Sequences alignment : Horizontal | Molecular properties | ||
Last update: 10 / 10 / 2001
Names
|
KCNK3
(TASK1, TBAK-1, OAT-1) |
KCNK9
(TASK3) |
KCNK15 |
KCNK1
(TWIK-1) |
KCNK7
|
KCNK6
(TWIK-2, TOSS) |
KCNK2
(short TREK-1) |
KCNK2
(long TREK-1) |
KCNK10
(TREK-2) |
KCNK4
(TRAAK) |
KCNK16
(TALK-1) |
KNCK17
(TALK-2, TASK-4) |
KCNK5
(TASK-2) |
KCNK12
(THIK-2) |
KCNK13
(THIK1) |
Accession number
|
NM_002246 | XM_005290 | NM_022358 | NM_002245 | AF110522 | XM_009174 | AF129399 |
AF325671
|
XM_012342 | NM_016611 | AAK49532 | AF358910_1 | XM_004481 | XM_010888 | XM_012341 |
N-terminus
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
M
|
M
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
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|
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|
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|
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|
L
|
F
|
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|
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|
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|
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|
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|
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|
|
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|
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|
-
|
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|
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|
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|
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|
A
|
F
|
-
|
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|
-
|
-
|
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|
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|
|
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|
-
|
-
|
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|
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|
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|
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|
S
|
L
|
-
|
-
|
-
|
-
|
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|
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|
|
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|
-
|
-
|
-
|
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|
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|
-
|
A
|
Y
|
-
|
-
|
-
|
-
|
-
|
-
|
|
-
|
-
|
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|
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|
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|
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|
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|
S
|
T
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
R
|
D
|
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|
-
|
-
|
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|
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|
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|
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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P
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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L
|
L
|
V
|
G
|
V
|
I
|
I
|
V
|
V
|
L
|
A
|
A
|
V
|
L
|
|
V
|
V
|
V
|
F
|
L
|
L
|
I
|
I
|
T
|
S
|
L
|
L
|
I
|
A
|
G
|
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
G
|
A
|
A
|
T
|
A
|
A
|
A
|
|
A
|
A
|
A
|
V
|
V
|
L
|
T
|
T
|
L
|
L
|
T
|
G
|
A
|
T
|
A
|
|
V
|
V
|
V
|
V
|
V
|
L
|
V
|
V
|
V
|
V
|
I
|
V
|
I
|
V
|
V
|
|
F
|
F
|
F
|
F
|
F
|
V
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
|
D
|
D
|
D
|
S
|
Q
|
A
|
K
|
K
|
R
|
R
|
Q
|
W
|
E
|
S
|
S
|
|
A
|
A
|
A
|
S
|
A
|
R
|
A
|
A
|
A
|
A
|
L
|
T
|
V
|
A
|
A
|
|
L
|
L
|
L
|
V
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
Names
|
KCNK3
(TASK1, TBAK-1, OAT-1) |
KCNK9
(TASK3) |
KCNK15 |
KCNK1
(TWIK-1) |
KCNK7
|
KCNK6
(TWIK-2, TOSS) |
KCNK2
(short TREK-1) |
KCNK2
(long TREK-1) |
KCNK10
(TREK-2) |
KCNK4
(TRAAK) |
KCNK16
(TALK-1) |
KNCK17
(TALK-2, TASK-4) |
KCNK5
(TASK-2) |
KCNK12
(THIK-2) |
KCNK13
(THIK1) |
External loop
|
S
|
S
|
S
|
L
|
G
|
G
|
Q
|
Q
|
Q
|
Q
|
R
|
G
|
E
|
S
|
L
|
E
|
D
|
E
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
Q
|
R
|
P
|
P
|
A
|
|
P
|
H
|
A
|
Y
|
P
|
H
|
H
|
Q
|
F
|
H
|
A
|
A
|
H
|
G
|
H
|
|
E
|
E
|
E
|
E
|
A
|
E
|
E
|
E
|
E
|
E
|
E
|
A
|
W
|
E
|
E
|
|
L
|
M
|
S
|
D
|
C
|
A
|
I
|
I
|
S
|
Q
|
A
|
Q
|
K
|
A
|
R
|
|
I
|
R
|
G
|
L
|
R
|
R
|
S
|
S
|
S
|
Q
|
Q
|
D
|
E
|
E
|
Q
|
|
E
|
E
|
R
|
L
|
L
|
L
|
Q
|
Q
|
Q
|
A
|
S
|
S
|
A
|
A
|
A
|
|
R
|
E
|
Q
|
R
|
Q
|
R
|
R
|
R
|
K
|
Q
|
R
|
S
|
K
|
R
|
K
|
|
Q
|
E
|
R
|
Q
|
A
|
A
|
T
|
T
|
N
|
R
|
D
|
R
|
K
|
A
|
Q
|
|
R
|
K
|
L
|
E
|
E
|
E
|
T
|
T
|
T
|
E
|
Q
|
S
|
N
|
R
|
R
|
|
L
|
L
|
L
|
L
|
L
|
L
|
I
|
I
|
I
|
L
|
F
|
F
|
Y
|
W
|
W
|
|
E
|
K
|
V
|
R
|
R
|
E
|
V
|
V
|
A
|
G
|
Q
|
Q
|
Y
|
G
|
E
|
|
L
|
A
|
Q
|
K
|
A
|
T
|
I
|
I
|
L
|
E
|
L
|
R
|
T
|
A
|
E
|
|
R
|
E
|
K
|
L
|
E
|
L
|
Q
|
Q
|
E
|
V
|
E
|
D
|
Q
|
T
|
R
|
|
Q
|
E
|
R
|
K
|
L
|
R
|
K
|
K
|
K
|
R
|
K
|
K
|
K
|
L
|
L
|
|
Q
|
I
|
G
|
R
|
A
|
A
|
Q
|
Q
|
A
|
E
