Laetitia DAVIDOVIC – IPMC

Recherche

Intranet

Thème

Guillaume CINQUANTA

Biographie pas encore disponible.

Projets

Microbiota, immunity, and neurodevelopment

Publications

Fabregat-Safont D, Coadic L, Haro N, Montané-Garcia M, Canaguier J, Mallaret G, Davidovic L, Pozo ÓJ, Improving the detectability of low-abundance p-cresol in biological matrices by chemical derivatization and LC-MS/MS determination., Talanta 2025 Aug; 290(): 127770.

Yuan WL, Cissé AH, Tafflet M, El Khoury E, Khalfallah O, Davidovic L, Charles MA, Heude B, The Adverse Influence of Maternal Glycaemia During Pregnancy on Offspring’s Cardiometabolic Health Profiles., Acta Paediatr 2025 Apr; (): .

Canaguier J, Mallaret G, Paraschivescu C, Barbosa S, Le Merrer J, Becker J, Glaichenhaus N, Davidovic L, Perinatal exposure to the autism-linked metabolite p-Cresol has limited impact on early development in mice but lasting effects on adult social behavior., Sci Rep 2025 Apr; 15(1): 12934.

Lion M, Ibrahim EC, Caccomo-Garcia E, Bourret J, Cinquanta G, Khalfallah O, Glaichenhaus N, Davidovic L, Courtet P, Turecki G, Tzavara E, Belzeaux R, A specific GPR56/ADGRG1 splicing isoform is associated with antidepressant response in major depressive disorder., Eur Neuropsychopharmacol 2025 Apr; 93(): 5-14.

Edouard W Khandjian, Tom Moss, Timothy M Rose, Claude Robert, Laetitia Davidovic, The fragile X proteins’ enigma: to be or not to be nucleolar, Frontiers in Cell and Developmental Biology, 2024, 12, ⟨10.3389/fcell.2024.1448209⟩.

Herbein M, Barbosa S, Collet O, Khalfallah O, Navarro M, Bailhache M, Iv N, Aouizerate B, Sutter-Dallay AL, Koehl M, Capuron L, Ellul P, Peyre H, Van der Waerden J, Melchior M, Côté S, Heude B, Glaichenhaus N, Davidovic L, Galera C, Cord serum cytokines at birth and children’s trajectories of mood dysregulation symptoms from 3 to 8 years: The EDEN birth cohort., Brain Behav Immun Health 2024 Jul; 38(): 100768.

Strube W, Aksar A, Bauer I, Barbosa S, Benros M, Blankenstein C, Campana M, Davidovic L, Glaichenhaus N, Falkai P, Görlitz T, Hansbauer M, Heilig D, Khalfallah O, Leboyer M, Martinuzzi E, Mayer S, Moussiopoulou J, Papazova I, Perić N, Wagner E, Schneider-Axmann T, Simon J, Hasan A, Effects of add-on Celecoxib treatment on patients with schizophrenia spectrum disorders and inflammatory cytokine profile trial (TargetFlame): study design and methodology of a multicentre randomized, placebo-controlled trial., J Neural Transm (Vienna) 2023 Aug; 130(8): 1039-1048.

Khalfallah O, Barbosa S, Phillippat C, Slama R, Galera C, Heude B, Glaichenhaus N, Davidovic L, Cytokines as mediators of the associations of prenatal exposure to phenols, parabens, and phthalates with internalizing behaviours at age 3 in boys: A mixture exposure and mediation approach., Environ Res 2023 Jul; 229(): 115865.

Doré E, Joly-Beauparlant C, Morozumi S, Mathieu A, Lévesque T, Allaeys I, Duchez AC, Cloutier N, Leclercq M, Bodein A, Payré C, Martin C, Petit-Paitel A, Gelb MH, Rangachari M, Murakami M, Davidovic L, Flamand N, Arita M, Lambeau G, Droit A, Boilard E, The interaction of secreted phospholipase A2-IIA with the microbiota alters its lipidome and promotes inflammation, JCI Insight 2022 Jan; 7(2): .

