Nomenclature of the potassium channel superfamily
Last update: 16 / 12 / 2003
Dendrogram of the 71 cloned mammalian K+ channels :
Legend: TM; Transmembrane segment, P; pore
domain
Table of content
FAMILIES:
KCNA Voltage dependent:
shaker related |
KCNH Voltage dependent: eag
related |
KCNAB Voltage dependent: ß
subunit |
KCNJ Inward rectifier |
KCNB Voltage dependent:
shab related |
KCNK Background
channels |
KCNC Voltage dependent:
shaw related |
KCNM Calcium activated: large
conductance |
KCNDVoltage dependent: shal
related |
KCNN Calcium activated:
intermediate and small conductance |
KCNEVoltage dependent: IsK
related |
KCNQ Voltage dependent: KQT
related |
KCNF Voltage dependent: auxillary
subunit |
KCNS Voltage dependent: auxillary
subunit |
KCNG Voltage dependent: auxillary
subunit |
. |
Sources:
UCL
(London) web site: The potassium channel gene family nomenclature
Gutman
GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M,
Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A,
Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon
D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino
S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, & Wymore RS (2003)
"International Union of Pharmacology. XLI. Compendium of Voltage-Gated
Ion Channels: Potassium Channels." Pharmacol Rev 55(4): 583-586.
.
KCNA FAMILY
Assembly: x4
Voltage dependent: shaker
related |
Human gene names |
Channel names
(IUPHAR)
|
Other names |
Chromosomal localization |
KCNA1 |
Kv1.1 |
RBK1, HUK(1), MBK1, RCK1, MK1, HBK1, AEMK |
12p13.3 |
KCNA2 |
Kv1.2 |
MK2, RCK5, NGK1, HuK(IV), BK2, BGK5, XSha2, HBK5, RAK, HK4 |
1p13
|
KCNA3 |
Kv1.3 |
MK3, HLK3, hPCN3, RCK3, RGK5, KV3, MBK3, HuK(III), HGK5, n-channel |
1p13.3 |
KCNA4 |
Kv1.4 |
RCK4, RHK1, HuK(II), HK1, hPCN2, RK4, RK8, MK4 |
11p14.3-15.2 |
KCNA5 |
Kv1.5 |
HK2, hPCN1, KV1, RK3, HCK1, fHK, RMK2, HuK(II) |
12p13.3 |
KCNA6 |
Kv1.6 |
HBK2, RCK2, KV2, MK1.6 |
12p13.3 |
KCNA7 |
Kv1.7 |
HAK6, MK6 |
19q13.3 |
KCNA9 |
withdrawn, see KCNQ1 |
- |
- |
KCNA10 |
Kv1.8 |
Kcn1, KCNA10, Kv1.10 |
1p13.3-22.1 |
Back to beginning
Voltage dependent: ß subunit |
Human gene names |
Channel names |
Other names |
Chromosomal localization |
KCNAB1 |
KvBeta3 |
KCNA1B, hKvb3, Kvb1.3 |
3q26.1 |
KCNAB2 |
KvBeta2 |
KCNA2B, Kvb2.1, Kvb2.2 |
1p36.3 |
KCNAB3 |
|
KCNAB3 |
17p13.1 |
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KCNB FAMILY
Assembly: x4
Voltage dependent: shab
related |
Human gene names |
Channel names |
Other names |
Chromosomal localization |
KCNB1 |
Kv2.1 |
hDRK1, DHK1, MShab, DRK1 |
20q13.11-13.13 |
KCNB2 |
Kv2.2 |
CDRK |
8q12-13 |
KCNB3 |
Kv8.1 |
Kv2.3, HNKA |
8q22.3-22.4 |
Back to beginning
KCNC FAMILY
Assembly: x4
Voltage dependent: shaw
related |
Human gene names |
Channel names (IUPHAR) |
Other names |
Chromosomal localization |
KCNC1 |
Kv3.1 |
