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03
Jul
2025
Inserm : les chercheurs de l'IPMC accueillent les malades

Le 14 juin 2025, l’IPMC a accueilli plusieurs associations de patients pour une matinée d’échanges autour de la douleur, de […]

Publications

2025
Thierry Coppola, Gwénola Poupon, Hélène Rangone, Stéphane Martin and Patricia Lebrun, Adaptive Gene Expression Induced by a Combination of IL-1β and LPS in Primary Cultures of Mouse Astrocytes, Cells 2025 14:1737.
2024
Chato-Astrain I, Pronot M, Coppola T, Martin S, Molecular Organization and Regulation of the Mammalian Synapse by the Post-Translational Modification SUMOylation. Cells 2024 Feb; 13(5): .
2023
Thierry Coppola, Guillaume Daziano, Ilona Legroux, Sophie Béraud-Dufour, Nicolas Blondeau, Patricia Lebrun, Unlocking Therapeutic Synergy: Tailoring Drugs for Comorbidities such as Depression and Diabetes through Identical Molecular Targets in Different Cell Types, Cells, 2023, 12 (23), pp.2768. ⟨10.3390/cells12232768⟩.
2021
Hodges NJ, Coppola TM, Peters CM, Larssen BC, Now you see me, now you don’t: Adapting practice through target exclusion negatively impacts motor learning., Hum Mov Sci 2021 Oct; 79(): 102850.
2021
Guillaume Daziano, Nicolas Blondeau, Sophie Béraud-Dufour, Amar Abderrahmani, Carole Rovère, Catherine Heurteaux, Jean Mazella, Patricia Lebrun, Thierry Coppola, Sortilin-derived peptides promote pancreatic beta-cell survival through CREB signaling pathway, Pharmacological Research, 2021, 167, pp.105539. ⟨10.1016/j.phrs.2021.105539⟩.
2020
Veronika Leláková, Sophie Béraud-Dufour, Jan Hošek, Karel Šmejkal, Vilailak Prachyawarakorn, Phanruethai Pailee, Catherine Widmann, Jiří Václavík, Thierry Coppola, Jean Mazella, Nicolas Blondeau, Catherine Heurteaux, Therapeutic potential of prenylated stilbenoid macasiamenene F through its anti-inflammatory and cytoprotective effects on LPS-challenged monocytes and microglia, Journal of Ethnopharmacology, 2020, pp.113147. ⟨10.1016/j.jep.2020.113147⟩.
2019
Coppola T, Mangold JF, Cantrell S, Permar SR, Impact of Maternal Immunity on Congenital Cytomegalovirus Birth Prevalence and Infant Outcomes: A Systematic Review., Vaccines (Basel) 2019 Sep; 7(4): .
2019
Thierry Coppola, Sophie Béraud-Dufour, Patricia Lebrun, Nicolas Blondeau, Bridging the Gap Between Diabetes and Stroke in Search of High Clinical Relevance Therapeutic Targets, NeuroMolecular Medicine, 2019, ⟨10.1007/s12017-019-08563-5⟩.
2019
Coppola T, Becken B, Van Mater H, McDonald MT, Panayotti GM, A case report of mevalonate kinase deficiency in a 14-month-old female with fevers and lower extremity weakness., BMC Pediatr 2019 Jul; 19(1): 245.
2019
Nicolas Blondeau, Sophie Béraud-Dufour, Patricia Lebrun, Céline Hivelin, Thierry Coppola, Sortilin in Glucose Homeostasis: From Accessory Protein to Key Player?, Frontiers in Pharmacology, 2019, 9, ⟨10.3389/fphar.2018.01561⟩.
2017
Hivelin C, Mazella J, Coppola T, Sortilin derived propeptide regulation during adipocyte differentiation and inflammation., Biochem Biophys Res Commun 2017 Jan; 482(1): 87-92.
2016
Béraud-Dufour S, Devader C, Massa F, Roulot M, Coppola T, Mazella J, Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation., Int J Mol Sci 2016 Nov; 17(11): .
