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Cavbeta-subunit displacement is a key step to induce the reluctant state of P/Q calcium channels by direct G protein regulation.
A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons.
Publication: Conformational States of the Small G Protein Arf-1 in Complex with the Guanine Nucleotide Exchange Factor ARNO-Sec7
Team: Molecular pathophysiology of phospholipases A2 and their mediators
Sophie BERAUD-DUFOUR