Mounia CHAMI – IPMC

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Thème

Cristine ALVES DA COSTA

Présentation

Mounia Chami received her Doctoral degree in Molecular and Cellular Biology from the University of Paris XI. Under the guidance of Prof Cristian Bréchot and Prof Patrizia Paterlini-Bréchot, she investigated the mechanisms underlying apoptosis associated with hepatitis B and hepatitis C viruses.

She subsequently joined the laboratory of Prof. Rosario Rizzuto at the University of Ferrara with an EMBO postdoctoral fellowship. Later, she obtained a Junior INSERM researcher contract and joined the laboratory of Prof Patrizia Paterlini-Bréchot. During this period, Mounia Chami specialized in subcellular calcium signaling and the dynamics and functions of the endoplasmic reticulum (ER) and mitochondria.

Mounia Chami was later appointed as a team leader at the Italian Institute of Technology in the Department of Neuroscience, headed by Prof Fabio Benfenati, where she initiated her research on Alzheimer’s disease (AD). She then obtained a permanent INSERM senior researcher position. As a principal investigator in Dr Frédéric Checler’s team at the IPMC; Mounia Chami led research projects exploring the mechanisms and impacts of ER calcium signaling deregulations and mitochondrial disturbances in AD.

Since 2024, Mounia Chami has been leading the AlzPark team.

Événements

M. CHAMI invite le Dr Maud GRATUZE

« Microglia : Super-Hero or Villain in Alzheimer’s Disease ? Dr. Maud GRATUZEInstitut de Neurophysiopathologie, INP- UMR7051Faculté des Sciences Médicales et […]

Mounia CHAMI invite le Dr Richard SEAGER

«Investigating the AMPK-MFF-SUMO pathway to modulate mitochondrial dynamics as a target for neuroprotection »

Publications

Mary A, Barale S, Eysert F, Valverde A, Lacas-Gervais S, Bauer C, Eddarkaoui S, Buée L, Buée-Scherrer V, Checler F, Chami M, Hampered AMPK-ULK1 cascade in Alzheimer’s disease (AD) instigates mitochondria dysfunctions and AD-related alterations which are alleviated by metformin., Alzheimers Res Ther 2025 Jun; 17(1): 127.

Lauritzen I, Bini A, Bécot A, Gay AS, Badot C, Pagnotta S, Chami M, Checler F, Presenilins as hub proteins controlling the endocytic and autophagic pathways and small extracellular vesicle secretion., J Extracell Vesicles 2025 Jan; 14(1): e70019.

Eysert F, Kinoshita PF, Lagarde J, Lacas-Gervais S, Xicota L, Dorothée G, Bottlaender M, Checler F, Potier MC, Sarazin M, Chami M, Mitochondrial alterations in fibroblasts from sporadic Alzheimer’s disease (AD) patients correlate with AD-related clinical hallmarks., Acta Neuropathol Commun 2024 Jun; 12(1): 90.

Vaillant-Beuchot L, Eysert F, Duval B, Kinoshita PF, Pardossi-Piquard R, Bauer C, Eddarkaoui S, Buée L, Checler F, Chami M, The amyloid precursor protein and its derived fragments concomitantly contribute to the alterations of mitochondrial transport machinery in Alzheimer’s disease., Cell Death Dis 2024 May; 15(5): 367.

Iravanian S, Uzelac I, Shah AD, Toye MJ, Lloyd MS, Burke MA, Daneshmand MA, Attia TS, Vega JD, El-Chami MF, Merchant FM, Cherry EM, Bhatia NK, Fenton FH, Complex repolarization dynamics in ex vivo human ventricles are independent of the restitution properties., Europace 2023 Dec; 25(12): .

Iravanian S, Uzelac I, Shah AD, Toye MJ, Lloyd MS, Burke MA, Daneshmand MA, Attia TS, Vega JD, El-Chami M, Merchant FM, Cherry EM, Bhatia NK, Fenton FH, Higher-Order Dynamics Beyond Repolarization Alternans in Ex-Vivo Human Ventricles are Independent of the Restitution Properties., medRxiv 2023 Aug; (): .

Xicota L, Lagarde J, Eysert F, Grenier-Boley B, Rivals I, Botté A, Forlani S, Landron S, Gautier C, Gabriel C, Bottlaender M, Lambert JC, Chami M, Sarazin M, Potier MC, Modifications of the endosomal compartment in fibroblasts from sporadic Alzheimer’s disease patients are associated with cognitive impairment., Transl Psychiatry 2023 Feb; 13(1): 54.

