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IPMC Valuation Manager

Senior expert in technology transfer at the Scientific Directorate of CNRS Innovation

Scientific Delegate to the CNRS's Deputy Director General for Innovation

Publications

2019
Arhatte M, Gunaratne GS, El Boustany C, Kuo IY, Moro C, Duprat F, Plaisant M, Duval H, Li D, Picard N, Couvreux A, Duranton C, Rubera I, Pagnotta S, Lacas-Gervais S, Ehrlich BE , Marchant JS, Savage AM, van Eeden FJM, Wilkinson RN, Demolombe S, Honoré E, Patel A, TMEM33 regulates intracellular calcium homeostasis in renal tubular epithelial cells. Nat Commun 2019 May; 10(1): 2024.
2016
Martins JR, Penton D, Peyronnet R, Arhatte M, Moro C, Picard N, Kurt B, Patel A, Honoré E, Demolombe S, Piezo1-dependent regulation of urinary osmolarity. Pflugers Arch 2016 Jul; 468(7): 1197-1206.
2016
Retailleau K, Arhatte M, Demolombe S, Jodar M, Baudrie V, Offermanns S, Feng Y, Patel A, Honoré E, Duprat F, Smooth muscle filamin A is a major determinant of conduit artery structure and function at the adult stage. Pflugers Arch 2016 Jul; 468(7): 1151-1160.
2016
Retailleau K, Arhatte M, Demolombe S, Peyronnet R, Baudrie V, Jodar M, Bourreau J, Henrion D, Offermanns S, Nakamura F, Feng Y, Patel A, Duprat F, Honoré E, Arterial Myogenic Activation through Smooth Muscle Filamin A., Cell Rep 2016 Mar; 14(9): 2050-2058.
2015
Retailleau K, Duprat F, Arhatte M, Ranade SS, Peyronnet R, Martins JR, Jodar M, Moro C, Offermanns S, Feng Y, Demolombe S, Patel A, Honoré E, Piezo1 in Smooth Muscle Cells Is Involved in Hypertension-Dependent Arterial Remodeling. Cell Rep 2015 Nov; 13(6): 1161-1171.
2015
Patel A, Demolombe S, Honoré E, An alternative to force., Elife 2015 Jun; 4(): .
2014
Sivagangabalan G, Nazzari H, Bignolais O, Maguy A, Naud P, Farid T, Massé S, Gaborit N, Varro A, Nair K, Backx P, Vigmond E, Nattel S, Demolombe S, Nanthakumar K, Regional ion channel gene expression heterogeneity and ventricular fibrillation dynamics in human hearts., PLoS One 2014; 9(1): e82179.
2013
Peyronnet R, Martins JR, Duprat F, Demolombe S, Arhatte M, Jodar M, Tauc M, Duranton C, Paulais M, Teulon J, Honoré E, Patel A, Piezo1-dependent stretch-activated channels are inhibited by Polycystin-2 in renal tubular epithelial cells. EMBO Rep 2013 Dec; 14(12): 1143-8.
2013
Demolombe S, Duprat F, Honoré E, Patel A, Slower Piezo1 inactivation in dehydrated hereditary stomatocytosis (xerocytosis). Biophys J 2013 Aug; 105(4): 833-4.
2012
Jeyaraj D, Haldar SM, Wan, Circadian rhythms govern cardiac repolarization and arrhythmogenesis., Nature 2012 Feb; 483(7387): 96-9.
2011
Bignolais O, Quang KL, Naud P, El Harchi A, Briec F, Piron J, Bourge A, Leoni AL, Charpentier F, Demolombe S, Early ion-channel remodeling and arrhythmias precede hypertrophy in a mouse model of complete atrioventricular block., J Mol Cell Cardiol 2011 Nov; 51(5): 713-21.
2010
Gaborit N, Varro A, Le Bouter S, Szuts V, Escande D, Nattel S, Demolombe S, Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts., J Mol Cell Cardiol 2010 Oct; 49(4): 639-46.
2010
Jonsson MK, Vos MA, Duker G, Demolombe S, van Veen TA, Gender disparity in cardiac electrophysiology: implications for cardiac safety pharmacology., Pharmacol Ther 2010 Jul; 127(1): 9-18.