Cissé AH, Taine M, Tafflet M, de Lauzon-Guillain B, Clément K, Khalfallah O, Davidovic L, Lioret S, Charles MA, Heude B, Cord blood leptin level and a common variant of its receptor as determinants of the BMI trajectory: The EDEN mother-child cohort., Pediatr Obes 2022 Nov; 17(11): e12955.

Foiselle M, Barbosa S, Godin O, Wu CL, Boukouaci W, Andre M, Aouizerate B, Berna F, Barau C, Capdevielle D, Vidailhet P, Chereau I, Davidovic L, Dorey JM, Dubertret C, Dubreucq J, Faget C, Fond G, Leigner S, Llorca PM, Mallet J, Misdrahi D, Martinuzzi E, Passerieux C, Rey R, Pignon B, Urbach M, Schürhoff F, Glaichenhaus N, Leboyer M, Tamouza R, Immuno-metabolic profile of patients with psychotic disorders and metabolic syndrome. Results from the FACE-SZ cohort., Brain Behav Immun Health 2022 Jul; 22(): 100436.

Radmanish M, Khalfallah O, Glaichenhaus N, Forhan A, Heude B, Charles MA, Davidovic L, Plancoulaine S, Sleep duration trajectories associated with levels of specific serum cytokines at age 5: A longitudinal study in preschoolers from the EDEN birth cohort., Brain Behav Immun Health 2022 May; 21(): 100429.

Marion Cremoni, Sébastien Cuozzo, Emanuela Martinuzzi, Susana Barbosa, Nadia Ben Hassen, Filippo Massa, Elisa Demonchy, Matthieu Durand, Olivier Thaunat, Vincent Esnault, Moglie Le Quintrec, Sophie Caillard, Nicolas Glaichenhaus, Antoine Sicard, Low T Cell Responsiveness in the Early Phase of COVID-19 Associates with Progression to Severe Pneumonia in Kidney Transplant Recipients, Viruses, 2022, 14 (3), pp.542. ⟨10.3390/v14030542⟩.

Aminata Cissé, Marion Taine, Muriel Tafflet, Blandine de Lauzon-Guillain, Karine Clément, Olfa Khalfallah, Laetitia Davidovic, Sandrine Lioret, Marie Charles, Barbara Heude, Cord blood leptin level and a common variant of its receptor as determinants of the BMI trajectory: The EDEN mother–child cohort, Pediatric Obesity, In press, 17 (11), pp.e12955. ⟨10.1111/ijpo.12955⟩.

Marianne Foiselle, Susana Barbosa, Ophélia Godin, Ching-Lien Wu, Wahid Boukouaci, Myrtille Andre, Bruno Aouizerate, Fabrice Berna, Caroline Barau, Delphine Capdevielle, Pierre Vidailhet, Isabelle Chereau, Laetitia Davidovic, Jean-Michel Dorey, Caroline Dubertret, Julien Dubreucq, Catherine Faget, Guillaume Fond, Sylvain Leigner, Pierre-Michel Llorca, Jasmina Mallet, David Misdrahi, Emanuela Martinuzzi, Christine Passerieux, Romain Rey, Baptiste Pignon, Mathieu Urbach, Franck Schürhoff, Nicolas..., Immuno-metabolic profile of patients with psychotic disorders and metabolic syndrome. Results from the FACE-SZ cohort, Brain, Behavior & Immunity - Health, 2022, 22, pp.100436. ⟨10.1016/j.bbih.2022.100436⟩.

Paraschivescu C, Barbosa S, Van Steenwinckel J, Gressens P, Glaichenhaus N, Davidovic L, Early Life Exposure to Tumor Necrosis Factor Induces Precocious Sensorimotor Reflexes Acquisition and Increases Locomotor Activity During Mouse Postnatal Development., Front Behav Neurosci 2022 ; 16(): 845458.

