Hélène MARIE – IPMC

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Dr Marie received her PhD in Neuroscience from University College London, UK in 2000. She then completed her postdoctoral training at Stanford University in Dr Malenka’s laboratory. In 2005, she became an independent group leader at the European Brain Research Institute (EBRI) in Rome, Italy. In 2010, she moved to France to join the CNRS at the Institute of Molecular and Cellular Pharmacology (IPMC) in Sophia-Antipolis, creating her ATIP-Avenir team. Dr Marie currently continues to lead this research team (co-led by Dr Barik) and her research projects aim to understand the synaptic mechanisms leading to memory loss in Alzheimer’s disease. Her recent work has highlighted the role of different peptides derived from the amyloid precursor protein (APP) in the modulation of synaptic function. Since 2024, she has also become Deputy Director of the IPMC.

Events

H. MARIE invites Dr. Paolo GIACOBINI

«The «scent»-sational role of GnRH neurons»

Jade DUNOT's Thesis

«AETA, a new neuromodulator of the NMDA receptor in the hippocampus and its role in Alzheimer’s disease« Thesis Director: Hélène […]

Hélène Marie invites Dr. Naomi Moreno

«APOE Isoforms: Tau Polymorphism and Bioactivity»

News

IPMC Publication / Neuron / Marie-Barik Team

An APP fragment controls both ionotropic and non-ionotropic NMDA receptor signaling Link to article Neuron Article […]

Publication IPMC / Biological Psychiatry / Dr. Sebastian Fernandez /Equipe Marie/Barik

«"A common thread between stress and anxiety: the VTA-amygdala pathway" Link to the article: https://www.biologicalpsychiatryjournal.com/article/S0006-3223(25)01121-7/fulltext

Projects

Alzheimer's disease (AD)

Amyloid precursor protein (APP) is a key protein involved in the etiology of AD. This protein is cleaved into several […]

Publications

Dunot J, Moreno S, Gandin C, Pousinha PA, Amici M, Dupuis J, Anisimova M, Winschel A, Uriot M, Petshow SJ, Mensch M, Bethus I, Giudici C, Hampel H, Wefers B, Wurst W, Naumann R , Ashby MC, Laube B, Zito K, Mellor JR, Groc L, Willem M, Marie H, APP fragment controls both ionotropic and non-ionotropic signaling of NMDA receptors. Neuron 2024 Aug; 112(16): 2708-2720.e9.

Dunot J, Ribera A, Pousinha PA, Marie H, Spatiotemporal insights of APP function. Curr Opin Neurobiol 2023 Oct; 82(): 102754.

Rodrigues YE, Tigaret CM, Marie H, O'Donnell C, Veltz R, A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics. Elife 2023 Aug; 12(): .

Rajão-Saraiva J, Dunot J, Ribera A, Temido-Ferreira M, Coelho JE, König S, Moreno S, Enguita FJ, Willem M, Kins S, Marie H, Lopes LV, Pousinha PA, Age-dependent NMDA receptor function is regulated by the amyloid precursor protein. Aging Cell 2023 Mar; 22(3): e13778.

Dainauskas JJ, Vitale P, Moreno S, Marie H, Migliore M, Saudargiene A, Altered synaptic plasticity at hippocampal CA1-CA3 synapses in Alzheimer's disease: integration of amyloid precursor protein intracellular domain and amyloid beta effects into computational models. Front Comput Neurosci 2023; 17(): 1305169.

Dainauskas JJ, Marie H, Migliore M, Saudargiene A, GluN2B-NMDAR subunit contribution on synaptic plasticity: A phenomenological model for CA3-CA1 synapses. Front Synaptic Neurosci 2023; 15(): 1113957.

Bianchi D, Migliore R, Vitale P, Garad M, Pousinha PA, Marie H, Lessmann V, Migliore M, Membrane electrical properties of mouse hippocampal CA1 pyramidal neurons during strong inputs. Biophys J 2022 Feb; 121(4): 644-657.

Brigas HC, Ribeiro M, Coelho JE, Gomes R, Gomez-Murcia V, Carvalho K, Faivre E, Costa-Pereira S, Darrigues J, de Almeida AA, Buée L, Dunot J, Marie H, Pousinha PA, Blum D, Silva-Santos B, Lopes LV, Ribot JC, IL-17 triggers the onset of cognitive and synaptic deficits in early stages of Alzheimer's disease. Cell Rep 2021 Aug; 36(9): 109574.