2010
Leoni AL, Gavillet B, Rougier JS, Marionneau C, Probst V, Le Scouarnec S, Schott JJ, Demolombe S, Bruneval P, Huang CL, Colledge WH, Grace AA, Le Marec H, Wilde AA, Mohler PJ, Escande D, Abriel H, Charpentier F, Variable Na(v)1.5 protein expression from the wild-type allele correlates with the penetrance of cardiac conduction disease in the Scn5a(+/-) mouse model., PLoS One 2010 Feb; 5(2): e9298.
2010
Nattel S, Frelin Y, Gaborit N, Louault C, Demolombe S, Ion-channel mRNA-expression profiling: Insights into cardiac remodeling and arrhythmic substrates., J Mol Cell Cardiol 2010 Jan; 48(1): 96-105.
2009
Choveau FS, El Harchi A, Rodriguez N, Louérat-Oriou B, Baró I, Demolombe S, Charpentier F, Loussouarn G, Transfer of rolf S3-S4 linker to HERG eliminates activation gating but spares inactivation., Biophys J 2009 Sep; 97(5): 1323-34.
2009
Alders M, Koopmann TT, Christiaans I, Postema PG, Beekman L, Tanck MW, Zeppenfeld K, Loh P, Koch KT, Demolombe S, Mannens MM, Bezzina CR, Wilde AA, Haplotype-sharing analysis implicates chromosome 7q36 harboring DPP6 in familial idiopathic ventricular fibrillation., Am J Hum Genet 2009 Apr; 84(4): 468-76.
2009
Benamer N, Moha Ou Maati H, Demolombe S, Cantereau A, Delwail A, Bois P, Bescond J, Faivre JF, Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts., J Mol Cell Cardiol 2009 Apr; 46(4): 508-17.
2009
Gaborit N, Wichter T, Varro A, Szuts V, Lamirault G, Eckardt L, Paul M, Breithardt G, Schulze-Bahr E, Escande D, Nattel S, Demolombe S, Transcriptional profiling of ion channel genes in Brugada syndrome and other right ventricular arrhythmogenic diseases., Eur Heart J 2009 Feb; 30(4): 487-96.
2008
Cardin S, Pelletier P, Libby E, Le Bouter S, Xiao L, Kääb S, Demolombe S, Glass L, Nattel S, Marked differences between atrial and ventricular gene-expression remodeling in dogs with experimental heart failure., J Mol Cell Cardiol 2008 Dec; 45(6): 821-31.
2008
Le Scouarnec S, Bhasin N, Vieyres C, Hund TJ, Cunha SR, Koval O, Marionneau C, Chen B, Wu Y, Demolombe S, Song LS, Le Marec H, Probst V, Schott JJ, Anderson ME, Mohler PJ, Dysfunction in ankyrin-B-dependent ion channel and transporter targeting causes human sinus node disease., Proc Natl Acad Sci USA 2008 Oct; 105(40): 15617-22.
2008
Marionneau C, Brunet S, Flagg TP, Pilgram TK, Demolombe S, Nerbonne JM, Distinct cellular and molecular mechanisms underlie functional remodeling of repolarizing K+ currents with left ventricular hypertrophy., Circ Res 2008 Jun; 102(11): 1406-15.
2008
Watanabe H, Koopmann TT, Le Scouarnec S, Yang T, Ingram CR, Schott JJ, Demolombe S, Probst V, Anselme F, Escande D, Wiesfeld AC, Pfeufer A, Kääb S, Wichmann HE, Hasdemir C, Aizawa Y, Wilde AA, Roden DM, Bezzina CR, Sodium channel β1 subunit mutations associated with Brugada syndrome and cardiac conduction disease in humans., J Clin Invest 2008 Jun; 118(6): 2260-8.
2007
Gaborit N, Le Bouter S, Szuts V, Varro A, Escande D, Nattel S, Demolombe S, Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart., J Physiol 2007 Jul; 582(Pt 2): 675-93.
