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Team leader

https://cvscience.aviesan.fr/cv/507/stephane-martin

ORCID 0000-0001-6771-7645 

https://scholar.google.com/S_Martin

https://www.ipmc.cnrs.fr/author/martin

https://bsky.app/profile/sumo-lab.bsky.social

Events

13
Mar
2025
Thesis
Thesis by Isabel CHATO ASTRAIN

«"Pathophysiology of the FMRP-R138Q missense mutation in Fragile X Syndrome in mice" Thesis Supervisor: Dr. Stéphane […]

IPMC

Publications

2025
Thierry Coppola, Gwénola Poupon, Hélène Rangone, Stéphane Martin and Patricia Lebrun, Adaptive Gene Expression Induced by a Combination of IL-1β and LPS in Primary Cultures of Mouse Astrocytes, Cells 2025 14:1737.
2025
Ung DC, Martin S, Hérault Y, Laumonnier F, The PTCHD1 protein: A prominent actor in brain function and in neurodevelopmental disorders., Neurosci Biobehav Rev 2025 Jul; 176(): 106307.
2024
Chato-Astrain I, Pronot M, Coppola T, Martin S, Molecular Organization and Regulation of the Mammalian Synapse by the Post-Translational Modification SUMOylation. Cells 2024 Feb; 13(5): .
2022
Stéphane Martin, Frédéric Laumonnier, Translational Research Methods in Neurodevelopmental Disorders (2022), .
2022
Pronot M, Poupon G, Pizzamiglio L, Prieto M, Chato-Astrain I, Lacagne I, Schorova L, Folci A, Brau F, Martin S, Bidirectional regulation of synaptic SUMOylation by Group 1 metabotropic glutamate receptors. Cell Mol Life Sci 2022 Jun; 79(7): 378.
2022
Kieffer F, Hilal F, Gay AS, Debayle D, Pronot M, Poupon G, Lacagne I, Bardoni B, Martin S, Gwizdek C, Combining affinity purification and mass spectrometry to define the network of the nuclear proteins interacting with the N-terminal region of FMRP. Front Mol Biosci 2022; 9(): 954087.
2022
Kieffer F, Pronot M, Gay AS, Debayle D, Gwizdek C, Proteomics datasets of developing rat brain: Synaptic proteome and SUMO2/3-ylome. Data Brief 2022 Jun; 42(): 108151.
2021
Prieto M, Folci A, Poupon G, Schiavi S, Buzzelli V, Pronot M, François U, Pousinha P, Lattuada N, Abelanet S, Castagnola S, Chafai M, Khayachi A, Gwizdek C, Brau F, Deval E, Francolini M , Bardoni B, Humeau Y, Trezza V, Martin S, Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice. Nat Commun 2021 Mar; 12(1): 1557.
2021
Pronot M, Kieffer F, Gay AS, Debayle D, Forquet R, Poupon G, Schorova L, Martin S, Gwizdek C, Proteomic Identification of an Endogenous Synaptic SUMOyloma in the Developing Rat Brain. Front Mol Neurosci 2021; 14():780535.
2020
Prieto M, Folci A, Martin S, Post-translational modifications of the Fragile X Mental Retardation Protein in neuronal function and dysfunction. Mol Psychiatry 2020 Aug; 25(8): 1688-1703.
2019
Schorova L, Pronot M, Poupon G, Prieto M, Folci A, Khayachi A, Brau F, Cassé F, Gwizdek C, Martin S, The synaptic balance between sumoylation and desumoylation is maintained by the activation of metabotropic mGlu5 receptors. Cell Mol Life Sci 2019 Aug; 76(15): 3019-3031.
2019
Maurin T, Melancia F, Jarjat M, Castro L, Costa L, Delhaye S, Khayachi A, Castagnola S, Mota E, Di Giorgio A, Servadio M, Drozd M, Poupon G, Schiavi S, Sardone L, Azoulay S, Ciranna L, Martin S, Vincent P, Trezza V, Bardoni B, Involvement of Phosphodiesterase 2A Activity in the Pathophysiology of Fragile X Syndrome. Cereb Cortex 2019 Jul; 29(8): 3241-3252.
2018
