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Leader

Events

10
Jan
2025
11:00 am
Conference
T. HARAYAMA invites Prof. Giovanni D’ANGELO

The lipotype hypothesis, by Professor Giovanni D'Angelo, EPFL (Swiss Federal Institute of Technology Lausanne): Single-cell genomics techniques have enabled deep profiling […]
05
May
2025
Conference
Takeshi HARAYAMA invites Dr. Takao SHIMIZU

“Biological functions of DHA-rich membrane in vivo”

IPMC

Projects

Project
2024
Research on congenital generalized lipodystrophy type 1

The first axis of our research is to understand the cellular mechanism of the genetic disease “generalized congenital lipodystrophy of […]
Project
2024
Research on the link between lipid composition and signaling

The second axis of our research is to understand how the fatty acids of membrane lipids affect the lateral organization and […]

Publications

2025
Jiménez-Rojo N, Feng S, Morstein J, Pritzl SD, Asaro A, López S, Xu Y, Harayama T, Vepřek NA, Arp CJ, Reynders M, Novak AJE, Kanshin E, Lipfert J, Ueberheide B, Muñiz M, Lohmüller T, Riezman H, Trauner D, Optical Control of Membrane Viscosity Modulates ER-to-Golgi Trafficking., ACS Cent Sci 2025 Sep; 11(9): 1736-1752.
2025
Carpentier M, Omrane M, Shaaban R, Träger J, El Khallouki N, Le Lay S, Patat J, Palard M, Zouiouich M, Combot Y, Harayama T, Vigouroux C, Schauer K, Giordano F, Prieur X, Thiam AR, Seipin Governs caveolin-1 trafficking through modulating sphingolipid-glycerolipid balance., Cell Rep 2025 Sep; 44(10): 116320.
2025
Rodriguez-Gallardo S, Harayama T, Nothing can replace polyunsaturated lipids., Elife 2025 Aug; 14(): .
2025
Gollowitzer A, Pein H, Rao Z, Waltl L, Bereuter L, Loeser K, Meyer T, Jafari V, Witt F, Winkler R, Su F, Große S, Thürmer M, Grander J, Hotze M, Harder S, Espada L, Magnutzki A, Gstir R, Weinigel C, Rummler S, Bonn G, Pachmayr J, Ermolaeva M, Harayama T, Schlüter H, Kosan C, Heller R, Thedieck K, Schmitt M, Shimizu T, Popp J, Shindou H, Kwiatkowski M, Koeberle A, Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation., Nat Common 2025 Feb; 16(1): 1774.
2025
Chen XW, Don AS, Fedorova M, Harayama T, Krahmer N, Nagata S, Narayan P, Nicholas D, Nowinski SM, Saheki Y, Semenkovich CF, Zhao X, Zou Y, Time for lipid cell biology., Nat Cell Biol 2025 Feb; 27(2): 169-174.
2024
Takeda H, Matsuzawa Y, Takeuchi M, Takahashi M, Nishida K, Harayama T, Todoroki Y, Shimizu K, Sakamoto N, Oka T, Maekawa M, Chung MH, Kurizaki Y, Kiuchi S, Tokiyoshi K, Buyantogtokh B, Kurata M, Kvasnička A, Takeda U, Uchino H, Hasegawa M, Miyamoto J, Tanabe K, Takeda S, Mori T, Kumakubo R, Tanaka T, Yoshino T, Okamoto M, Takahashi H, Arita M, Tsugawa H, MS-DIAL 5 multimodal mass spectrometry data mining unveils lipidome complexities., Nat Common 2024 Nov; 15(1): 9903.
2023
Harayama T, Metabolic bias: Lipid structures as determinants of their metabolic fates. Biochemistry 2023 Dec; 215(): 34-41.
2022
Jose GP, Harayama T, Unique acyl chains mark phosphoinositides for recycling., EMBO J 2022 Sep; 41(18): e112163.
2021
Hamano F, Matoba K, Hashidate-Yoshida T, Suzuki T, Miura K, Hishikawa D, Harayama T, Yuki K, Kita Y, Noda NN, Shimizu T, Shindou H, Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA., FASEB J 2021 Jun; 35(6): e21501.
2021
Hannich JT, Loizides-Mangold U, Sinturel F, Harayama T, Vandereycken B, Saini C, Gosselin P, Brulhart-Meynet MC, Robert M, Chanon S, Durand C, Paz Montoya J, David FPA, Guessous I, Pataky Z, Golay A, Jornayvaz FR, Philippe J, Dermitzakis ET, Brown SA, Lefai E, Riezman H, Dibner C, Ether lipids, sphingolipids and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients., Acta Physiol (Oxf) 2021 May; 232(1): e13610.
2020
Harayama T, Shimizu T, Roles of polyunsaturated fatty acids, from mediators to membranes., J Lipid Res 2020 Aug; 61(8): 1150-1160.