Khandjian EW, Robert C, Davidovic L, FMRP, a multifunctional RNA-binding protein in quest of a new identity., Front Genet 2022 ; 13(): 976480.

Khalfallah O, Barbosa S, Martinuzzi E, Davidovic L, Yolken R, Glaichenhaus N, Monitoring inflammation in psychiatry: Caveats and advice., Eur Neuropsychopharmacol 2022 Jan; 54(): 126-135.

Gros M, Nunes AM, Daoudlarian D, Pini J, Martinuzzi E, Barbosa S, Ramirez M, Puma A, Villa L, Cavalli M, Grecu N, Garcia J, Siciliano G, Solé G, Juntas-Morales R, Jones PL, Jones T, Glaichenhaus N, Sacconi S, Identification of Serum Interleukin 6 Levels as a Disease Severity Biomarker in Facioscapulohumeral Muscular Dystrophy., J Neuromuscul Dis 2022 ; 9(1): 83-93.

Massa F, Cremoni M, Gérard A, Grabsi H, Rogier L, Blois M, Couzin C, Hassen NB, Rouleau M, Barbosa S, Martinuzzi E, Fayada J, Bernard G, Favre G, Hofman P, Esnault VLM, Czerkinsky C, Seitz-Polski B, Glaichenhaus N, Sicard A, Safety and cross-variant immunogenicity of a three-dose COVID-19 mRNA vaccine regimen in kidney transplant recipients., EBioMedicine 2021 Nov; 73(): 103679.

Gonzales J, Marchix J, Aymeric L, Le Berre-Scoul C, Zoppi J, Bordron P, Burel M, Davidovic L, Richard JR, Gaman A, Lejuste F, Brouillet JZ, Le Vacon F, Chaffron S, Leboyer M, Boudin H, Neunlist M, Fecal Supernatant from Adult with Autism Spectrum Disorder Alters Digestive Functions, Intestinal Epithelial Barrier, and Enteric Nervous System., Microorganisms 2021 Aug; 9(8): .

Susana Barbosa, Emanuela Martinuzzi, Iris E Sommer, Paola Dazzan, Philip Mcguire, Celso Arango, Covadonga M Diaz-Caneja, W Wolfgang Wolfgang Fleischhacker, Dan Rujescu, Birte Glenthøj, Inge Winter-van Rossum, René Sylvain Kahn, Robert Yolken, Shon Lewis, Richard Drake, Stefan Leucht, Cyprien Gilet, Olfa Khalfallah, Laetitia Davidovic, El Chérif Ibrahim, Raoul Belzeaux, Marion Leboyer, Nicolas Glaichenhaus, Baseline levels of C-reactive protein and proinflammatory cytokines are not associated with early response to amisulpride in patients with First Episode Psychosis: the OPTiMiSE cohort study, Schizophrenia Bulletin Open, 2021, ⟨10.1093/schizbullopen/sgab017⟩.

Bermudez-Martin P, Becker JAJ, Caramello N, Fernandez SP, Costa-Campos R, Canaguier J, Barbosa S, Martinez-Gili L, Myridakis A, Dumas ME, Bruneau A, Cherbuy C, Langella P, Callebert J, Launay JM, Chabry J, Barik J, Le Merrer J, Glaichenhaus N, Davidovic L, The microbial metabolite p-Cresol induces autistic-like behaviors in mice by remodeling the gut microbiota., Microbiome 2021 Jul; 9(1): 157.

Martinuzzi E, Barbosa S, Courtet P, Olié E, Guillaume S, Ibrahim EC, Daoudlarian D, Davidovic L, Glaichenhaus N, Belzeaux R, Blood cytokines differentiate bipolar disorder and major depressive disorder during a major depressive episode: Initial discovery and independent sample replication., Brain Behav Immun Health 2021 May; 13(): 100232.