Mensch M, Dunot J, Yishan SM, Harris SS, Blistein A, Avdiu A, Pousinha PA, Giudici C, Busche MA, Jedlicka P, Willem M, Marie H, Aη-α and Aη-β peptides odd LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo. Alzheimers Res Ther 2021 Jul; 13(1): 125.

Vitale P, Salgueiro-Pereira AR, Lupascu CA, Willem M, Migliore R, Migliore M, Marie H, Analysis of Age-Dependent Alterations in Excitability Properties of CA1 Pyramidal Neurons in an APPPS1 Model of Alzheimer's Disease. Front Aging Neurosci 2021; 13(): 668948.

Kartalou GI, Salgueiro-Pereira AR, Endres T, Lesnikova A, Casarotto P, Pousinha P, Delanoe K, Edelmann E, Castrén E, Gottmann K, Marie H, Lessmann V, Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model., Int J Mol Sci 2020 Nov; 21(23): .

Temido-Ferreira M, Ferreira DG, Batalha VL, Marques-Morgado I, Coelho JE, Pereira P, Gomes R, Pinto A, Carvalho S, Canas PM, Cuvelier L, Buée-Scherrer V, Faivre E, Baqi Y, Müller CE , Pimentel J, Schiffmann SN, Buée L, Bader M, Outeiro TF, Blum D, Cunha RA, Marie H, Pousinha PA, Lopes LV, Age-related shift in LTD is dependent on neuronal adenosine A2A receptors interplay with mGluR5 and NMDA receptors. Mol Psychiatry 2020 Aug; 25(8): 1876-1900.

Pousinha PA, Mouska , Marie H, The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding. Cell Rep 2019 Oct; 29(2): 317-331.e5.

Fernandez SP, Broussot L, Marti F, Contesse T, Mouska X, Soiza-Reilly M, Marie H, Faure P, Barik J, Mesopontin cholinergic inputs to midbrain dopamine neurons drive stress-induced depressive-like behaviors. Nat Common 2018 Oct; 9(1): 4449.

Kootar S, Frandemiche ML, Dhib G, Mouska X, Lorivel T, Poupon-Silvestre G, Hunt H, Tronche F, Bethus I, Barik J, Marie H, Identification of an acute functional cross-talk between amyloid-β and glucocorticoid receptors at hippocampal excitatory synapses. Neurobiol Dis 2018 Oct; 118(): 117-128.

Morel C, Fernandez SP, Pantouli F, Meye FJ, Marti F, Tolu S, Parnaudeau S, Marie H, Tronche F, Maskos U, Moretti M, Gotti C, Han MH, Bailey A, Mameli M, Barik J, Faure P , Nicotinic receptors mediate stress-nicotine detrimental interplay via dopamine cells' activity. Mol Psychiatry 2018 Jul; 23(7): 1597-1605.

Willem M, Tahirovic S, Busche MA, Ovsepian SV, Chafai M, Kootar S, Hornburg D, Evans LD, Moore S, Daria A, Hampel H, Müller V, Giudici C, Nuscher B, Wenninger-Weinzierl A, Kremmer E, Heneka MT, Thal DR, Giedraitis V, Lannfelt L, Müller U, Livesey FJ, Meissner F, Herms J, Konnerth A, Marie H, Haass C, η-Secretase processing of APP inhibits neuronal activity in the hippocampus. Nature 2015 Oct; 526(7573): 443-7.

Lanté F, Chafai M, Raymond EF, Pereira AR, Mouska X, Kootar S, Barik J, Bethus I, Marie H, Subchronic glucocorticoid receptor inhibition rescues early episodic memory and synaptic plasticity deficits in a mouse model of Alzheimer's disease. Neuropsychopharmacology 2015 Jun; 40(7): 1772-81.

Middei S, Ammassari-Teule M, Marie H, Synaptic plasticity under learning challenge. Neurobiol Learn Mem 2014 Nov; 115(): 108-15.

Marcantoni A, Raymond EF, Carbone E, Marie H, Firing properties of entorhinal cortex neurons and early alterations in an Alzheimer's disease transgenic model. Pflugers Arch 2014 Jul; 466(7): 1437-50.