2016
Céline Hivelin, Sophie Béraud-Dufour, Christelle Devader, Amar Abderrahmani, Sébastien Moreno, Hamid Moha Ou Maati, Alaeddine Djillani, Catherine Heurteaux, Marc Borsotto, Jean Mazella, Thierry Coppola, Potentiation of Calcium Influx and Insulin Secretion in Pancreatic Beta Cell by the Specific TREK-1 Blocker Spadin, Journal of diabetes research, 2016, 2016, pp.Article ID 3142175. ⟨10.1155/2016/3142175⟩.
2014
Fabienne Massa, Christelle Devader, Sandra Lacas-Gervais, Sophie Béraud-Dufour, Thierry Coppola, Jean Mazella, Impairement of HT29 Cancer Cells Cohesion by the Soluble Form of Neurotensin Receptor-3., Genes and Cancer, 2014, 5 (7-8), pp.240-249. ⟨10.18632/genesandcancer.22⟩.
2013
Fabienne Massa, Christelle Devader, Sophie Béraud-Dufour, Frédéric Brau, Thierry Coppola, Jean Mazella, Focal adhesion kinase dependent activation of the PI3 kinase pathway by the functional soluble form of neurotensin receptor-3 in HT29 cells., International Journal of Biochemistry and Cell Biology, 2013, 45 (5), pp.952-9. ⟨10.1016/j.biocel.2013.01.020⟩.
2013
Christelle Devader, Sophie Béraud-Dufour, Thierry Coppola, Jean Mazella, The Anti-Apoptotic Role of Neurotensin, Cells, 2013, 2 (1), pp.124-135. ⟨10.3390/cells2010124⟩.
2012
Jean Mazella, Sophie Béraud-Dufour, Christelle Devader, Fabienne Massa, Thierry Coppola, Neurotensin and its receptors in the control of glucose homeostasis., Frontiers in Endocrinology, 2012, 3, pp.143. ⟨10.3389/fendo.2012.00143⟩.
2012
Moha Ou Maati H, Veyssiere J, Labbal F, Coppola T, Gandin C, Widmann C, Mazella J, Heurteaux C, Borsotto M, Spadin as a new antidepressant: absence of TREK-1-related side effects., Neuropharmacology 2012 Jan; 62(1): 278-88.
2011
Fabienne Massa, Aurélie Tormo, Sophie Béraud-Dufour, Thierry Coppola, Jean Mazella, Neurotensin-induced Erk1/2 phosphorylation and growth of human colonic cancer cells are independent from growth factors receptors activation, Biochemical and Biophysical Research Communications, 2011, 414 (1), pp.118-122. ⟨10.1016/j.bbrc.2011.09.034⟩.
2011
Gammelsaeter R, Coppola T, Marcaggi P, Storm-Mathisen J, Chaudhry FA, Attwell D, Regazzi R, Gundersen V, A role for glutamate transporters in the regulation of insulin secretion., PLoS One 2011 ; 6(8): e22960.
2010
Sophie Béraud-Dufour, Amar Abderrahmani, Jacques Noel, Frédéric Brau, Gérard Waeber, Jean Mazella, Thierry Coppola, Neurotensin is a regulator of insulin secretion in pancreatic beta-cells., International Journal of Biochemistry and Cell Biology, 2010, 42 (10), pp.1681-8. ⟨10.1016/j.biocel.2010.06.018⟩.
2010
Mazella J, Pétrault O, Lucas G, Deval E, Béraud-Dufour S, Gandin C, El-Yacoubi M, Widmann C, Guyon A, Chevet E, Taouji S, Conductier G, Corinus A, Coppola T, Gobbi G, Nahon JL, Heurteaux C, Borsotto M, Spadin, a sortelin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol 2010 Apr; 8(4): e1000355.
2009
Sophie Béraud-Dufour, Thierry Coppola, Fabienne Massa, Jean Mazella, Neurotensin receptor-2 and -3 are crucial for the anti-apoptotic effect of neurotensin on pancreatic beta-TC3 cells., International Journal of Biochemistry and Cell Biology, 2009, 41 (12), pp.2398-402.