Khayachi A, Gwizdek C, Poupon G, Alcor D, Chafai M, Cassé F, Maurin T, Prieto M, Folci A, De Graeve F, Castagnola S, Gautier R, Schorova L, Loriol C, Pronot M, Besse F, Brau F, Deval E, Bardoni B, Martin S, Sumoylation regulates FMRP-mediated dendritic spine elimination and maturation. Nat Commun 2018 Feb; 9(1): 757.
2018
Ung DC, Iacono G, Méziane H, Blanchard E, Papon MA, Selten M, van Rhijn JR, Montjean R, Rucci J, Martin S, Fleet A, Birling MC, Marouillat S, Roepman R, Selloum M, Lux A, Thépault RA, Hamel P, Mittal K, Vincent JB, Dorseuil O, Stunnenberg HG, Billuart P, Nadif Kasri N, Hérault Y, Laumonnier F, Ptchd1 deficiency induces excitatory synaptic and cognitive dysfunctions in mice. Mol Psychiatry 2018 May; 23(5): 1356-1367.
2018
Castagnola S, Delhaye S, Folci A, Paquet A, Brau F, Duprat F, Jarjat M, Grossi M, Béal M, Martin S, Mantegazza M, Bardoni B, Maurin T, New Insights Into the Role of Cav2 Protein Family in Calcium Flux Deregulation in Fmr1-KO Neurons. Front Mol Neurosci 2018; 11(): 342.
2017
Wilkinson KA, Martin S, Tyagarajan SK, Arancio O, Craig TJ, Guo C, Fraser PE, Goldstein SAN, Henley JM, Commentary: Analysis of SUMO1-conjugation at synapses. Front Cell Neurosci 2017; 11(): 345.
2016
Xiong H, Cassé F, Zhou M, Xiong ZQ, Joels M, Martin S, Krugers HJ, Interactions between N-Ethylmaleimide-sensitive factor and GluA2 contribute to effects of glucocorticoid hormones on AMPA receptor function in the rodent hippocampus. Hippocampus 2016 Jul; 26(7): 848-56.
2016
Schorova L, Martin S, Sumoylation in Synaptic Function and Dysfunction. Front Synaptic Neurosci 2016; 8(): 9.
2015
Xiong H, Cassé F, Zhou Y, Zhou M, Xiong ZQ, Joëls M, Martin S, Krugers HJ, mTOR is essential for corticosteroid effects on hippocampal AMPA receptor function and fear memory. Learn Mem 2015 Dec; 22(12): 577-83.
2015
Devader C, Khayachi A, Veyssière J, Moha Ou Maati H, Roulot M, Moreno S, Borsotto M, Martin S, Heurteaux C, Mazella J, In vitro and in vivo regulation of synaptogenesis by the novel antidepressant spadin. Br J Pharmacol 2015 May; 172(10): 2604-17.
2015
Broken F, Martin S, Tracking the activity-dependent diffusion of synaptic proteins using restricted photoconversion of Dendra2. Front Cell Neurosci 2015; 9(): 367.
2014
Loriol C, Cassé F, Khayachi A, Poupon G, Chafai M, Deval E, Gwizdek C, Martin S, mGlu5 receptors regulate synaptic sumoylation via a transient PKC-dependent diffusional trapping of Ubc9 into spines. Nat Commun 2014 Oct;5():5113.
2013
Gwizdek C, Cassé F, Martin S, Protein sumoylation in brain development, neuronal morphology and spinogenesis. Neuromolecular Med 2013 Dec; 15(4): 677-91.
2013
Loriol C, Khayachi A, Poupon G, Gwizdek C, Martin S, Activity-dependent regulation of the sumoylation machinery in rat hippocampal neurons. Biol Cell 2013 Jan; 105(1): 30-45.
2012
Loriol C, Parisot J, Poupon G, Gwizdek C, Martin S, Developmental regulation and spatiotemporal redistribution of the sumoylation machinery in the rat central nervous system. PLoS One 2012;7(3):e33757.
2012
Bouschet T, Martin S, Henley JM, Regulation of calcium sensing receptor trafficking by RAMPs. Adv Exp Med Biol 2012; 744(): 39-48.
2009
Martin S, [Extranuclear functions of protein sumoylation in the central nervous system]. Med Sci (Paris) 2009; 25(8-9): 693-8.
2009
