Mounia CHAMI – IPMC

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Thème

Frédéric CHECLER

Charlotte BAUER

Biographie pas encore disponible.

Événements

M. CHAMI invite le Dr Maud GRATUZE

« Microglia : Super-Hero or Villain in Alzheimer’s Disease ? Dr. Maud GRATUZEInstitut de Neurophysiopathologie, INP- UMR7051Faculté des Sciences Médicales et […]

Publications

Eysert F, Kinoshita PF, Lagarde J, Lacas-Gervais S, Xicota L, Dorothée G, Bottlaender M, Checler F, Potier MC, Sarazin M, Chami M, Mitochondrial alterations in fibroblasts from sporadic Alzheimer’s disease (AD) patients correlate with AD-related clinical hallmarks., Acta Neuropathol Commun 2024 Jun; 12(1): 90.

Vaillant-Beuchot L, Eysert F, Duval B, Kinoshita PF, Pardossi-Piquard R, Bauer C, Eddarkaoui S, Buée L, Checler F, Chami M, The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease., Cell Death Dis 2024 May; 15(5): 367.

Iravanian S, Uzelac I, Shah AD, Toye MJ, Lloyd MS, Burke MA, Daneshmand MA, Attia TS, Vega JD, El-Chami MF, Merchant FM, Cherry EM, Bhatia NK, Fenton FH, Complex repolarization dynamics in ex vivo human ventricles are independent of the restitution properties., Europace 2023 Dec; 25(12): .

Iravanian S, Uzelac I, Shah AD, Toye MJ, Lloyd MS, Burke MA, Daneshmand MA, Attia TS, Vega JD, El-Chami M, Merchant FM, Cherry EM, Bhatia NK, Fenton FH, Higher-Order Dynamics Beyond Repolarization Alternans in Ex-Vivo Human Ventricles are Independent of the Restitution Properties., medRxiv 2023 Aug; (): .

Afram E, Lauritzen I, Bourgeois A, El Manaa W, Duplan E, Chami M, Valverde A, Charlotte B, Pardossi-Piquard R, Checler F, The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aβ production., Cell Mol Life Sci 2023 Mar; 80(4): 97.

Xicota L, Lagarde J, Eysert F, Grenier-Boley B, Rivals I, Botté A, Forlani S, Landron S, Gautier C, Gabriel C, Bottlaender M, Lambert JC, Chami M, Sarazin M, Potier MC, Modifications of the endosomal compartment in fibroblasts from sporadic Alzheimer’s disease patients are associated with cognitive impairment., Transl Psychiatry 2023 Feb; 13(1): 54.

Mary A, Eysert F, Checler F, Chami M, Mitophagy in Alzheimer’s disease: Molecular defects and therapeutic approaches., Mol Psychiatry 2023 Jan; 28(1): 202-216.

El Manaa W, Duplan E, Goiran T, Lauritzen I, Vaillant Beuchot L, Lacas-Gervais S, Morais VA, You H, Qi L, Salazar M, Ozcan U, Chami M, Checler F, Alves da Costa C, Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology., Autophagy 2021 Dec; 17(12): 4363-4385.

Mary A, Vaillant-Beuchot L, Checler F, Chami M, [Mitochondrial dysfunction and mitophagy failure in Alzheimer’s disease]., Med Sci (Paris) 2021 Oct; 37(10): 843-847.

Valverde A, Dunys J, Lorivel T, Debayle D, Gay AS, Caillava C, Chami M, Checler F, Dipeptidyl peptidase 4 contributes to Alzheimer’s disease-like defects in a mouse model and is increased in sporadic Alzheimer’s disease brains., J Biol Chem 2021 Aug; 297(2): 100963.

Valverde A, Dunys J, Lorivel T, Debayle D, Gay AS, Lacas-Gervais S, Roques BP, Chami M, Checler F, Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer’s disease (AD) mouse model and is increased at early stage in sporadic AD brain., Acta Neuropathol 2021 Jun; 141(6): 823-839.

Chami M, Calcium Signalling in Alzheimer’s Disease: From Pathophysiological Regulation to Therapeutic Approaches., Cells 2021 Jan; 10(1): .

Daniel Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, Iannis Adamopoulos, Khosrow Adeli, Timon Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat Aggarwal, Maria Agnello, Patrizia Agostinis, Javed Agrewala, Alexander Agrotis, Patricia Aguilar, S. Tariq Ahmad, Zubair Ahmed, Ulises Ahumada-Castro, Sonja Aits, Shu Aizawa, Yunus Akkoc, To..., Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition), Autophagy, 2021, 17 (1), pp.1-382. ⟨10.1080/15548627.2020.1797280⟩.