Mary A, Vaillant-Beuchot L, Checler F, Chami M, [Mitochondrial dysfunction and mitophagy failure in Alzheimer’s disease]., Med Sci (Paris) 2021 Oct; 37(10): 843-847.

Chami M, Calcium Signalling in Alzheimer’s Disease: From Pathophysiological Regulation to Therapeutic Approaches., Cells 2021 Jan; 10(1): .

Eysert F, Kinoshita PF, Mary A, Vaillant-Beuchot L, Checler F, Chami M, Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer’s Disease., Int J Mol Sci 2020 Dec; 21(24): .

Goiran T, Duplan E, Chami M, Bourgeois A, El Manaa W, Rouland L, Dunys J, Lauritzen I, You H, Stambolic V, Biféri MG, Barkats M, Pimplikar SW, Sergeant N, Colin M, Morais VA, Pardossi-Piquard R, Checler F, Alves da Costa C, β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models., Biol Psychiatry 2018 Mar; 83(5): 416-427.

Lacampagne A, Liu X, Reiken S, Bussiere R, Meli AC, Lauritzen I, Teich AF, Zalk R, Saint N, Arancio O, Bauer C, Duprat F, Briggs CA, Chakroborty S, Stutzmann GE, Shelanski ML, Checler F, Chami M, Marks AR, Post-translational remodeling of ryanodine receptor induces calcium leak leading to Alzheimer’s disease-like pathologies and cognitive deficits., Acta Neuropathol 2017 Nov; 134(5): 749-767.

Ayciriex S, Gerber H, Osuna GM, Chami M, Stahlberg H, Shevchenko A, Fraering PC, The lipidome associated with the γ-secretase complex is required for its integrity and activity., Biochem J 2016 Feb; 473(3): 321-34.

Chami L, Buggia-Prévot V, Duplan E, Del Prete D, Chami M, Peyron JF, Checler F, Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations., J Biol Chem 2015 Dec; 290(50): 29758.

Bidaux G, Borowiec AS, Gordienko D, Beck B, Shapovalov GG, Lemonnier L, Flourakis M, Vandenberghe M, Slomianny C, Dewailly E, Delcourt P, Desruelles E, Ritaine A, Polakowska R, Lesage J, Chami M, Skryma R, Prevarskaya N, Epidermal TRPM8 channel isoform controls the balance between keratinocyte proliferation and differentiation in a cold-dependent manner., Proc Natl Acad Sci U S A 2015 Jun; 112(26): E3345-54.

Williams V, Brichler S, Khan E, Chami M, Dény P, Kremsdorf D, Gordien E, Large hepatitis delta antigen activates STAT-3 and NF-κB via oxidative stress., J Viral Hepat 2012 Oct; 19(10): 744-53.

Oulès B, Del Prete D, Greco B, Zhang X, Lauritzen I, Sevalle J, Moreno S, Paterlini-Bréchot P, Trebak M, Checler F, Benfenati F, Chami M, Ryanodine receptor blockade reduces amyloid-β load and memory impairments in Tg2576 mouse model of Alzheimer disease., J Neurosci 2012 Aug; 32(34): 11820-34.

Chami L, Buggia-Prévot V, Duplan E, Del Prete D, Chami M, Peyron JF, Checler F, Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations., J Biol Chem 2012 Jul; 287(29): 24573-84.

Mbaya E, Oulès B, Caspersen C, Tacine R, Massinet H, Pennuto M, Chrétien D, Munnich A, Rötig A, Rizzuto R, Rutter GA, Paterlini-Bréchot P, Chami M, Calcium signalling-dependent mitochondrial dysfunction and bioenergetics regulation in respiratory chain Complex II deficiency., Cell Death Differ 2010 Dec; 17(12): 1855-66.

Huber C, Oulès B, Bertoli M, Chami M, Fradin M, Alanay Y, Al-Gazali LI, Ausems MG, Bitoun P, Cavalcanti DP, Krebs A, Le Merrer M, Mortier G, Shafeghati Y, Superti-Furga A, Robertson SP, Le Goff C, Muda AO, Paterlini-Bréchot P, Munnich A, Cormier-Daire V, Identification of CANT1 mutations in Desbuquois dysplasia., Am J Hum Genet 2009 Nov; 85(5): 706-10.

