Project: Reprogramming of lipid homeostatic pathways by ZIKV proteins

About

Many viruses exploit host cell membranes and lipid metabolism to ensure their replication. The Zika virus, in particular, hijacks membranes of the endoplasmic reticulum and lipid transport mechanisms to create specialized structures, called replication organelles, which are necessary for its multiplication.
Our team is studying how lipid transfer proteins, particularly OSBP and its partners, are used by the viruses to remodel cell membranes. We seek to identify the molecular mechanisms involved and understand how the virus reprograms the lipid metabolism of the infected cell.
This research could lead to the identification of new antiviral targets and contribute to the development of innovative therapeutic strategies against viral infections.