Galera C, Barbosa S, Collet O, Khalfallah O, Aouizerate B, Sutter-Dalley AL, Koehl M, Capuron L, Van der Waerden J, Melchior M, Côté S, Heude B, Glaichenhaus N, Davidovic L, Cord Serum Cytokines at Birth and Children’s Anxiety-Depression Trajectories From 3 to 8 Years: The EDEN Mother-Child Cohort., Biol Psychiatry 2021 Mar; 89(6): 541-549.

Nalpas N, Hoyles L, Anselm V, Ganief T, Martinez-Gili L, Grau C, Droste-Borel I, Davidovic L, Altafaj X, Dumas ME, Macek B, An integrated workflow for enhanced taxonomic and functional coverage of the mouse fecal metaproteome., Gut Microbes 2021 ; 13(1): 1994836.

Barbosa S, Khalfallah O, Forhan A, Galera C, Heude B, Glaichenhaus N, Davidovic L, Immune activity at birth and later psychopathology in childhood., Brain Behav Immun Health 2020 Oct; 8(): 100141.

Barbosa S, Khalfallah O, Forhan A, Galera C, Heude B, Glaichenhaus N, Davidovic L, Serum cytokines associated with behavior: A cross-sectional study in 5-year-old children., Brain Behav Immun 2020 Jul; 87(): 377-387.

Van Dijck A, Barbosa S, Bermudez-Martin P, Khalfallah O, Gilet C, Martinuzzi E, Elinck E, Kooy RF, Glaichenhaus N, Davidovic L, Reduced serum levels of pro-inflammatory chemokines in fragile X syndrome., BMC Neurol 2020 Apr; 20(1): 138.

Paraschivescu C, Barbosa S, Lorivel T, Glaichenhaus N, Davidovic L, Cytokine changes associated with the maternal immune activation (MIA) model of autism: A penalized regression approach., PLoS One 2020 ; 15(8): e0231609.

Martinuzzi E, Barbosa S, Daoudlarian D, Ali WBH, Gilet C, Fillatre L, Khalfallah O, Troudet R, Jamain S, Fond G, Sommer I, Leucht S, Dazzan P, McGuire P, Arango C, Diaz-Caneja CM, Fleischhacker W, Rujescu D, Glenthøj B, Winter I, Kahn RS, Yolken R, Lewis S, Drake R, Davidovic L, Leboyer M, Glaichenhaus N, Correction: Stratification and prediction of remission in first-episode psychosis patients: the OPTiMiSE cohort study., Transl Psychiatry 2019 Jun; 9(1): 171.

Leboucher A, Pisani DF, Martinez-Gili L, Chilloux J, Bermudez-Martin P, Van Dijck A, Ganief T, Macek B, Becker JAJ, Le Merrer J, Kooy RF, Amri EZ, Khandjian EW, Dumas ME, Davidovic L, The translational regulator FMRP controls lipid and glucose metabolism in mice and humans., Mol Metab 2019 Mar; 21(): 22-35.

Martinuzzi E, Barbosa S, Daoudlarian D, Bel Haj Ali W, Gilet C, Fillatre L, Khalfallah O, Troudet R, Jamain S, Fond G, Sommer I, Leucht S, Dazzan P, McGuire P, Arango C, Diaz-Caneja CM, Fleischhacker W, Rujescu D, Glenthøj B, Winter I, Kahn RS, Yolken R, Lewis S, Drake R, Davidovic L, Leboyer M, Glaichenhaus N, Stratification and prediction of remission in first-episode psychosis patients: the OPTiMiSE cohort study., Transl Psychiatry 2019 Jan; 9(1): 20.

Leboucher A, Bermudez-Martin P, Mouska X, Amri EZ, Pisani DF, Davidovic L, Fmr1-Deficiency Impacts Body Composition, Skeleton, and Bone Microstructure in a Mouse Model of Fragile X Syndrome., Front Endocrinol (Lausanne) 2019 ; 10(): 678.