|
L
|
W
|
L
|
R
|
A
|
|
E
|
R
|
A
|
R
|
A
|
Q
|
T
|
N
|
E
|
K
|
R
|
E
|
H
|
N
|
N
|
|
L
|
I
|
L
|
F
|
F
|
L
|
F
|
F
|
F
|
F
|
F
|
L
|
L
|
F
|
F
|
|
R
|
K
|
R
|
L
|
Q
|
L
|
I
|
I
|
L
|
L
|
L
|
L
|
L
|
S
|
S
|
|
A
|
G
|
R
|
E
|
A
|
Q
|
S
|
A
|
R
|
R
|
E
|
Q
|
K
|
A
|
R
|
|
R
|
K
|
K
|
E
|
E
|
R
|
Q
|
Q
|
D
|
A
|
N
|
N
|
E
|
A
|
G
|
|
Y
|
Y
|
F
|
H
|
H
|
S
|
H
|
H
|
H
|
H
|
Y
|
F
|
F
|
H
|
H
|
|
-
|
-
|
-
|
-
|
R
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
-
|
-
|
-
|
E
|
A
|
P
|
S
|
A
|
V
|
P
|
T
|
T
|
P
|
-
|
-
|
|
N
|
N
|
G
|
C
|
C
|
C
|
C
|
C
|
C
|
C
|
C
|
C
|
C
|
G
|
N
|
|
L
|
I
|
F
|
L
|
L
|
V
|
V
|
V
|
V
|
V
|
L
|
L
|
L
|
V
|
L
|
|
S
|
S
|
S
|
S
|
P
|
A
|
N
|
N
|
S
|
S
|
D
|
D
|
G
|
A
|
S
|
|
Q
|
S
|
A
|
E
|
P
|
A
|
S
|
S
|
P
|
D
|
Q
|
R
|
Q
|
E
|
R
|
|
G
|
E
|
E
|
Q
|
G
|
P
|
T
|
T
|
Q
|
Q
|
W
|
P
|
E
|
P
|
D
|
|
G
|
D
|
D
|
Q
|
A
|
A
|
E
|
E
|
E
|
E
|
A
|
A
|
G
|
E
|
E
|
|
Y
|
Y
|
Y
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
M
|
L
|
L
|
L
|
L
|
|
E
|
R
|
R
|
E
|
E
|
D
|
D
|
D
|
E
|
G
|
E
|
D
|
D
|
R
|
R
|
|
E
|
Q
|
E
|
Q
|
E
|
A
|
E
|
E
|
T
|
L
|
Q
|
S
|
K
|
A
|
G
|
|
L
|
L
|
L
|
F
|
L
|
F
|
L
|
L
|
L
|
L
|
F
|
L
|
I
|
F
|
F
|
|
E
|
E
|
E
|
L
|
L
|
V
|
I
|
I
|
I
|
I
|
V
|
I
|
L
|
L
|
L
|
|
R
|
L
|
R
|
G
|
G
|
E
|
Q
|
Q
|
Q
|
K
|
Q
|
R
|
E
|
R
|
R
|
|
V
|
V
|
L
|
R
|
T
|
R
|
Q
|
Q
|
H
|
E
|
V
|
D
|
V
|
H
|
H
|
|
V
|
I
|
A
|
V
|
A
|
V
|
I
|
I
|
A
|
V
|
I
|
V
|
V
|
Y
|
Y
|
|
L
|
L
|
L
|
L
|
L
|
L
|
V
|
V
|
L
|
A
|
M
|
V
|
S
|
E
|
E
|
|
R
|
Q
|
Q
|
E
|
A
|
A
|
A
|
T
|
D
|
D
|
E
|
Q
|
D
|
A
|
E
|
|
L
|
S
|
A
|
A
|
T
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
|
K
|
E
|
E
|
S
|
Q
|
G
|
I
|
I
|
D
|
L
|
W
|
Y
|
A
|
L
|
T
|
|
P
|
P
|
P
|
N
|
A
|
R
|
N
|
N
|
N
|
G
|
V
|
K
|
G
|
A
|
R
|
|
H
|
H
|
H
|
Y
|
H
|
L
|
A
|
A
|
A
|
G
|
K
|
N
|
Q
|
A
|
A
|
|
K
|
R
|
R
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
|
A
|
A
|
A
|
V
|
V
|
R
|
I
|
I
|
V
|
A
|
V
|
A
|
V
|
V
|
I
|
|
G
|
G
|
G
|
S
|
S
|
V
|
I
|
I
|
S
|
D
|
N
|
S
|
A
|
R
|
R
|
|
-
|
-
|
-
|
V
|
T
|
V
|
P
|
P
|
P
|
P
|
P
|
L
|
I
|
A
|
V
|
|
-
|
-
|
-
|
L
|
L
|
L
|
L
|
L
|
I
|
E
|
K
|
L
|
T
|
D
|
D
|
|
-
|
-
|
-
|
S
|
G
|
A
|
G
|
G
|
G
|
T
|
G
|
S
|
G
|
A
|
N
|
|
-
|
-
|
-
|
N
|
N
|
N
|
N
|
N
|
N
|
N
|
N
|
N
|
N
|
L
|
V
|
|
-
|
-
|
-
|
A
|
S
|
A
|
T
|
N
|
S
|
S
|
S
|
T
|
Q
|
R
|
R
|
|
-
|
-
|
-
|
S
|
S
|
S
|
S
|
S
|
S
|
T
|
T
|
T
|
T
|
P
|
P
|
|
V
|
V
|
R
|
G
|
E
|
G
|
N
|
N
|
N
|
S
|
N
|
S
|
-
|
R
|
R
|
|
Q
|
Q
|
Q
|
N
|
G
|
S
|
Q
|
Q
|
N
|
N
|
-
|
-
|
-
|
-
|
-
|
|
-
|
-
|
-
|
W
|
R
|
A
|
I
|
V
|
S
|
S
|
P
|
M
|
F
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
N
|
S
|
S
|
S
|
S
|
S
|
G
|
N
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
A
|
H
|
H
|
H
|
H
|
N
|
R
|
N
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
S
|
-
|
-
|
-
|
S
|
-
|
-
|
-
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
D
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
P
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
-
|
-
|
-
|
N
|
T
|
A
|
-
|
-
|
-
|
A
|
-
|
-
|
-
|
-
|
-
|
Names |
KCNK3
(TASK1, TBAK-1, OAT-1) |
KCNK9
(TASK3) |
KCNK15 |
KCNK1
(TWIK-1) |
KCNK7
|
KCNK6
(TWIK-2, TOSS) |
KCNK2
(short TREK-1) |
KCNK2
(long TREK-1) |
KCNK10
(TREK-2) |
KCNK4
(TRAAK) |
KCNK16
(TALK-1) |
KNCK17
(TALK-2, TASK-4) |
KCNK5
(TASK-2) |
KCNK12
(THIK-2) |
KCNK13
(THIK1) |
P1
|
W
|
W
|
W
|
W
|
W
|
W
|
W
|
W
|
W
|
W
|
W
|
W
|
W
|
W
|
W
|
R
|
K
|
K
|
D
|
D
|
D
|
D
|
D
|
D
|
D
|
D
|
E
|
N
|
D
|
D
|
|
F
|
F
|
F
|
F
|
L
|
F
|
L
|
L
|
L
|
L
|
F
|
L
|
W
|
F
|
F
|
|
A
|
A
|
P
|
T
|
P
|
A
|
G
|
G
|
G
|
G
|
G
|
V
|
P
|
P
|
T
|
|
G
|
G
|
G
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
S
|
G
|
N
|
G
|
G
|
|
S
|
S
|
S
|
A
|
A
|
A
|
S
|
S
|
A
|
A
|
S
|
S
|
A
|
A
|
A
|
|
F
|
F
|
F
|
L
|
L
|
L
|
F
|
F
|
F
|
F
|
F
|
F
|
M
|
F
|
F
|
|
Y
|
Y
|
Y
|
F
|
L
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
I
|
Y
|
Y
|
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
S
|
A
|
S
|
A
|
V
|
V
|
|
I
|
I
|
I
|
S
|
A
|
S
|
G
|
G
|
G
|
G
|
G
|
V
|
A
|
G
|
G
|
|
T
|
T
|
T
|
T
|
S
|
T
|
T
|
T
|
T
|
T
|
T
|
S
|
T
|
T
|
T
|
|
V
|
V
|
V
|
V
|
I
|
L
|
V
|
V
|
V
|
I
|
V
|
T
|
V
|
V
|
V
|
|
I
|
I
|
I
|
L
|
L
|
I
|
I
|
I
|
I
|
I
|
V
|
I
|
I
|
V
|
V
|
|
T
|
T
|
T
|
S
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
S
|
S
|
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
|
I
|
I
|
I
|
T
|
T
|
V
|
I
|
I
|
I
|
I
|
I
|
I
|
I
|
I
|
I
|
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
F
|
F
|
Y
|
Y
|
Y
|
Y
|
Y
|
F
|
F
|
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
|
H
|
H
|
H
|
H
|
H
|
Y
|
N
|
N
|
N
|
N
|
N
|
N
|
N
|
M
|
M
|
|
A
|
A
|
A
|
T
|
M
|
T
|
I
|
I
|
I
|
V
|
L
|
L
|
V
|
T
|
T
|
|
A
|
A
|
A
|
V
|
A
|
T
|
S
|
S
|
A
|
A
|
A
|
S
|
A
|
T
|
T
|
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
L
|
P
|
P
|
P
|
P
|
P
|
|
S
|
G
|
G
|
L
|
L
|
L
|
R
|
R
|
S
|
R
|
S
|
N
|
K
|
A
|
A
|
|
T
|
T
|
T
|
S
|
S
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
|
D
|
D
|
D
|
D
|
P
|
D
|
E
|
E
|
E
|
D
|
E
|
M
|
P
|
V
|
V
|
|
G
|
A
|
S
|
G
|
G
|
A
|
G
|
G
|
G
|
A
|
A
|
A
|
A
|
G
|
G
|
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
