JobPost-Doctoral Position: Molecular and Cellular Mechanisms in the Human Respiratory Tract (M/F)
About
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General Information
Job title: Post-Doctoral Fellowship: Molecular and cellular mechanisms in the human respiratory tract (M/F)
Reference: UMR7275-LAUZAR-002
Number of Positions: 1
Workplace: VALBONNE
Publication date: Monday, March 31, 2025
Contract type: Researcher on a fixed-term contract
Contract duration: 24 months
Expected start date: June 1, 2025
Workload: Full
Salary: 3021 to 4208 gross per month depending on experience
Desired level of study: Doctorate
Desired experience: 1 to 4 years
CN Section(s): 22 – Cell Biology, Development, Evolution-Development, Reproduction
Missions
The postdoctoral researcher will work on a translational project funded by the French National Research Agency (ANR) in 2024, which aims to improve our understanding of chronic respiratory diseases through cutting-edge genomics and cell biology approaches. The postdoctoral researcher will contribute to identifying a new pathway for regulating cellular balance in the airways, within the context of chronic respiratory pathologies such as chronic obstructive pulmonary disease (COPD) and ciliary dyskinesia.
Activities
The approaches used by the laboratory involve primary culture models of differentiated bronchial epithelium at the air-liquid interface, targeted gene inactivation by CRISPR-Cas9, imaging, single-cell and spatial transcriptomic approaches, and chromatin studies. The project includes a bioinformatics analysis component to which the postdoc will contribute in collaboration with the team's bioinformaticians.
The project is being conducted in close collaboration with clinical teams from 3 university hospitals and the laboratory's genomics and bioinformatics platforms.
SKILLS
The candidate must demonstrate proven skills in several of the following fields: cell and molecular biology, developmental biology, genomics, respiratory physiology.
A background in research projects on lung biology or lung diseases is desirable.
Bioinformatics skills are not required to apply, but training and experience in bioinformatics will be greatly appreciated.
The candidate should ideally have some initial postdoctoral experience with the ambition of applying for research fellow positions.
Work context
The position is available at the Institute of Molecular and Cellular Pharmacology in Valbonne – Sophia Antipolis (Alpes Maritimes). The IPMC comprises 22 research teams and shared services, with a total staff of over 250 people.
The successful candidate will work within the "Physiological Genomics of Eukaryotes" research team, led by Dr. Pascal Barbry, on projects directed by Dr. Laure-Emmanuelle Zaragosi. The team, which employs a quantitative biology approach, brings together experimentalists and bioinformaticians. It was the first French team to be involved in the international Human Cell Atlas consortium.
The project is being carried out in close collaboration with a team from the University of Reims Champagne Ardenne, and a team from the Trousseau University Hospital in Paris.
The position is located in a sector related to the protection of scientific and technical potential (PPST), and therefore requires, in accordance with regulations, that your arrival be authorized by the competent authority of the MESR.