NGK2, KV4, Raw2, Raw2a, |
11p14.3-15.2 |
KCNC2 |
Kv3.2 |
RKShIIIA, Raw1, Kv3.2a, rKv3.2b, rKv3.2c |
19q13.3-q13.4 |
KCNC3 |
Kv3.3 |
RKShIIID, Kv3.3b |
19q13.3 |
KCNC4 |
Kv3.4 |
HKShIIIC, Raw3 |
1p21 |
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KCND FAMILY
Assembly: x4
Voltage dependent: shal
related |
Human gene names |
Channel names (IUPHAR) |
Other names |
Chromosomal localization |
KCND1 |
Kv4.1 |
mShal, RShal |
Xp11.23 |
KCND2 |
Kv4.2 |
Shal1, RK5 |
7q31 |
KCND3 |
Kv4.3 |
- |
1p13 |
Back to beginning
KCNE FAMILY
Structure:
Voltage dependent: IsK related |
Human gene names |
Channel names (IUPHAR) |
Other names |
Chromosomal localization |
KCNE1 |
- |
minK/Isk |
21q22.1-q22.2 |
KCNE2 |
- |
MiRP1 |
21q22.1 |
KCNE3 |
- |
MiRP2 |
- |
KCNE4 |
- |
MiRP3 |
- |
KCNE1L |
- |
AMMECR2 |
Xq22.3 |
Back to beginning
KCNF, KCNG FAMILIES
Assembly: x4
Voltage dependent: auxillary subunit |
Human gene names |
Channel names (IUPHAR) |
Other names |
Chromosomal localization |
KCNF1 |
Kv5.1 |
IK8, KH1, KCNF1 |
2p25 |
KCNG1 |
Kv6.1 |
K13, KH2 |
20q13 |
KCNG2 |
Kv6.2 |
KCNF2 |
18q22-18q23 |
KCNG3 |
Kv6.3 |
Kv10.1 |
2p21 |
KCNG4 |
Kv6.4 |
Kv6.3 |
16q24.1 |
Back to beginning
KCNH FAMILY
Assembly: x4
Voltage dependent: eag related |
Human gene names |
Channel names (IUPHAR) |
Other names |
Chromosomal localization |
KCNH1 |
Kv10.1 |
eag1a, eag1b, KCNH1a, KCNH1b, meag, reag |
1q32.1-32.3 |
KCNH2 |
Kv11.1 |
erg1, herg, LQT2, HERG, Hergb |
7q35-36 |
KCNH3 |
Kv12.2 |
BEC1, Elk2 |
12q13 |
KCNH4 |
Kv12.3 |
BEC2, elk1 |
17q21.31 |
KCNH5 |
Kv10.2 |
eag2 |
14q24.3 |
KCNH6 |
Kv11.2 |
erg2, herg2 |
17 |
KCNH7 |
Kv11.3 |
erg3, herg3 |
2q24.3 |
KCNH8 |
Kv12.1 |
elk1, elk3 |
3p24.3 |
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KCNJ FAMILY
Assembly: x4
Inward rectifier |
Human gene names |
Channel names (IUPHAR) |
Other names |
Chromosomal localization |
KCNJ1 |
Kir1.1 |
ROMK1 |
11q24 |
KCNJ2 |
Kir2.1 |
IRK1 |
17q23.1-24.2 |
KCNJ3 |
Kir3.1 |
GIRK1, KGA |
2q24.1 |
KCNJ4 |
Kir2.3 |
IRK3, HIR, HRK1, hIRK2 |
22q13.1 |
KCNJ5 |
Kir3.4 |
CIR, KATP1, GIRK4 |
11q23 |
KCNJ6 |
Kir3.2b, Kir3.2d |
BIR1, GIRK2B, GIRK2D, KATP2 |
21q22.1 |
KCNJ7 |
withdrawn, see KCNJ6 |
- |
- |
KCNJ8 |
Kir6.1 |
uKATP-1 |
12p11.23 |
KCNJ9 |
Kir3.3 |
GIRK3 |
1q21-23 |
KCNJ10 |
Kir4.1, Kir1.2 |
BIR10, KAB-2 |
1q22-23 |
KCNJ11 |
Kir6.2 |
BIR |
11p15.1 |
KCNJ12 |
Kir2.2 |
IRK2 |
17p11.1 |
KCNJ13 |
Kir7.1, Kir1.4 |
- |
2q37 |
KCNJ14 |
Kir2.4 |
IRK4 |
19q13.1-13.3 |
KCNJ15 |
Kir4.2, Kir1.3 |
ROMK3 |
21q22.2 |
KCNJ16 |
Kir5.1 |
BIR9 |
17q23.1-24.2 |
KCNJN1 |
Kir2.2v |
- |
17p11.2-p11.1 |
Back to beginning
KCNK FAMILY
Assembly: x2
Visit
my web site on "Background" or "Leak" or "K2P"
or "Tandem pore" or "Two P domain" Potassium Channels
Background channels |
Human gene names |
Channel names (IUPHAR) |
Other names |
Chromosomal localization |
KCNK1 |
K2p1.1 |
