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Last update: 26 / 5 / 2005
Genomic and structural properties of non mammalian K2P
References for non mammalian K2P
Reviews
Saccharomyces cerevisiae : TOK1 /
YKC1 / YORK / DUK1
Drosophila melanogaster : ORK1 (KCNKØ)
Arabidopsis thaliana : KCO1
Caenorhabditis elegans : TWKs
Aplysia californica: AcK2p1, AcK2p2
Please Email me your comments and suggestions
(delete the word NOSPAM): duprat@NOSPAMunice.fr
| Names | Amino acids | Chromosomal localisation | NCBI accession number | Species | Original cloning paper | List of all references |
| TOK1 (YKC1, YORK, DUK1) | 691 | . | U28005 | Saccharomyces cerevisiae | Ketchum et al. (1995) |  |
| ORK1 (KCNKØ) | 618 | 1 | U55321 | Drosophila melanogaster | Goldstein et al. (1996) | |
| KCO1 | 363 | . | X97323 | Arabidopsis thaliana | Czempinski K et al. (1997) | |
| TWK18 | . | . | . | Caenorhabditis elegans | Kunkel et al. (2000) | |
Maser P, Thomine S, Schroeder JI, Ward JM, Hirschi
K, Sze H, Talke IN, Amtmann A, Maathuis FJ, Sanders D, Harper JF, Tchieu J,
Gribskov M, Persans MW, Salt DE, Kim SA & Guerinot ML (2001)
"Phylogenetic relationships within cation transporter families of Arabidopsis."
Plant Physiol. 126(4): 1646-1667.
Very AA & Sentenac H. (2003)
"Molecular mechanisms and regulation of K+ transport in higher plants."
Annu Rev Plant Biol. 54: 575-603.
Saccharomyces cerevisiae : TOK1 / YKC1 / YORK / DUK1
Ketchum KA, Joiner WJ, Sellers
AJ, Kaczmarek LK & Goldstein SA (1995)
“A new family of outwardly
rectifying potassium channel proteins with two pore domains in tandem.”
Nature 376(6542): 690-695.
Zhou XL, Vaillant B, Loukin
SH, Kung C & Saimi Y (1995)
"YKC1 encodes the depolarization-activated K+
channel in the plasma membrane of yeast." FEBS Lett 373(2):170-176
Reid JD, Lukas W, Shafaatian R,
Bertl A, Scheurmann-Kettner C, Guy HR & North RA. (1996)
"The S.
cerevisiae outwardly-rectifying potassium channel (DUK1) identifies a new
family of channels with duplicated pore domains." Receptors Channels. 4(1):
51-62.
Lesage F, Guillemare E, Fink M,
Duprat F, Lazdunski M, Romey G & Barhanin J (1996)
“A
pH-sensitive yeast outward rectifier K+ channel with two pore domains and novel
gating properties.” J Biol Chem 271(8): 4183-4187.
Loukin SH, Vaillant B, Zhou XL,
Spalding EP, Kung C & Saimi Y. (1997)
"Random mutagenesis reveals a
region important for gating of the yeast K+ channel Ykc1." EMBO J. 16(16):
4817-4825.
Vergani P, Miosga T, Jarvis SM
& Blatt MR (1997)
"Extracellular K+ and Ba2+ mediate
voltage-dependent inactivation of the outward-rectifying K+ channel encoded by
the yeast gene TOK1", FEBS Lett 405(3): 337-344
Gray AT, Winegar BD, Leonoudakis
DJ, Forsayeth JR & Yost CS (1998)
"TOK1 is a volatile anesthetic
stimulated K+ channel". Anesthesiology 88(4):1076-1084.
Bertl A, Bihler H, Reid JD, Kettner
C & Slayman CL (1998)
"Physiological characterization of the yeast
plasma membrane outward rectifying K+ channel, DUK1 (TOK1), in situ". J Membr
Biol 162(1): 67-80.
Vergani P, Hamilton D, Jarvis S
& Blatt MR (1998)
“Mutations in the pore regions of the yeast
K+ channel YKC1 affect gating by extracellular K+.” EMBO J 17(24):
7190-8.
Yost CS, Gray AT, Winegar BD &
Leonoudakis D (1998)
"Baseline K+ channels as targets of general
anesthetics: studies of the action of volatile anesthetics on TOK1.", Toxicol
Lett. 23, 100-101:293-300.
Vergani, P. & M. R. Blatt
(1999).
“Mutations in the yeast two pore K+ channel YKC1 identify
functional differences between the pore domains.” FEBS Lett 458(3):
285-291.
Ahmed A, Sesti F, Ilan N, Shih TM,
Sturley SL & Goldstein SA (1999)
"A molecular target for viral
killer toxin: TOK1 potassium channels", Cell 99(3): 283-291.
Fairman C, Zhou X & Kung C
(1999)
"Potassium uptake through the TOK1 K+ channel in the budding
yeast", J Membr Biol 168(2): 149-57
Kindler CH, Yost CS & Gray AT.
(1999)
" Local anesthetic inhibition of baseline potassium channels
with two pore domains in tandem." Anesthesiology. 90(4): 1092-1102.
Loukin SH & Saimi Y
(1999)
"K(+)-dependent composite gating of the yeast K(+) channel,
Tok1.", Biophys J. 77(6): 3060-3070.
Sesti F, Shih TM, Nikolaeva N &
Goldstein SA. (2001)
"Immunity to k1 killer toxin. internal tok1
blockade." Cell 105(5): 637-644.
Saldana C, Naranjo D, Coria
R, Pena A, Vaca L. (2001)
"Splitting the two pore domains from TOK1 results in two cationic channels
with novel functional properties." J Biol Chem. 277(7): 4797-4805.
