Emmanuel DEVAL

2025

Toft M, Meynier M, Di Scampamorte HL, Vallée C, Salinas M, Zhang P, Tacco J, Gay AS, Bourinet E, Lingueglia E, Deval E, Short RFamide, CFamide and FCamide peptides as novel positive modulators of ASIC 3 with similar potentiating effects but different reversibility., Neuropharmacology 2025 Dec; (): 110813.

2024

Ahmed Negm, Katharina Stobbe, Selma Ben Fradj, Clara Sanchez, Arnaud Landra-Willm, Margaux Richter, Lucile Fleuriot, Delphine Debayle, Emmanuel Deval, Eric Lingueglia, Carole Rovere, Jacques Noel, Acid-sensing ion channel 3 mediates pain hypersensitivity associated with high-fat diet consumption in mice, Pain, 2024, 165 (2), pp.470-489. ⟨10.1097/j.pain.0000000000003030⟩.

2023

Chafaï M, Delrocq A, Inquimbert P, Pidoux L, Delanoe K, Toft M, Brau F, Lingueglia E, Veltz R, Deval E, Dual contribution of ASIC1a channels in the spinal processing of pain information by deep projection neurons revealed by computational modeling., PLoS Comput Biol 2023 Apr; 19(4): e1010993.

2023

Khoury S, Colas J, Breuil V, Kosek E, Ahmed AS, Svensson CI, Marchand F, Deval E, Ferreira T, Identification of Lipid Biomarkers for Chronic Joint Pain Associated with Different Joint Diseases., Biomolecules 2023 Feb; 13(2): .

2022

Verkest C, Salinas M, Diochot S, Deval E, Lingueglia E, Baron A, Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects., Toxins (Basel) 2022 Oct; 14(10): .

2022

Jacquot F, Khoury S, Labrum B, Delanoe K, Pidoux L, Barbier J, Delay L, Bayle A, Aissouni Y, Barriere DA, Kultima K, Freyhult E, Hugo A, Kosek E, Ahmed AS, Jurczak A, Lingueglia E, Svensson CI, Breuil V, Ferreira T, Marchand F, Deval E, Lysophosphatidylcholine 16:0 mediates chronic joint pain associated to rheumatic diseases through acid-sensing ion channel 3., Pain 2022 Oct; 163(10): 1999-2013.

2022

Jurczak A, Delay L, Barbier J, Simon N, Krock E, Sandor K, Agalave NM, Rudjito R, Wigerblad G, Rogóż K, Briat A, Miot-Noirault E, Martinez-Martinez A, Brömme D, Grönwall C, Malmström V, Klareskog L, Khoury S, Ferreira T, Labrum B, Deval E, Jiménez-Andrade JM, Marchand F, Svensson CI, Antibody-induced pain-like behavior and bone erosion: links to subclinical inflammation, osteoclast activity, and acid-sensing ion channel 3-dependent sensitization., Pain 2022 Aug; 163(8): 1542-1559.

2022

Pidoux L, Delanoe K, Barbier J, Marchand F, Lingueglia E, Deval E, Single Subcutaneous Injection of Lysophosphatidyl-Choline Evokes ASIC3-Dependent Increases of Spinal Dorsal Horn Neuron Activity., Front Mol Neurosci 2022 ; 15(): 880651.

2021

Prieto M, Folci A, Poupon G, Schiavi S, Buzzelli V, Pronot M, François U, Pousinha P, Lattuada N, Abelanet S, Castagnola S, Chafai M, Khayachi A, Gwizdek C, Brau F, Deval E, Francolini M, Bardoni B, Humeau Y, Trezza V, Martin S, Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice., Nat Commun 2021 Mar; 12(1): 1557.

2018

Khayachi A, Gwizdek C, Poupon G, Alcor D, Chafai M, Cassé F, Maurin T, Prieto M, Folci A, De Graeve F, Castagnola S, Gautier R, Schorova L, Loriol C, Pronot M, Besse F, Brau F, Deval E, Bardoni B, Martin S, Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation., Nat Commun 2018 Feb; 9(1): 757.

2016

Marra S, Ferru-Clément R, Breuil V, Delaunay A, Christin M, Friend V, Sebille S, Cognard C, Ferreira T, Roux C, Euller-Ziegler L, Noel J, Lingueglia E, Deval E, Non-acidic activation of pain-related Acid-Sensing Ion Channel 3 by lipids., EMBO J 2016 Feb; 35(4): 414-28.

2016

Devader C, Moreno S, Roulot M, Deval E, Dix T, Morales CR, Mazella J, Increased Brain Neurotensin and NTSR2 Lead to Weak Nociception in NTSR3/Sortilin Knockout Mice., Front Neurosci 2016 ; 10(): 542.

2015

Deval E, Lingueglia E, Acid-Sensing Ion Channels and nociception in the peripheral and central nervous systems., Neuropharmacology 2015 Jul; 94(): 49-57.