Vaillant-Beuchot L, Mary A, Pardossi-Piquard R, Bourgeois A, Lauritzen I, Eysert F, Kinoshita PF, Cazareth J, Badot C, Fragaki K, Bussiere R, Martin C, Mary R, Bauer C, Pagnotta S, Paquis-Flucklinger V, Buée-Scherrer V, Buée L, Lacas-Gervais S, Checler F, Chami M, Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains., Acta Neuropathol 2021 Jan; 141(1): 39-65.

Eysert F, Kinoshita PF, Mary A, Vaillant-Beuchot L, Checler F, Chami M, Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer’s Disease., Int J Mol Sci 2020 Dec; 21(24): .

Chami M, Checler F, Alterations of the Endoplasmic Reticulum (ER) Calcium Signaling Molecular Components in Alzheimer’s Disease., Cells 2020 Dec; 9(12): .

Chami M, Checler F, Targeting Post-Translational Remodeling of Ryanodine Receptor: A New Track for Alzheimer’s Disease Therapy?, Curr Alzheimer Res 2020 ; 17(4): 313-323.

Bussiere R, Oulès B, Mary A, Vaillant-Beuchot L, Martin C, El Manaa W, Vallée D, Duplan E, Paterlini-Bréchot P, Alves Da Costa C, Checler F, Chami M, Upregulation of the Sarco-Endoplasmic Reticulum Calcium ATPase 1 Truncated Isoform Plays a Pathogenic Role in Alzheimer’s Disease., Cells 2019 Nov; 8(12): .

Goiran T, Duplan E, Chami M, Bourgeois A, El Manaa W, Rouland L, Dunys J, Lauritzen I, You H, Stambolic V, Biféri MG, Barkats M, Pimplikar SW, Sergeant N, Colin M, Morais VA, Pardossi-Piquard R, Checler F, Alves da Costa C, β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models., Biol Psychiatry 2018 Mar; 83(5): 416-427.

Lacampagne A, Liu X, Reiken S, Bussiere R, Meli AC, Lauritzen I, Teich AF, Zalk R, Saint N, Arancio O, Bauer C, Duprat F, Briggs CA, Chakroborty S, Stutzmann GE, Shelanski ML, Checler F, Chami M, Marks AR, Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s disease-like pathologies and cognitive deficits., Acta Neuropathol 2017 Nov; 134(5): 749-767.

Bussiere R, Lacampagne A, Reiken S, Liu X, Scheuerman V, Zalk R, Martin C, Checler F, Marks AR, Chami M, Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor., J Biol Chem 2017 Jun; 292(24): 10153-10168.

Del Prete D, Suski JM, Oulès B, Debayle D, Gay AS, Lacas-Gervais S, Bussiere R, Bauer C, Pinton P, Paterlini-Bréchot P, Wieckowski MR, Checler F, Chami M, Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes., J Alzheimers Dis 2017 ; 55(4): 1549-1570.

Ayciriex S, Gerber H, Osuna GM, Chami M, Stahlberg H, Shevchenko A, Fraering PC, The lipidome associated with the γ-secretase complex is required for its integrity and activity., Biochem J 2016 Feb; 473(3): 321-34.

Bidaux G, Borowiec AS, Gordienko D, Beck B, Shapovalov GG, Lemonnier L, Flourakis M, Vandenberghe M, Slomianny C, Dewailly E, Delcourt P, Desruelles E, Ritaine A, Polakowska R, Lesage J, Chami M, Skryma R, Prevarskaya N, Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner., Proc Natl Acad Sci U S A 2015 Jun; 112(26): E3345-54.

Del Prete D, Checler F, Chami M, Ryanodine receptors: physiological function and deregulation in Alzheimer disease., Mol Neurodegener 2014 Jun; 9(): 21.

Chami M, Checler F, Ryanodine receptors: dual contribution to Alzheimer disease?, Channels (Austin) 2014 ; 8(3): 168.

Williams V, Brichler S, Khan E, Chami M, Dény P, Kremsdorf D, Gordien E, Large hepatitis delta antigen activates STAT-3 and NF-κB via oxidative stress., J Viral Hepat 2012 Oct; 19(10): 744-53.

Oulès B, Del Prete D, Greco B, Zhang X, Lauritzen I, Sevalle J, Moreno S, Paterlini-Bréchot P, Trebak M, Checler F, Benfenati F, Chami M, Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease., J Neurosci 2012 Aug; 32(34): 11820-34.

Chami L, Buggia-Prévot V, Duplan E, Del Prete D, Chami M, Peyron JF, Checler F, Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations., J Biol Chem 2012 Jul; 287(29): 24573-84.