A
|
G
|
G
|
G
|
Names |
KCNK3
(TASK1, TBAK-1, OAT-1) |
KCNK9
(TASK3) |
KCNK15 |
KCNK1
(TWIK-1) |
KCNK7
|
KCNK6
(TWIK-2, TOSS) |
KCNK2
(short TREK-1) |
KCNK2
(long TREK-1) |
KCNK10
(TREK-2) |
KCNK4
(TRAAK) |
KCNK16
(TALK-1) |
KNCK17
(TALK-2, TASK-4) |
KCNK5
(TASK-2) |
KCNK12
(THIK-2) |
KCNK13
(THIK1) |
M2
|
K
|
K
|
K
|
K
|
K
|
K
|
K
|
K
|
K
|
R
|
Q
|
R
|
R
|
K
|
K
|
V
|
A
|
V
|
A
|
A
|
A
|
I
|
I
|
I
|
L
|
V
|
L
|
L
|
A
|
I
|
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
|
C
|
C
|
C
|
C
|
C
|
S
|
C
|
C
|
C
|
C
|
C
|
C
|
C
|
L
|
L
|
|
M
|
M
|
M
|
I
|
M
|
I
|
I
|
I
|
I
|
I
|
V
|
I
|
V
|
I
|
I
|
|
F
|
F
|
F
|
I
|
V
|
A
|
I
|
I
|
L
|
F
|
F
|
F
|
F
|
A
|
F
|
|
Y
|
Y
|
Y
|
Y
|
Y
|
F
|
Y
|
Y
|
Y
|
Y
|
Y
|
F
|
Y
|
Y
|
Y
|
|
A
|
A
|
A
|
S
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
G
|
G
|
G
|
|
L
|
V
|
L
|
V
|
A
|
L
|
L
|
L
|
I
|
L
|
L
|
L
|
L
|
L
|
L
|
|
L
|
L
|
L
|
I
|
L
|
L
|
L
|
L
|
F
|
V
|
L
|
V
|
F
|
F
|
V
|
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
|
I
|
I
|
I
|
I
|
L
|
V
|
I
|
I
|
I
|
I
|
I
|
I
|
V
|
C
|
C
|
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
A
|
S
|
|
L
|
L
|
L
|
F
|
A
|
T
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
G
|
S
|
|
T
|
T
|
T
|
T
|
S
|
T
|
F
|
F
|
F
|
F
|
N
|
N
|
C
|
T
|
T
|
|
L
|
L
|
L
|
L
|
-
|
M
|
G
|
G
|
G
|
G
|
V
|
L
|
L
|
I
|
I
|
|
V
|
V
|
V
|
L
|
L
|
L
|
F
|
F
|
F
|
I
|
I
|
V
|
T
|
L
|
L
|
|
M
|
M
|
T
|
F
|
A
|
L
|
L
|
L
|
L
|
L
|
F
|
V
|
W
|
F
|
F
|
|
F
|
F
|
F
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
I
|
F
|
F
|
|
Q
|
Q
|
Q
|
T
|
V
|
T
|
A
|
A
|
A
|
A
|
N
|
N
|
S
|
N
|
N
|
|
S
|
S
|
S
|
A
|
A
|
A
|
G
|
G
|
G
|
G
|
H
|
R
|
A
|
L
|
L
|
|
L
|
L
|
L
|
V
|
T
|
S
|
V
|
V
|
I
|
V
|
L
|
L
|
L
|
F
|
F
|
|
G
|
G
|
G
|
V
|
L
|
A
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
L
|
L
|
|
E
|
E
|
E
|
Q
|
R
|
Q
|
D
|
D
|
D
|
D
|
T
|
-
|
K
|
E
|
E
|
|
R
|
R
|
R
|
R
|
H
|
R
|
Q
|
Q
|
Q
|
R
|
G
|
-
|
F
|
R
|
R
|
|
I
|
M
|
L
|
I
|
C
|
L
|
L
|
L
|
L
|
L
|
L
|
-
|
F
|
I
|
L
|
|
N
|
N
|
N
|
T
|
L
|
S
|
G
|
G
|
G
|
G
|
-
|
-
|
-
|
I
|
I
|
|
T
|
T
|
A
|
V
|
L
|
L
|
T
|
T
|
T
|
S
|
R
|
H
|
G
|
S
|
T
|
|
L
|
F
|
V
|
H
|
P
|
L
|
I
|
I
|
I
|
S
|
A
|
L
|
G
|
L
|
I
|
|
V
|
V
|
V
|
V
|
V
|
L
|
F
|
F
|
F
|
L
|
H
|
M
|
R
|
L
|
I
|
|
R
|
R
|
R
|
T
|
L
|
T
|
G
|
G
|
G
|
R
|
L
|
Q
|
A
|
A
|
A
|
|
Intracellular loop
|
Y
|
Y
|
R
|
R
|
S
|
H
|
K
|
K
|
K
|
H
|
A
|
Q
|
K
|
F
|
Y
|
L
|
L
|
L
|
R
|
R
|
V
|
G
|
G
|
S
|
G
|
A
|
G
|
R
|
I
|
I
|
|
L
|
L
|
L
|
P
|
P
|
P
|
I
|
I
|
I
|
I
|
I
|
V
|
L
|
M
|
M
|
|
H
|
K
|
L
|
V
|
R
|
L
|
A
|
A
|
A
|
G
|
E
|
N
|
G
|
R
|
K
|
|
R
|
R
|
A
|
L
|
A
|
S
|
K
|
K
|
R
|
H
|
R
|
H
|
Q
|
A
|
S
|
|
A
|
I
|
A
|
Y
|
W
|
W
|
V
|
V
|
V
|
I
|
W
|
W
|
F
|
C
|
C
|
|
K
|
K
|
K
|
F
|
V
|
L
|
E
|
E
|
E
|
E
|
E
|
A
|
L
|
R
|
H
|
|
K
|
K
|
C
|
H
|
A
|
S
|
D
|
D
|
K
|
A
|
D
|
S
|
T
|
E
|
Q
|
|
G
|
C
|
C
|
I
|
V
|
M
|
T
|
T
|
V
|
I
|
R
|
R
|
K
|
R
|
R
|
|
L
|
C
|
L
|
R
|
H
|
R
|
F
|
F
|
F
|
F
|
P
|
L
|
R
|
Q
|
Q
|
|
G
|
G
|
G
|
-
|
-
|
-
|
I
|
I
|
R
|
L
|
-
|
G
|
G
|
L
|
L
|
|
-
|
-
|
-
|
-
|
-
|
-
|
K
|
K
|
K
|
K
|
-
|
G
|
-
|
R
|
R
|
|
-
|
-
|
-
|
W
|
W
|
W
|
W
|
W
|
K
|
W
|
-
|
T
|
-
|
R
|
R
|
|
-
|
-
|
-
|
G
|
Q
|
G
|
N
|
N
|
Q
|
H
|
-
|
W
|
-
|
S
|
R
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
G
|
G
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
L
|
A
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
L
|
L
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
P
|
P
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
A
|
Q
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
T
|
E
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
F
|
S
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
R
|
L
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
R
|
K
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
G
|
D
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
A
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
A
|
G
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
L
|
Q
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
C
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
E
|
E
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
A
|
V
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
D
|
D
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
S
|
|
M
|
M
|
L
|
F
|
L
|
W
|
V
|
V
|
V
|
V
|
R
|
Q
|
V
|
L
|
L
|
|
R
|
R
|
R
|
S
|
S
|
D
|
S
|
S
|
S
|
P
|
R
|
D
|
S
|
A
|
A
|
|
Names
|
KCNK3
(TASK1, TBAK-1, OAT-1) |
KCNK9
(TASK3) |
KCNK15 |
KCNK1
(TWIK-1) |
KCNK7
|
KCNK6
(TWIK-2, TOSS) |
KCNK2
(short TREK-1) |
KCNK2
(long TREK-1) |
KCNK10
(TREK-2) |
KCNK4
(TRAAK) |
KCNK16
(TALK-1) |
KNCK17
(TALK-2, TASK-4) |
KCNK5
(TASK-2) |
KCNK12
(THIK-2) |
KCNK13
(THIK1) |
M3
|
R
|
N
|
W
|
K
|
P
|
P
|
Q
|
Q
|
Q
|
P
|
S
|
P
|
L
|
G
|
G
|
A
|
T
|
T
|
Q
|
A
|
R
|
T
|
T
|
T
|
E
|
Q
|
D
|
R
|
W
|
W
|
|
D
|
D
|
C
|
V
|
R
|
R
|
K
|
K
|
K
|
L
|
V
|
K
|
K
|
K
|
K
|
|
V
|
V
|
V
|
V
|
A
|
A
|
I
|
I
|
I
|
V
|
L
|
A
|
A
|
P
|
P
|
|
S
|
S
|
S
|
A
|
A
|
A
|
R
|
R
|
R
|
R
|
Q
|
R
|
Q
|
S
|
S
|
|
M
|
M
|
T
|
I
|
L
|
C
|
I
|
I
|
V
|
V
|
V
|
W
|
I
|
V
|
V
|
|
A
|
E
|
E
|
V
|
L
|
W
|
I
|
I
|
I
|
L
|
L
|
L
|
T
|
Y
|