Khalfallah O, Jarjat M, Davidovic L, Nottet N, Cestèle S, Mantegazza M, Bardoni B, Depletion of the Fragile X Mental Retardation Protein in Embryonic Stem Cells Alters the Kinetics of Neurogenesis., Stem Cells 2017 Feb; 35(2): 374-385.

El Fatimy R, Davidovic L, Tremblay S, Jaglin X, Dury A, Robert C, De Koninck P, Khandjian EW, Tracking the Fragile X Mental Retardation Protein in a Highly Ordered Neuronal RiboNucleoParticles Population: A Link between Stalled Polyribosomes and RNA Granules., PLoS Genet 2016 Jul; 12(7): e1006192.

Maurin T, Melko M, Abekhoukh S, Khalfallah O, Davidovic L, Jarjat M, D'Antoni S, Catania MV, Moine H, Bechara E, Bardoni B, The FMRP/GRK4 mRNA interaction uncovers a new mode of binding of the Fragile X mental retardation protein in cerebellum., Nucleic Acids Res 2015 Sep; 43(17): 8540-50.

Dumas ME, Davidovic L, Metabolic Profiling and Phenotyping of Central Nervous System Diseases: Metabolites Bring Insights into Brain Dysfunctions., J Neuroimmune Pharmacol 2015 Sep; 10(3): 402-24.

Vicario A, Colliva A, Ratti A, Davidovic L, Baj G, Gricman Ł, Colombrita C, Pallavicini A, Jones KR, Bardoni B, Tongiorgi E, Dendritic targeting of short and long 3′ UTR BDNF mRNA is regulated by BDNF or NT-3 and distinct sets of RNA-binding proteins., Front Mol Neurosci 2015 ; 8(): 62.

Matic K, Eninger T, Bardoni B, Davidovic L, Macek B, Quantitative phosphoproteomics of murine Fmr1-KO cell lines provides new insights into FMRP-dependent signal transduction mechanisms., J Proteome Res 2014 Oct; 13(10): 4388-97.

Zongaro S, Hukema R, D'Antoni S, Davidovic L, Barbry P, Catania MV, Willemsen R, Mari B, Bardoni B, The 3′ UTR of FMR1 mRNA is a target of miR-101, miR-129-5p and miR-221: implications for the molecular pathology of FXTAS at the synapse., Hum Mol Genet 2013 May; 22(10): 1971-82.

Davidovic L, Durand N, Khalfallah O, Tabet R, Barbry P, Mari B, Sacconi S, Moine H, Bardoni B, A novel role for the RNA-binding protein FXR1P in myoblasts cell-cycle progression by modulating p21/Cdkn1a/Cip1/Waf1 mRNA stability., PLoS Genet 2013 Mar; 9(3): e1003367.

Dumas ME, Davidovic L, Metabolic phenotyping and systems biology approaches to understanding neurological disorders., F1000Prime Rep 2013 ; 5(): 18.

Laetitia Davidovic, Vincent Navratil, Carmela M Bonaccorso, Maria Vincenza Catania, Barbara Bardoni, Marc-Emmanuel Dumas, A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse model., Genome Research, 2011, 21 (12), pp.2190-202. ⟨10.1101/gr.116764.110⟩.

Shi H, Chen S, Jin H, Xu C, Dong G, Zhao Q, Wang W, Zhang H, Lin W, Zhang J, Davidovic L, Yao L, Fan D, Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathway., Cancer Sci 2009 Sep; 100(9): 1585-90.

Bensaid M, Melko M, Bechara EG, Davidovic L, Berretta A, Catania MV, Gecz J, Lalli E, Bardoni B, FRAXE-associated mental retardation protein (FMR2) is an RNA-binding protein with high affinity for G-quartet RNA forming structure., Nucleic Acids Res 2009 Mar; 37(4): 1269-79.

Bechara EG, Didiot MC, Melko M, Davidovic L, Bensaid M, Martin P, Castets M, Pognonec P, Khandjian EW, Moine H, Bardoni B, A novel function for fragile X mental retardation protein in translational activation., PLoS Biol 2009 Jan; 7(1): e16.