2007
Cardin S, Libby E, Pelletier P, Le Bouter S, Shiroshita-Takeshita A, Le Meur N, Léger J, Demolombe S, Ponton A, Glass L, Nattel S, Contrasting gene expression profiles in two canine models of atrial fibrillation., Circ Res 2007 Feb; 100(3): 425-33.
2006
Lamirault G, Gaborit N, Le Meur N, Chevalier C, Lande G, Demolombe S, Escande D, Nattel S, Léger JJ, Steenman M, Gene expression profile associated with chronic atrial fibrillation and underlying valvular heart disease in man., J Mol Cell Cardiol 2006 Jan; 40(1): 173-84.
2005
Leoni AL, Marionneau C, Demolombe S, Le Bouter S, Mangoni ME, Escande D, Charpentier F, Chronic heart rate reduction remodels ion channel transcripts in the mouse sinoatrial node but not in the ventricle., Physiol Genomics 2005 Dec; 24(1): 4-12.
2005
Guo W, Jung WE, Marionneau C, Aimond F, Xu H, Yamada KA, Schwarz TL, Demolombe S, Nerbonne JM, Targeted deletion of Kv4.2 eliminates I(to,f) and results in electrical and molecular remodeling, with no evidence of ventricular hypertrophy or myocardial dysfunction., Circ Res 2005 Dec; 97(12): 1342-50.
2005
Bendahhou S, Marionneau C, Haurogne K, Larroque MM, Derand R, Szuts V, Escande D, Demolombe S, Barhanin J, In vitro molecular interactions and distribution of KCNE family with KCNQ1 in the human heart., Cardiovasc Res 2005 Aug; 67(3): 529-38.
2005
Demolombe S, Marionneau C, Le Bouter S, Charpentier F, Escande D, Functional genomics of cardiac ion channel genes., Cardiovasc Res 2005 Aug; 67(3): 438-47.
2005
Demolombe S, Lonesome Kv4.2 channels., J Mol Cell Cardiol 2005 Aug; 39(2): 401-2.
2005
Gaborit N, Steenman M, Lamirault G, Le Meur N, Le Bouter S, Lande G, Léger J, Charpentier F, Christ T, Dobrev D, Escande D, Nattel S, Demolombe S, Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation., Traffic 2005 Jul; 112(4): 471-81.
2005
Ouvrard-Pascaud A, Sainte-Marie Y, Bénitah JP, Perrier R, Soukaseum C, Nguyen Dinh Cat A, Royer A, Le Quang K, Charpentier F, Demolombe S, Mechta-Grigoriou F, Beggah AT, Maison-Blanche P, Oblin ME, Delcayre C, Fishman GI, Farman N, Escoubet B, Jaisser F, Conditional mineralocorticoid receptor expression in the heart leads to life-threatening arrhythmias., Traffic 2005 Jun; 111(23): 3025-33.
2005
Royer A, van Veen TA, Le Bouter S, Marionneau C, Griol-Charhbili V, Léoni AL, Steenman M, van Rijen HV, Demolombe S, Goddard CA, Richer C, Escoubet B, Jarry-Guichard T, Colledge WH, Gros D, de Bakker JM, Grace AA, Escande D, Charpentier F, Mouse model of SCN5A-linked hereditary Lenègre's disease: age-related conduction slowing and myocardial fibrosis., Traffic 2005 Apr; 111(14): 1738-46.
2005
Royer A, Demolombe S, El Harchi A, Le Quang K, Piron J, Toumaniantz G, Mazurais D, Bellocq C, Lande G, Terrenoire C, Motoike HK, Chevallier JC, Loussouarn G, Clancy CE, Escande D, Charpentier F, Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity., Cardiovasc Res 2005 Jan; 65(1): 128-37.
2005
Marionneau C, Couette B, Liu J, Li H, Mangoni ME, Nargeot J, Lei M, Escande D, Demolombe S, Specific pattern of ionic channel gene expression associated with pacemaker activity in the mouse heart., J Physiol 2005 Jan; 562(Pt 1): 223-34.