Y
|
|
N
|
N
|
N
|
H
|
Q
|
H
|
S
|
S
|
S
|
S
|
G
|
A
|
C
|
H
|
Y
|
|
M
|
M
|
L
|
A
|
A
|
L
|
T
|
T
|
T
|
A
|
L
|
G
|
T
|
V
|
V
|
|
V
|
V
|
V
|
V
|
V
|
V
|
I
|
I
|
I
|
M
|
A
|
S
|
V
|
L
|
M
|
|
L
|
T
|
V
|
L
|
A
|
A
|
I
|
I
|
L
|
L
|
L
|
G
|
I
|
L
|
L
|
|
I
|
V
|
A
|
L
|
L
|
L
|
F
|
F
|
F
|
F
|
F
|
A
|
F
|
I
|
I
|
|
G
|
G
|
G
|
G
|
G
|
L
|
I
|
I
|
I
|
L
|
L
|
L
|
I
|
L
|
L
|
|
F
|
F
|
L
|
F
|
L
|
G
|
L
|
L
|
L
|
L
|
T
|
L
|
V
|
G
|
C
|
|
F
|
F
|
L
|
V
|
L
|
V
|
F
|
F
|
A
|
I
|
L
|
S
|
W
|
L
|
T
|
|
S
|
S
|
A
|
T
|
V
|
V
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
F
|
A
|
|
C
|
C
|
C
|
V
|
A
|
V
|
C
|
C
|
C
|
C
|
T
|
L
|
V
|
A
|
S
|
|
I
|
M
|
A
|
S
|
S
|
T
|
V
|
V
|
I
|
L
|
L
|
L
|
L
|
V
|
I
|
|
S
|
G
|
A
|
C
|
S
|
V
|
L
|
L
|
V
|
L
|
V
|
L
|
V
|
L
|
L
|
|
T
|
T
|
T
|
F
|
F
|
C
|
F
|
F
|
F
|
F
|
I
|
F
|
H
|
L
|
I
|
|
L
|
L
|
L
|
F
|
V
|
F
|
V
|
V
|
V
|
V
|
L
|
L
|
L
|
S
|
S
|
|
C
|
C
|
A
|
F
|
L
|
L
|
A
|
A
|
T
|
L
|
I
|
L
|
V
|
C
|
C
|
|
I
|
I
|
L
|
I
|
L
|
V
|
L
|
L
|
I
|
T
|
F
|
L
|
I
|
C
|
C
|
|
G
|
G
|
G
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
P
|
A
|
A
|
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
T
|
P
|
P
|
P
|
S
|
S
|
|
A
|
A
|
V
|
A
|
L
|
V
|
I
|
I
|
V
|
F
|
M
|
L
|
F
|
A
|
A
|
|
A
|
A
|
A
|
V
|
V
|
I
|
I
|
I
|
I
|
V
|
V
|
L
|
V
|
M
|
M
|
|
F
|
F
|
F
|
F
|
L
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
Y
|
Y
|
|
S
|
S
|
S
|
S
|
W
|
A
|
K
|
K
|
K
|
C
|
S
|
S
|
M
|
T
|
T
|
|
H
|
Q
|
H
|
V
|
G
|
H
|
H
|
H
|
Y
|
Y
|
H
|
H
|
V
|
S
|
P
|
|
Y
|
C
|
F
|
L
|
L
|
L
|
I
|
I
|
I
|
M
|
V
|
M
|
T
|
V
|
I
|
|
loop
|
E
|
E
|
E
|
E
|
Q
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
E
|
H
|
E
|
G
|
D
|
G
|
E
|
G
|
G
|
G
|
D
|
G
|
G
|
G
|
G
|
G
|
|
-
|
-
|
-
|
D
|
D
|
A
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
Names |
KCNK3
(TASK1, TBAK-1, OAT-1) |
KCNK9
(TASK3) |
KCNK15 |
KCNK1
(TWIK-1) |
KCNK7
|
KCNK6
(TWIK-2, TOSS) |
KCNK2
(short TREK-1) |
KCNK2
(long TREK-1) |
KCNK10
(TREK-2) |
KCNK4
(TRAAK) |
KCNK16
(TALK-1) |
KNCK17
(TALK-2, TASK-4) |
KCNK5
(TASK-2) |
KCNK12
(THIK-2) |
KCNK13
(THIK1) |
P2
|
W
|
W
|
W
|
W
|
C
|
W
|
W
|
W
|
W
|
W
|
W
|
W
|
W
|
W
|
W
|
T
|
S
|
T
|
N
|
S
|
S
|
S
|
S
|
T
|
S
|
S
|
S
|
N
|
D
|
S
|
|
F
|
F
|
F
|
F
|
L
|
F
|
A
|
A
|
A
|
K
|
F
|
Y
|
Y
|
Y
|
Y
|
|
F
|
F
|
F
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
S
|
T
|
I
|
V
|
F
|
|
Q
|
H
|
H
|
E
|
G
|
D
|
D
|
D
|
E
|
E
|
E
|
E
|
E
|
D
|
D
|
|
A
|
A
|
A
|
S
|
A
|
A
|
A
|
A
|
S
|
A
|
G
|
G
|
G
|
S
|
S
|
|
Y
|
Y
|
Y
|
F
|
V
|
F
|
I
|
I
|
I
|
I
|
F
|
F
|
L
|
L
|
L
|
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
|
Y
|
Y
|
Y
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
Y
|
F
|
F
|
|
C
|
C
|
C
|
C
|
C
|
C
|
V
|
V
|
V
|
V
|
A
|
A
|
S
|
C
|
C
|
|
F
|
F
|
F
|
F
|
F
|
F
|
V
|
V
|
V
|
I
|
F
|
F
|
F
|
F
|
F
|
|
I
|
I
|
I
|
I
|
S
|
I
|
I
|
I
|
V
|
V
|
I
|
I
|
I
|
V
|
V
|
|
T
|
T
|
T
|
S
|
S
|
S
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
A
|
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
I
|
F
|
F
|
|
T
|
T
|
T
|
S
|
S
|
S
|
T
|
T
|
T
|
T
|
S
|
S
|
S
|
S
|
S
|
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
T
|
|
I
|
I
|
I
|
I
|
I
|
I
|
I
|
I
|
V
|
V
|
I
|
V
|
I
|
I
|
I
|
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
|
F
|
F
|
F
|
L
|
L
|
L
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
F
|
|
G
|
G
|
G
|
G
|
E
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
|
D
|
D
|
D
|
D
|
D
|
D
|
D
|
D
|
D
|
D
|
D
|
D
|
D
|
D
|
D
|
|
Y
|
Y
|
F
|
Y
|
L
|
Y
|
Y
|
Y
|
F
|
Y
|
Y
|
Y
|
F
|
L
|
L
|
|
V
|
V
|
V
|
V
|
L
|
V
|
V
|
V
|
V
|
V
|
V
|
V
|
V
|
V
|
V
|
|
A
|
A
|
A
|
P
|
P
|
P
|
A
|
A
|
A
|
A
|
V
|
I
|
A
|
S
|
S
|
|
L
|
L
|
L
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
S
|
S
|
|
Q
|
Q
|
Q
|
E
|
R
|
E
|
G
|
G
|
G
|
A
|
T
|
M
|
V
|
Q
|
Q
|
|
K
|
T
|
S
|
G
|
G
|
A
|
-
|
-
|
N
|
-
|
D
|
N
|
N
|
H
|
N
|
|
D
|
K
|
G
|
-
|
R
|
P
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
-
|
-
|
-
|
-
|
S
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
Q
|
G
|
E
|
Y
|
L
|
-
|
S
|
S
|
A
|
D
|
P
|
P
|
P
|
A
|
A
|
|
M4
|
A
|
A
|
A
|
N
|
H
|
G
|
D
|
D
|
G
|
P
|
S
|
S
|
S
|
A
|
H
|
L
|
L
|
L
|
Q
|
P
|
Q
|
I
|
I
|
I
|
R
|
K
|
Q
|
A
|
Y
|
Y
|
|
Q
|
Q
|
Q
|
K
|
V
|
P
|
E
|
E
|
N
|
Q
|
H
|
R
|
N
|
R
|
E
|
|
T
|
K
|
R
|
F
|
I
|
Y
|
Y
|
Y
|
Y
|
D
|
Y
|
Y
|
Y
|
N
|
S
|
|
Q
|
K
|
K
|
R
|
Y
|
R
|
L
|
L
|
R
|
S
|
I
|
P
|
H
|
Q
|
Q
|
|
P
|
P
|
L
|
E
|
H
|
A
|
D
|
D
|
E
|
P
|
S
|
L
|
A
|
G
|
G
|
|
Q
|
L
|
P
|
L
|
L
|
L
|
F
|
F
|
W
|
A
|
V
|
W
|
L
|
L
|
L
|
|
Y
|
Y
|
Y
|
Y
|
G
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
|
V
|
V
|
V
|
K
|
Q
|
K
|
K
|
K
|
K
|
Q
|
R
|
K
|
R
|
R
|
R
|
|
A
|
A
|
A
|
I
|
L
|
V
|
P
|
P
|
P
|
P
|
S
|
N
|
Y
|
L
|
F
|
|
F
|
F
|
F
|
G
|
A
|
L
|
V
|
V
|
L
|
L
|
L
|
M
|
F
|
G
|
A
|
|
S
|
S
|
S
|
I
|
L
|
V
|
V
|
V
|
V
|
V
|
A
|
V
|
V
|
N
|
N
|
|
F
|
F
|
F
|
T
|
L
|
T
|
W
|
W
|
W
|
W
|
A
|
S
|
E
|
F
|
F
|
|
V
|
M
|
L
|
C
|
G
|
V
|
F
|
F
|
F
|
F
|
I
|
L
|
L
|
L
|
V
|
|
Y
|
Y
|
Y
|
Y
|
Y
|
Y
|
W
|
W
|
W
|
W
|
W
|
W
|
W
|
F
|
F
|
|
I
|
I
|
I
|
L
|
L
|
L
|
I
|
I
|
I
|
I
|
I
|
I
|
I
|
I
|
I
|
|
L
|
L
|
L
|
L
|
L
|
F
|
L
|
L
|
L
