LE, Grandjean V, Repetto E, Trabucchi M, From benchmarking HITS-CLIP peak detection programs to a new method for identification of miRNA-binding sites from Ago2-CLIP data., Nucleic Acids Res 2017 May; 45(9): e71.

Arguel MJ, LeBrigand K, Paquet A, Ruiz García S, Zaragosi LE, Barbry P, Waldmann R, A cost effective 5΄ selective single cell transcriptome profiling approach with improved UMI design., Nucleic Acids Res 2017 Apr; 45(7): e48.

Mercey O, Popa A, Cavard A, Paquet A, Chevalier B, Pons N, Magnone V, Zangari J, Brest P, Zaragosi LE, Ponzio G, Lebrigand K, Barbry P, Marcet B, Characterizing isomiR variants within the microRNA-34/449 family., FEBS Lett 2017 Mar; 591(5): 693-705.

Repetto E, Lichtenstein L, Hizir Z, Tekaya N, Benahmed M, Ruidavets JB, Zaragosi LE, Perret B, Bouchareychas L, Genoux A, Lotte R, Ruimy R, Ferrières J, Barbry P, Martinez LO, Trabucchi M, RNY-derived small RNAs as a signature of coronary artery disease., BMC Med 2015 Oct; 13(): 259.

Chevalier B, Adamiok A, Mercey O, Revinski DR, Zaragosi LE, Pasini A, Kodjabachian L, Barbry P, Marcet B, miR-34/449 control apical actin network formation during multiciliogenesis through small GTPase pathways., Nat Commun 2015 Sep; 6(): 8386.

Cibois M, Luxardi G, Chevalier B, Thomé V, Mercey O, Zaragosi LE, Barbry P, Pasini A, Marcet B, Kodjabachian L, BMP signalling controls the construction of vertebrate mucociliary epithelia., Development 2015 Jul; 142(13): 2352-63.

Zaragosi LE, Dadone B, Michiels JF, Marty M, Pedeutour F, Dani C, Bianchini L, Syndecan-1 regulates adipogenesis: new insights in dedifferentiated liposarcoma tumorigenesis., Carcinogenesis 2015 Jan; 36(1): 32-40.

Barbry P, Zaragosi LE, An ABC of ciliogenesis., Nat Cell Biol 2014 Sep; 16(9): 826-7.

Villageois P, Wdziekonski B, Zaragosi LE, Plaisant M, Mohsen-Kanson T, Lay N, Ladoux A, Peraldi P, Dani C, Regulators of human adipose-derived stem cell self-renewal., Am J Stem Cells 2012 ; 1(1): 42-7.

Zaragosi LE, Wdziekonski B, Brigand KL, Villageois P, Mari B, Waldmann R, Dani C, Barbry P, Small RNA sequencing reveals miR-642a-3p as a novel adipocyte-specific microRNA and miR-30 as a key regulator of human adipogenesis., Genome Biol 2011 Jul; 12(7): R64.

Simonet T, Zaragosi LE, Philippe C, Lebrigand K, Schouteden C, Augereau A, Bauwens S, Ye J, Santagostino M, Giulotto E, Magdinier F, Horard B, Barbry P, Waldmann R, Gilson E, The human TTAGGG repeat factors 1 and 2 bind to a subset of interstitial telomeric sequences and satellite repeats., Cell Res 2011 Jul; 21(7): 1028-38.

Marcet B, Chevalier B, Luxardi G, Coraux C, Zaragosi LE, Cibois M, Robbe-Sermesant K, Jolly T, Cardinaud B, Moreilhon C, Giovannini-Chami L, Nawrocki-Raby B, Birembaut P, Waldmann R, Kodjabachian L, Barbry P, Control of vertebrate multiciliogenesis by miR-449 through direct repression of the Delta/Notch pathway., Nat Cell Biol 2011 Jun; 13(6): 693-9.

Zaragosi LE, Wdziekonski B, Villageois P, Keophiphath M, Maumus M, Tchkonia T, Bourlier V, Mohsen-Kanson T, Ladoux A, Elabd C, Scheideler M, Trajanoski Z, Takashima Y, Amri EZ, Lacasa D, Sengenes C, Ailhaud G, Clément K, Bouloumie A, Kirkland JL, Dani C, Activin a plays a critical role in proliferation and differentiation of human adipose progenitors., Diabetes 2010 Oct; 59(10): 2513-21.

Elabd C, Basillais A, Beaupied H, Breuil V, Wagner N, Scheideler M, Zaragosi LE, Massiéra F, Lemichez E, Trajanoski Z, Carle G, Euller-Ziegler L, Ailhaud G, Benhamou CL, Dani C, Amri EZ, Oxytocin controls differentiation of human mesenchymal stem cells and reverses osteoporosis., Stem Cells 2008 Sep; 26(9): 2399-407.

Scheideler M, Elabd C, Zaragosi LE, Chiellini C, Hackl H, Sanchez-Cabo F, Yadav S, Duszka K, Friedl G, Papak C, Prokesch A, Windhager R, Ailhaud G, Dani C, Amri EZ, Trajanoski Z, Comparative transcriptomics of human multipotent stem cells during adipogenesis and osteoblastogenesis., BMC Genomics 2008 Jul; 9(): 340.

Zaragosi LE, Wdziekonski B, Fontaine C, Villageois P, Peraldi P, Dani C, Effects of GSK3 inhibitors on in vitro expansion and differentiation of human adipose-derived stem cells into adipocytes., BMC Cell Biol 2008 Feb; 9(): 11.

Elabd C, Chiellini C, Massoudi A, Cochet O, Zaragosi LE, Trojani C, Michiels JF, Weiss P, Carle G, Rochet N, Dechesne CA, Ailhaud G, Dani C, Amri EZ, Human adipose tissue-derived multipotent stem cells differentiate in vitro and in vivo into osteocyte-like cells., Biochem Biophys Res Commun 2007 Sep; 361(2): 342-8.

Zaragosi LE, Billon N, Ailhaud G, Dani C, Nucleofection is a valuable transfection method for transient and stable transgene expression in adipose tissue-derived stem cells., Stem Cells 2007 Mar; 25(3): 790-7.

Zaragosi LE, Ailhaud G, Dani C, Autocrine fibroblast growth factor 2 signaling is critical for self-renewal of human multipotent adipose-derived stem cells., Stem Cells 2006 Nov; 24(11): 2412-9.