Putative assembly Mammalian 2P channels Current viewer



Functional properties of mammalian 2P domains K+ Channels

Last update: 21 / 5 / 2003

Note: All information from various articles is presented including discrepancies.

Table of contents

See my page on the Nomenclature of the K+ channels superfamily

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Biophysical properties

Names Oocytes resting potential (mV) Current at +50 mV (µA) Conductance (pS)
(physiological K+)		 Flickering Mean open time (ms) Activation
[Tau]		 Inactivation
[Tau]		 IV curve in normal K+ IV curve in symetrical K+ Names
KCNK1
(K2p1.1, TWIK-1)		 -76 0.5 19 (+80 mV) very 1.9 (+80 mV) very rapid no Weak inward rectifier Inward rectifier KCNK1
(K2p1.1, TWIK-1)
KCNK2
(K2p2.1, TREK-1)		 -72 2 48 (+50 mV) very . very rapid no Outward rectifier Saturating at negative potentials KCNK2
(K2p2.1, TREK-1)
KCNK3
(K2p3.1, TASK-1, TBAK-1, OAT-1)		 -85 2 14.6 (-80 mV)
16 (negative potentials)		 yes 0.8 / 2 (-100 mV) very rapid no Outward rectifier Linear KCNK3
(K2p3.1, TASK-1, TBAK-1, OAT-1)
KCNK4
(K2p4.1, TRAAK, KT4.1)		 -88 2 46 (positive potentials) yes . very rapid no Outward rectifier Linear KCNK4
(K2p4.1, TRAAK, KT4.1)
KCNK5
(K2p5.1, TASK-2)		 -79 1.5 15 (positive potentials) very . yes
[61 ms (+50 mV)]		 . Outward rectifier Saturating at negative potentials KCNK5
(K2p5.1, TASK-2)
KCNK6
(K2p6.1, TWIK-2, TOSS)		 . 0.3 < 5 . . very rapid yes
[218 ms]		 Inward rectifier Inward rectifier KCNK6
(K2p6.1, TWIK-2, TOSS)
KCNK7 ne ne ne ne ne ne ne ne ne KCNK7
KCNK9
(K2p9.1, TASK-3, KT3.2)		 -79 / -93 42 / 2.4 27 (-100 mV) yes 1.1 (-60 mV) yes
[2 / 4 ms (positive potentials)]		 no Outward rectifier Outward rectifier KCNK9
(K2p9.1, TASK-3, KT3.2)
KCNK10
(K2p10.1, TREK-2)		 -74 . 68 / 100 (+40 mV) yes 0.9 (-40 mV) yes no Outward rectifier Linear / Outward rectifier KCNK10
(K2p10.1, TREK-2)
KCNK12
(K2p12.1, THIK-2)		 ne ne ne ne ne ne ne ne ne KCNK12
(K2p12.1, THIK-2)
KCNK13
(K2p13.1, THIK-1)		 . 20 . . . yes
[0.97 ms]		 no Outward rectifier Weak inward rectifier KCNK13
(K2p13.1, THIK-1)
KCNK15
(K2p15.1, TASK-5, KT3.3)		 ne ne ne ne ne ne ne ne ne KCNK15
(K2p15.1, TASK-5, KT3.3)
KCNK16
(K2p16.1, TALK-1)		 -71.9 1 . . . very rapid no Outward rectifier Linear KCNK16
(K2p16.1, TALK-1)
KCNK17
(K2p17.1, TALK-2, TASK-4)		 -55.5 1 . . . very rapid no Outward rectifier Saturating at negative potentials KCNK17
(K2p17.1, TALK-2, TASK-4)
KCNK18
(K2p18.1, TRESK-1, TRESK-2)		 . . . yes . rapid slow Outward rectifier Saturating at negative potentials KCNK18
(K2p18.1, TRESK-1, TRESK-2)
Names Oocytes resting potential (mV) Current at +50 mV (µA) Conductance (pS)
(physiological K+)		 Flickering Mean open time (ms) Activation
[Tau]		 Inactivation
[Tau]		 IV curve in normal K+ IV curve in symetrical K+ Names

Legend: ne: no expression


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Pharmacology

Effects of various drugs on the 2P current, tested in physiological K+.