|
L
|
L
|
L
|
Y
|
L
|
L
|
|
T
|
V
|
L
|
L
|
L
|
L
|
V
|
V
|
V
|
L
|
L
|
F
|
L
|
L
|
M
|
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
G
|
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
L
|
M
|
L
|
V
|
V
|
|
T
|
T
|
T
|
I
|
L
|
V
|
A
|
A
|
A
|
A
|
A
|
A
|
A
|
C
|
C
|
|
V
|
V
|
V
|
A
|
A
|
A
|
Y
|
Y
|
Y
|
Y
|
W
|
W
|
W
|
C
|
C
|
|
I
|
I
|
I
|
M
|
M
|
M
|
F
|
F
|
F
|
F
|
L
|
L
|
L
|
I
|
I
|
|
G
|
G
|
G
|
L
|
L
|
V
|
A
|
A
|
A
|
A
|
A
|
A
|
S
|
Y
|
Y
|
|
A
|
A
|
A
|
V
|
L
|
L
|
A
|
A
|
A
|
S
|
L
|
L
|
L
|
S
|
S
|
|
F
|
F
|
F
|
V
|
A
|
V
|
V
|
V
|
V
|
V
|
I
|
I
|
F
|
L
|
L
|
|
L
|
L
|
L
|
L
|
V
|
L
|
L
|
L
|
L
|
L
|
L
|
I
|
V
|
F
|
F
|
|
N
|
N
|
N
|
E
|
E
|
Q
|
S
|
S
|
S
|
T
|
P
|
K
|
N
|
N
|
N
|
|
L
|
L
|
L
|
T
|
T
|
T
|
M
|
M
|
M
|
T
|
L
|
L
|
W
|
V
|
V
|
|
V
|
V
|
V
|
F
|
F
|
F
|
I
|
I
|
I
|
I
|
G
|
I
|
K
|
I
|
I
|
|
V
|
V
|
V
|
C
|
S
|
R
|
G
|
G
|
G
|
G
|
P
|
L
|
V
|
S
|
S
|
|
L
|
L
|
L
|
E
|
E
|
H
|
D
|
D
|
D
|
N
|
L
|
S
|
S
|
I
|
I
|
|
R
|
R
|
R
|
L
|
L
|
V
|
W
|
W
|
W
|
W
|
L
|
Q
|
M
|
L
|
L
|
|
F
|
F
|
F
|
H
|
P
|
S
|
L
|
L
|
L
|
L
|
L
|
L
|
F
|
I
|
I
|
|
M
|
L
|
L
|
E
|
Q
|
D
|
R
|
R
|
R
|
R
|
H
|
E
|
V
|
K
|
K
|
|
T
|
T
|
V
|
L
|
V
|
L
|
V
|
V
|
V
|
V
|
-
|
T
|
E
|
Q
|
Q
|
|
M
|
M
|
A
|
K
|
R
|
H
|
I
|
I
|
L
|
V
|
-
|
P
|
V
|
V
|
S
|
|
N
|
N
|
S
|
K
|
A
|
G
|
S
|
S
|
S
|
S
|
-
|
G
|
H
|
L
|
L
|
|
A
|
S
|
A
|
F
|
M
|
L
|
K
|
K
|
K
|
R
|
R
|
R
|
K
|
N
|
N
|
|
E
|
E
|
D
|
R
|
G
|
T
|
K
|
K
|
K
|
R
|
C
|
V
|
A
|
W
|
W
|
|
D
|
D
|
W
|
K
|
K
|
E
|
T
|
T
|
T
|
T
|
C
|
C
|
I
|
M
|
I
|
|
E
|
E
|
P
|
M
|
F
|
L
|
K
|
K
|
K
|
R
|
Q
|
S
|
K
|
L
|
L
|
|
K
|
R
|
E
|
F
|
F
|
I
|
E
|
E
|
E
|
A
|
L
|
C
|
K
|
R
|
R
|
|
R
|
R
|
R
|
Y
|
R
|
L
|
E
|
E
|
E
|
E
|
W
|
C
|
R
|
K
|
K
|
|
D
|
D
|
-
|
V
|
P
|
L
|
V
|
V
|
V
|
M
|
L
|
H
|
R
|
L
|
M
|
|
A
|
A
|
-
|
K
|
S
|
P
|
G
|
G
|
G
|
G
|
L
|
H
|
R
|
S
|
D
|
|
E
|
E
|
-
|
-
|
G
|
P
|
E
|
E
|
E
|
G
|
S
|
S
|
R
|
C
|
S
|
|
H
|
E
|
-
|
-
|
-
|
P
|
F
|
F
|
I
|
L
|
L
|
S
|
R
|
R
|
G
|
|
R
|
R
|
-
|
-
|
-
|
C
|
R
|
R
|
K
|
T
|
R
|
K
|
K
|
C
|
C
|
|
A
|
A
|
-
|
-
|
-
|
P
|
A
|
A
|
A
|
A
|
Q
|
E
|
E
|
C
|
C
|
|
L
|
S
|
-
|
-
|
-
|
A
|
H
|
H
|
H
|
Q
|
G
|
D
|
S
|
A
|
P
|
|
L
|
L
|
-
|
-
|
-
|
S
|
A
|
A
|
A
|
A
|
C
|
F
|
F
|
R
|
Q
|
|
T
|
A
|
-
|
-
|
-
|
F
|
A
|
A
|
A
|
A
|
G
|
K
|
E
|
C
|
C
|
|
R
|
G
|
A
|
-
|
-
|
-
|
E
|
E
|
E
|
S
|
A
|
S
|
S
|
C
|
Q
|
|
N
|
N
|
A
|
-
|
-
|
-
|
W
|
W
|
W
|
W
|
K
|
Q
|
S
|
P
|
-
|
Names |
KCNK3
(TASK1, TBAK-1, OAT-1) |
KCNK9
(TASK3) |
KCNK15 |
KCNK1
(TWIK-1) |
KCNK7
|
KCNK6
(TWIK-2, TOSS) |
KCNK2
(short TREK-1) |
KCNK2
(long TREK-1) |
KCNK10
(TREK-2) |
KCNK4
(TRAAK) |
KCNK16
(TALK-1) |
KNCK17
(TALK-2, TASK-4) |
KCNK5
(TASK-2) |
KCNK12
(THIK-2) |
KCNK13
(THIK1) |
C-Terminus
|
G
|
R
|
R
|
-
|
-
|
-
|
T
|
T
|
K
|
T
|
-
|
S
|
P
|
A
|
-
|
Q
|
-
|
-
|
-
|
-
|
-
|
A
|
A
|
A
|
G
|
-
|
W
|
H
|
-
|
-
|
|
A
|
-
|
-
|
-
|
-
|
-
|
N
|
N
|
N
|
T
|
-
|
R
|
S
|
-
|
-
|
|
G
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
R
|
-
|
-
|
|
G
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
K
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
A
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
L
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
Q
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
V
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
K
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
G
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
-
|
-
|
|
G
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
T
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
A
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
K
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
D
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
V
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
N
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
I
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
F
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
F
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
L
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
K
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
K
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
E
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
E
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
T
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
Y
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
N
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
D
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
L
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
I
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
K
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
Q
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
I
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
G
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
K
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
K
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
A
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
M
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
K
|
-
|
-
|
|
G
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
