Publication: Sex-Specific Behavioral Characteristics of Juvenile and Adult Haploinsufficient Scn2a+/− Female Mice, Model of Autism Spectrum Disorder.

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https://doi.org/10.1111/gbb.70034

Variants in the SCN2A gene (Nav1.2 sodium channel) cause neurodevelopmental and epileptic disorders and are strongly associated with ASD.
ASD shows a male-biased prevalence, though female cases may be underestimated; it remains unclear whether this reflects greater masking abilities or genuine differences in symptom presentation.
In Scn2a+/− male mice, ASD-like traits appear in youth but less with age.
Female Scn2a+/− mice display a milder phenotype than males, with specific characteristics, ,
This indicates that sex-specific phenotypic differences can exist, consistent with distinct underlying biological mechanisms.