About
Expertise: Biochemistry of protein membrane interactions through reconstitution approaches. Our aim in SPHERES is to obtain a quantitative view of the surface of LD in adipocytes in terms of protein and lipid composition, relative surface occupancy, domain formation and dynamics, and reactivity to lipases.
Events
«Lipid droplet biogenesis and proteome acquisition»
«Tardigrade Extremotorlerance Life at the Edge»
«Diversity of hydrophobic tails of membrane lipids: metabolism and functions» Jury Chair: Dr. Bruno Antonny, Research Director, […]
« Electrostatic energy gates the ATP-releasing Pannexin 1 channel
«From Cell Communication to Organelle Positioning for Gneome Protection«
«Interfacial Biochemistry and Cell Biology of Perilipins and FAM114A Proteins« Thesis Supervisor: Dr. Bruno Antonny, Research Director, […]
« Going with the flow: how cell membrane tension dynamics impact cellular processes from bacteria to B-cells«
«Shaping the juvenile-to-adult transition in Drosophila: steroid hormone secretion, chemosensing, and mechanosensing»
Projects
In 2003, we showed that COPI protein coat disassembly is extremely sensitive to the curvature of the […]
The fluid nature of lipid membranes makes their structural study difficult, so many parameters used for […]
OSBP, a lipid transfer protein, is a fascinating molecular machine. First, OSBP transports a key cellular lipid, cholesterol. […]
Classic cell lines make it possible to study basic functions; for example, vesicular traffic or contact sites […]
In 2020, the laboratory started a new project funded by the European Research Council (ERC) Synergy SPHERES: droplet hypertrophy […]
Tools
The following link provides access to HeliQuest, a bioinformatics tool allowing the analysis of amphipathic helices and searching for sequences presenting […]
A bioinformatics tool for determining the presence of lipid arrangement defects in models of biological membranes obtained […]