JobPhD: Cellular circuits in chronic respiratory diseases (Marie Slodowska-Curie Action)
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Job title: PhD: Cellular circuits in chronic respiratory diseases (Marie Slodowska-Curie Action)
Reference: UMR7275-LAUZAR-001
Number of Positions: 1
Workplace: VALBONNE
Publication date: Monday, February 24, 2025
Contract type: Fixed-term contract for PhD students
Contract duration: 36 months
Thesis start date: September 1, 2025
Workload: Full
Remuneration: The minimum remuneration is €2200.00 per month
CN Section(s): 24 – Physiology, pathophysiology, biology of cancer
This doctorate is part of the "RESPIRE-EXCEL" doctoral network.
Asthma and COPD (Chronic Obstructive Pulmonary Disease) are widespread chronic respiratory illnesses that represent a significant social and economic burden. Traditional treatments often follow a "one-size-fits-all" approach, simply suppressing symptoms without providing real improvements in health. The MSCA RESPIRE-EXCEL doctoral network is poised to revolutionize this approach by introducing precision medicine tailored to each patient.
The goal of this doctoral project is to provide a detailed analysis of early cellular events in the airways of patients in the early stages of COPD, in order to discover potential early markers and therapeutic targets for this chronic disease. The project will explore in detail our novel single-cell atlas obtained from airway biopsies of COPD patients and spatially map dysregulated pathways using spatial transcriptomics. The use of in vitro and ex vivo models will allow for the identification of disease-associated states and the cellular specificity of responses to cigarette smoke. The doctoral candidate will also integrate all of this data with longitudinal cohort data to link cellular mechanisms to patient data. This translational medicine doctoral project offers candidates a unique opportunity to gain hands-on experience in both laboratory techniques and bioinformatics, fostering dual expertise that is highly sought after in today's biomedical landscape.
A 6-month stay is planned at the Helmholtz Center in Munich, Germany, for the bioinformatics part.
Knowledge and skills specific to this doctoral project:
The candidate must hold a master's degree in the fields of cell and molecular biology, development, genomics and physiology.
A degree in bioinformatics is not required, but training and experience in bioinformatics will be greatly appreciated.
Candidates must submit their application on the MSCA platform:
https://werkenbijumcg.nl/vacatures/solliciteren?url=https://www.tangram-tis.nl/10420/Kandidaten/Inschrijven/10419%2D02S0009EMP
The position is available at the Institute of Molecular and Cellular Pharmacology (IPMC) in Valbonne – Sophia Antipolis (Alpes-Maritimes). The IPMC comprises 22 research teams and shared services, with a total staff of over 250 people. The successful candidate will work within the "Physiological Genomics of Eukaryotes" research team, led by Dr. Pascal Barbry, the first French team to have participated in the international Human Cell Atlas consortium.
The position is located in a sector related to the protection of scientific and technical potential (PPST), and therefore requires, in accordance with regulations, that your arrival be authorized by the competent authority of the MESR.