Loukin SH & Saimi Y
(2002)
"Carboxyl Tail Prevents Yeast K(+) Channel Closure: Proposal of an Integrated
Model of TOK1 Gating." Biophys J. 82(2): 781-792.
Roberts SK. (2003)
"TOK Homologue in Neurospora crassa: First Cloning and Functional Characterization
of an Ion Channel in a Filamentous Fungus." Eukaryot Cell. 2(1): 181-190.
Baev D, Rivetta A, Li XS, Vylkova S, Bashi E,
Slayman CL & Edgerton M (2003)
"Killing of Candida albicans by Human Salivary Histatin 5 Is Modulated,
but Not Determined, by the Potassium Channel TOK1." Infect Immun. 71(6):
3251-3260.
Johansson I & Blatt MR (2005)
"Interactive domains between pore loops of the yeast K + channel TOK1 associate
with extracellular K + sensitivity." Biochem J. Nov 16; [Epub ahead of
print]
Drosophila melanogaster : ORK1 (KCNKØ)
Goldstein SAN, Price LA, Rosenthal
DN & Pausch MH (1996)
"ORK1, a potassium-selective leak channel with
two pore domains cloned from Drosophila melanogaster by expression in
Saccharomyces cerevisiae." Proc Natl Acad Sci U S A. 93(23):13256-13261.
Zilberberg N, Ilan N,
Gonzalez-Colaso R & Goldstein SAN (2000)
"Opening and closing of
KCNKØ potassium leak channels is tightly regulated", J Gen Physiol
116(5): 721-734.
Ilan N & Goldstein SAN
(2001)
"KCNKØ: Single, Cloned Potassium Leak Channels Are
Multi-Ion Pores.", Biophys J. 80(1): 241-253.
Zilberberg N, Ilan N &
Goldstein SAN (2001)
"KCNKØ: Opening and Closing the 2-P-Domain Potassium Leak Channel Entails
"C-Type" Gating of the Outer Pore.", Neuron 32 (4): 635-648.
Note: The human nomenclature KCNKØ has been wrongly use in these papers for a D. melanogaster channel, trying to force this non mammalian channel as the first cloned mammalian 2P domain K+ channel.
Czempinski K, Zimmermann S, Ehrhardt T &
Muller-Rober B (1997)
“New structure and function in plant K+
channels: KCO1, an outward rectifier with a steep Ca2+ dependency .” EMBO
J 16(10): 2565-75.
Schonknecht G, Spoormaker
P, Steinmeyer R, Bruggeman L, Ache P, Dutta R, Reintanz B, Godde M, Hedrich
R & Palme K (2002)
"KCO1 is a component of the slow-vacuolar (SV) ion channel." FEBS
Lett. 511(1-3): 28-32.
Czempinski K, Frachisse JM, Maurel C, Barbier-Brygoo
H & Mueller-Roeber B. (2002)
"Vacuolar membrane localization of the Arabidopsis 'two-pore' K+ channel
KCO1." Plant J. 29(6): 809-820.
Becker
D, Geiger D, Dunkel M, Roller A, Bertl A, Latz A, Carpaneto A, Dietrich P, Roelfsema
MR, Voelker C, Schmidt D, Mueller-Roeber B, Czempinski K & Hedrich R (2004)
"AtTPK4, an Arabidopsis tandem-pore K+ channel, poised to control the pollen
membrane voltage in a pH- and Ca2+-dependent manner." Proc Natl Acad Sci
U S A [Epub ahead of print].
Aubourg
S, Brunaud V, Bruyere C, Cock M, Cooke R, Cottet A, Couloux A, Dehais P, Deleage
G, Duclert A, Echeverria M, Eschbach A, Falconet D, Filippi G, Gaspin C, Geourjon
C, Grienenberger JM, Houlne G, Jamet E, Lechauve F, Leleu O, Leroy P, Mache
R, Meyer C, Nedjari H, Negrutiu I, Orsini V, Peyretaillade E, Pommier C, Raes
J, Risler JL, Riviere S, Rombauts S, Rouze P, Schneider M, Schwob P, Small I,
Soumayet-Kampetenga G, Stankovski D, Toffano C, Tognolli M, Caboche M &
Lecharny A (2005)
"GeneFarm, structural and functional annotation of Arabidopsis gene and
protein families by a network of experts." Nucleic Acids Res 33(Database
Issue): D641-D646.
See also the web site: http://genoplante-info.infobiogen.fr/Genefarm/
Wei A, Jegla T & Salkoff L (1996)
"Eight potassium channel families revealed by the C. elegans genome project."
Neuropharmacology 35(7): 805-829.
Kunkel MT, Johnstone DB, Thomas JH & Salkoff
L (2000)
"Mutants of a temperature-sensitive two-P domain potassium channel" J Neurosci
20: 7517-7524
Salkoff L, Butler A, Fawcett G, Kunkel M, McArdle
C, Paz-y-Mino G, Nonet M, Walton N, Wang ZW, Yuan A & Wei A (2001)
"Evolution tunes the excitability of individual neurons. Neuroscience."
103(4): 853-859.
Aplysia californica: AcK2p1, AcK2p2
Jezzini
SH & Moroz LL. (2004)
"Identification and distribution of a two-pore domain potassium channel
in the CNS of Aplysia californica." Mol Brain Res. 127(1-2): 27-38.
Jezzini
SH, Reagin S, Kohn AB, & Moroz LL. (2006)
"Molecular characterization and expression of a two-pore domain potassium
channel in the CNS of Aplysia californica." Brain Res. 1094(1): 47-56;
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