Eric HONORE – IPMC

Recherche

Intranet

Thème

Présentation

Chef d’équipe

Événements

Eric HONORE invite le Dr. Al-Jamal KHULOUD

« Drug Delivery to Brain, Cancer & Beyond »

Projets

Project 1: Obesity under pressure

The increase in the prevalence of overweight/obese people worldwide has reached epidemic proportions, with at least 600 million clinically obese […]

Project 2: Piezo1 in pulmonary hypertension

The pulmonary circulation is a low-pressure low resistance system allowing the whole cardiac output to cross the lung 52-54. Pulmonary […]

Project 3: Role of macrophage Piezo1 in atherosclerosis

Atherosclerosis (AS) is a metabolic and inflammatory disease of the large arteries 58-61. Coronary artery disease is the most common […]

Project 4: Opening Piezo1 in red blood cells to fight malaria

In our group, Dominique Douguet develops computational methods and creates databases for virtual screening and de novo molecular design, drug […]

Publications

Glogowska E, Jose GP, Dias Araújo AR, Arhatte M, Divita R, Borowczyk C, Barouillet T, Wang B, Brau F, Peyronnet R, Patel A, Mesmin B, Harayama T, Antonny B, Xu A, Yvan-Charvet L, Honoré E, Potentiation of macrophage Piezo1 by atherogenic 7-ketocholesterol., Cell Rep 2025 Apr; 44(4): 115542.

Knoepp F, Abid S, Houssaini A, Lipskaia L, Gökyildirim MY, Born E, Marcos E, Arhatte M, Glogowska E, Vienney N, Günther A, Kraut S, Breitenborn-Mueller I, Quanz K, Fenner-Nau D, Derumeaux G, Weissmann N, Honoré E, Adnot S, Piezo1 in PASMCs: Critical for Hypoxia-Induced Pulmonary Hypertension Development., Circ Res 2025 Apr; (): .

Lohia R, Allegrini B, Berry L, Guizouarn H, Cerdan R, Abkarian M, Douguet D, Honoré E, Wengelnik K, Pharmacological activation of PIEZO1 in human red blood cells prevents Plasmodium falciparum invasion., Cell Mol Life Sci 2023 Apr; 80(5): 124.

Diaz-Canestro C, Chen J, Liu Y, Han H, Wang Y, Honoré E, Lee CH, Lam KSL, Tse MA, Xu A, A machine-learning algorithm integrating baseline serum proteomic signatures predicts exercise responsiveness in overweight males with prediabetes., Cell Rep Med 2023 Feb; 4(2): 100944.

Chen K, Cheong LY, Gao Y, Zhang Y, Feng T, Wang Q, Jin L, Honoré E, Lam KSL, Wang W, Hui X, Xu A, Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects., Nat Commun 2022 Dec; 13(1): 7838.

Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, Honoré E, Offermanns S, Author Correction: Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice., Nat Commun 2022 Jul; 13(1): 4058.

Glogowska E, Arhatte M, Chatelain FC, Lesage F, Xu A, Grashoff C, Discher DE, Patel A, Honoré E, Piezo1 and Piezo2 foster mechanical gating of K2P channels., Cell Rep 2021 Nov; 37(9): 110070.

Wang S, Cao S, Arhatte M, Li D, Shi Y, Kurz S, Hu J, Wang L, Shao J, Atzberger A, Wang Z, Wang C, Zang W, Fleming I, Wettschureck N, Honoré E, Offermanns S, Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice., Nat Commun 2020 May; 11(1): 2303.

Douguet D, Patel A, Xu A, Vanhoutte PM, Honoré E, Piezo Ion Channels in Cardiovascular Mechanobiology., Trends Pharmacol Sci 2019 Dec; 40(12): 956-970.

Douguet D, Honoré E, Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels., Cell 2019 Oct; 179(2): 340-354.

Douguet D, Patel A, Honoré E, Structure and function of polycystins: insights into polycystic kidney disease., Nat Rev Nephrol 2019 Jul; 15(7): 412-422.

Arhatte M, Gunaratne GS, El Boustany C, Kuo IY, Moro C, Duprat F, Plaisant M, Duval H, Li D, Picard N, Couvreux A, Duranton C, Rubera I, Pagnotta S, Lacas-Gervais S, Ehrlich BE, Marchant JS, Savage AM, van Eeden FJM, Wilkinson RN, Demolombe S, Honoré E, Patel A, TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells., Nat Commun 2019 May; 10(1): 2024.

Ma S, Cahalan S, LaMonte G, Grubaugh ND, Zeng W, Murthy SE, Paytas E, Gamini R, Lukacs V, Whitwam T, Loud M, Lohia R, Berry L, Khan SM, Janse CJ, Bandell M, Schmedt C, Wengelnik K, Su AI, Honore E, Winzeler EA, Andersen KG, Patapoutian A, Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection., Cell 2018 Apr; 173(2): 443-455.e12.

