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03
Juil
2025
Inserm : les chercheurs de l'IPMC accueillent les malades

Le 14 juin 2025, l’IPMC a accueilli plusieurs associations de patients pour une matinée d’échanges autour de la douleur, de […]

Publications

2024
Marchot P, Fajloun Z, Legros C, Benoit É, Diochot S, Report from the 29th Meeting on Toxinology, « Toxins: From the Wild to the Lab », Organized by the French Society of Toxinology on 30 November-1 December 2023., Toxins (Basel) 2024 Mar; 16(3): .
2024
Mesirca P, Chemin J, Barrère C, Torre E, Gallot L, Monteil A, Bidaud I, Diochot S, Lazdunski M, Soong TW, Barrère-Lemaire S, Mangoni ME, Nargeot J, Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine., Nat Commun 2024 Jan; 15(1): 54.
2023
Landra-Willm A, Karapurkar A, Duveau A, Chassot AA, Esnault L, Callejo G, Bied M, Häfner S, Lesage F, Wdziekonski B, Baron A, Fossat P, Marsollier L, Gasull X, Boué-Grabot E, Kienzler MA, Sandoz G, A photoswitchable inhibitor of TREK channels controls pain in wild-type intact freely moving animals., Nat Commun 2023 Mar; 14(1): 1160.
2023
Marchot P, Benoit É, Fajloun Z, Diochot S, Report from the 28th Meeting on Toxinology, « Toxins: What’s up, Doc? », Organized by the French Society of Toxinology on 28-29 November 2022., Toxins (Basel) 2023 Feb; 15(2): .
2022
Jurczak A, Delay L, Barbier J, Simon N, Krock E, Sandor K, Agalave NM, Rudjito R, Wigerblad G, Rogóż K, Briat A, Miot-Noirault E, Martinez-Martinez A, Brömme D, Grönwall C, Malmström V, Klareskog L, Khoury S, Ferreira T, Labrum B, Deval E, Jiménez-Andrade JM, Marchand F, Svensson CI, Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3-dependent sensitization., Pain 2022 Aug; 163(8): 1542-1559.
2022
Ladant D, Marchot P, Diochot S, Prévost G, Popoff MR, Benoit E, Report from the 27th (Virtual) Meeting on Toxinology, « Toxins: Mr Hyde or Dr Jekyll? », Organized by the French Society of Toxinology, 9-10 December 2021., Toxins (Basel) 2022 Feb; 14(2): .
2021
Maatoug S, Cheikh A, Khamessi O, Tabka H, Landoulsi Z, Guigonis JM, Diochot S, Bendahhou S, Benkhalifa R, Cross Pharmacological, Biochemical and Computational Studies of a Human Kv3.1b Inhibitor from Androctonus australis Venom., Int J Mol Sci 2021 Nov; 22(22): .
2021
Ávalos Prado P, Landra-Willm A, Verkest C, Ribera A, Chassot AA, Baron A, Sandoz G, TREK channel activation suppresses migraine pain phenotype., iScience 2021 Sep; 24(9): 102961.
2021
Verkest C, Häfner S, Ávalos Prado P, Baron A, Sandoz G, Migraine and Two-Pore-Domain Potassium Channels., Neuroscientist 2021 Jun; 27(3): 268-284.
2021
Prieto M, Folci A, Poupon G, Schiavi S, Buzzelli V, Pronot M, François U, Pousinha P, Lattuada N, Abelanet S, Castagnola S, Chafai M, Khayachi A, Gwizdek C, Brau F, Deval E, Francolini M, Bardoni B, Humeau Y, Trezza V, Martin S, Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice., Nat Commun 2021 Mar; 12(1): 1557.
2021
Diochot S, Pain-related toxins in scorpion and spider venoms: a face to face with ion channels., J Venom Anim Toxins Incl Trop Dis 2021 ; 27(): e20210026.
2020
Marchot P, Diochot S, Popoff MR, Benoit E, Report from the 26th Meeting on Toxinology, « Bioengineering of Toxins », Organized by the French Society of Toxinology (SFET) and Held in Paris, France, 4-5 December 2019., Toxins (Basel) 2020 Jan; 12(1): .
2019
Nicolas S, Zoukimian C, Bosmans F, Montnach J, Diochot S, Cuypers E, De Waard S, Béroud R, Mebs D, Craik D, Boturyn D, Lazdunski M, Tytgat J, De Waard M, Chemical Synthesis, Proper Folding, Nav Channel Selectivity Profile and Analgesic Properties of the Spider Peptide Phlotoxin 1., Toxins (Basel) 2019 Jun; 11(6): .
