Métabolisme et fonctions des lipides membranaires – IPMC

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Intranet

Theme

Arf proteins: membrane transport, epithelial morphology and cancer

Mechanisms of regulation of gene expression in pathophysiology

Members

Takeshi HARAYAMA

CNRS researcher

About

Lipids in cell membranes contain extremely diverse fatty acids, which differ depending on cell types. The fatty acid composition of lipids can also be affected by diseases, or more simply by the type of fat we consume. However, it remains unclear how differences in fatty acids affect membrane lipid functions. Solving this problem may reveal new disease mechanisms and explain how dietary fatty acids can affect our health. We address this question by manipulating the lipid composition of cells using genetic and chemical biology tools.

Tool development
We are also developing more widely applicable research tools, such as highly efficient CRISPR-Cas9-based gene disruption strategies. We are also exploring how to advance research through robot-assisted laboratory automation.

Events

T. HARAYAMA invites Prof. Giovanni D’ANGELO

The lipotype hypothesis, by Professor Giovanni D'Angelo, EPFL (Swiss Federal Institute of Technology Lausanne): Single-cell genomics techniques have enabled deep profiling […]

Takeshi HARAYAMA invites Dr. Takao SHIMIZU

“Biological functions of DHA-rich membrane in vivo”

Projects

Research on the link between lipid composition and signaling

The second axis of our research is to understand how the fatty acids of membrane lipids affect the lateral organization and […]

Research on congenital generalized lipodystrophy type 1

The first axis of our research is to understand the cellular mechanism of the genetic disease “generalized congenital lipodystrophy of […]

Publications

Jiménez-Rojo N, Feng S, Morstein J, Pritzl SD, Asaro A, López S, Xu Y, Harayama T, Vepřek NA, Arp CJ, Reynders M, Novak AJE, Kanshin E, Lipfert J, Ueberheide B, Muñiz M, Lohmüller T, Riezman H, Trauner D, Optical Control of Membrane Viscosity Modulates ER-to-Golgi Trafficking., ACS Cent Sci 2025 Sep; 11(9): 1736-1752.

Carpentier M, Omrane M, Shaaban R, Träger J, El Khallouki N, Le Lay S, Patat J, Palard M, Zouiouich M, Combot Y, Harayama T, Vigouroux C, Schauer K, Giordano F, Prieur X, Thiam AR, Seipin Governs caveolin-1 trafficking through modulating sphingolipid-glycerolipid balance., Cell Rep 2025 Sep; 44(10): 116320.

Rodriguez-Gallardo S, Harayama T, Nothing can replace polyunsaturated lipids., Elife 2025 Aug; 14(): .

Gollowitzer A, Pein H, Rao Z, Waltl L, Bereuter L, Loeser K, Meyer T, Jafari V, Witt F, Winkler R, Su F, Große S, Thürmer M, Grander J, Hotze M, Harder S, Espada L, Magnutzki A, Gstir R, Weinigel C, Rummler S, Bonn G, Pachmayr J, Ermolaeva M, Harayama T, Schlüter H, Kosan C, Heller R, Thedieck K, Schmitt M, Shimizu T, Popp J, Shindou H, Kwiatkowski M, Koeberle A, Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation., Nat Common 2025 Feb; 16(1): 1774.

Chen XW, Don AS, Fedorova M, Harayama T, Krahmer N, Nagata S, Narayan P, Nicholas D, Nowinski SM, Saheki Y, Semenkovich CF, Zhao X, Zou Y, Time for lipid cell biology., Nat Cell Biol 2025 Feb; 27(2): 169-174.

Takeda H, Matsuzawa Y, Takeuchi M, Takahashi M, Nishida K, Harayama T, Todoroki Y, Shimizu K, Sakamoto N, Oka T, Maekawa M, Chung MH, Kurizaki Y, Kiuchi S, Tokiyoshi K, Buyantogtokh B, Kurata M, Kvasnička A, Takeda U, Uchino H, Hasegawa M, Miyamoto J, Tanabe K, Takeda S, Mori T, Kumakubo R, Tanaka T, Yoshino T, Okamoto M, Takahashi H, Arita M, Tsugawa H, MS-DIAL 5 multimodal mass spectrometry data mining unveils lipidome complexities., Nat Common 2024 Nov; 15(1): 9903.

Harayama T, Antonny B, Beyond Fluidity: The Role of Lipid Unsaturation in Membrane Function. Cold Spring Harb Perspect Biol 2023 Jul; 15(7): .

Harayama T, Metabolic bias: Lipid structures as determinants of their metabolic fates. Biochemistry 2023 Dec; 215(): 34-41.

Jose GP, Harayama T, Unique acyl chains mark phosphoinositides for recycling., EMBO J 2022 Sep; 41(18): e112163.

Hamano F, Matoba K, Hashidate-Yoshida T, Suzuki T, Miura K, Hishikawa D, Harayama T, Yuki K, Kita Y, Noda NN, Shimizu T, Shindou H, Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA., FASEB J 2021 Jun; 35(6): e21501.

Hannich JT, Loizides-Mangold U, Sinturel F, Harayama T, Vandereycken B, Saini C, Gosselin P, Brulhart-Meynet MC, Robert M, Chanon S, Durand C, Paz Montoya J, David FPA, Guessous I, Pataky Z, Golay A, Jornayvaz FR, Philippe J, Dermitzakis ET, Brown SA, Lefai E, Riezman H, Dibner C, Ether lipids, sphingolipids and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients., Acta Physiol (Oxf) 2021 May; 232(1): e13610.

Harayama T, Shimizu T, Roles of polyunsaturated fatty acids, from mediators to membranes., J Lipid Res 2020 Aug; 61(8): 1150-1160.