2008
Thierry Coppola, Sophie Béraud-Dufour, Aurélie Antoine, Jean-Pierre Vincent, Jean Mazella, Neurotensin protects pancreatic beta cells from apoptosis., International Journal of Biochemistry and Cell Biology, 2008, 40 (10), pp.2296-302. ⟨10.1016/j.biocel.2008.03.015⟩.
2006
Abderrahmani A, Cheviet S, Ferdaoussi M, Coppola T, Waeber G, Regazzi R, ICER induced by hyperglycemia represses the expression of genes essential for insulin exocytosis., EMBO J 2006 Mar; 25(5): 977-86.
2005
Cheviet S, Coppola T, Regazzi R, Functional assays for the investigation of the role of Rab GTPase effectors in dense core granule release., Methods Enzymol 2005 ; 403(): 57-71.
2004
Abderrahmani A, Niederhauser G, Plaisance V, Roehrich ME, Lenain V, Coppola T, Regazzi R, Waeber G, Complexin I regulates glucose-induced secretion in pancreatic beta-cells., J Cell Sci 2004 May; 117(Pt 11): 2239-47.
2004
Cheviet S, Coppola T, Haynes LP, Burgoyne RD, Regazzi R, The Rab-binding protein Noc2 is associated with insulin-containing secretory granules and is essential for pancreatic beta-cell exocytosis., Mol Endocrinol 2004 Jan; 18(1): 117-26.
2003
Waselle L, Coppola T, Fukuda M, Iezzi M, El-Amraoui A, Petit C, Regazzi R, Involvement of the Rab27 binding protein Slac2c/MyRIP in insulin exocytosis., Mol Biol Cell 2003 Oct; 14(10): 4103-13.
2002
Coppola T, Frantz C, Perret-Menoud V, Gattesco S, Hirling H, Regazzi R, Pancreatic beta-cell protein granuphilin binds Rab3 and Munc-18 and controls exocytosis., Mol Biol Cell 2002 Jun; 13(6): 1906-15.
2002
Coppola T, Perret-Menoud V, Gattesco S, Magnin S, Pombo I, Blank U, Regazzi R, The death domain of Rab3 guanine nucleotide exchange protein in GDP/GTP exchange activity in living cells., Biochem J 2002 Mar; 362(Pt 2): 273-9.
2002
Frantz C, Coppola T, Regazzi R, Involvement of Rho GTPases and their effectors in the secretory process of PC12 cells., Exp Cell Res 2002 Feb; 273(2): 119-26.
2001
Coppola T, Magnin-Luthi S, Perret-Menoud V, Gattesco S, Schiavo G, Regazzi R, Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin., J Biol Chem 2001 Aug; 276(35): 32756-62.
2001
Coppola T, Hirling H, Perret-Menoud V, Gattesco S, Catsicas S, Joberty G, Macara IG, Regazzi R, Rabphilin dissociated from Rab3 promotes endocytosis through interaction with Rabaptin-5., J Cell Sci 2001 May; 114(Pt 9): 1757-64.
2001
Gundersen CB, Aguado F, Sou S, Mastrogiacomo A, Coppola T, Kornblum HI, Umbach JA, Cysteine string proteins are associated with cortical granules of Xenopus laevis oocytes., Cell Tissue Res 2001 Feb; 303(2): 211-9.
2000
Randhawa VK, Bilan PJ, Khayat ZA, Daneman N, Liu Z, Ramlal T, Volchuk A, Peng XR, Coppola T, Regazzi R, Trimble WS, Klip A, VAMP2, but not VAMP3/cellubrevin, mediates insulin-dependent incorporation of GLUT4 into the plasma membrane of L6 myoblasts., Mol Biol Cell 2000 Jul; 11(7): 2403-17.
1999
Coppola T, Perret-Menoud V, Lüthi S, Farnsworth CC, Glomset JA, Regazzi R, Disruption of Rab3-calmodulin interaction, but not other effector interactions, prevents Rab3 inhibition of exocytosis., EMBO J 1999 Nov; 18(21): 5885-91.