2004
Lamirault G, Steenman M, Le Meur N, Demolombe S, Trochu JN, Léger JJ, DNA chip technology in cardiovascular research., Arch Mal Coeur Vaiss 2004 Dec; 97(12): 1251-5.
2004
Le Bouter S, El Harchi A, Marionneau C, Bellocq C, Chambellan A, van Veen T, Boixel C, Gavillet B, Abriel H, Le Quang K, Chevalier JC, Lande G, Léger JJ, Charpentier F, Escande D, Demolombe S, Long-term amiodarone administration remodels expression of ion channel transcripts in the mouse heart., Traffic 2004 Nov; 110(19): 3028-35.
2004
Gouas L, Bellocq C, Berthet M, Potet F, Demolombe S, Forhan A, Lescasse R, Simon F, Balkau B, Denjoy I, Hainque B, Baró I, Guicheney P, New KCNQ1 mutations leading to haploinsufficiency in a general population; Defective trafficking of a KvLQT1 mutant., Cardiovasc Res 2004 Jul; 63(1): 60-8.
2004
Carpenter F, Demolombe S, Escande D, Cardiac channelopathies: from men to mice., Ann Med 2004; 36 Suppl 1(): 28-34.
2003
Herfst LJ, Potet F, Bezzina CR, Groenewegen WA, Le Marec H, Hoorntje TM, Demolombe S, Baró I, Escande D, Jongsma HJ, Wilde AA, Rook MB, Na+ channel mutation leading to loss of function and non-progressive cardiac conduction defects., J Mol Cell Cardiol 2003 May; 35(5): 549-57.
2003
Probst V, Kyndt F, Potet F, Trochu JN, Mialet G, Demolombe S, Schott JJ, Baró I, Escande D, Le Marec H, Haploinsufficiency in combination with aging causes SCN5A-linked hereditary Lenègre disease., J Am Coll Cardiol 2003 Feb; 41(4): 643-52.
2003
Le Bouter S, Demolombe S, Chambellan A, Bellocq C, Aimond F, Toumaniantz G, Lande G, Siavoshian S, Baró I, Pond AL, Nerbonne JM, Léger JJ, Escande D, Charpentier F, Microarray analysis reveals complex remodeling of cardiac ion channel expression with altered thyroid status: relationship to cellular and integrated electrophysiology., Circ Res 2003 Feb; 92(2): 234-42.
2003
Péréon Y, Lande G, Demolombe S, Nguyen The Tich S, Sternberg D, Le Marec H, David A, Paramyotonia congenita with an SCN4A mutation affecting cardiac repolarization., Neurology 2003 Jan; 60(2): 340-2.
2001
Kyndt F, Probst V, Potet F, Demolombe S, Chevallier JC, Baro I, Moisan JP, Boisseau P, Schott JJ, Escande D, Le Marec H, Novel SCN5A mutation leading either to isolated cardiac conduction defect or Brugada syndrome in a large French family., Traffic 2001 Dec; 104(25): 3081-6.
2001
Franco D, Demolombe S, Kupershmidt S, Dumaine R, Dominguez JN, Roden D, Antzelevitch C, Escande D, Moorman AF, Divergent expression of delayed rectifier K(+) channel subunits during mouse heart development., Cardiovasc Res 2001 Oct; 52(1): 65-75.
2001
Demolombe S, Lande G, Charpentier F, van Roon MA, van den Hoff MJ, Toumaniantz G, Baro I, Guihard G, Le Berre N, Corbier A, de Bakker J, Opthof T, Wilde A, Moorman AF, Escande D, Transgenic mice overexpressing human KvLQT1 dominant-negative isoform. Part I: Phenotypic characterization., Cardiovasc Res 2001 May; 50(2): 314-27.
2001
Lande G, Demolombe S, Bammert A, Moorman A, Charpentier F, Escande D, Transgenic mice overexpressing human KvLQT1 dominant-negative isoform. Part II: Pharmacological profile., Cardiovasc Res 2001 May; 50(2): 328-34.
2001
Demolombe S, Franco D, de Boer P, Kuperschmidt S, Roden D, Pereon Y, Jarry A, Moorman AF, Escande D, Differential expression of KvLQT1 and its regulator IsK in mouse epithelia., Am J Physiol Cell Physiol 2001 Feb; 280(2): C359-72.
