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Événements

10
Jan
2025
11:00 am
Conférence
T. HARAYAMA invite le Pr. Giovanni D'ANGELO

The lipotype Hypothesis Pr. Giovanni D’AngeloEPFL (Ecole Polytechnique Fédérale de Lausanne) Single-cell genomics techniques have allowed for the deep profiling […]
05
Mai
2025
Conférence
Takeshi HARAYAMA invite le Dr. Takao SHIMIZU

“Biological functions of DHA-rich membrane in vivo”

IPMC

Projets

Projet
2024
Recherche sur la lipodystrophie congénitale généralisée de type 1

Le premier axe de notre recherche est de comprendre le mécanisme cellulaire de la maladie génétique « lipodystrophie congénitale généralisée de […]
Projet
2024
Recherche sur le lien entre la composition lipidique et la signalisation

Le deuxième axe de notre recherche est de comprendre comment les acides gras des lipides membranaires affectent l’organisation latérale et […]

Publications

2025
Edyta Glogowska, Gregor P. Jose, Ana Rita Dias Araújo, Malika Arhatte, Raphael Divita, Coraline Borowczyk, Thibault Barouillet, Baile Wang, Frédéric Brau, Rémi Peyronnet, Amanda Patel, Bruno Mesmin, Takeshi Harayama, Bruno Antonny, Aimin Xu, Laurent Yvan-Charvet, Eric Honoré, Potentiation of macrophage Piezo1 by atherogenic 7-ketocholesterol, .
2025
Jiménez-Rojo N, Feng S, Morstein J, Pritzl SD, Asaro A, López S, Xu Y, Harayama T, Vepřek NA, Arp CJ, Reynders M, Novak AJE, Kanshin E, Lipfert J, Ueberheide B, Muñiz M, Lohmüller T, Riezman H, Trauner D, Optical Control of Membrane Viscosity Modulates ER-to-Golgi Trafficking., ACS Cent Sci 2025 Sep; 11(9): 1736-1752.
2025
Carpentier M, Omrane M, Shaaban R, Träger J, El Khallouki N, Le Lay S, Patat J, Palard M, Zouiouich M, Combot Y, Harayama T, Vigouroux C, Schauer K, Giordano F, Prieur X, Thiam AR, Seipin Governs caveolin-1 trafficking through modulating sphingolipid-glycerolipid balance., Cell Rep 2025 Sep; 44(10): 116320.
2025
Rodriguez-Gallardo S, Harayama T, Nothing can replace polyunsaturated lipids., Elife 2025 Aug; 14(): .
2025
Gollowitzer A, Pein H, Rao Z, Waltl L, Bereuter L, Loeser K, Meyer T, Jafari V, Witt F, Winkler R, Su F, Große S, Thürmer M, Grander J, Hotze M, Harder S, Espada L, Magnutzki A, Gstir R, Weinigel C, Rummler S, Bonn G, Pachmayr J, Ermolaeva M, Harayama T, Schlüter H, Kosan C, Heller R, Thedieck K, Schmitt M, Shimizu T, Popp J, Shindou H, Kwiatkowski M, Koeberle A, Attenuated growth factor signaling during cell death initiation sensitizes membranes towards peroxidation., Nat Commun 2025 Feb; 16(1): 1774.
2025
Chen XW, Don AS, Fedorova M, Harayama T, Krahmer N, Nagata S, Narayan P, Nicholas D, Nowinski SM, Saheki Y, Semenkovich CF, Zhao X, Zou Y, Time for lipid cell biology., Nat Cell Biol 2025 Feb; 27(2): 169-174.
2024
Takeda H, Matsuzawa Y, Takeuchi M, Takahashi M, Nishida K, Harayama T, Todoroki Y, Shimizu K, Sakamoto N, Oka T, Maekawa M, Chung MH, Kurizaki Y, Kiuchi S, Tokiyoshi K, Buyantogtokh B, Kurata M, Kvasnička A, Takeda U, Uchino H, Hasegawa M, Miyamoto J, Tanabe K, Takeda S, Mori T, Kumakubo R, Tanaka T, Yoshino T, Okamoto M, Takahashi H, Arita M, Tsugawa H, MS-DIAL 5 multimodal mass spectrometry data mining unveils lipidome complexities., Nat Commun 2024 Nov; 15(1): 9903.
2023
Harayama T, Metabolic bias: Lipid structures as determinants of their metabolic fates., Biochimie 2023 Dec; 215(): 34-41.
2022
Jose GP, Harayama T, Unique acyl chains mark phosphoinositides for recycling., EMBO J 2022 Sep; 41(18): e112163.
2021
Hamano F, Matoba K, Hashidate-Yoshida T, Suzuki T, Miura K, Hishikawa D, Harayama T, Yuki K, Kita Y, Noda NN, Shimizu T, Shindou H, Mutagenesis and homology modeling reveal a predicted pocket of lysophosphatidylcholine acyltransferase 2 to catch Acyl-CoA., FASEB J 2021 Jun; 35(6): e21501.
2021
Hannich JT, Loizides-Mangold U, Sinturel F, Harayama T, Vandereycken B, Saini C, Gosselin P, Brulhart-Meynet MC, Robert M, Chanon S, Durand C, Paz Montoya J, David FPA, Guessous I, Pataky Z, Golay A, Jornayvaz FR, Philippe J, Dermitzakis ET, Brown SA, Lefai E, Riezman H, Dibner C, Ether lipids, sphingolipids and toxic 1-deoxyceramides as hallmarks for lean and obese type 2 diabetic patients., Acta Physiol (Oxf) 2021 May; 232(1): e13610.
2020
Harayama T, Shimizu T, Roles of polyunsaturated fatty acids, from mediators to membranes., J Lipid Res 2020 Aug; 61(8): 1150-1160.