2014

Loriol C, Cassé F, Khayachi A, Poupon G, Chafai M, Deval E, Gwizdek C, Martin S, mGlu5 receptors regulate synaptic sumoylation via a transient PKC-dependent diffusional trapping of Ubc9 into spines., Nat Commun 2014 Oct; 5(): 5113.

2013

Devilliers M, Busserolles J, Lolignier S, Deval E, Pereira V, Alloui A, Christin M, Mazet B, Delmas P, Noel J, Lazdunski M, Eschalier A, Activation of TREK-1 by morphine results in analgesia without adverse side effects., Nat Commun 2013 ; 4(): 2941.

2012

Delaunay A, Gasull X, Salinas M, Noël J, Friend V, Lingueglia E, Deval E, Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions., Proc Natl Acad Sci U S A 2012 Aug; 109(32): 13124-9.

2011

Deval E, Noël J, Gasull X, Delaunay A, Alloui A, Friend V, Eschalier A, Lazdunski M, Lingueglia E, Acid-sensing ion channels in postoperative pain., J Neurosci 2011 Apr; 31(16): 6059-66.

2010

Deval E, Gasull X, Noël J, Salinas M, Baron A, Diochot S, Lingueglia E, Acid-sensing ion channels (ASICs): pharmacology and implication in pain., Pharmacol Ther 2010 Dec; 128(3): 549-58.

2010

Noël J, Salinas M, Baron A, Diochot S, Deval E, Lingueglia E, Current perspectives on acid-sensing ion channels: new advances and therapeutic implications., Expert Rev Clin Pharmacol 2010 May; 3(3): 331-46.

2010

Mazella J, Pétrault O, Lucas G, Deval E, Béraud-Dufour S, Gandin C, El-Yacoubi M, Widmann C, Guyon A, Chevet E, Taouji S, Conductier G, Corinus A, Coppola T, Gobbi G, Nahon JL, Heurteaux C, Borsotto M, Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design., PLoS Biol 2010 Apr; 8(4): e1000355.

2009

Noël J, Zimmermann K, Busserolles J, Deval E, Alloui A, Diochot S, Guy N, Borsotto M, Reeh P, Eschalier A, Lazdunski M, The mechano-activated K+ channels TRAAK and TREK-1 control both warm and cold perception., EMBO J 2009 May; 28(9): 1308-18.

2009

Ettaiche M, Deval E, Pagnotta S, Lazdunski M, Lingueglia E, Acid-sensing ion channel 3 in retinal function and survival., Invest Ophthalmol Vis Sci 2009 May; 50(5): 2417-26.

2008

Deval E, Noël J, Lay N, Alloui A, Diochot S, Friend V, Jodar M, Lazdunski M, Lingueglia E, ASIC3, a sensor of acidic and primary inflammatory pain., EMBO J 2008 Nov; 27(22): 3047-55.

2006

Ettaiche M, Deval E, Cougnon M, Lazdunski M, Voilley N, Silencing acid-sensing ion channel 1a alters cone-mediated retinal function., J Neurosci 2006 May; 26(21): 5800-9.

2006

Lingueglia E, Deval E, Lazdunski M, FMRFamide-gated sodium channel and ASIC channels: a new class of ionotropic receptors for FMRFamide and related peptides., Peptides 2006 May; 27(5): 1138-52.

2006

Deval E, Friend V, Thirant C, Salinas M, Jodar M, Lazdunski M, Lingueglia E, Regulation of sensory neuron-specific acid-sensing ion channel 3 by the adaptor protein Na+/H+ exchanger regulatory factor-1., J Biol Chem 2006 Jan; 281(3): 1796-807.

2004

Deval E, Salinas M, Baron A, Lingueglia E, Lazdunski M, ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1., J Biol Chem 2004 May; 279(19): 19531-9.

2004

Diochot S, Baron A, Rash LD, Deval E, Escoubas P, Scarzello S, Salinas M, Lazdunski M, A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons., EMBO J 2004 Apr; 23(7): 1516-25.

2003

Deval E, Baron A, Lingueglia E, Mazarguil H, Zajac JM, Lazdunski M, Effects of neuropeptide SF and related peptides on acid sensing ion channel 3 and sensory neuron excitability., Neuropharmacology 2003 Apr; 44(5): 662-71.

2002

Baron A, Deval E, Salinas M, Lingueglia E, Voilley N, Lazdunski M, Protein kinase C stimulates the acid-sensing ion channel ASIC2a via the PDZ domain-containing protein PICK1., J Biol Chem 2002 Dec; 277(52): 50463-8.

2002

Anzai N, Deval E, Schaefer L, Friend V, Lazdunski M, Lingueglia E, The multivalent PDZ domain-containing protein CIPP is a partner of acid-sensing ion channel 3 in sensory neurons., J Biol Chem 2002 May; 277(19): 16655-61.