2019
Royal P, Andres-Bilbe A, Ávalos Prado P, Verkest C, Wdziekonski B, Schaub S, Baron A, Lesage F, Gasull X, Levitz J, Sandoz G, Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK., Neuron 2019 Jan; 101(2): 232-245.e6.
2018
Verkest C, Piquet E, Diochot S, Dauvois M, Lanteri-Minet M, Lingueglia E, Baron A, Effects of systemic inhibitors of acid-sensing ion channels 1 (ASIC1) against acute and chronic mechanical allodynia in a rodent model of migraine., Br J Pharmacol 2018 Nov; 175(21): 4154-4166.
2018
Khayachi A, Gwizdek C, Poupon G, Alcor D, Chafai M, Cassé F, Maurin T, Prieto M, Folci A, De Graeve F, Castagnola S, Gautier R, Schorova L, Loriol C, Pronot M, Besse F, Brau F, Deval E, Bardoni B, Martin S, Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation., Nat Commun 2018 Feb; 9(1): 757.
2016
Diochot S, Alloui A, Rodrigues P, Dauvois M, Friend V, Aissouni Y, Eschalier A, Lingueglia E, Baron A, Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain., Pain 2016 Mar; 157(3): 552-559.
2016
Devader C, Moreno S, Roulot M, Deval E, Dix T, Morales CR, Mazella J, Increased Brain Neurotensin and NTSR2 Lead to Weak Nociception in NTSR3/Sortilin Knockout Mice., Front Neurosci 2016 ; 10(): 542.
2014
Loriol C, Cassé F, Khayachi A, Poupon G, Chafai M, Deval E, Gwizdek C, Martin S, mGlu5 receptors regulate synaptic sumoylation via a transient PKC-dependent diffusional trapping of Ubc9 into spines., Nat Commun 2014 Oct; 5(): 5113.
2014
Salinas M, Besson T, Delettre Q, Diochot S, Boulakirba S, Douguet D, Lingueglia E, Binding site and inhibitory mechanism of the mambalgin-2 pain-relieving peptide on acid-sensing ion channel 1a., J Biol Chem 2014 May; 289(19): 13363-73.
2014
Martin-Eauclaire MF, Bosmans F, Céard B, Diochot S, Bougis PE, A first exploration of the venom of the Buthus occitanus scorpion found in southern France., Toxicon 2014 Mar; 79(): 55-63.
2014
Lingueglia E, [Acid-Sensing Ion Channels (ASICs) in pain]., Biol Aujourdhui 2014 ; 208(1): 13-20.
2013
Baron A, Diochot S, Salinas M, Deval E, Noël J, Lingueglia E, Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels., Toxicon 2013 Dec; 75(): 187-204.
2013
Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, , Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, D..., The Concise Guide to PHARMACOLOGY 2013/14: overview., Br J Pharmacol 2013 Dec; 170(8): 1449-58.
2013
Fromy B, Lingueglia E, Sigaudo-Roussel D, Saumet JL, Lazdunski M, [An ionic channel involved in the skin protection against pressure]., Med Sci (Paris) 2013 Feb; 29(2): 130-2.
2013
Devilliers M, Busserolles J, Lolignier S, Deval E, Pereira V, Alloui A, Christin M, Mazet B, Delmas P, Noel J, Lazdunski M, Eschalier A, Activation of TREK-1 by morphine results in analgesia without adverse side effects., Nat Commun 2013 ; 4(): 2941.
2012
Diochot S, Baron A, Salinas M, Douguet D, Scarzello S, Dabert-Gay AS, Debayle D, Friend V, Alloui A, Lazdunski M, Lingueglia E, Black mamba venom peptides target acid-sensing ion channels to abolish pain., Nature 2012 Oct; 490(7421): 552-5.
2012
Delaunay A, Gasull X, Salinas M, Noël J, Friend V, Lingueglia E, Deval E, Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions., Proc Natl Acad Sci U S A 2012 Aug; 109(32): 13124-9.
2012
Fromy B, Lingueglia E, Sigaudo-Roussel D, Saumet JL, Lazdunski M, Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers., Nat Med 2012 Aug; 18(8): 1205-7.
2010
Noël J, Salinas M, Baron A, Diochot S, Deval E, Lingueglia E, Current perspectives on acid-sensing ion channels: new advances and therapeutic implications., Expert Rev Clin Pharmacol 2010 May; 3(3): 331-46.
2010
Mazella J, Pétrault O, Lucas G, Deval E, Béraud-Dufour S, Gandin C, El-Yacoubi M, Widmann C, Guyon A, Chevet E, Taouji S, Conductier G, Corinus A, Coppola T, Gobbi G, Nahon JL, Heurteaux C, Borsotto M, Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design., PLoS Biol 2010 Apr; 8(4): e1000355.
