JobPostdoctoral Researcher (M/F): Electrophysiology of brain slices from mouse models and cultured cells for functional analysis of sodium channel mutations
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Postdoctoral researcher (initial 1-year contract renewable up to 3 years) responsible for the development and execution of experimental protocols (in particular electrophysiological recordings in brain slices of mouse models, primary cultured neurons, and transfected cell lines), within the framework of research projects on models of neurodevelopmental disorders and epilepsies linked to mutations in sodium channel genes. Sodium channel mutations are implicated in different types of neurodevelopmental disorders, which include developmental epileptic encephalopathies (DEEs) characterized by drug-resistant seizures, cognitive/behavioral deficits, movement disorders, and mortality, often due to sudden unexpected death in epilepsy (SUDEP). The team is expert in the study of experimental models of these pathologies (Mantegazza et al., 2021, Physiological Reviews, 101(4):1633 https://doi.org/10.1152/physrev.00025.2020; Chever et al. 2021 JCI https://doi.org/10.1172/JCI142203; Brunklaus et al. 2022 https://doi.org/10.1093/brain/awac210; Guerrini et al 2023 Physiological Reviews 103(1):433) https://doi.org/10.1152/physrev.00063.2021; Rusina et al. 2023 J.Neurochemistry https://onlinelibrary.wiley.com/doi/10.1111/jnc.15947). The general objectives of the research project are: 1) to better understand the pathological mechanisms of genetic variants (effects on the properties of the channel, the neuron and the neuronal network) 2) to better target therapeutic treatments and understand the mechanisms of action.
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