Martins JR, Penton D, Peyronnet R, Arhatte M, Moro C, Picard N, Kurt B, Patel A, Honoré E, Demolombe S, Piezo1-dependent regulation of urinary osmolarity., Pflugers Arch 2016 Jul; 468(7): 1197-1206.

Retailleau K, Arhatte M, Demolombe S, Jodar M, Baudrie V, Offermanns S, Feng Y, Patel A, Honoré E, Duprat F, Smooth muscle filamin A is a major determinant of conduit artery structure and function at the adult stage., Pflugers Arch 2016 Jul; 468(7): 1151-1160.

Retailleau K, Arhatte M, Demolombe S, Peyronnet R, Baudrie V, Jodar M, Bourreau J, Henrion D, Offermanns S, Nakamura F, Feng Y, Patel A, Duprat F, Honoré E, Arterial Myogenic Activation through Smooth Muscle Filamin A., Cell Rep 2016 Mar; 14(9): 2050-2058.

Retailleau K, Duprat F, Arhatte M, Ranade SS, Peyronnet R, Martins JR, Jodar M, Moro C, Offermanns S, Feng Y, Demolombe S, Patel A, Honoré E, Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling., Cell Rep 2015 Nov; 13(6): 1161-1171.

Patel A, Demolombe S, Honoré E, An alternative to force., Elife 2015 Jun; 4(): .

Honoré E, Martins JR, Penton D, Patel A, Demolombe S, The Piezo Mechanosensitive Ion Channels: May the Force Be with You!, Rev Physiol Biochem Pharmacol 2015 ; 169(): 25-41.

Delmas P, Coste B, Honoré E, A special issue on physiological aspects of mechanosensing., Pflugers Arch 2015 Jan; 467(1): 1-2.

Peyronnet R, Martins JR, Duprat F, Demolombe S, Arhatte M, Jodar M, Tauc M, Duranton C, Paulais M, Teulon J, Honoré E, Patel A, Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells., EMBO Rep 2013 Dec; 14(12): 1143-8.

Demolombe S, Duprat F, Honoré E, Patel A, Slower Piezo1 inactivation in dehydrated hereditary stomatocytosis (xerocytosis)., Biophys J 2013 Aug; 105(4): 833-4.

Nilius B, Honoré E, Sensing pressure with ion channels., Trends Neurosci 2012 Aug; 35(8): 477-86.

Peyronnet R, Sharif-Naeini R, Folgering JH, Arhatte M, Jodar M, El Boustany C, Gallian C, Tauc M, Duranton C, Rubera I, Lesage F, Pei Y, Peters DJ, Somlo S, Sachs F, Patel A, Honoré E, Duprat F, Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels., Cell Rep 2012 Mar; 1(3): 241-50.

Bagriantsev SN, Peyronnet R, Clark KA, Honoré E, Minor DL, Multiple modalities converge on a common gate to control K2P channel function., EMBO J 2011 Jul; 30(17): 3594-606.

Hassane S, Claij N, Jodar M, Dedman A, Lauritzen I, Duprat F, Koenderman JS, van der Wal A, Breuning MH, de Heer E, Honore E, DeRuiter MC, Peters DJ, Pkd1-inactivation in vascular smooth muscle cells and adaptation to hypertension., Lab Invest 2011 Jan; 91(1): 24-32.

Patel A, Honoré E, Polycystins and renovascular mechanosensory transduction., Nat Rev Nephrol 2010 Sep; 6(9): 530-8.

Patel A, Sharif-Naeini R, Folgering JR, Bichet D, Duprat F, Honoré E, Canonical TRP channels and mechanotransduction: from physiology to disease states., Pflugers Arch 2010 Aug; 460(3): 571-81.

Giamarchi A, Feng S, Rodat-Despoix L, Xu Y, Bubenshchikova E, Newby LJ, Hao J, Gaudioso C, Crest M, Lupas AN, Honoré E, Williamson MP, Obara T, Ong AC, Delmas P, A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes., EMBO J 2010 Apr; 29(7): 1176-91.

Sharif-Naeini R, Folgering JH, Bichet D, Duprat F, Delmas P, Patel A, Honoré E, Sensing pressure in the cardiovascular system: Gq-coupled mechanoreceptors and TRP channels., J Mol Cell Cardiol 2010 Jan; 48(1): 83-9.

Sharif-Naeini R, Folgering JH, Bichet D, Duprat F, Lauritzen I, Arhatte M, Jodar M, Dedman A, Chatelain FC, Schulte U, Retailleau K, Loufrani L, Patel A, Sachs F, Delmas P, Peters DJ, Honoré E, Polycystin-1 and -2 dosage regulates pressure sensing., Cell 2009 Oct; 139(3): 587-96.