T
|
-
|
-
|
|
G
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
-
|
-
|
|
G
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
G
|
-
|
-
|
|
G
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
G
|
-
|
-
|
|
S
|
N
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
G
|
-
|
-
|
|
A
|
S
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
E
|
-
|
-
|
Names |
KCNK3
(TASK1, TBAK-1, OAT-1) |
KCNK9
(TASK3) |
KCNK15 |
KCNK1
(TWIK-1) |
KCNK7
|
KCNK6
(TWIK-2, TOSS) |
KCNK2
(short TREK-1) |
KCNK2
(long TREK-1) |
KCNK10
(TREK-2) |
KCNK4
(TRAAK) |
KCNK16
(TALK-1) |
KNCK17
(TALK-2, TASK-4) |
KCNK5
(TASK-2) |
KCNK12
(THIK-2) |
KCNK13
(THIK1) |
C-Terminus
|
H
|
M
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
T
|
-
|
-
|
T
|
V
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
G
|
-
|
-
|
|
T
|
I
|
-
|
-
|
-
|
-
|
V
|
V
|
V
|
V
|
A
|
Q
|
P
|
P
|
R
|
|
D
|
H
|
-
|
-
|
-
|
-
|
T
|
T
|
T
|
T
|
A
|
G
|
G
|
G
|
G
|
|
T
|
I
|
P
|
-
|
-
|
-
|
A
|
A
|
A
|
A
|
P
|
P
|
P
|
A
|
L
|
|
A
|
P
|
P
|
-
|
-
|
-
|
E
|
E
|
E
|
R
|
G
|
D
|
G
|
P
|
L
|
|
S
|
E
|
S
|
K
|
P
|
N
|
F
|
F
|
F
|
V
|
R
|
R
|
L
|
L
|
R
|
|
S
|
E
|
-
|
D
|
V
|
A
|
K
|
K
|
R
|
T
|
R
|
E
|
G
|
A
|
S
|
|
T
|
P
|
P
|
K
|
T
|
D
|
E
|
E
|
E
|
Q
|
P
|
P
|
P
|
R
|
R
|
|
A
|
R
|
R
|
D
|
A
|
E
|
T
|
T
|
T
|
R
|
R
|
E
|
Q
|
R
|
R
|
|
A
|
P
|
P
|
E
|
E
|
D
|
R
|
R
|
R
|
A
|
R
|
S
|
G
|
N
|
N
|
|
A
|
S
|
P
|
D
|
D
|
D
|
R
|
R
|
R
|
G
|
G
|
H
|
G
|
A
|
V
|
|
G
|
R
|
G
|
Q
|
Q
|
R
|
R
|
R
|
R
|
P
|
S
|
S
|
G
|
I
|
V
|
|
G
|
P
|
A
|
V
|
G
|
V
|
L
|
L
|
L
|
A
|
-
|
P
|
L
|
T
|
M
|
|
G
|
R
|
P
|
H
|
G
|
D
|
S
|
S
|
S
|
A
|
-
|
Q
|
P
|
P
|
P
|
|
G
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
P
|
-
|
Q
|
A
|
G
|
G
|
|
F
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
R
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
N
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
V
|
Y
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
Y
|
K
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
A
|
A
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
E
|
D
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
V
|
V
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
L
|
P
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
|
H
|
D
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
P
|
-
|
G
|
L
|
-
|
-
|
|
F
|
L
|
-
|
-
|
-
|
-
|
V
|
V
|
V
|
P
|
-
|
-
|
P
|
-
|
-
|
|
Q
|
Q
|
-
|
-
|
-
|
-
|
E
|
E
|
E
|
E
|
-
|
-
|
P
|
-
|
-
|
|
S
|
S
|
-
|
-
|
-
|
-
|
I
|
I
|
I
|
K
|
-
|
-
|
S
|
-
|
-
|
|
M
|
V
|
-
|
-
|
-
|
-
|
Y
|
Y
|
H
|
E
|
-
|
-
|
L
|
-
|
-
|
|
C
|
C
|
-
|
-
|
-
|
-
|
D
|
D
|
D
|
Q
|
-
|
-
|
V
|
-
|
-
|
|
S
|
S
|
-
|
-
|
-
|
-
|
K
|
K
|
K
|
P
|
-
|
-
|
P
|
-
|
-
|
|
C
|
C
|
-
|
-
|
-
|
-
|
F
|
F
|
L
|
L
|
-
|
-
|
L
|
-
|
-
|
|
L
|
T
|
-
|
-
|
-
|
-
|
Q
|
Q
|
Q
|
L
|
-
|
-
|
V
|
-
|
-
|
|
W
|
C
|
-
|
-
|
-
|
-
|
R
|
R
|
R
|
P
|
T
|
C
|
V
|
S
|
S
|
|
Y
|
Y
|
-
|
I
|
I
|
I
|
A
|
A
|
A
|
P
|
A
|
Y
|
Y
|
R
|
V
|
|
K
|
R
|
E
|
I
|
L
|
L
|
T
|
T
|
A
|
P
|
A
|
P
|
S
|
L
|
R
|
|
S
|
S
|
S
|
E
|
G
|
G
|
S
|
S
|
T
|
P
|
R
|
E
|
K
|
R
|
N
|
|
R
|
Q
|
R
|
H
|
Q
|
P
|
I
|
I
|
I
|
C
|
G
|
G
|
N
|
R
|
R
|
|
E
|
D
|
G
|
D
|
D
|
Q
|
K
|
K
|
R
|
P
|
V
|
P
|
R
|
R
|
C
|
|
K
|
-
|
-
|
Q
|
E
|
P
|
-
|
-
|
S
|
A
|
Q
|
M
|
V
|
L
|
N
|
|
L
|
-
|
-
|
L
|
L
|
E
|
-
|
-
|
M
|
Q
|
V
|
G
|
P
|
A
|
I
|
|
Q
|
-
|
-
|
S
|
A
|
S
|
-
|
-
|
E
|
P
|
T
|
I
|
T
|
A
|
S
|
|
Y
|
Y
|
-
|
F
|
L
|
H
|
-
|
-
|
R
|
L
|
P
|
I
|
L
|
L
|
I
|
|
S
|
G
|
-
|
S
|
S
|
Q
|
R
|
R
|
R
|
G
|
Q
|
Q
|
E
|
G
|
E
|
|
I
|
G
|
-
|
S
|
T
|
Q
|
K
|
K
|
R
|
R
|
D
|
H
|
E
|
A
|
T
|
|
P
|
R
|
L
|
I
|
L
|
L
|
L
|
L
|
L
|
P
|
F
|
L
|
V
|
D
|
D
|
|
M
|
S
|
W
|
T
|
P
|
S
|
S
|
S
|
G
|
R
|
P
|
E
|
S
|
P
|
G
|
|
I
|
V
|
L
|
D
|
P
|
A
|
A
|
A
|
L
|
S
|
I
|
P
|
Q
|
A
|
V
|
|
I
|
A
|
P
|
Q
|
A
|
S
|
E
|
E
|
D
|
P
|
S
|
S
|
T
|
A
|
A
|
|
P
|
P
|
R
|
A
|
A
|
S
|
L
|
L
|
Q
|
S
|
K
|
A
|
L
|
R
|
-
|
|
R
|
Q
|
R
|
A
|
P
|
H
|
A
|
A
|
R
|
P
|
K
|
H
|
R
|
D
|
E
|
|
D
|
N
|
P
|
G
|
-
|
-
|
G
|
G
|
A
|
P
|
G
|
A
|
S
|
S
|
S
|
|
L
|
S
|
A
|
M
|
-
|
-
|
N
|
N
|
H
|
E
|
L
|
A
|
K
|
D
|
D
|
|
S
|
F
|
R
|
K
|
-
|
-
|
H
|
H
|
S
|
K
|
G
|
G
|
G
|
A
|
T
|
|
T
|
S
|
S
|
E
|
-
|
-
|
N
|
N
|
L
|
A
|
S
|
C
|
H
|
E
|
D
|
|
S
|
A
|
V
|
D
|
-
|
-
|
Q
|
Q
|
D
|
Q
|
-
|
G
|
V
|
G
|
G
|
|
D
|
K
|
G
|
Q
|
-
|
-
|
E
|
E
|
M
|
L
|
-
|
K
|
S
|
R
|
R
|
|
T
|
L
|
S
|
K
|
-
|
-
|
L
|
L
|
L
|
P
|
-
|
D
|
R
|
R
|
R
|
|
C
|
A
|
A
|
Q
|
A
|
-
|
T
|
T
|
S
|
S
|
-
|
S
|
S
|
L
|
L
|
Names |
KCNK3
(TASK1, TBAK-1, OAT-1) |
KCNK9
(TASK3) |
KCNK15 |
KCNK1
(TWIK-1) |
KCNK7
|
KCNK6
(TWIK-2, TOSS) |
KCNK2
(short TREK-1) |
KCNK2
(long TREK-1) |
KCNK10
(TREK-2) |
KCNK4
(TRAAK) |
KCNK16
(TALK-1) |
KNCK17
(TALK-2, TASK-4) |
KCNK5
(TASK-2) |
KCNK12
(THIK-2) |
KCNK13
(THIK1) |
C-Terminus
|
V
|
P
|
S
|
N
|
S
|
-
|
P
|
P
|
P
|
P
|
-
|
-
|
P
|
S
|
S
|
E
|
H
|
V
|
E
|
G
|
-
|
C
|
C
|
E
|
P
|
-
|
-
|
D
|
G
|
G
|
|
Q
|
Y
|
F
|
P
|
-
|
-
|
R
|
R
|
K
|
T
|
-
|
-
|
E
|
E
|
E
|
|
S
|
F
|
C
|
F
|
-
|
-
|
R
|
R
|
R
|
A
|
-
|
-
|
E
|
L
|
M
|
|
H
|
H
|
H
|
V
|
-
|
-
|
-
|
-
|
S
|
S
|
-
|
-
|
A
|
I
|
I
|
|
S
|
S
|
-
|
-
|
-
|
-
|
-
|
-
|
V
|
-
|
-
|
-
|
V
|
S
|
S
