JobPostdoctoral Researcher (M/F): In vivo studies of murine models of neurodevelopmental disorders and epilepsies linked to mutations in sodium channel genes
About
Postdoctoral researcher (initial 1-year contract renewable up to 3 years) responsible for the development and conduct of experimental protocols within the framework of research projects on models of neurodevelopmental disorders and epilepsies linked to mutations in sodium channel genes. Sodium channel mutations are implicated in different types of neurodevelopmental disorders, which include developmental epileptic encephalopathies (DEEs) characterized by drug-resistant seizures, cognitive/behavioral deficits, movement disorders, and mortality, often due to sudden unexpected death in epilepsy (SUDEP). The team is expert in the study of murine models of these pathologies (Mantegazza et al., 2021, Physiological Reviews, 101(4):1633 https://doi.org/10.1152/physrev.00025.2020 ; Guerrini et al 2023 Physiological Reviews 103(1):433) https://doi.org/10.1152/physrev.00063.2021; Rusina et al. 2023 J.Neurochemistry https://onlinelibrary.wiley.com/doi/10.1111/jnc.15947; Capitano et al. 2024 PNAS https://doi.org/10.1073/pnas.2316364121).
The general objectives of the research project are: 1) to better understand the pathological mechanisms in animal models; 2) to develop treatments by directly targeting the initial genetic dysfunction as well as homeostatic and pathological remodeling; 3) to identify biomarkers of SUDEP.
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