Lin W, Zhang J, Zhang J, Liu X, Fei Z, Li X, Davidovic L, Tang Z, Shen L, Deng Y, Yang A, Han H, Zhang X, Yao L, RNAi-mediated inhibition of MSP58 decreases tumour growth, migration and invasion in a human glioma cell line., J Cell Mol Med 2009 ; 13(11-12): 4608-22.

Laetitia Davidovic, Sabrina Sacconi, Elias G. Bechara, Severine Delplace, Marilyn Allegra, Claude Desnuelle, Barbara Bardoni, Alteration of expression of muscle-specific isoforms of the Fragile X Related Protein 1 (FXR1P) in facio-scapulohumeral muscular distrophy patients., Journal of Medical Genetics, 2008, epub ahead of print. ⟨10.1136/jmg.2008.060541⟩.

Davidovic L, Jaglin XH, Lepagnol-Bestel AM, Tremblay S, Simonneau M, Bardoni B, Khandjian EW, The fragile X mental retardation protein is a molecular adaptor between the neurospecific KIF3C kinesin and dendritic RNA granules., Hum Mol Genet 2007 Dec; 16(24): 3047-58.

Bechara E, Davidovic L, Melko M, Bensaid M, Tremblay S, Grosgeorge J, Khandjian EW, Lalli E, Bardoni B, Fragile X related protein 1 isoforms differentially modulate the affinity of fragile X mental retardation protein for G-quartet RNA structure., Nucleic Acids Res 2007 ; 35(1): 299-306.

Davidovic L, Bechara E, Gravel M, Jaglin XH, Tremblay S, Sik A, Bardoni B, Khandjian EW, The nuclear microspherule protein 58 is a novel RNA-binding protein that interacts with fragile X mental retardation protein in polyribosomal mRNPs from neurons., Hum Mol Genet 2006 May; 15(9): 1525-38.

Bardoni B, Davidovic L, Bensaid M, Khandjian EW, The fragile X syndrome: exploring its molecular basis and seeking a treatment., Expert Rev Mol Med 2006 Apr; 8(8): 1-16.

Davidovic L, Tremblay S, Gravel M, De Koninck P, Khandjian EW, [The fragile X syndrome: one protein missing and 1001 disoriented mRNAs]., Med Sci (Paris) 2006 Jan; 22(1): 41-6.

Plante I, Davidovic L, Ouellet DL, Gobeil LA, Tremblay S, Khandjian EW, Provost P, Dicer-derived microRNAs are utilized by the fragile X mental retardation protein for assembly on target RNAs., J Biomed Biotechnol 2006 ; 2006(4): 64347.

Huot ME, Bisson N, Davidovic L, Mazroui R, Labelle Y, Moss T, Khandjian EW, The RNA-binding protein fragile X-related 1 regulates somite formation in Xenopus laevis., Mol Biol Cell 2005 Sep; 16(9): 4350-61.

Davidovic L, Huot ME, Khandjian EW, Lost once, the Fragile X Mental Retardation protein is now back onto brain polyribosomes., RNA Biol 2005 Jan; 2(1): 1-3.

Edouard Khandjian, Marc-Etienne Huot, Sandra Tremblay, Laetitia Davidovic, Rachid Mazroui, Barbara Bardoni, Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles, Proceedings of the National Academy of Sciences of the United States of America, 2004, 101 (36), pp.13357-13362. ⟨10.1073/pnas.0405398101⟩.

Khandjian EW, Huot ME, Tremblay S, Davidovic L, Mazroui R, Bardoni B, Biochemical evidence for the association of fragile X mental retardation protein with brain polyribosomal ribonucleoparticles., Proc Natl Acad Sci U S A 2004 Sep; 101(36): 13357-62.

Koonin EV, Makarova KS, Rogozin IB, Davidovic L, Letellier MC, Pellegrini L, The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers., Genome Biol 2003 ; 4(3): R19.