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
F
|
-
|
-
|
-
|
A
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
A
|
-
|
-
|
-
|
R
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
A
|
-
|
-
|
-
|
-
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
L
|
-
|
-
|
-
|
-
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
D
|
-
|
-
|
-
|
A
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
T
|
A
|
-
|
-
|
P
|
M
|
M
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
G
|
L
|
-
|
-
|
E
|
R
|
K
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
R
|
D
|
-
|
-
|
D
|
D
|
D
|
|
S
|
I
|
-
|
-
|
-
|
-
|
-
|
-
|
F
|
Y
|
-
|
-
|
S
|
L
|
L
|
|
P
|
S
|
V
|
A
|
-
|
-
|
-
|
-
|
K
|
P
|
-
|
-
|
S
|
T
|
L
|
|
G
|
Y
|
H
|
T
|
-
|
-
|
-
|
-
|
A
|
S
|
-
|
-
|
P
|
A
|
A
|
|
G
|
K
|
K
|
Q
|
Q
|
T
|
-
|
-
|
S
|
E
|
-
|
-
|
A
|
S
|
A
|
|
G
|
I
|
L
|
S
|
A
|
D
|
-
|
-
|
S
|
N
|
-
|
-
|
P
|
N
|
N
|
|
G
|
E
|
E
|
S
|
P
|
Y
|
T
|
T
|
Q
|
L
|
-
|
-
|
E
|
K
|
K
|
|
R
|
E
|
R
|
A
|
A
|
A
|
L
|
L
|
E
|
A
|
-
|
-
|
V
|
V
|
A
|
|
Y
|
I
|
C
|
C
|
C
|
S
|
S
|
S
|
S
|
F
|
-
|
-
|
F
|
S
|
S
|
|
S
|
S
|
A
|
V
|
-
|
I
|
V
|
V
|
I
|
I
|
-
|
-
|
M
|
L
|
L
|
|
D
|
P
|
R
|
D
|
-
|
P
|
N
|
N
|
N
|
D
|
-
|
-
|
N
|
A
|
A
|
|
T
|
S
|
D
|
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|
-
|
R
|
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|
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|
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|
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|
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|
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|
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|
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|
|
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|
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|
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|
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|
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|
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|
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|
|
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|
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|
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|
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|
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|
D
|
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|
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|
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
R
|
K
|
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|
|
R
|
N
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
Names |
KCNK3
(TASK1, TBAK-1, OAT-1) |
KCNK9
(TASK3) |
KCNK15 |
KCNK1
(TWIK-1) |
KCNK7
|
KCNK6
(TWIK-2, TOSS) |
KCNK2
(short TREK-1) |
KCNK2
(long TREK-1) |
KCNK10
(TREK-2) |
KCNK4
(TRAAK) |
KCNK16
(TALK-1) |
KNCK17
(TALK-2, TASK-4) |
KCNK5
(TASK-2) |
KCNK12
(THIK-2) |
KCNK13
(THIK1) |
C-Terminus
|
S
|
P
|
S
|
-
|
-
|
-
|
T
|
T
|
T
|
Q
|
-
|
-
|
S
|
S
|
S
|
G
|
-
|
-
|
-
|
-
|
-
|
N
|
N
|
K
|
S
|
-
|
-
|
D
|
E
|
E
|
|
A
|
-
|
-
|
-
|
-
|
-
|
E
|
E
|
R
|
E
|
-
|
-
|
E
|
T
|
M
|
|
P
|
-
|
-
|
-
|
-
|
-
|
R
|
R
|
K
|
R
|
-
|
-
|
E
|
A
|
A
|
|
R
|
-
|
-
|
-
|
-
|
-
|
D
|
D
|
N
|
G
|
-
|
-
|
T
|
N
|
N
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
K
|
-
|
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|
-
|
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|
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|
-
|
|
-
|
-
|
-
|
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|
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|
-
|
-
|
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|
D
|
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|
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|
-
|
K
|
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|
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|
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
|
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|
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|
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|
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|
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|
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|
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|
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|
P
|
-
|
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|
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|
N
|
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|
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|
|
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|
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|
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|
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|
-
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
D
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
-
|
-
|
-
|
-
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
Y
|
-
|
-
|
