Project: Role of VAPA-mediated membrane contact sites in lung surfactant production

About

This project aims to understand how membrane contact sites contribute to the production of pulmonary surfactant, a lipid-rich substance essential for breathing. Surfactant is produced by specialized organelles in type-2 alveolar epithelial cells and reduces surface tension in the alveoli, preventing them from collapse during breathing.
We are studying in particular the role of VAPA, a key player at endoplasmic reticulum membrane contact sites, in the formation and maturation of these organelles called lamellar bodies. This project aims to identify the molecular mechanisms that control the lipid transport necessary for surfactant production.
This work will provide a better understanding of the cellular basis of certain lung diseases linked to surfactant dysfunction and could pave the way for new therapeutic approaches.