2000
Péréon Y, Demolombe S, Baró I, Drouin E, Charpentier F, Escande D, Differential expression of KvLQT1 isoforms across the human ventricular wall., Am J Physiol Heart Circ Physiol 2000 Jun; 278(6): H1908-15.
1999
Mohammad-Panah R, Demolombe S, Neyroud N, Guicheney P, Kyndt F, van den Hoff M, Baró I, Escande D, Mutations in a dominant-negative isoform correlate with phenotype in inherited cardiac arrhythmias., Am J Hum Genet 1999 Apr; 64(4): 1015-23.
1999
Leblais V, Demolombe S, Vallette G, Langin D, Baró I, Escande D, Gauthier C, beta3-adrenoceptor controls the cystic fibrosis transmembrane conductance regulator through a cAMP/protein kinase A-independent pathway., J Biol Chem 1999 Mar; 274(10): 6107-13.
1998
Clancy JP, Hong JS, Bebök Z, King SA, Demolombe S, Bedwell DM, Sorscher EJ, Cystic fibrosis transmembrane conductance regulator (CFTR) nucleotide-binding domain 1 (NBD-1) and CFTR truncated within NBD-1 target to the epithelial plasma membrane and increase anion permeability., Biochemistry 1998 Oct; 37(43): 15222-30.
1998
Hollande E, Fanjul M, Chemin-Thomas C, Devaux C, Demolombe S, Van Rietschoten J, Guy-Crotte O, Figarella C, Targeting of CFTR protein is linked to the polarization of human pancreatic duct cells in culture., Eur J Cell Biol 1998 Jul; 76(3): 220-7.
1998
Pollard H, Remy JS, Loussouarn G, Demolombe S, Behr JP, Escande D, Polyethylenimine but not cationic lipids promotes transgene delivery to the nucleus in mammalian cells., J Biol Chem 1998 Mar; 273(13): 7507-11.
1998
Demolombe S, Baró I, Péréon Y, Bliek J, Mohammad-Panah R, Pollard H, Morid S, Mannens M, Wilde A, Barhanin J, Charpentier F, Escande D, A dominant negative isoform of the long QT syndrome 1 gene product., J Biol Chem 1998 Mar; 273(12): 6837-43.
1998
Mohammad-Panah R, Demolombe S, Riochet D, Leblais V, Loussouarn G, Pollard H, Baró I, Escande D, Hyperexpression of recombinant CFTR in heterologous cells alters its physiological properties., Am J Physiol 1998 Feb; 274(2): C310-8.
1996
Loussouarn G, Demolombe S, Mohammad-Panah R, Escande D, Baró I, Expression of CFTR controls cAMP-dependent activation of epithelial K+ currents., Am J Physiol 1996 Nov; 271(5 Pt 1): C1565-73.
1996
Demolombe S, Escande D, ATP-binding cassette proteins as targets for drug discovery., Trends Pharmacol Sci 1996 Aug; 17(8): 273-5.
1996
Demolombe S, Baró I, Bebok Z, Clancy JP, Sorscher EJ, Thomas-Soumarmon A, Pavirani A, Escande D, A method for the rapid detection of recombinant CFTR during gene therapy in cystic fibrosis., Gene Ther 1996 Aug; 3(8): 685-94.
1996
Henry P, Demolombe S, Pucéat M, Escande D, Adenosine A1 stimulation activates delta-protein kinase C in rat ventricular myocytes., Circ Res 1996 Jan; 78(1): 161-5.
1994
Demolombe S, Baró I, Laurent M, Gelding AS, Pavirani A, Escande D, Abnormal subcellular localization of mutated CFTR protein in a cystic fibrosis epithelial cell line., Eur J Cell Biol 1994 Oct; 65(1): 214-9.
1991
Tigaud JD, Demolombe S, Bastion Y, Bryon PA, Coiffier B, Ifosfamide continuous infusion plus etoposide in the treatment of elderly patients with aggressive lymphoma: a phase II study., Hematol Oncol 1991; 9(4-5): 225-33.