ProjectResearch on generalized congenital lipodystrophy type 1

About

The first focus of our research is to understand the cellular mechanism of the genetic disease "generalized congenital lipodystrophy type 1." This disease is caused by mutations in the AGPAT2 gene and affects the generation of functional adipocytes. We previously discovered that AGPAT2 and related enzymes are important regulators of fatty acids present in cellular lipids. Based on this, we are investigating the link between adipocyte generation and membrane lipid composition.