Chami M, Oulès B, Szabadkai G, Tacine R, Rizzuto R, Paterlini-Bréchot P, Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress., Mol Cell 2008 Dec; 32(5): 641-51.

Chami M, Benali NL, Bréchot C, Paterlini-Bréchot P, [Impact of calcium signaling in liver carcinogenesis]., Med Sci (Paris) 2007 Feb; 23(2): 133-5.

Chami M, Oulès B, Paterlini-Bréchot P, Cytobiological consequences of calcium-signaling alterations induced by human viral proteins., Biochim Biophys Acta 2006 Nov; 1763(11): 1344-62.

Benali-Furet NL, Chami M, Houel L, De Giorgi F, Vernejoul F, Lagorce D, Buscail L, Bartenschlager R, Ichas F, Rizzuto R, Paterlini-Bréchot P, Hepatitis C virus core triggers apoptosis in liver cells by inducing ER stress and ER calcium depletion., Oncogene 2005 Jul; 24(31): 4921-33.

Chami M, Prandini A, Campanella M, Pinton P, Szabadkai G, Reed JC, Rizzuto R, Bcl-2 and Bax exert opposing effects on Ca2+ signaling, which do not depend on their putative pore-forming region., J Biol Chem 2004 Dec; 279(52): 54581-9.

Szabadkai G, Simoni AM, Chami M, Wieckowski MR, Youle RJ, Rizzuto R, Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis., Mol Cell 2004 Oct; 16(1): 59-68.

Rizzuto R, Pinton P, Ferrari D, Chami M, Szabadkai G, Magalhães PJ, Di Virgilio F, Pozzan T, Calcium and apoptosis: facts and hypotheses., Oncogene 2003 Nov; 22(53): 8619-27.

Chami M, Ferrari D, Nicotera P, Paterlini-Bréchot P, Rizzuto R, Caspase-dependent alterations of Ca2+ signaling in the induction of apoptosis by hepatitis B virus X protein., J Biol Chem 2003 Aug; 278(34): 31745-55.

Paterlini-Bréchot P, Saigo K, Murakami Y, Chami M, Gozuacik D, Mugnier C, Lagorce D, Bréchot C, Hepatitis B virus-related insertional mutagenesis occurs frequently in human liver cancers and recurrently targets human telomerase gene., Oncogene 2003 Jun; 22(25): 3911-6.

Gozuacik D, Chami M, Lagorce D, Faivre J, Murakami Y, Poch O, Biermann E, Knippers R, Bréchot C, Paterlini-Bréchot P, Identification and functional characterization of a new member of the human Mcm protein family: hMcm8., Nucleic Acids Res 2003 Jan; 31(2): 570-9.

Ferrari D, Pinton P, Szabadkai G, Chami M, Campanella M, Pozzan T, Rizzuto R, Endoplasmic reticulum, Bcl-2 and Ca2+ handling in apoptosis., Cell Calcium 2002 ; 32(5-6): 413-20.

Gozuacik D, Murakami Y, Saigo K, Chami M, Mugnier C, Lagorce D, Okanoue T, Urashima T, Bréchot C, Paterlini-Bréchot P, Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging., Oncogene 2001 Sep; 20(43): 6233-40.

Siegrist S, Féral C, Chami M, Solhonne B, Mattéi MG, Rajpert-De Meyts E, Guellaën G, Bulle F, hH-Rev107, a class II tumor suppressor gene, is expressed by post-meiotic testicular germ cells and CIS cells but not by human testicular germ cell tumors., Oncogene 2001 Aug; 20(37): 5155-63.

Chami M, Gozuacik D, Lagorce D, Brini M, Falson P, Peaucellier G, Pinton P, Lecoeur H, Gougeon ML, le Maire M, Rizzuto R, Bréchot C, Paterlini-Bréchot P, SERCA1 truncated proteins unable to pump calcium reduce the endoplasmic reticulum calcium concentration and induce apoptosis., J Cell Biol 2001 Jun; 153(6): 1301-14.

Chami M, Gozuacik D, Saigo K, Capiod T, Falson P, Lecoeur H, Urashima T, Beckmann J, Gougeon ML, Claret M, le Maire M, Bréchot C, Paterlini-Bréchot P, Hepatitis B virus-related insertional mutagenesis implicates SERCA1 gene in the control of apoptosis., Oncogene 2000 Jun; 19(25): 2877-86.