1999
Joberty G, Stabila PF, Coppola T, Macara IG, Regazzi R, High affinity Rab3 binding is dispensable for Rabphilin-dependent potentiation of stimulated secretion., J Cell Sci 1999 Oct; 112 ( Pt 20)(): 3579-87.
1996
Mazella J, Botto JM, Guillemare E, Coppola T, Sarret P, Vincent JP, Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain., J Neurosci 1996 Sep; 16(18): 5613-20.
1996
Coppola T, Gundersen C, Widespread expression of human cysteine string proteins., FEBS Lett 1996 Aug; 391(3): 269-72.
1995
Mougneau E, Altare F, Wakil AE, Zheng S, Coppola T, Wang ZE, Waldmann R, Locksley RM, Glaichenhaus N, Expression cloning of a protective Leishmania antigen., Science 1995 Apr; 268(5210): 563-6.
1994
Lesage F, Duprat F, Fink M, Guillemare E, Coppola T, Lazdunski M, Hugnot JP, Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. FEBS Lett 1994 Oct; 353(1): 37-42.
1994
Coppola T, Waldmann R, Borsotto M, Heurteaux C, Romey G, Mattéi MG, Lazdunski M, Molecular cloning of a murine N-type calcium channel alpha 1 subunit. Evidence for isoforms, brain distribution, and chromosomal localization., FEBS Lett 1994 Jan; 338(1): 1-5.
1992
Auguste P, Hugues M, Borsotto M, Thibault J, Romey G, Coppola T, Lazdunski M, Characterization and partial purification from pheochromocytoma cells of an endogenous equivalent of scyllatoxin, a scorpion toxin which blocks small conductance Ca(2+)-activated K+ channels., Brain Res 1992 Dec; 599(2): 230-6.
1989
Brice A, Berrard S, Raynaud B, Ansieau S, Coppola T, Weber MJ, Mallet J, Complete sequence of a cDNA encoding an active rat choline acetyltransferase: a tool to investigate the plasticity of cholinergic phenotype expression., J Neurosci Res 1989 Jul; 23(3): 266-73.
1989
Miraglia del Giudice M, Decimo F, Miraglia del Giudice M, Coppola T, [Possible factors of early sensitization in infant allergic asthma]., Arch Monaldi Mal Torace 1989 ; 44(4-6): 615-24.
1989
Barhanin J, Borsotto M, Coppola T, Fosset M, Hosey MM, Mourre C, Pauron D, Qar J, Romey G, Schmid A, Biochemistry, molecular pharmacology, and functional control of Ca2+ channels., Ann N Y Acad Sci 1989 ; 560(): 15-26.
1988
Lazdunski M, Barhanin J, Borsotto M, Cognard C, Cooper C, Coppola T, Fosset M, Galizzi JP, Hosey MM, Mourre C, Molecular properties of structure and regulation of the calcium channel., Ann N Y Acad Sci 1988 ; 522(): 134-49.
1987
Barhanin J, Coppola T, Schmid A, Borsotto M, Lazdunski M, The calcium channel antagonists receptor from rabbit skeletal muscle. Reconstitution after purification and subunit characterization., Eur J Biochem 1987 May; 164(3): 525-31.
1986
Schmid A, Barhanin J, Mourre C, Coppola T, Borsotto M, Lazdunski M, Antibodies reveal the cytolocalization and subunit structure of the 1,4-dihydropyridine component of the neuronal Ca2+ channel., Biochem Biophys Res Commun 1986 Sep; 139(3): 996-1002.
1986
Schmid A, Barhanin J, Coppola T, Borsotto M, Lazdunski M, Immunochemical analysis of subunit structures of 1,4-dihydropyridine receptors associated with voltage-dependent Ca2+ channels in skeletal, cardiac, and smooth muscles., Biochemistry 1986 Jun; 25(12): 3492-5.
1984
Miraglia del Giudice M, Capristo AF, Mirra G, Maiello N, Coppola T, [Controlled double-blind study on the efficacy of clofedanol-sobrerol in the treatment of pediatric pertussis]., Minerva Pediatr 1984 Dec; 36(23-24): 1199-206.