JobPostdoctoral Researcher (M/F): Study of the molecular basis of the mechanism of action of a new inhibitor of the canonical Wnt signaling pathway

About

Job Title: Postdoctoral Researcher (M/F): Study of the molecular basis of the mechanism of action of a new inhibitor of the canonical Wnt signaling pathway
Reference: UMR7275-CARRUG-002
Number of Positions: 1
Workplace: VALBONNE
Publication date: Monday, January 13, 2025
Contract type: Researcher on a fixed-term contract
Contract duration: 24 months
Expected start date: March 1, 2025
Workload: Full
Salary: between 3021 euros and 4208 euros gross depending on experience
Desired level of study: Doctorate
Desired experience: 1 to 4 years
CN Section(s): 24 – Physiology, pathophysiology, biology of cancer

Missions

Our team, "Gene Regulation Mechanisms in Pathophysiology," has long been interested in the role of Wnt signaling in the development, function, and pathology of the adrenal cortex, having been the first to demonstrate that the secreted protein augurin is a novel modulator of canonical Wnt signaling. This important discovery has opened new perspectives in our understanding of augurin's function in pathophysiology. We are seeking a candidate to work on an exciting project aimed at characterizing the molecular mechanisms of repression of canonical Wnt signaling by augurin and its derived peptides. These studies will allow us to uncover the molecular basis of the action of augurin and its derived peptides and will provide the necessary background for the development of augurin-specific agonists and antagonists. Because of their secreted nature and potential for pharmacological manipulation, augurin-derived peptides are attractive targets for the discovery of new therapeutic agents for human pathologies related to defects or dysregulation of the Wnt signaling pathway, such as cancer, neuronal diseases, developmental and skeletal disorders, and cardiovascular diseases.

Apply on the CNRS Job Portal