Mbaya E, Oulès B, Caspersen C, Tacine R, Massinet H, Pennuto M, Chrétien D, Munnich A, Rötig A, Rizzuto R, Rutter GA, Paterlini-Bréchot P, Chami M, Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency., Cell Death Differ 2010 Dec; 17(12): 1855-66.

Huber C, Oulès B, Bertoli M, Chami M, Fradin M, Alanay Y, Al-Gazali LI, Ausems MG, Bitoun P, Cavalcanti DP, Krebs A, Le Merrer M, Mortier G, Shafeghati Y, Superti-Furga A, Robertson SP, Le Goff C, Muda AO, Paterlini-Bréchot P, Munnich A, Cormier-Daire V, Identification of CANT1 mutations in Desbuquois dysplasia., Am J Hum Genet 2009 Nov; 85(5): 706-10.

Chami M, Oulès B, Szabadkai G, Tacine R, Rizzuto R, Paterlini-Bréchot P, Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress., Mol Cell 2008 Dec; 32(5): 641-51.

Chami M, Benali NL, Bréchot C, Paterlini-Bréchot P, [Impact of calcium signaling in liver carcinogenesis]., Med Sci (Paris) 2007 Feb; 23(2): 133-5.

Chami M, Oulès B, Paterlini-Bréchot P, Cytobiological consequences of calcium-signaling alterations induced by human viral proteins., Biochim Biophys Acta 2006 Nov; 1763(11): 1344-62.

Benali-Furet NL, Chami M, Houel L, De Giorgi F, Vernejoul F, Lagorce D, Buscail L, Bartenschlager R, Ichas F, Rizzuto R, Paterlini-Bréchot P, Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion., Oncogene 2005 Jul; 24(31): 4921-33.

Chami M, Prandini A, Campanella M, Pinton P, Szabadkai G, Reed JC, Rizzuto R, Bcl-2 and Bax exert opposing effects on Ca2+ signaling, which do not depend on their putative pore-forming region., J Biol Chem 2004 Dec; 279(52): 54581-9.

Szabadkai G, Simoni AM, Chami M, Wieckowski MR, Youle RJ, Rizzuto R, Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis., Mol Cell 2004 Oct; 16(1): 59-68.

Rizzuto R, Pinton P, Ferrari D, Chami M, Szabadkai G, Magalhães PJ, Di Virgilio F, Pozzan T, Calcium and apoptosis: facts and hypotheses., Oncogene 2003 Nov; 22(53): 8619-27.

Chami M, Ferrari D, Nicotera P, Paterlini-Bréchot P, Rizzuto R, Caspase-dependent alterations of Ca2+ signaling in the induction of apoptosis by hepatitis B virus X protein., J Biol Chem 2003 Aug; 278(34): 31745-55.

Paterlini-Bréchot P, Saigo K, Murakami Y, Chami M, Gozuacik D, Mugnier C, Lagorce D, Bréchot C, Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene., Oncogene 2003 Jun; 22(25): 3911-6.

Gozuacik D, Chami M, Lagorce D, Faivre J, Murakami Y, Poch O, Biermann E, Knippers R, Bréchot C, Paterlini-Bréchot P, Identification and functional characterization of a new member of the human Mcm protein family: hMcm8., Nucleic Acids Res 2003 Jan; 31(2): 570-9.

Ferrari D, Pinton P, Szabadkai G, Chami M, Campanella M, Pozzan T, Rizzuto R, Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis., Cell Calcium 2002 ; 32(5-6): 413-20.

Gozuacik D, Murakami Y, Saigo K, Chami M, Mugnier C, Lagorce D, Okanoue T, Urashima T, Bréchot C, Paterlini-Bréchot P, Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging., Oncogene 2001 Sep; 20(43): 6233-40.

Siegrist S, Féral C, Chami M, Solhonne B, Mattéi MG, Rajpert-De Meyts E, Guellaën G, Bulle F, hH-Rev107, a class II tumor suppressor gene, is expressed by post-meiotic testicular germ cells and CIS cells but not by human testicular germ cell tumors., Oncogene 2001 Aug; 20(37): 5155-63.

Chami M, Gozuacik D, Lagorce D, Brini M, Falson P, Peaucellier G, Pinton P, Lecoeur H, Gougeon ML, le Maire M, Rizzuto R, Bréchot C, Paterlini-Bréchot P, SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis., J Cell Biol 2001 Jun; 153(6): 1301-14.

Chami M, Gozuacik D, Saigo K, Capiod T, Falson P, Lecoeur H, Urashima T, Beckmann J, Gougeon ML, Claret M, le Maire M, Bréchot C, Paterlini-Bréchot P, Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis., Oncogene 2000 Jun; 19(25): 2877-86.