Martin S, Henley JM, Holman D, Zhou M, Wiegert O, van Spronsen M, Joëls M, Hoogenraad CC, Krugers HJ, Corticosterone alters AMPAR mobility and facilitates bidirectional synaptic plasticity. PLoS One 2009;4(3):e4714.
2008
Martin S, Bouschet T, Jenkins EL, Nishimune A, Henley JM, Bidirectional regulation of kainate receptor surface expression in hippocampal neurons. J Biol Chem 2008 Dec; 283(52): 36435-40.
2008
Bouschet T, Martin S, Henley JM, Regulation of calcium-sensing-receptor trafficking and cell-surface expression by GPCRs and RAMPs. Trends Pharmacol Sci 2008 Dec; 29(12): 633-9.
2008
Rocca DL, Martin S, Jenkins EL, Hanley JG, Inhibition of Arp2/3-mediated actin polymerization by PICK1 regulates neuronal morphology and AMPA receptor endocytosis. Nat Cell Biol 2008 Mar; 10(3): 259-71.
2007
Martin S, Wilkinson KA, Nishimune A, Henley JM, Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction. Nat Rev Neurosci 2007 Dec; 8(12): 948-59.
2007
Jaskolski F, Martin S, Henley JM, Retaining synaptic AMPARs., Neuron 2007 Sep; 55(6): 825-7.
2007
Bouschet T, Martin S, Kanamarlapudi V, Mundell S, Henley JM, The calcium-sensing receptor changes cell shape via a beta-arrestin-1 ARNO ARF6 ELMO protein network. J Cell Sci 2007 Aug; 120(Pt 15): 2489-97.
2007
Martin S, Nishimune A, Mellor JR, Henley JM, SUMOylation regulates kainate-receptor-mediated synaptic transmission. Nature 2007 May; 447(7142): 321-5.
2006
Navarro V, Martin S, Mazella J, Internalization-dependent regulation of HT29 cell proliferation by neurotensin. Peptides 2006 Oct; 27(10): 2502-7.
2005
Bouschet T, Martin S, Henley JM, Receptor-activity-modifying proteins are required for forward trafficking of the calcium-sensing receptor to the plasma membrane. J Cell Sci 2005 Oct; 118(Pt 20): 4709-20.
2005
Martin S, Dicou E, Vincent JP, Mazella J, Neurotensin and the neurotensin receptor-3 in microglial cells. J Neurosci Res 2005 Aug; 81(3): 322-6.
2005
Hirbec H, Martin S, Henley JM, Syntenin is involved in the developmental regulation of neuronal membrane architecture. Mol Cell Neurosci 2005 Apr; 28(4): 737-46.
2004
Martin S, Henley JM, Activity-dependent endocytic sorting of kainate receptors to recycling or degradation pathways. EMBO J 2004 Dec; 23(24): 4749-59.
2004
Morinville A, Martin S, Lavallée M, Vincent JP, Beaudet A, Mazella J, Internalization and trafficking of neurotensin via NTS3 receptors in HT29 cells. Int J Biochem Cell Biol 2004 Nov; 36(11): 2153-68.
2003
Martin S, Vincent JP, Mazella J, Involvement of the neurotensin receptor-3 in the neurotensin-induced migration of human microglia. J Neurosci 2003 Feb; 23(4): 1198-205.
2002
Martin S, Navarro V, Vincent JP, Mazella J, Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line. Gastroenterology 2002 Oct; 123(4): 1135-43.
2002
Martin S, Vincent JP, Mazella J, Recycling ability of the mouse and the human neurotensin type 2 receptors depends on a single tyrosine residue. J Cell Sci 2002 Jan; 115(Pt 1): 165-73.
2001
Navarro V, Martin S, Sarret P, Nielsen MS, Petersen CM, Vincent J, Mazella J, Pharmacological properties of the mouse neurotensin receptor 3. Maintenance of cell surface receptor during internalization of neurotensin. FEBS Lett 2001 Apr; 495(1-2): 100-5.
1999
Martin S, Botto JM, Vincent JP, Mazella J, Pivotal role of an aspartate residue in sodium sensitivity and coupling to G proteins of neurotensin receptors. Mol Pharmacol 1999 Feb; 55(2): 210-5.