Dedman A, Sharif-Naeini R, Folgering JH, Duprat F, Patel A, Honoré E, The mechano-gated K(2P) channel TREK-1., Eur Biophys J 2009 Mar; 38(3): 293-303.

Honoré E, Alternative translation initiation further increases the molecular and functional diversity of ion channels., J Physiol 2008 Dec; 586(23): 5605-6.

Sharif-Naeini R, Dedman A, Folgering JH, Duprat F, Patel A, Nilius B, Honoré E, TRP channels and mechanosensory transduction: insights into the arterial myogenic response., Pflugers Arch 2008 Jun; 456(3): 529-40.

Gottlieb P, Folgering J, Maroto R, Raso A, Wood TG, Kurosky A, Bowman C, Bichet D, Patel A, Sachs F, Martinac B, Hamill OP, Honoré E, Revisiting TRPC1 and TRPC6 mechanosensitivity., Pflugers Arch 2008 Mar; 455(6): 1097-103.

Folgering JH, Sharif-Naeini R, Dedman A, Patel A, Delmas P, Honoré E, Molecular basis of the mammalian pressure-sensitive ion channels: focus on vascular mechanotransduction., Prog Biophys Mol Biol 2008 ; 97(2-3): 180-95.

Duprat F, Lauritzen I, Patel A, Honoré E, The TASK background K2P channels: chemo- and nutrient sensors., Trends Neurosci 2007 Nov; 30(11): 573-80.

Chemin J, Patel AJ, Duprat F, Sachs F, Lazdunski M, Honore E, Up- and down-regulation of the mechano-gated K(2P) channel TREK-1 by PIP (2) and other membrane phospholipids., Pflugers Arch 2007 Oct; 455(1): 97-103.

Honoré E, The neuronal background K2P channels: focus on TREK1., Nat Rev Neurosci 2007 Apr; 8(4): 251-61.

Chemin J, Patel AJ, Delmas P, Sachs F, Lazdunski M, Honore E, Regulation of the Mechano-Gated K2P Channel TREK-1 by Membrane Phospholipids., Curr Top Membr 2007 ; 59(): 155-70.

Bichet D, Peters D, Patel AJ, Delmas P, Honoré E, Cardiovascular polycystins: insights from autosomal dominant polycystic kidney disease and transgenic animal models., Trends Cardiovasc Med 2006 Nov; 16(8): 292-8.

Giamarchi A, Padilla F, Coste B, Raoux M, Crest M, Honoré E, Delmas P, The versatile nature of the calcium-permeable cation channel TRPP2., EMBO Rep 2006 Aug; 7(8): 787-93.

Honoré E, Patel AJ, Chemin J, Suchyna T, Sachs F, Desensitization of mechano-gated K2P channels., Proc Natl Acad Sci U S A 2006 May; 103(18): 6859-64.

Lauritzen I, Chemin J, Honoré E, Jodar M, Guy N, Lazdunski M, Jane Patel A, Cross-talk between the mechano-gated K2P channel TREK-1 and the actin cytoskeleton., EMBO Rep 2005 Jul; 6(7): 642-8.

Chemin J, Patel A, Duprat F, Zanzouri M, Lazdunski M, Honoré E, Lysophosphatidic acid-operated K+ channels., J Biol Chem 2005 Feb; 280(6): 4415-21.

Chemin J, Patel AJ, Duprat F, Lauritzen I, Lazdunski M, Honoré E, A phospholipid sensor controls mechanogating of the K+ channel TREK-1., EMBO J 2005 Jan; 24(1): 44-53.

Franks NP, Honoré E, The TREK K2P channels and their role in general anaesthesia and neuroprotection., Trends Pharmacol Sci 2004 Nov; 25(11): 601-8.

Buckler K, Honoré E, Molecular strategies for studying oxygen-sensitive K+ channels., Methods Enzymol 2004 ; 381(): 233-56.

Lauritzen I, Zanzouri M, Honoré E, Duprat F, Ehrengruber MU, Lazdunski M, Patel AJ, K+-dependent cerebellar granule neuron apoptosis. Role of task leak K+ channels., J Biol Chem 2003 Aug; 278(34): 32068-76.

Patel AJ, Honore E, 2P domain K+ channels: novel pharmacological targets for volatile general anesthetics., Adv Exp Med Biol 2003 ; 536(): 9-23.

Honoré E, Maingret F, Lazdunski M, Patel AJ, An intracellular proton sensor commands lipid- and mechano-gating of the K(+) channel TREK-1., EMBO J 2002 Jun; 21(12): 2968-76.

Maingret F, Honoré E, Lazdunski M, Patel AJ, Molecular basis of the voltage-dependent gating of TREK-1, a mechano-sensitive K(+) channel., Biochem Biophys Res Commun 2002 Mar; 292(2): 339-46.

Patel A, Honore E, The TREK two P domain K+ channels., J Physiol 2002 Mar; 539(Pt 3): 647.