2009
Salinas M, Lazdunski M, Lingueglia E, Structural elements for the generation of sustained currents by the acid pain sensor ASIC3., J Biol Chem 2009 Nov; 284(46): 31851-9.
2009
Noël J, Zimmermann K, Busserolles J, Deval E, Alloui A, Diochot S, Guy N, Borsotto M, Reeh P, Eschalier A, Lazdunski M, The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception., EMBO J 2009 May; 28(9): 1308-18.
2009
Ettaiche M, Deval E, Pagnotta S, Lazdunski M, Lingueglia E, Acid-sensing ion channel 3 in retinal function and survival., Invest Ophthalmol Vis Sci 2009 May; 50(5): 2417-26.
2009
Diochot S, Lazdunski M, Sea anemone toxins affecting potassium channels., Prog Mol Subcell Biol 2009 ; 46(): 99-122.
2008
Deval E, Noël J, Lay N, Alloui A, Diochot S, Friend V, Jodar M, Lazdunski M, Lingueglia E, ASIC3, a sensor of acidic and primary inflammatory pain., EMBO J 2008 Nov; 27(22): 3047-55.
2006
Ettaiche M, Deval E, Cougnon M, Lazdunski M, Voilley N, Silencing acid-sensing ion channel 1a alters cone-mediated retinal function., J Neurosci 2006 May; 26(21): 5800-9.
2006
Deval E, Friend V, Thirant C, Salinas M, Jodar M, Lazdunski M, Lingueglia E, Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1., J Biol Chem 2006 Jan; 281(3): 1796-807.
2004
Deval E, Salinas M, Baron A, Lingueglia E, Lazdunski M, ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1., J Biol Chem 2004 May; 279(19): 19531-9.
2004
Diochot S, Baron A, Rash LD, Deval E, Escoubas P, Scarzello S, Salinas M, Lazdunski M, A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons., EMBO J 2004 Apr; 23(7): 1516-25.
2003
Deval E, Baron A, Lingueglia E, Mazarguil H, Zajac JM, Lazdunski M, Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability., Neuropharmacology 2003 Apr; 44(5): 662-71.
2002
Baron A, Deval E, Salinas M, Lingueglia E, Voilley N, Lazdunski M, Protein kinase C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1., J Biol Chem 2002 Dec; 277(52): 50463-8.
2002
Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E, The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons., J Biol Chem 2002 May; 277(19): 16655-61.
2001
Poët M, Tauc M, Lingueglia E, Cance P, Poujeol P, Lazdunski M, Counillon L, Exploration of the pore structure of a peptide-gated Na+ channel., EMBO J 2001 Oct; 20(20): 5595-602.
2001
Baron A, Schaefer L, Lingueglia E, Champigny G, Lazdunski M, Zn2+ and H+ are coactivators of acid-sensing ion channels., J Biol Chem 2001 Sep; 276(38): 35361-7.
1999
Sakai H, Lingueglia E, Champigny G, Mattei MG, Lazdunski M, Cloning and functional expression of a novel degenerin-like Na+ channel gene in mammals., J Physiol 1999 Sep; 519 Pt 2(Pt 2): 323-33.
1999
Coscoy S, de Weille JR, Lingueglia E, Lazdunski M, The pre-transmembrane 1 domain of acid-sensing ion channels participates in the ion pore., J Biol Chem 1999 Apr; 274(15): 10129-32.
1998
Darboux I, Lingueglia E, Pauron D, Barbry P, Lazdunski M, A new member of the amiloride-sensitive sodium channel family in Drosophila melanogaster peripheral nervous system., Biochem Biophys Res Commun 1998 May; 246(1): 210-6.
1998
Darboux I, Lingueglia E, Champigny G, Coscoy S, Barbry P, Lazdunski M, dGNaC1, a gonad-specific amiloride-sensitive Na+ channel., J Biol Chem 1998 Apr; 273(16): 9424-9.
1998
Coscoy S, Lingueglia E, Lazdunski M, Barbry P, The Phe-Met-Arg-Phe-amide-activated sodium channel is a tetramer., J Biol Chem 1998 Apr; 273(14): 8317-22.
1997
Lingueglia E, de Weille JR, Bassilana F, Heurteaux C, Sakai H, Waldmann R, Lazdunski M, A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells., J Biol Chem 1997 Nov; 272(47): 29778-83.
1995
Lingueglia E, Champigny G, Lazdunski M, Barbry P, Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel., Nature 1995 Dec; 378(6558): 730-3.