TWIK-1, hOHO, DPK |
1q42-43 |
KCNK2 |
K2p2.1 |
TREK-1, TPKC1 |
1q41 |
KCNK3 |
K2p3.1 |
TASK-1, TBAK-1, OAT-1 |
2p23.3-24.1 |
KCNK4 |
K2p4.1 |
TRAAK |
11q13 |
KCNK5 |
K2p5.1 |
TASK-2 |
6p21 |
KCNK6 |
K2p6.1 |
TWIK-2, TOSS |
19q13.1 |
KCNK7 |
K2p7.1 |
kcnk8 |
11q13 |
KCNK8 |
reserved |
- |
- |
KCNK9 |
K2p9.1 |
TASK-3 |
8q24.3 |
KCNK10 |
K2p10.1 |
TREK-2 |
14q31 |
KCNK11 |
reserved |
- |
- |
KCNK12 |
K2p12.1 |
THIK-2 |
2p22-21 |
KCNK13 |
K2p13.1 |
THIK-1 |
14q24.1-24.3 |
KCNK14 |
reserved |
- |
- |
KCNK15 |
K2p15.1 |
TASK-5, KT3.3 |
20q12 |
KCNK16 |
K2p16.1 |
TALK-1 |
6p21.1-21.2 |
KCNK17 |
K2p17.1 |
TALK-2, TASK-4 |
6p21.1-21.2 |
- |
- |
TRESK |
10 |
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KCNM FAMILY
Calcium-activated: large conductance |
Human gene names |
Channel names (IUPHAR) |
Other names |
Chromosomal localization |
KCNMA1 |
KCa1.1 |
slo, BK, maxi K+ |
10q22 |
KCNMB1 |
- |
hslo-beta |
5q34 |
KCNMB2 |
- |
- |
3q26.2-q27.1 |
KCNMB3 |
- |
- |
3q26.3-q27 |
KCNMB3L |
- |
|
22q11 |
KCNMB4 |
- |
- |
12q |
Back to beginning
KCNN FAMILY
Assembly: x4
Calcium-activated: intermediate
and small conductance |
Human gene names |
Channel names (IUPHAR) |
Other names |
Chromosomal localization |
KCNN1 |
KCa2.1 |
SK1, SKCa1 |
19p13.1 |
KCNN2 |
KCa2.2 |
SK2, SKCa2 |
5q23.1-23.2 |
KCNN3 |
KCa2.3 |
SK3, SKCa3, hKCa3 |
1q21.3 |
KCNN4 |
KCa3.1 |
SK4, Kca4, IKCa1, IK1 |
19q13.2 |
Back to beginning
KCNQ FAMILY
Assembly: x4
Voltage dependent: KQT related |
Human gene names |
Channel names (IUPHAR) |
Other names |
Chromosomal localization |
KCNQ1 |
Kv7.1 |
KCNA9, KVLQT1, LQT1 |
11p15.5 |
KCNQ2 |
Kv7.2 |
KvEBN1 |
20q13.3 |
KCNQ3 |
Kv7.3 |
KvEBN2 |
8q24.22-q24.3 |
KCNQ4 |
Kv7.4 |
- |
1p34 |
KCNQ5 |
Kv7.5 |
- |
6q14 |
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KCNS FAMILY
Assembly: x4
Voltage dependent |
Human gene names |
Channel names (IUPHAR) |
Other names |
Chromosomal localization |
KCNS1 |
Kv9.1 |
- |
20q12-13.2 |
KCNS2 |
Kv9.2 |
- |
8q22 |
KCNS3 |
Kv9.3 |
- |
2p24 |
Back to beginning
KCNT FAMILY
Assembly: x4
Voltage dependent |
Human gene names |
Channel names (IUPHAR) |
Other names |
Chromosomal localization |
KCNT1 |
KCa4.1 |
- |
9q34.3 |
KCNT2 |
KCa4.2 |
Slack, Slo2 |
1q31.3 |
Back to beginning
KCNU FAMILY
Assembly: x4
Voltage dependent |
Human gene names |
Channel names (IUPHAR) |
Other names |
Chromosomal localization |
KCNU1 |
KCa5.1 |
- |
8p11.22 |
Back to beginning
KCNV FAMILY
Assembly: x4
Voltage dependent |
Human gene names |
Channel names (IUPHAR) |
Other names |
Chromosomal localization |
KCNV1 |
Kv8.1 |
KCNB3, Kv2.3 |
8q22.3-8q24.1 |
KCNV2 |
Kv8.2 |
- |
9p24.2 |
Back to beginning
Sources:
UCL (London) web
site: The potassium channel gene family nomenclature
International Union of Pharmacology (IUPHAR): "Compendium of Voltage-gated
Ion Channels", IUPHAR Media Editor