-
|
-
|
-
|
-
|
|
-
|
-
|
-
|
-
|
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|
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|
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|
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|
K
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
-
|
-
|
|
-
|
-
|
-
|
-
|
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|
-
|
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|
-
|
Y
|
-
|
-
|
-
|
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|
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|
-
|
|
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|
-
|
-
|
-
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
C
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
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|
C
|
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|
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|
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|
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|
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|
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|
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|
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|
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|
|
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|
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|
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|
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|
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|
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|
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|
L
|
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|
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|
A
|
Y
|
C
|
|
S
|
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|
P
|
-
|
-
|
-
|
-
|
-
|
A
|
P
|
-
|
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|
K
|
P
|
P
|
|
S
|
S
|
P
|
-
|
-
|
-
|
V
|
V
|
M
|
R
|
-
|
-
|
A
|
R
|
H
|
|
V
|
I
|
S
|
-
|
-
|
-
|
L
|
L
|
L
|
A
|
-
|
-
|
P
|
S
|
Q
|
|
S
|
S
|
S
|
-
|
-
|
-
|
P
|
P
|
T
|
P
|
-
|
-
|
L
|
V
|
T
|
|
T
|
P
|
P
|
-
|
-
|
-
|
P
|
P
|
D
|
R
|
-
|
-
|
N
|
C
|
S
|
|
G
|
G
|
G
|
-
|
-
|
-
|
L
|
L
|
C
|
G
|
-
|
-
|
M
|
V
|
T
|
|
L
|
L
|
V
|
-
|
-
|
-
|
L
|
L
|
I
|
R
|
-
|
-
|
G
|
N
|
L
|
|
H
|
H
|
V
|
-
|
-
|
-
|
K
|
K
|
Q
|
R
|
-
|
-
|
E
|
T
|
A
|
|
S
|
S
|
R
|
-
|
-
|
-
|
T
|
T
|
Q
|
R
|
-
|
-
|
F
|
R
|
R
|
|
L
|
F
|
G
|
-
|
-
|
-
|
E
|
E
|
H
|
P
|
-
|
-
|
P
|
Q
|
D
|
|
S
|
T
|
G
|
-
|
-
|
-
|
S
|
S
|
A
|
N
|
-
|
-
|
S
|
N
|
N
|
|
T
|
D
|
Q
|
-
|
-
|
-
|
I
|
I
|
E
|
P
|
-
|
-
|
S
|
G
|
E
|
Names
|
KCNK3
(TASK1, TBAK-1, OAT-1) |
KCNK9
(TASK3) |
KCNK15 |
KCNK1
(TWIK-1) |
KCNK7
|
KCNK6
(TWIK-2, TOSS) |
KCNK2
(short TREK-1) |
KCNK2
(long TREK-1) |
KCNK10
(TREK-2) |
KCNK4
(TRAAK) |
KCNK16
(TALK-1) |
KNCK17
(TALK-2, TASK-4) |
KCNK5
(TASK-2) |
KCNK12
(THIK-2) |
KCNK13
(THIK1) |
C-Terminus
|
F
|
H
|
A
|
-
|
-
|
-
|
Y
|
Y
|
L
|
P
|
-
|
-
|
S
|
F
|
F
|
R
|
Q
|
P
|
-
|
-
|
-
|
L
|
L
|
E
|
R
|
-
|
-
|
E
|
S
|
S
|
|
G
|
R
|
R
|
-
|
-
|
-
|
N
|
N
|
N
|
K
|
-
|
-
|
S
|
G
|
G
|
|
L
|
L
|
P
|
-
|
-
|
-
|
G
|
G
|
G
|
P
|
-
|
-
|
T
|
G
|
G
|
|
M
|
M
|
G
|
-
|
-
|
-
|
L
|
L
|
M
|
V
|
-
|
-
|
F
|
V
|
V
|
|
K
|
K
|
A
|
-
|
-
|
-
|
T
|
T
|
I
|
R
|
-
|
-
|
T
|
G
|
G
|
|
R
|
R
|
R
|
-
|
-
|
-
|
P
|
P
|
P
|
P
|
-
|
-
|
S
|
A
|
A
|
|
R
|
R
|
W
|
-
|
-
|
-
|
H
|
H
|
T
|
R
|
-
|
-
|
T
|
L
|
F
|
|
S
|
K
|
K
|
-
|
-
|
-
|
C
|
C
|
D
|
G
|
-
|
-
|
E
|
G
|
A
|
|
S
|
S
|
S
|
-
|
-
|
-
|
A
|
A
|
T
|
P
|
-
|
-
|
S
|
I
|
I
|
|
V
|
V
|
I
|
-
|
-
|
-
|
G
|
G
|
K
|
G
|
-
|
-
|
E
|
M
|
M
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
D
|
-
|
-
|
-
|
L
|
N
|
N
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
R
|
-
|
-
|
-
|
S
|
N
|
N
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
E
|
R
|
-
|
-
|
V
|
R
|
R
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
P
|
P
|
-
|
-
|
P
|
L
|
L
|
|
-
|
-
|
-
|
-
|
-
|
-
|
E
|
E
|
E
|
R
|
-
|
-
|
Y
|
A
|
A
|
|
-
|
-
|
-
|
-
|
-
|
-
|
E
|
E
|
N
|
D
|
-
|
-
|
E
|
E
|
E
|
|
-
|
-
|
-
|
-
|
-
|
-
|
I
|
I
|
N
|
K
|
-
|
-
|
Q
|
T
|
T
|
|
-
|
-
|
-
|
-
|
-
|
-
|
A
|
A
|
S
|
G
|
-
|
-
|
L
|
S
|
S
|
|
-
|
-
|
-
|
-
|
-
|
-
|
V
|
V
|
L
|
V
|
-
|
-
|
M
|
A
|
G
|
|
-
|
-
|
-
|
-
|
-
|
-
|
I
|
I
|
L
|
P
|
-
|
-
|
N
|
S
|
D
|
|
-
|
-
|
-
|
-
|
-
|
-
|
E
|
E
|
E
|
V
|
-
|
-
|
E
|
R
|
R
|
|
-
|
-
|
-
|
-
|
-
|
-
|
N
|
N
|
D
|
-
|
-
|
-
|
Y
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
I
|
M
|
R
|
-
|
-
|
-
|
N
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
K
|
K
|
N
|
-
|
-
|
-
|
K
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
A
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
N
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
S
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
P
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
K
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
G
|
-
|
-
|
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
-
|
T
|
-
|
-
|
Sequences alignment : Horizontal | Molecular properties | ||