Names Ba2+ Gd3+ Cs+ TEA 4-AP Quinine Quinidine Riluzole CHCl3 Halothane Isoflurane Lidocaïne Bupivacaïne Names
KCNK1
(K2p1.1, TWIK-1)		 inhibitioninhibition . No effect inhibition No effect inhibitioninhibition inhibitioninhibition . . . . . . KCNK1
(K2p1.1, TWIK-1)
KCNK2
(K2p2.1, TREK-1)		 inhibitioninhibition / No effect inhibition / No effect No effect No effect No effect No effect inhibitioninhibition / No effect Activation
then
inhibitioninhibition		 ActivationActivation Activation ActivationActivation . . KCNK2
(K2p2.1, TREK-1)
KCNK3
(K2p3.1, TASK-1, TBAK-1, OAT-1)		 inhibition / No effect . No effect No effect No effect inhibition inhibition . inhibition / No effect Activation Activation inhibitioninhibition inhibitioninhibition KCNK3
(K2p3.1, TASK-1, TBAK-1, OAT-1)
KCNK4
(K2p4.1, TRAAK, KT4.1)		 inhibition / No effect inhibitioninhibition No effect No effect No effect No effect No effect Activation No effect No effect No effect . . KCNK4
(K2p4.1, TRAAK, KT4.1)
KCNK5
(K2p5.1, TASK-2)		 inhibition . No effect No effect No effect inhibitioninhibition inhibitioninhibition . Activation Activation No effect inhibitioninhibition inhibitioninhibition KCNK5
(K2p5.1, TASK-2)
KCNK6
(K2p6.1, TWIK-2, TOSS)		 inhibitioninhibition No effect No effect No effect No effect inhibitioninhibition / No effect inhibitioninhibition / No effect . inhibition inhibition No effect . No effect KCNK6
(K2p6.1, TWIK-2, TOSS)
KCNK7 ne ne ne ne ne ne ne ne ne ne ne ne ne KCNK7
KCNK9
(K2p9.1, TASK-3, KT3.2)		 inhibition . No effect No effect . . inhibition . . . . inhibition inhibition KCNK9
(K2p9.1, TASK-3, KT3.2)
KCNK10
(K2p10.1, TREK-2)		 No effect No effect . No effect . . inhibitioninhibition / No effect Activation Activation Activation Activation No effect No effect KCNK10
(K2p10.1, TREK-2)
KCNK12
(K2p12.1, THIK-2)		 ne ne ne ne ne ne ne ne ne ne ne ne ne KCNK12
(K2p12.1, THIK-2)
KCNK13
(K2p13.1, THIK-1)		 inhibitioninhibition . . . . . . . . inhibition . . . KCNK13
(K2p13.1, THIK-1)
KCNK15
(K2p15.1, TASK-5, KT3.3)		 ne ne ne ne ne ne ne ne ne ne ne ne ne KCNK15
(K2p15.1, TASK-5, KT3.3)
KCNK16
(K2p16.1, TALK-1)		 inhibitioninhibition . No effect inhibition No effect inhibitioninhibition inhibitioninhibition . inhibition inhibition No effect . . KCNK16
(K2p16.1, TALK-1)
KCNK17
(K2p17.1, TALK-2, TASK-4)		 inhibitioninhibition . No effect inhibition No effect Activation inhibition . inhibitioninhibition inhibitioninhibition Activation . . KCNK17
(K2p17.1, TALK-2, TASK-4)
KCNK18
(K2p18.1, TRESK-1, TRESK-2)		 inhibition . . inhibition No effect inhibitioninhibition inhibition . . . . inhibitioninhibition . KCNK18
(K2p18.1, TRESK-1, TRESK-2)
Names Ba2+ Gd3+ Cs+ TEA 4-AP Quinine Quinidine Riluzole CHCl3 Halothane Isoflurane Lidocaïne Bupivacaïne Names

Legend: ne: no expression, ActivationActivation: strong activation, Activation: activation, No effect: no effect, inhibition: inhibition, inhibitioninhibition:strong inhibition, . (dot): not tested, /: opposite effects in various studies


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Regulation

Names PKC AMPc [Ca2+]in Acidic external pH Alkaline external pH Acidic internal pH Alkaline internal pH Arachidonate Stretch Heat Names
KCNK1
(K2p1.1, TWIK-1)		 Activation No effect No effect No effect No effect inhibitioninhibition ActivationActivation . . . KCNK1
(K2p1.1, TWIK-1)
KCNK2
(K2p2.1, TREK-1)		 inhibitioninhibition inhibitioninhibition No effect inhibition Activation Activation inhibition ActivationActivation ActivationActivation ActivationActivation KCNK2
(K2p2.1, TREK-1)
KCNK3
(K2p3.1, TASK-1, TBAK-1, OAT-1)		 No effect inhibition / No effect No effect inhibition ActivationActivation inhibition / No effect Activation / No effect inhibition / No effect No effect No effect KCNK3
(K2p3.1, TASK-1, TBAK-1, OAT-1)
KCNK4
(K2p4.1, TRAAK, KT4.1)		 No effect No effect No effect inhibition Activation No effect No effect ActivationActivation ActivationActivation Activation KCNK4
(K2p4.1, TRAAK, KT4.1)
KCNK5
(K2p5.1, TASK-2)		 Activation / No effect No effect . inhibitioninhibition ActivationActivation inhibition Activation No effect . . KCNK5
(K2p5.1, TASK-2)
KCNK6
(K2p6.1, TWIK-2, TOSS)		 Activation / No effect Activation / No effect . inhibition / No effect No effect inhibition Activation Activation / No effect . inhibition KCNK6
(K2p6.1, TWIK-2, TOSS)
KCNK7 ne ne ne ne ne ne ne ne ne ne KCNK7
KCNK9
(K2p9.1, TASK-3, KT3.2)		 No effect No effect No effect inhibitioninhibition ActivationActivation No effect No effect . No effect . KCNK9
(K2p9.1, TASK-3, KT3.2)
KCNK10
(K2p10.1, TREK-2)		 No effect inhibition . No effect No effect Activation inhibition ActivationActivation ActivationActivation . KCNK10
(K2p10.1, TREK-2)
KCNK12
(K2p12.1, THIK-2)		 ne ne ne ne ne ne ne ne ne ne KCNK12
(K2p12.1, THIK-2)
.KCNK13
(K2p13.1, THIK-1)		 . . . inhibition . No effect No effect ActivationActivation . No effect KCNK13
(K2p13.1, THIK-1)
KCNK15
(K2p15.1, TASK-5, KT3.3)		 ne ne ne ne ne ne ne ne ne ne KCNK15
(K2p15.1, TASK-5, KT3.3)
KCNK16
(K2p16.1, TALK-1)		 No effect No effect No effect inhibition Activation No effect No effect No effect . . KCNK16
(K2p16.1, TALK-1)
KCNK17
(K2p17.1, TALK-2, TASK-4)		 No effect No effect No effect No effect ActivationActivation No effect No effect No effect . . KCNK17
(K2p17.1, TALK-2, TASK-4)
KCNK18
(K2p18.1, TRESK-1, TRESK-2)		 . . . inhibition Activation inhibition Activation inhibition . No effect KCNK18
(K2p18.1, TRESK-1, TRESK-2)
Names PKC AMPc [Ca2+]in Acidic external pH Alkaline external pH Acidic internal pH Alkaline internal pH Arachidonate Stretch Heat Names

Legend: ne: no expression, ActivationActivation: strong activation, Activation: activation, No effect: no effect, inhibition: inhibition, inhibitioninhibition:strong inhibition, .(dot): not tested, /: opposite effects in various studies


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Channel names based on: International Union of Pharmacology (IUPHAR): "Compendium of Voltage-gated Ion Channels", IUPHAR Media Editor

 


Putative assembly Mammalian 2P channels Current viewer